|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-439 |
0e+00 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 825.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 1 MDST-ISVQPGEAPDSLHRARRAAWGSFAGAVVDWYDFLLYGITAALVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLG 79
Cdd:PRK09952 1 MDSTlISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 80 GIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKA 159
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 160 FYSSGVQVGYGVGLLLSTGLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSqdNAPQMKKR 239
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQH--EQAAAKKR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 240 LPVVEALLRHPGAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRI 319
Cdd:PRK09952 239 IPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 320 YITGALIGTLSGFPFFMALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPF 399
Cdd:PRK09952 319 YITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPF 398
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1790608800 400 IAAALVTFSGGSWHSVALYLTAGCLLSALTALLMKKHPVD 439
Cdd:PRK09952 399 IAAALVTYFGGSWHSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
20-432 |
0e+00 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 512.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 20 RRAAWGSFAGAVVDWYDFLLYGITAALVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMT 99
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 100 VWMMGIATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGL 179
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 180 VSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPqmkkRLPVVEALLRHPGAFLLIIAL 259
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVV----RAPLVEVLRRHWRALLLAIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 260 RLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALE 339
Cdd:cd17369 237 RLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 340 SQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTfSGGSWHSVALYL 419
Cdd:cd17369 317 TGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVA-ATGSWWPVALYL 395
|
410
....*....|...
gi 1790608800 420 TAGCLLSALTALL 432
Cdd:cd17369 396 AALAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
29-426 |
2.89e-162 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 462.90 E-value: 2.89e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 29 GAVVDWYDFLLYGITAALVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATA 108
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 109 CIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTS 188
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 189 DQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQdnapQMKKRLPVVEALLRHPGAFLLIIALRLCELLTMY 268
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEK----HKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 269 IVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILF 348
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1790608800 349 FALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTfSGGSWHSVALYLTAGCLLS 426
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVA-MTGDWYAIGYYLAALALIG 393
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
28-435 |
2.02e-82 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 259.15 E-value: 2.02e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 28 AGAVVDWYDFLLYGITAaLVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIAT 107
Cdd:cd17367 6 VGNLVEWYDWYVYAAFA-LYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 108 ACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLT 187
Cdd:cd17367 85 LVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 188 SDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPQMkkrlpVVEALLRHPGAFLLIIALRLCELLTM 267
Cdd:cd17367 165 GEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAG-----TLRELRRHPRELLLVVGLTAGGTLAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 268 YIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWIL 347
Cdd:cd17367 240 YTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 348 FFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTfSGGSWhSVALYLTAGCLLSA 427
Cdd:cd17367 320 FALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKS-IGHEW-VFFWYVAGLIAISL 397
|
....*...
gi 1790608800 428 LTALLMKK 435
Cdd:cd17367 398 VVYLRMPE 405
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
18-435 |
1.72e-74 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 241.15 E-value: 1.72e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 18 RARRAAWGSFAGAVVDWYDFLLYGITAaLVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLM 97
Cdd:PRK10642 13 KLRKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 98 MTVWMMGIATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLST 177
Cdd:PRK10642 92 ITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 178 GLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFeaQQSQDNAPQMKK-------RLPVVEALLRHP 250
Cdd:PRK10642 172 GVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAF--QQHVDKLEQGDReglqdgpKVSFKEIATKHW 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 251 GAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRIYITGALIGT 328
Cdd:PRK10642 250 RSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMIGML--FVQPVMGLLSDRFGRRPFVILGSVALF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 329 LSGFPFFMALESQSVFWILFFALMLAnIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTfS 408
Cdd:PRK10642 328 VLAIPAFILINSNVIGLIFAGLLMLA-VILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVE-S 404
|
410 420
....*....|....*....|....*..
gi 1790608800 409 GGSWHSVALYLTAGCLLSALTALLMKK 435
Cdd:PRK10642 405 TQNLMMPAYYLMVVAVIGLITGVTMKE 431
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
29-435 |
2.17e-73 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 234.94 E-value: 2.17e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 29 GAVVDWYDFLLYGITAALVfNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATA 108
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 109 CIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTS 188
Cdd:cd17366 86 CIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 189 DQQFLSWGWRLPFLFSVVLVLIALWIRNgmaesqefeaqqsqdnapqmkkrlpvveallrhpgAFLLIIALRLCELLTMY 268
Cdd:cd17366 166 EAQMLDWGWRIPFLIAAPLGLVGLYLRR-----------------------------------PLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 269 IVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILF 348
Cdd:cd17366 211 MLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 349 FALMLANIahdmVVCVQQPM---FTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFSGGSwHSVALYLTAGCLL 425
Cdd:cd17366 291 GLLVLGLL----LSCYTATMastLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNP-LMPAYYLMVAAVV 365
|
410
....*....|
gi 1790608800 426 SALTALLMKK 435
Cdd:cd17366 366 GLVAVLFLTE 375
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-431 |
4.02e-62 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 204.76 E-value: 4.02e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 25 GSFAGAVVDWYDFLLYGITAALVFnreffPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMG 104
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLA-----AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 105 IATACIGLLPSfnqigwwaPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLIS 184
Cdd:cd17316 78 LATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 185 SLTSDqqflSWGWRLPFLFSVVLVLIALWIRNGMaesqefeaqqsqdnapqmkkrlpvveallrhpgafLLIIALRLCEL 264
Cdd:cd17316 150 PLLSG----DWGWRILFLIGALPALLALLLRRRT-----------------------------------LLLILLWFFIS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 265 LTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQsvF 344
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS--P 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 345 WILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVtfSGGSWHSVALYLTAGCL 424
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAI 346
|
....*..
