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Conserved domains on  [gi|1736827932|emb|VVE04710|]
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3-hydroxyacyl-CoA dehydrogenase [Pandoraea cepalis]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase( domain architecture ID 11483206)

3-hydroxyacyl-CoA dehydrogenase (HCDH) catalyzes the NAD-dependent oxidation of 3-hydroxyacyl-CoA to form 3-oxoacyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 16-517 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


:

Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 805.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:PRK08268    6 SIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEALADLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK08268   86 DCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGLATDP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK08268  166 AVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGLDVNH 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 256 PVMESIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRYVDGKQQVPPEAPAPDTLPAsVWVSRADTRGFAAVVELL 335
Cdd:PRK08268  246 AVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYADGAKQPPAEAAPPAALPP-VWVSADVEGDLAALARLL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 336 GATGVTLESGDKPSATALIVVTPLGLDATTCAVEQGLDAARTVAVDTLLPLAGAKRHTLMTTPITTPEARNAAHALFAHG 415
Cdd:PRK08268  325 ERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAAAKRRTLMAAPATSPAARDAAHALFQQD 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 416 GTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVGARQLLTVLRNLQSFYGDQ 495
Cdd:PRK08268  405 GKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQALYGDP 484

                         490       500
                  ....*....|....*....|..
gi 1736827932 496 RYRPSPWLTRRAQLGVSLLTEE 517
Cdd:PRK08268  485 RYRPSPWLRRRAALGLSLRSEE 506
 
Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 16-517 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 805.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:PRK08268    6 SIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEALADLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK08268   86 DCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGLATDP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK08268  166 AVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGLDVNH 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 256 PVMESIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRYVDGKQQVPPEAPAPDTLPAsVWVSRADTRGFAAVVELL 335
Cdd:PRK08268  246 AVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYADGAKQPPAEAAPPAALPP-VWVSADVEGDLAALARLL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 336 GATGVTLESGDKPSATALIVVTPLGLDATTCAVEQGLDAARTVAVDTLLPLAGAKRHTLMTTPITTPEARNAAHALFAHG 415
Cdd:PRK08268  325 ERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAAAKRRTLMAAPATSPAARDAAHALFQQD 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 416 GTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVGARQLLTVLRNLQSFYGDQ 495
Cdd:PRK08268  405 GKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQALYGDP 484

                         490       500
                  ....*....|....*....|..
gi 1736827932 496 RYRPSPWLTRRAQLGVSLLTEE 517
Cdd:PRK08268  485 RYRPSPWLRRRAALGLSLRSEE 506
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 16-297 6.89e-125

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 366.36  E-value: 6.89e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:COG1250     1 EIKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:COG1250    81 DADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:COG1250   161 ETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTAL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1736827932 256 PVMESIYHQFYEEaRFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:COG1250   241 AVLEVLYEALGDP-RYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 20-197 1.69e-75

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 235.90  E-value: 1.69e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  20 LGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLADCQL 99
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDADL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 100 VVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPEVGD 179
Cdd:pfam02737  82 VIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVA 161

                         170
                  ....*....|....*...
gi 1736827932 180 ALLALGQRMGHTAVRCKD 197
Cdd:pfam02737 162 TTVELAKKIGKTPVVVKD 179
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 12-360 4.18e-44

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 166.17  E-value: 4.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  12 APGKTIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVL 91
Cdd:TIGR02441 330 KPQRPVKTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDY 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  92 EDLADCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGL 171
Cdd:TIGR02441 410 SGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHD 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 172 RTAPEVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASfADIDRiLREQAGFRLGTFELLDLTAL 251
Cdd:TIGR02441 490 GTSKDTLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDP-KKLDK-LTTKFGFPVGAATLADEVGV 567

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 252 DVSHPVMESIYHQFYEeaRFRPSPITAVR--FAGGLLGRKVGEGFYRYVDGKQQVPP------EAPAPDTLPASVWVSRA 323
Cdd:TIGR02441 568 DVAEHVAEDLGKAFGE--RFGGGSAELLSelVKAGFLGRKSGKGIFIYQEGKKGSKKvnsdadEILAQYKLPPKAEVSSP 645