gi 1790608800 425 LSALTAL 431
Cdd:cd17316 347 VALIVAL 353
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
25-434 |
4.42e-61 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 203.76 E-value: 4.42e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 25 GSFAGAVVDWYDFLLYGITAALVfNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMG 104
Cdd:cd17368 3 AATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 105 IATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLIS 184
Cdd:cd17368 82 LGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 185 SLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAqqsqdnAPQMKKRLPVVEALLRHPGAFLLIIALRLCEL 264
Cdd:cd17368 162 LTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLE------RKARPTRRELFALLANNRRIILLGMLLVAGST 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 265 LTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVF 344
Cdd:cd17368 236 VTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 345 WILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFsGGSWHSVALYLTAGCL 424
Cdd:cd17368 316 GRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIEL-TGSPLAPAWYLMGAAL 394
|
410
....*....|
gi 1790608800 425 LSALTALLMK 434
Cdd:cd17368 395 LGLLATLMLR 404
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
2-435 |
5.36e-55 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 188.48 E-value: 5.36e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 2 DSTISVQPGEAPDSLHRARRAAWGSFAGAVVDWYDFLLYGItAALVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGI 81
Cdd:PRK10406 3 ESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSF-CSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 82 IFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFY 161
Cdd:PRK10406 82 LFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 162 SSGVQVGYGVGLLLSTGLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPqmkkrlp 241
Cdd:PRK10406 162 ASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGS------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 242 vVEALLRHPGAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYI 321
Cdd:PRK10406 235 -LKGLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSML 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 322 TGALIGTLSGFPFFMALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIA 401
Cdd:PRK10406 314 CFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVA 393
|
410 420 430
....*....|....*....|....*....|....
gi 1790608800 402 AALVtfSGGSWHSVALYLTAGCLLSALTALLMKK 435
Cdd:PRK10406 394 LSLK--SIGMETAFFWYVTLMAVVAFLVSLMLHR 425
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
35-431 |
1.96e-48 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 171.28 E-value: 1.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 35 YDFLLYGITAALVfNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLP 114
Cdd:PRK15075 29 FDFFLFGFYATAI-AKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFVP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 115 SFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTSDQQFLS 194
Cdd:PRK15075 108 GYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLSPAQMAE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 195 WGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQdnaPQMKKrlpVVEALLRHPGAFLLIIALRLCELLTMYIVTAFA 274
Cdd:PRK15075 188 WGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHR---PSMRE---IFRSLAANWRIVLAGMLMVAMTTVSFYLITVYT 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 275 LNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFW-----ILFF 349
Cdd:PRK15075 262 PTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPALSWLVAAPSFArmlavELWL 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 350 ALMLANIAHDMVVCVqqpmfTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFSG-----GSWHSVAlyltAGCL 424
Cdd:PRK15075 342 SFLYGSYNGAMVVAL-----TEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGdkaapGYWLSFA----AVCG 412
|
....*..
gi 1790608800 425 LSALTAL 431
Cdd:PRK15075 413 LIATLVL 419
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-437 |
6.10e-33 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 128.19 E-value: 6.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 24 WGSFAGAVVDWYDFLLYGITAalvfnreffPQIGPAMGTLAAFA--TFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVW 101
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVL---------PALIAEFGLDEAEAglLGTVTLAGGAIGGILGGILADRFGRVRVLVITIL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 102 MMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVS 181
Cdd:cd17371 73 LFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 182 LISSLTSDQqflsWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSqdnAPQMKKRLPVVEALLRHP--GAFLLIIAL 259
Cdd:cd17371 145 LLFPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARA---ARRHFADRPSLRELFSPPllRTTLLASLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 260 RLCELLTMYIVTAFALNYSTQNLGLPRE------LFLNIGLLVGGLscltipCFAWLADRFGRRRIYITGALIGTLSGFP 333
Cdd:cd17371 218 ATGALGGYYGITTWLPSYLTGERGLSFEgsagylVVTILGGFLGYL------AGGFLADRIGRRNNFALFALGSAISILL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 334 FFMALESQSVFWILFFALMLANIAhdmVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFtPFIAAALVTfsGGSWH 413
Cdd:cd17371 292 YFFLPLSPTLILILGFPLGFFASG---PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLAT--SGSLG 365
|
410 420
....*....|....*....|....