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1736827932 324 DTRGFAAVVELLGATGVTLESG--DKPSATALIVVTPLG 360
Cdd:TIGR02441 646 EDIQIRLVSRFVNEAVLCLEEGilASPSEGDIGAVFGLG 684
 
Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 16-517 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 805.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:PRK08268    6 SIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEALADLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK08268   86 DCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGLATDP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK08268  166 AVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGLDVNH 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 256 PVMESIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRYVDGKQQVPPEAPAPDTLPAsVWVSRADTRGFAAVVELL 335
Cdd:PRK08268  246 AVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYADGAKQPPAEAAPPAALPP-VWVSADVEGDLAALARLL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 336 GATGVTLESGDKPSATALIVVTPLGLDATTCAVEQGLDAARTVAVDTLLPLAGAKRHTLMTTPITTPEARNAAHALFAHG 415
Cdd:PRK08268  325 ERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAAAKRRTLMAAPATSPAARDAAHALFQQD 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 416 GTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVGARQLLTVLRNLQSFYGDQ 495
Cdd:PRK08268  405 GKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQALYGDP 484

                         490       500
                  ....*....|....*....|..
gi 1736827932 496 RYRPSPWLTRRAQLGVSLLTEE 517
Cdd:PRK08268  485 RYRPSPWLRRRAALGLSLRSEE 506
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 16-297 6.89e-125

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 366.36  E-value: 6.89e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:COG1250     1 EIKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:COG1250    81 DADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:COG1250   161 ETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTAL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1736827932 256 PVMESIYHQFYEEaRFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:COG1250   241 AVLEVLYEALGDP-RYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 17-308 7.04e-92

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 282.39  E-value: 7.04e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLAD 96
Cdd:PLN02545    4 IKKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLGRIRCTTNLEELRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  97 CQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPE 176
Cdd:PLN02545   84 ADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSDE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 177 VGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSHP 256
Cdd:PLN02545  164 VFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHPMGPLHLADFIGLDTCLS 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1736827932 257 VMEsIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRYVDGKQQVPPEA 308
Cdd:PLN02545  244 IMK-VLHEGLGDSKYRPCPLLVQYVDAGRLGRKSGRGVYHYDGKKRGDPPRL 294
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 16-297 5.59e-91

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 279.54  E-value: 5.59e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:PRK05808    2 GIQKIGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATITKSLDRLVKKGKMTEADKEAALARITGTTDLDDLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK05808   82 DADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATSD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK05808  162 ATHEAVEALAKKIGKTPVEVKNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMKLGCNHPIGPLALADLIGLDTCL 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1736827932 256 PVMEsIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:PRK05808  242 AIME-VLYEGFGDSKYRPCPLLRKMVAAGWLGRKTGRGFYDY 282
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 16-305 6.49e-80

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 251.47  E-value: 6.49e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  16 TIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLA 95
Cdd:PRK07530    3 AIKKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATINGNLARQVAKGKISEEARAAALARISTATDLEDLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK07530   83 DCDLVIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATDE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK07530  163 ATFEAAKEFVTKLGKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLELADFIGLDTCL 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1736827932 256 PVMEsIYHQFYEEARFRPSPITAVRFAGGLLGRKVGEGFYRYvDGKQQVP 305
Cdd:PRK07530  243 SIMQ-VLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDY-RGEVPVP 290
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 20-197 1.69e-75

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 235.90  E-value: 1.69e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  20 LGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLADCQL 99
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDADL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 100 VVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPEVGD 179
Cdd:pfam02737  82 VIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVA 161

                         170
                  ....*....|....*...
gi 1736827932 180 ALLALGQRMGHTAVRCKD 197
Cdd:pfam02737 162 TTVELAKKIGKTPVVVKD 179
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 17-297 1.10e-71

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 229.87  E-value: 1.10e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLAD 96
Cdd:PRK07819    5 IQRVGVVGAGQMGAGIAEVCARAGVDVLVFETTEELATAGRNRIEKSLERAVSRGKLTERERDAALARLRFTTDLGDFAD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  97 CQLVVEAIIEKLDIKRDLFRSLEGIVAA-DAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK07819   85 RQLVIEAVVEDEAVKTEIFAELDKVVTDpDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVTSE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQR-MGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVS 254
Cdd:PRK07819  165 ATVARAEEFASDvLGKQVVRAQDRSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAHPMGPLRLSDLVGLDTV 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1736827932 255 HPVMESIYHQFyEEARFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:PRK07819  245 KAIADSMYEEF-KEPLYAPPPLLLRMVEAGLLGKKSGRGFYTY 286
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
17-304 1.91e-69