gi 1790608800 414 SVALYLTAGCLLSALTALLMKKHP 437
Cdd:cd17371 366 TAIAVFAAVYYIAGLVLALLLPET 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-437 |
4.46e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 108.81 E-value: 4.46e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 18 RARRAAWGSFAGAVVDWYDFLLYGItaalvfnreFFPQIGPAMG-TLAAFAT-FGVGFLFRPLGGIIFGHFGDRLGRKRM 95
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSV---------LAPPLAEEFGlSAAQLGLlFAIPVLVGALLRIPLGFLVDRFGPRRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 96 LMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLL 175
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 176 STGLVSLIssltsdqqFLSWGWRLPFL-FSVVLVLIALWIRNGMAESQEFEAQQSqdnapqmKKRLPVVEALLRHPgAFL 254
Cdd:COG2223 145 AAFLAPLL--------IAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAGAAAAA-------KASLRDQLEALRDP-RFW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 255 LIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPF 334
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 335 FMALESqsvFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASvVGGGFTPFIAAALVTFSgGSWHS 414
Cdd:COG2223 289 ALALGS---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDAT-GSYTA 363
|
410 420
....*....|....*....|...
gi 1790608800 415 VALYLTAGCLLSALTALLMKKHP 437
Cdd:COG2223 364 AFLVFAVLALVALVLTLLLYRRP 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-435 |
1.80e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 103.80 E-value: 1.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 18 RARRAAWGSFAGAVVDWYDFLLYGItaalvfnreFFPQIGPAMG-TLAAFAT-FGVGFLFRPLGGIIFGHFGDRLGRKRM 95
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSV---------AAPPLQADLGlSAAQLGLlASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 96 LMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLL 175
Cdd:COG2271 78 LAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 176 STGLVSLIssltsdqqFLSWGWRLPFLFSVVLVLIALWIRngmaesqefeaqqsqdnapqmkkrlpvveallrhpgaFLL 255
Cdd:COG2271 150 APPLLGWL--------LAAFGWRAAFLILGLPGLLLALLR-------------------------------------FWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 256 IIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYItgALIGTLSGFPFF 335
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV--LAIGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 336 MALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYqVASVVGGGFTPFIAAALVTFSGgsWHSV 415
Cdd:COG2271 263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDATG--YQAA 339
|
410 420
....*....|....*....|
gi 1790608800 416 ALYLTAGCLLSALTALLMKK 435
Cdd:COG2271 340 FLLLAALALLAALLALLLLR 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-393 |
4.64e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.66 E-value: 4.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 13 PDSLHRARRAAWGSFAGAVVDWYDFLLYGItaalvfnreFFPQIGPAMGTLAAFA--TFGVGFLFRPLGGIIFGHFGDRL 90
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLP---------ALPLIAADLGASPAQAglVVTAYLLGAALGAPLAGRLADRF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 91 GRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYG 170
Cdd:COG2814 73 GRRRVLLLGLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 171 VGLLLSTGLVSLISSLtsdqqflsWGWRLPFLFSVVLVLIALWIRNGMAEsqefeaqqsqDNAPQMKKRLPVVEALLRHP 250
Cdd:COG2814 145 LGPALGPLLGGLLADL--------FGWRWVFLVNAVLALLALLLLLRLLP----------ESRPAARARLRGSLRELLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 251 GAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLS 330
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1790608800 331 GFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVG 393
Cdd:COG2814 287 LLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-338 |
1.18e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.49 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 12 APDSLHRARRAAWGSFAGAVVDWYDFLLYGITAALVfnREFFPQIGPAMGTLAAfatfgVGFLFRPLGGIIFGHFGDRLG 91
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI--AADLGASSAQLGWIVS-----AYLLGRAIGLLLFGRLGDRYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 92 RKRMLMMTVWMMGIATACIGLLPSfnqigwwaPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGV 171
Cdd:COG0477 78 RKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 172 GLLLSTGLVSLISSLtsdqqflsWGWRLPFLFSVVLVLIALWIRNGMAESqefeaqqsqdnapqmkKRLPVVEALLRHPG 251
Cdd:COG0477 150 GLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPES----------------RGLLLALLALALAA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 252 AFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSG 331
Cdd:COG0477 206 LLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLL 285
|
....*..
gi 1790608800 332 FPFFMAL 338
Cdd:COG0477 286 LLLLLLA 292
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
34-404 |
4.55e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 86.17 E-value: 4.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 34 WYDFLLYG-ITAALVFNREFF------PQIGPAMGTLAAFATFGVGflfRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIA 106
Cdd:pfam00083 13 GYDTGVIGaFLTLIDFFKNFGlsksvsSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKKSLLIANVLFVIG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 107 TACIGLlpSFNQIGWWapvLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVsLISSL 186
Cdd:pfam00083 90 AVLQGA--AKGKWSVY---QLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFG-LGLNK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 187 TSDqqflSWGWRLPFLFSVV---LVLIAL------------------------WIRNGMAESQEFEAQQSQDNAPQMKKR 239
Cdd:pfam00083 164 TSN----SDGWRIPLGLQLVpalLLIIGLlflpesprwlvekgrleearevlaKLRGVPDVDRELDEIKDSLEAGQEAEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 240 LPVVEALLRH--PGAFLLIIALRLCELLTMYivtAFALNYST---QNLGLPRELFLNIGllVGGLSCLTIPCFAWLADRF 314
Cdd:pfam00083 240 ASWKELFSTKtrRQRLLIGVMLQIFQQLTGI---NAIFYYSTtifENLGLSDSFLVTII--VGVVNFVFTFIAIFLVDRF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 315 GRRRIYITGALIGTLSGF----PFFMALESQSVFWILF-FALMLANIAHDMVV-CVQQPMFTELFGASYRYSGAGVGYQ- 387
Cdd:pfam00083 315 GRRPLLLLGAAGMAICFVilgiVALLGVSKSDWAGIVAiVFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKAMALATAa 394
|
410
....*....|....*....