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 224.28  E-value: 1.91e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLED-LA 95
Cdd:PRK09260    1 IEKLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLESAQQEIASIFEQGVARGKLTEAARQAALARLSYSLDLKAaVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK09260   81 DADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSH 255
Cdd:PRK09260  161 ETVQVAKEVAEQMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELGDLVGLDTRL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1736827932 256 PVMESIYHQFYEeaRFRPSPITAVRFAGGLLGRKVGEGFYRYVDGKQQV 304
Cdd:PRK09260  241 NNLKYLHETLGE--KYRPAPLLEKYVKAGRLGRKTGRGVYDYTNRENVP 287
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 17-297 4.68e-65

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 213.48  E-value: 4.68e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGkieasSVEATMGRLQACSVLED-LA 95
Cdd:PRK06130    4 IQNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEGALERARGVIERALGVYAPLG-----IASAGMGRIRMEAGLAAaVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK06130   79 GADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRC-KDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRL---GTFELLDLTAL 251
Cdd:PRK06130  159 QTVATTMALLRSIGKRPVLVkKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLaltGPLEQRDMNGL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1736827932 252 DVSHPVMESIYHQFyeEARFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:PRK06130  239 DVHLAVASYLYQDL--ENRTTPSPLLEEKVEAGELGAKSGQGFYAW 282
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 17-289 4.02e-60

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 200.10  E-value: 4.02e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDT---LDKLAAKGKIEASSVEATMGRLQACSVLED 93
Cdd:PRK06035    3 IKVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNAMELIESGpygLRNLVEKGKMSEDEAKAIMARIRTSTSYES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  94 LADCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRT 173
Cdd:PRK06035   83 LSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 174 APEVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDV 253
Cdd:PRK06035  163 SEETFNTTVELSKKIGKIPIEVADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLAFGFPMGPFELMDIIGIDT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1736827932 254 SHPVMESIYHQfYEEARFRPsPITAVRFA-GGLLGRK 289
Cdd:PRK06035  243 VYHIAEYLYEE-TGDPQFIP-PNSLKQMVlNGYVGDK 277
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
24-315 1.53e-47

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 175.44  E-value: 1.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  24 GAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLEDLADCQLVVEA 103
Cdd:PRK11730  320 GAGIMGGGIAYQSASKGVPVIMKDINQKALDLGMTEAAKLLNKQVERGKIDGAKMAGVLSSIRPTLDYAGFERVDVVVEA 399

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 104 IIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPEVGDALLA 183
Cdd:PRK11730  400 VVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRMPLVEVIRGEKTSDETIATVVA 479

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 184 LGQRMGHTAVRCKDMPGFIVNH------AGRGMnteglrVASEGvASFADIDRILREQAGFRLGTFELLDLTALDVSHPV 257
Cdd:PRK11730  480 YASKMGKTPIVVNDCPGFFVNRvlfpyfAGFSQ------LLRDG-ADFRQIDKVMEKQFGWPMGPAYLLDVVGIDTAHHA 552

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1736827932 258 MESIYHQFYEE-ARFRPSPITAVrFAGGLLGRKVGEGFYRYVDGKQQVPPEAPAPDTLP 315
Cdd:PRK11730  553 QAVMAEGFPDRmKKDYRDAIDVL-FEAKRFGQKNGKGFYRYEEDKKGKPKKEVDPAVYE 610
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 12-360 4.18e-44

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 166.17  E-value: 4.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  12 APGKTIDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVL 91
Cdd:TIGR02441 330 KPQRPVKTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDY 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  92 EDLADCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGL 171
Cdd:TIGR02441 410 SGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHD 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 172 RTAPEVGDALLALGQRMGHTAVRCKDMPGFIVNHAGRGMNTEGLRVASEGVASfADIDRiLREQAGFRLGTFELLDLTAL 251
Cdd:TIGR02441 490 GTSKDTLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDP-KKLDK-LTTKFGFPVGAATLADEVGV 567