gi 1790608800 388 --VASVVGGGFTPFIAAAL 404
Cdd:pfam00083 395 nwLANFLIGFLFPIITDAI 413
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
59-439 |
5.77e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 85.72 E-value: 5.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 59 AMGTLAAFATFgVGFLFRPLGGIIFGHFGDRLGRKRMLMM-TVWMMGIATACIGLLPSFNQIG--WWAPVLLVFLRAVQG 135
Cdd:COG2211 47 LVGLILLVARL-WDAITDPLIGALSDRTRTRWGRRRPWILiGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 136 FAVGGEWggaALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTSDQQflSWGWRLPFL-FSVVLVLIALWI 214
Cdd:COG2211 126 LVNIPYS---ALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALiFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 215 RNGMAESQEFEAQqsqdnapqmKKRLPVVEALLRHPGAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGL 294
Cdd:COG2211 201 FFGTKERPVPEEE---------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 295 LVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQsvFWILFFALMLANIAHDMVVCVQQPMFTELFG 374
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN--LWLLLVLAALAGIGLGAILVLPWAMLADVVD 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 375 ASYRYSG---AGV---GYQVASVVGGGFTPFIAAALVTFSGGSWHSV----------ALYLTAGCLLSALTALLMKKHPV 438
Cdd:COG2211 350 YDEWKTGrrrEGLyfgIFTFAIKLGQALAGALAGLLLALFGYVAGAAqspsaltgirLLFFLLPAVLLLLAALLLLFYPL 429
|
.
gi 1790608800 439 D 439
Cdd:COG2211 430 T 430
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-435 |
1.33e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALL 148
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--------WQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 149 SVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLtsdqqflsWGWRLPFLFSVVLVLIALWIRNGMAEsqefEAQQ 228
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLLLP----EPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 229 SQDNAPQMKKRLPVVEALLRHPGAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFA 308
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 309 WLADRFGRRRIYITGALIGTLSGFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQV 388
Cdd:cd17325 257 KLSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FNT 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1790608800 389 ASVVGGGFTPFIAAALVTFSGGSWhsvALYLTAGCLLSALTALLMKK 435
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFAT---PFLAAAALLLLAAVLFLLLR 375
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
20-409 |
3.94e-16 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 79.97 E-value: 3.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 20 RRAAWGSFAGAVVDWYDFLLygitaalVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMT 99
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFML-------IFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 100 VWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGlllstgl 179
Cdd:PRK12307 90 IVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIG------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 180 vSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPQMKKRLPVVE----ALLRHPGafll 255
Cdd:PRK12307 155 -NIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSlsmkGLFNRAQ---- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 256 iIALRLCELLTMYIVtaFALNYSTQNL--------GLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIG 327
Cdd:PRK12307 230 -FPLTLCVFIVLFSI--FGANWPIFGLlptylageGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 328 TLSGFP-FFMALESQSVFWILFFALMLANIAHDMVVcvqqPMFT-ELFGASYRYSGAGVGYQVASvVGGGFTPFIAAALV 405
Cdd:PRK12307 307 FLFIFPlFRIPQDNYLLLGACLFGLMATNVGVGGLV----PKFLyDYFPLEVRGLGTGLIYNLAA-TSGTFNSMAATWLG 381
|
....