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 252 DVSHPVMESIYHQFYEeaRFRPSPITAVR--FAGGLLGRKVGEGFYRYVDGKQQVPP------EAPAPDTLPASVWVSRA 323
Cdd:TIGR02441 568 DVAEHVAEDLGKAFGE--RFGGGSAELLSelVKAGFLGRKSGKGIFIYQEGKKGSKKvnsdadEILAQYKLPPKAEVSSP 645

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1736827932 324 DTRGFAAVVELLGATGVTLESG--DKPSATALIVVTPLG 360
Cdd:TIGR02441 646 EDIQIRLVSRFVNEAVLCLEEGilASPSEGDIGAVFGLG 684
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 28-297 3.00e-43

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 155.99  E-value: 3.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  28 MGRGIAQIAAQAGLRVKLYDTNASAVQA-------ALGTLRDTLDKLAAKGKIEASSVEATMGRLQ---ACSVLEDLADC 97
Cdd:PRK08269    1 MGQGIALAFAFAGHDVTLIDFKPRDAAGwraldaeARAEIERTLAALVALGRIDAAQADAVLARIAvvaRDGAADALADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  98 QLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPEV 177
Cdd:PRK08269   81 DLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 178 GDALLALGQRMGHTAVRCKDMPGFIVNH-AGRGMNtEGLRVASEGVASFADIDRILREQAGFR---LGTFELLDLTALDV 253
Cdd:PRK08269  161 VDRLAALLERIGKVPVVCGPSPGYIVPRiQALAMN-EAARMVEEGVASAEDIDKAIRTGFGLRfavLGLLEFIDWGGCDI 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1736827932 254 ----SHPVMESIyhqfyEEARFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:PRK08269  240 lyyaSRYLAGEI-----GPDRFAPPAIVVRNMEEGRDGLRTGAGFYDY 282
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
10-297 1.55e-42

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 161.22  E-value: 1.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  10 ANAPGKTIDVLGIVGAGAMGRGIAQI-AAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQAC 88
Cdd:PRK11154  302 SDAKPRPVNKVGVLGGGLMGGGIAYVtATKAGLPVRIKDINPQGINHALKYSWDLLDKKVKRRHLKPSERDKQMALISGT 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  89 SVLEDLADCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVI 168
Cdd:PRK11154  382 TDYRGFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVI 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 169 DGLRTAPEVGDALLALGQRMGHTAVRCKDMPGFIVNHA-GRGMNtEGLRVASEGVaSFADIDRILREqAGFRLGTFELLD 247
Cdd:PRK11154  462 PHAKTSAETIATTVALAKKQGKTPIVVRDGAGFYVNRIlAPYIN-EAARLLLEGE-PIEHIDAALVK-FGFPVGPITLLD 538

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1736827932 248 LTALDVSHPVMESIYHQFYEeaRFRPSPITAVRFAGGLLGRKVGEGFYRY 297
Cdd:PRK11154  539 EVGIDVGTKIIPILEAALGE--RFSAPAAFDKLLNDDRKGRKNGRGFYLY 586
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
22-297 7.04e-39

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 143.16  E-value: 7.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  22 IVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAAlgtlRDTLDKLAAK-----GKIEASSVEATMGRLQACSVLEDLA- 95
Cdd:PRK08293    8 VAGAGVLGSQIAFQTAFHGFDVTIYDISDEALEKA----KERIAKLADRyvrdlEATKEAPAEAALNRITLTTDLAEAVk 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK08293   84 DADLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEATGRPEKFLALHFANEIWKNNTAEIMGHPGTDP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 176 EVGDALLALGQRMGHTAVRC-KDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVS 254
Cdd:PRK08293  164 EVFDTVVAFAKAIGMVPIVLkKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAPMGPFGILDIVGLDTA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1736827932 255 HPVMEsiyhqFYEEARFRPSPITAVRFA-----GGLLGRKVGEGFYRY 297
Cdd:PRK08293  244 YNITS-----NWAEATDDENAKKAAALLkeyidKGKLGVATGEGFYNY 286
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 21-250 8.34e-35