gi 1790608800 406 TFSG 409
Cdd:PRK12307 382 ITMG 385
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
18-404 |
8.98e-16 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 79.36 E-value: 8.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 18 RARRAAWGSFAGAVVDWYDFLLygITAALV-FNREFfpqigpAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRML 96
Cdd:PRK03893 17 AQWKAFSAAWLGYLLDGFDFVL--ITLVLTeVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 97 MMTVWMMGIATACIGLLPsfnqiGWWapVLLVFlRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLS 176
Cdd:PRK03893 89 VISIVLFSVGTLACGFAP-----GYW--TLFIA-RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 177 TGLVSLISSLtsdqqflsWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQsQDNAP---------QMKKRLP------ 241
Cdd:PRK03893 161 AQVYSLVVPV--------WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKH-AGKAPvrtmvdilyRGEHRIInilltl 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 242 -------VVEALLRHPGAFLLIIAL----------------RLCELLTMYIVTAFALNYS--TQNLgLPRELFLNIGLLV 296
Cdd:PRK03893 232 aaaaalwFCFAGNLQNAAIVAVLGLlcaaifisfmvqssgkRWPTGVMLMVVVLFAFLYSwpIQAL-LPTYLKTDLGYDP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 297 GGLS-CLTIPCF---------AWLADRFGRRRIYITGALIGTLSGFPFFmALESQSVFWI---LFFALMLANIAHDMVvc 363
Cdd:PRK03893 311 HTVAnVLFFSGFgaavgccvgGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVWVLgllLFFQQMLGQGISGLL-- 387
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1790608800 364 vqqPMF-TELFGASYRYSGAGVGYQVASvVGGGFTPFIAAAL 404
Cdd:PRK03893 388 ---PKLiGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALI 425
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
69-398 |
3.99e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 3.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALL 148
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 149 SVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSltsdqqflSWGWRLPFLFSVVLVLIALWIrngMAESQEFEAQQ 228
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LFGWRAAFLILAILSLLAAVL---LLLPRPPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 229 SQDNAPQMKKRLPVVEALLRHPGAFLLIIALrLCELLTMYIVTAFALNYSTQnLGLPRELFLNIGLLVGGLSCLTIPCFA 308
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 309 WLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILfFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQV 388
Cdd:pfam07690 257 RLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL-LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-YNT 334
|
330
....*....|
gi 1790608800 389 ASVVGGGFTP 398
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
58-431 |
3.84e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 58 PAMGTLAAFATFGVGflfrpLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapvLLVFLRAVQGFA 137
Cdd:cd17324 34 AQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 138 VGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLtsdqqflsWGWRLPFLFSVVLVLIALWIrng 217
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL--------LGWRAAFLAIAVLALLAALL--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 218 maesQEFEAQQSQDNAPQMKKRLPVVEALLRHPGAFLLIIALrLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVG 297
Cdd:cd17324 170 ----LWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLIT-FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 298 GLSCLTIPCFAWLADRFGRRRIYITGALIgTLSGFPFFMALESqsvFWILFFALMLANIAHDMVVCVQQPMFTELFGASy 377
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPS---PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA- 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1790608800 378 rYSGAGVGYQVASVVGGGFTPFIAAalVTFSGGSWHSVALYLTAGCLLSALTAL 431
Cdd:cd17324 320 -RGLASSLYLAAYNLGGALGAALGG--LVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-432 |
3.39e-13 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 71.20 E-value: 3.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLfrpLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwaPVLLVFlRAVQGFAVGGEWGGAALL 148
Cdd:TIGR00898 136 FFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLVF-RLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 149 SVENAPQGKKAFYSSGVQVGYGVGLLLSTGL---------VSLISSLTSDQQFLSWgWRLP----FLFS------VVLVL 209
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVayfipdwrwLQLAVSLPTFLFFLLS-WFVPesprWLISqgrieeALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 210 IALWIRNGMAESQEFEAQQSQDNApQMKKRLPVVEALLRHPgaflliiALRLCELLTMYIVTAFALNYSTQNLGLPrELF 289
Cdd:TIGR00898 284 QRIAKINGKKLPAEVLSLSLEKDL-SSSKKQYSFLDLFRTP-------NLRKTTLCLMMLWFTTAFSYYGLVLDLG-NLG 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 290 LNI--GLLVGGLSCLTIPCFAWLA-DRFGRR-RIYITGALIGTLSGFPFFMALESQSVFWIL-FFALMLANIAHDMVVcv 364
Cdd:TIGR00898 355 GNIylDLFISGLVELPAKLITLLLiDRLGRRyTMAASLLLAGVALLLLLFVPVDLYFLRTALaVLGKFGITSAFQMVY-- 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1790608800 365 qqpMFT-ELFGASYRYSGAGVGyQVASVVGGGFTPFIAaalvtFSGGSWHSV--ALYLTAGCLLSALTALL 432
Cdd:TIGR00898 433 ---LYTaELYPTVVRNLGVGVC-STMARVGSIISPFLV-----YLGEKWLFLplVLFGGLALLAGILTLFL 494
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-405 |
8.27e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 69.69 E-value: 8.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 17 HRARRAAWGSFAGAVVDWYDFLLYGITAALVfNREFfpQIGPA-MGTLAAFATFGVGFlfrplGGIIFGHFGDRLGRKRM 95
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAI-SAEW--GLDPVqLGFLFSAGLIGMAF-----GALFFGPLADRIGRRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 96 LMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAF----YSSGVQVGYGV 171
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTavglMFCGYPIGAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 172 GLLLSTGLVSLIssltsdqqflswGWRLPFLFSVVLVLIALW-----------------------IRNGMAESQEFEAQQ 228