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 132.86  E-value: 8.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  21 GIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEATMGRLQACSVLED-LADCQL 99
Cdd:PRK06129    6 AIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLADaVADADY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 100 VVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPEVGD 179
Cdd:PRK06129   86 VQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLA 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1736827932 180 ALLALGQRMGHTAVRC-KDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFR---LGTFELLDLTA 250
Cdd:PRK06129  166 RAEALYRAAGQSPVRLrREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRwsfMGPFETIDLNA 240
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 200-297 1.88e-26

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 103.06  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 200 GFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFRLGTFELLDLTALDVSHPVMEsIYHQFYEEARFRPSPITAV 279
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILE-VLAEEFGDRAYRPPPLLEK 79

                          90
                  ....*....|....*...
gi 1736827932 280 RFAGGLLGRKVGEGFYRY 297
Cdd:pfam00725  80 LVEAGRLGRKTGKGFYKY 97
PRK07066 PRK07066
L-carnitine dehydrogenase;
17-243 1.85e-23

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 101.07  E-value: 1.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  17 IDVLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRDTLDKLAAKGKIEASSVEatmgRLQACSVLED-LA 95
Cdd:PRK07066    7 IKTFAAIGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRANVANAWPALERQGLAPGASPA----RLRFVATIEAcVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  96 DCQLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAP 175
Cdd:PRK07066   83 DADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAP 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1736827932 176 EVGDALLALGQRMGHTAVRC-KDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFR---LGTF 243
Cdd:PRK07066  163 EAVDAAMGIYRALGMRPLHVrKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRwsfMGTF 234
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 394-505 2.72e-18

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 85.16  E-value: 2.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 394 LMTTPITTPEARNAAHALFAH-GGTPVtVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLAL 472
Cdd:COG1250   152 VIRGPATSDETVATAVAFARRlGKTPV-VVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFEL 230

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1736827932 473 GDAVGARQLLTVLRNLQSFYGDQRYRPSPWLTR 505
Cdd:COG1250   231 ADLVGLDTALAVLEVLYEALGDPRYRPPPLLKK 263
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 427-510 3.67e-18

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 79.57  E-value: 3.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 427 GFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVGARQLLTVLRNLQSFYGDQRYRPSPWLTRR 506
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILEVLAEEFGDRAYRPPPLLEKL 80


                  ....
gi 1736827932 507 AQLG 510
Cdd:pfam00725  81 VEAG 84
PRK07531 PRK07531
carnitine 3-dehydrogenase;
22-244 1.05e-15

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 79.40  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  22 IVGAGAMGRGIAQIAAQAGLRVKLYDTNASA---VQAALGTLRDTLDKLAakgkieaSSVEATMGRLQACSVLED-LADC 97
Cdd:PRK07531    9 CIGGGVIGGGWAARFLLAGIDVAVFDPHPEAeriIGEVLANAERAYAMLT-------DAPLPPEGRLTFCASLAEaVAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  98 QLVVEAIIEKLDIKRDLFRSLEGIVAADAILASNTSSLSITAIAAACERPERVAGYHFFNPVPLMKVVEVIDGLRTAPE- 176
Cdd:PRK07531   82 DWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGGKTSPEt 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736827932 177 ---VGDALLALGQRMGHTAvrcKDMPGFIVNHAGRGMNTEGLRVASEGVASFADIDRILREQAGFR---LGTFE 244
Cdd:PRK07531  162 irrAKEILREIGMKPVHIA---KEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRwaqMGLFE 232
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 400-511 1.86e-11

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 65.14  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 400 TTPEARNAAHALFAHGGTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVGAR 479
Cdd:PLN02545  160 TSDEVFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHPMGPLHLADFIGLD 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1736827932 480 QLLTVLRNLQSFYGDQRYRPSP---------WLTRRAQLGV 511
Cdd:PLN02545  240 TCLSIMKVLHEGLGDSKYRPCPllvqyvdagRLGRKSGRGV 280
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
394-510 8.24e-11

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 62.89  E-value: 8.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 394 LMTTPITTPEARNAAHALfahgGTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALG 473
Cdd:PRK09260  156 LETSDETVQVAKEVAEQM----GKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELG 231

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1736827932 474 DAVGARQLLTVLRNLQSFYGDqRYRPSPWLTRRAQLG 510
Cdd:PRK09260  232 DLVGLDTRLNNLKYLHETLGE-KYRPAPLLEKYVKAG 267
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 394-510 7.64e-07