Cdd:TIGR00895 157 GGFLAGWLIPVF------------GWRSLFYVGGIAPLLLLLllmrflpesidflvskrpetvrrIVNAIAPQMQAEAQS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 229 SQDNAPQMKKRLPVVEALL---RHPGAFLLIIALRLCELLTMYIVTAFaLNYSTQNLGLPRELFLNIGLLVGGLSCLTIP 305
Cdd:TIGR00895 225 ALPEQKSTQGTKRSVFKALfqgKTARITVLLWLLYFMLLVGVYFLTNW-LPKLMVELGFSLSLAATGGALFNFGGVIGSI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 306 CFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILFFALMLANIAHDMVVCVQqpmfTELFGASYRYSGAGVG 385
Cdd:TIGR00895 304 IFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALM----ALFYPTAIRATGVGWA 379
|
410 420
....*....|....*....|
gi 1790608800 386 YQVASvVGGGFTPFIAAALV 405
Cdd:TIGR00895 380 IGIGR-LGAIIGPILAGYLL 398
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
81-434 |
1.85e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 65.28 E-value: 1.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 81 IIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapvLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAF 160
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 161 YSSGVQVGYGVGLLLSTGLVSLISSltsdqqflsWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPQMKKRl 240
Cdd:cd17474 124 AMGLYEAALGLGIAVGPLLGGLLAA---------ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKK- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 241 pvveaLLRHPGAFLLIIALrlceLLTMYIVTAFaLNYSTQNLGLPRELF-LNIGLLVGGLS---CLTIPCFA-WLADRFG 315
Cdd:cd17474 194 -----ALRGRGLLTFLVSA----FLYFFLYFAF-LTYLPFLLELLYGISpIIIGLLFAGWSvllALGSLFVGrLLKKRFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 316 RRRIYITGALIGTLSgfpfFMALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGG 395
Cdd:cd17474 264 ARRILVIGLLLYALS----LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL-YNFVRFLGQA 338
|
330 340 350
....*....|....*....|....*....|....*....
gi 1790608800 396 FTPFIAAALVTFSGGSWhsvaLYLTAGCLLSALTALLMK 434
Cdd:cd17474 339 VGPLLFGLLLEIFGLSA----PFLVGAAIALAAAVLLAL 373
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
65-433 |
1.81e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 58.75 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 65 AFATFGVGFLFrplGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapvLLVFLRAVQGFAVGGEWGG 144
Cdd:cd17317 30 VQTIFFLGVLI---GSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 145 AALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLvsliSSLTSDQQFLSWGWRLPFLFSVVLVLIALWIrngmaesqef 224
Cdd:cd17317 99 GFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALL----AYLIRDWRWLQLAISLPGLLFLLLLWWLPRR---------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 225 eaqqsqdnapqmkkrlpvveallrhpgafllIIALRLCELLTMyiVTAFALNYSTQNLGlpRELFLNIGL--LVGGLSCL 302
Cdd:cd17317 165 -------------------------------TIIVGLIWFVTS--LVYYGLSLNSSNLG--GNLYLNFFLsgLVEIPAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 303 TIPcfaWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILFFalMLANIAHDMVVCVQQPMFTELFGASYRYSGA 382
Cdd:cd17317 210 LAL---LLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLA--LVGKFAISAAFSVIYLYTAELYPTVVRNTGV 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1790608800 383 GVGYQVASvVGGGFTPFIaaalvTFSGGSWHSVALYLTAGC-LLSALTALLM 433
Cdd:cd17317 285 GLCSTVAR-VGAILAPFI-----VLLGKIGPLLPLIIFGVLaLLGGLLTLLL 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
69-431 |
5.90e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.44 E-value: 5.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALL 148
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 149 SVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSltsdqqFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQ 228
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 229 SQDNAPQMKKRLPVVEALLRhPGAFLLIIALrLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFA 308
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKN-PGLWLLLLAI-FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 309 WLADR-FGRRRIYITGALIGTLSGFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRysGAGVGYQ 387
Cdd:cd06174 261 LLSDRlIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR--GTAFGLL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1790608800 388 VASVVGGGFTPFIAAALVTFSGGSWHSVALYLTAGCLLSALTAL 431
Cdd:cd06174 335 NTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
26-404 |
1.04e-08 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 56.96 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 26 SFAGAVVDWYDFLLYGITAALVFNREFFPQIGPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVwMMGI 105
Cdd:TIGR00879 34 AIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIA-LLFV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 106 ATACIGLLPSFnqiGWWAPVLLVFlRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISS 185
Cdd:TIGR00879 113 IGAILMGLAAF---ALSVEMLIVG-RVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 186 LTSDQQF-----LSWGWRLPFLFSVVLVLIALW--IRNGMAESQEFEAQQSQDN---APQMKKRLPVVEALLRHPGAFLL 255
Cdd:TIGR00879 189 LNNTLGWriplgLQLIPAGLLFLGLFFLPESPRwlVGKGRVEEARKSLARLRGTsgeDKELLDELELIDIKRSIEKRSVQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 256 IIALRLCEL-------LTMYIVTAFA---------LNYST---QNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGR 316
Cdd:TIGR00879 269 PSWGSLFSStrrirrrLFLGVVLQWFqqftginaiMYYSPtifENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGR 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 317 RRIYITGALIGTLS----GFPFFMAL--ESQSVFWILFFALMLANIAHDM-VVCVQQPMFTELFGASYRYSG---AGVGY 386
Cdd:TIGR00879 349 RPLLLIGAAGMAIClfvlGILGASFVtgSSKSSGNVAIVFILLFIAFFAMgWGPVPWVIVSEIFPLSLRPKGisiAVAAN 428
|
410
....*....|....*...
gi 1790608800 387 QVASVVGGGFTPFIAAAL 404
Cdd:TIGR00879 429 WLANFIVGFLFPTMLESI 446
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-433 |
7.21e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 7.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 56 IGPAMGTLAAFATFGVGF----------LFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapv 125
Cdd:cd17473 18 IAPALPAIAQHFVPNSELlvpllltlpaLFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY-------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 126 LLVFLRAVQGFAVGGEWGGA-ALLSV--ENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLIssltsdqqflswGWRLPFL 202
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLAtALIGDyfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI------------GWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 203 F----SVVLVLIALWIRNGMAESQEFEAQQSQDNAPQMKKRLPVVEALlrhpgAFLLIIALRLCELLTMYIVTAFALNYS 278
Cdd:cd17473 158 VyllaLPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFL-----AFLAMLLFYVIPIQLPFLLQERGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 279 TQNlglprELFLNIGLLVGGLSCLtipCFAWLADRFGRRRIYITGALIGTLSgfpfFMALESQSVFWILFFALMLANIAH 358
Cdd:cd17473 233 ALI-----GLALAIASLAGAIGAL---LFGRLKRRLGKRRLLAIGFALMALG----FLLLALASGLWVVLLGAILAGLGF 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1790608800 359 DMVVCVQQPMFTELFGASYRysGAGVGYQVASVVGGGF-TPFIAAALVTFSGGswHSVALYLTAG-CLLSALTALLM 433
Cdd:cd17473 301 GLLLPTLNSWAMSLVPPELR--GRAMGIVTSAFFLGQFlSPLVLGPLVNLTGG--LSGAFLILGVlALVLAIVLLLL 373
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-437 |
8.95e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 53.81 E-value: 8.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALL 148
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 149 SVENAPQGKKafySSGVQVGYgVGLLLSTGLVSLISSLTSDQQflswGWRLPFLFS-----VVLVLIALWirngMAESQE 223
Cdd:PRK11551 128 TSEAVGPRLR---GTAVSLMY-CGVPFGGALASVIGVLAAGDA----AWRHIFYVGgvgplLLVPLLMRW----LPESRA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 224 FEAQqsqdnAPQMKKRLPVVEALLRhPGAFLLIIALRLCELLTMyIVTAFALNYSTQNL---GLPR------ELFLNIGl 294
Cdd:PRK11551 196 FAQA-----AGAGKQRAPVLRALFG-EGRATATLLLWISYFFTL-IVLYFLLNWLPSLLvgqGLSRsqaglvQIAFNIG- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 295 lvGGLSCLTIpcfAWLADRFGRRRIyitgaLIGTLSGFPFFMALESQSVFwilFFALMLANIAHDMVVCVQQPMFTELFG 374
Cdd:PRK11551 268 --GALGSLLI---GALMDRLRPRRV-----VLLIYAGILASLAALAAAPS---FAGMLLAGFAAGLFVVGGQSVLYALAP 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 375 ASYRYS--GAGVGYQVA-----SVVGggftPFIAAALVTfSGGSWHSVALYLTAGCLLSALTALLMKKHP 437
Cdd:PRK11551 335 LFYPTQvrGTGVGAAVAvgrlgSMAG----PLLAGQLLA-LGRSTVGVIGASIPVILVAALAALLLVSRP 399
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
166-439 |
9.47e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 53.76 E-value: 9.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 166 QVGYGVGLLLSTGLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDNAPqmkkrLPVVEA 245
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL-----LKSLKA 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 246 LLRHPgAFLLIIALRLCELLTMYIVTAFALNYSTQNLGlPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGAL 325
Cdd:cd17332 217 LLKNR-PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLL 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 326 IGTLsGFPFFMALESQSVFWILFFALmLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASV------VGGGFTPF 399
Cdd:cd17332 295 LAIL-GLLLLFFLPPGNLVLILVLAV-LAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVmtffrkLGLALAGA 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1790608800 400 IAAALVTFSG-----------GSWHSVALYLTAGCLLSALTALLMKKHPVD 439
Cdd:cd17332 373 LVGLILSLAGyvanaaaqsasALNGIRLLIAVLPAVLLLLALILMSFYPLD 423
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
59-357 |
1.16e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.33 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 59 AMGTLAAFATFGVGFLFRPLggiiFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwWAPVLLVFLR------- 131
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-----WLLLLLVALAgigsaaf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 132 ----AVQGFAVGGEWGGAALlsvenapqgkkAFYSSGVQVGYGVGLLLSTGLVSLissltsdQQFLSWGWRLPFLFSVVL 207
Cdd:cd17478 102 hpegARLASQAAGGRRGLAM-----------SIFSVGGNLGFALGPLIAAALVAL-------FGGLGLLILLIIPGLAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 208 VLIALWIRngmaesqefeaqQSQDNAPQMKKRLPVVEALLRHPGAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRE 287