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 50.76  E-value: 7.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 394 LMTTPITTPEARNAAHAlFAHGGTPVTVIR--DSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLA 471
Cdd:PRK07819  156 LVPTLVTSEATVARAEE-FASDVLGKQVVRaqDRSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAHPMGPLR 234

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1736827932 472 LGDAVGARQLLTVLRNLQSFYGDQRYRPSPWLTRRAQLG 510
Cdd:PRK07819  235 LSDLVGLDTVKAIADSMYEEFKEPLYAPPPLLLRMVEAG 273
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 400-510 8.37e-06

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 47.85  E-value: 8.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 400 TTPEARNAAHALFAHGG-TPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGY---AKGPLALGDA 475
Cdd:PRK06130  156 TSPQTVATTMALLRSIGkRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIrlaLTGPLEQRDM 235

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1736827932 476 VGarqlLTVLRNLQSF-YGD--QRYRPSPWLTRRAQLG 510
Cdd:PRK06130  236 NG----LDVHLAVASYlYQDleNRTTPSPLLEEKVEAG 269
2-Hacid_dh_C pfam02826
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; This domain is inserted ...
 14-70 8.63e-05

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family pfam00389.


Pssm-ID: 427007 [Multi-domain]  Cd Length: 178  Bit Score: 43.25  E-value: 8.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1736827932  14 GKTidvLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQ--AALGTLRDTLDKLAAK 70
Cdd:pfam02826  36 GKT---VGIIGLGRIGRAVAKRLKAFGMKVIAYDRYPKPEEeeEELGARYVSLDELLAE 91
SerA COG0111
Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism]; ...
 14-70 1.33e-04

Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism]; Phosphoglycerate dehydrogenase or related dehydrogenase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439881 [Multi-domain]  Cd Length: 314  Bit Score: 44.03  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1736827932  14 GKTidvLGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALG--TLRDTLDKLAAK 70
Cdd:COG0111   140 GKT---VGIVGLGRIGRAVARRLRAFGMRVLAYDPSPKPEEAADLgvGLVDSLDELLAE 195
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 399-510 3.03e-04

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 42.69  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 399 ITTPEAR-NAAHALFAHGGTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLALGDAVG 477
Cdd:PRK07530  158 IATDEATfEAAKEFVTKLGKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLELADFIG 237

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1736827932 478 ARQLLTVLRNLQSFYGDQRYRPSP---------WLTRRAQLG 510
Cdd:PRK07530  238 LDTCLSIMQVLHDGLADSKYRPCPllvkyveagWLGRKTGRG 279
fabG PRK05653
3-oxoacyl-ACP reductase FabG;
14-106 1.84e-03

3-oxoacyl-ACP reductase FabG;


Pssm-ID: 235546 [Multi-domain]  Cd Length: 246  Bit Score: 40.14  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932  14 GKTIDVLGivGAGAMGRGIAQIAAQAGLRVKLYDTNASAVQAALGTLRdtldklAAKGKIEASSVEATmgrlqacsvleD 93
Cdd:PRK05653    5 GKTALVTG--ASRGIGRAIALRLAADGAKVVIYDSNEEAAEALAAELR------AAGGEARVLVFDVS-----------D 65

                          90
                  ....*....|...
gi 1736827932  94 LADCQLVVEAIIE 106
Cdd:PRK05653   66 EAAVRALIEAAVE 78
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
395-479 2.02e-03

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 40.31  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736827932 395 MTTPITTPEARNAAHAlFAH--GGTPVTVIRDSAGFVAQRVIATIVNIGADIAQQRIAAPGDIDRAVTLGLGYAKGPLAL 472
Cdd:PRK08293  156 MGHPGTDPEVFDTVVA-FAKaiGMVPIVLKKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAPMGPFGI 234


                  ....*..
gi 1736827932 473 GDAVGAR 479
Cdd:PRK08293  235 LDIVGLD 241
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
20-87 3.32e-03

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 39.73  E-value: 3.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1736827932  20 LGIVGAGAMGRGIAQIAAQAGLRVKLYDTNASAVqaalgtlrdtlDKLAAKGKIEASSVEATMGRLQA 87
Cdd:PRK09599    3 LGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAV-----------EALAEEGATGADSLEELVAKLPA 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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