Cdd:cd17478 164 LLLLRLRP------------LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1790608800 288 --LFLNIGLLVGGLSCLTipcFAWLADRFGRRRIyitgaLIGTLSGFPFFMALESQSVFWILFFALMLANIA 357
Cdd:cd17478 232 agLLLSLFLFAGAIGTLI---GGPLSDRFGRRRV-----IIASLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-433 |
1.70e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 61 GTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWAPVLLVFLRAVQGFAVGG 140
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 141 EWGGA--ALLSVENAPQGkKAFYSSGVQVGYGVGLLLSTGLVSLissltsdqqflsWGWRLPFLFSVVLVLIALWIRNGM 218
Cdd:cd06173 112 ARQALlpELVPKEQLVRA-NALNSLATQLARIIGPALGGLLVAL------------LGPGGAFAINALSFLLSALLLLFI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 219 AesQEFEAQQSQDNAPQMKKRLPVVEALLRHPGAFLLIIALRLCELLTMYIVTAFALnYSTQNLGLPRELF------LNI 292
Cdd:cd06173 179 R--RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL-LAKEVLGGGAAGYglllaaFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 293 GLLVGGLSCltipcfAWLADRFGRRRIYITGALIGTLSGFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQPMFTEL 372
Cdd:cd06173 256 GALLGALLL------GRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1790608800 373 FGASYR---YSGAGVGYQVASVVGGGFTPFIAAALvtfsggSWHSVALYLTAGCLLSALTALLM 433
Cdd:cd06173 326 VPDELRgrvFSVYNALNSGAMPLGALLAGLLADAL------GLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-433 |
2.59e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 30 AVVDWYDFLLYGITAALVFnREFfpQIGPA-MGTLAAFATFGVGflfrpLGGIIFGHFGDRLGRKRMLMMTVWMMGIATA 108
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALA-QDW--GLSPAqLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 109 CIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGlllstglvSLISSLTS 188
Cdd:cd17365 80 LTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLG--------AALGGFLA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 189 DQQFLSWGWRLPFLFSVVLVLIAlwirngmaesqefeaqqsqdnapqmkkrLPVVEALLRHPGAF---LLIIALRLCELL 265
Cdd:cd17365 144 AALIPAFGWRSVFLLGGVPPLIL----------------------------LPLLRGTLLLWVTFfmgLLLVYLLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 266 TMYIVTAFALnySTQNLGLpreLFLNIGLLVGGLscltipCFAWLADRFGRRRIYITGALigtLSGFPFFMALESQSVFW 345
Cdd:cd17365 196 KLMVEAGYSL--SQALTIT---LLLNIGGVIGSL------LLGWLADRFGPKRVLALFFA---LGAVSLALLGVSPASLV 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 346 ILFFALMLANIAHDMVVCVQQPMFTELFGASYRysGAGVGYQVA-SVVGGGFTPFIAAALVTfSGGSWHSVALYLTAGCL 424
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGLYALAARFYPTEVR--ATGVGWALGvGRLGAILGPLLGGLLLA-AGLGPESVFLALAIPAA 338
|
....*....
gi 1790608800 425 LSALTALLM 433
Cdd:cd17365 339 LGALAVLLL 347
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
79-215 |
3.42e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 51.89 E-value: 3.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 79 GGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLlpSFNQIGWWAPVLLVFLRAVQGFAVGGEWGGAALLSVENAPQGKK 158
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSAL--SPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1790608800 159 AFYSSGVQVGYGVGLLLStGLVSLISSLTSDQQF-------LSWGWRLPFLFSVVLVLIALWIR 215
Cdd:cd17364 133 GALIAAVFAMQGFGILAG-AIVTLILSAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR 195
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
55-437 |
4.11e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.78 E-value: 4.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 55 QIGPAMGTLAAFAtFGVGFLfrpLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQ 134
Cdd:COG0738 39 GLSDAQAGLLLFA-FFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 135 GFAVGGEWGGAALLSVENAPQgKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTsdqqfLSWGWRLPFL-FSVVLVLIALW 213
Cdd:COG0738 107 GLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLG-----LSLSWHLPYLiLAVLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 214 IRNGMAESQEFEAQQSQDNAPQMKKrlpvveaLLRHPGAFLLIIALrLCELLTMYIVTAFALNYSTQNLGLPREL----- 288
Cdd:COG0738 181 FLRSKLPEIEEEEEEAAGSAASLKS-------LLKNPRLLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATaalgl 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 289 -FLNIGLLVGGLSCltipcfAWLADRFGRRRIYITGALIGTLSGFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQP 367
Cdd:COG0738 253 sLFWGGMTIGRFLG------GFLLKRFGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFS 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1790608800 368 MFTELFGasyRYSGAGVGYQ-VASVVGGGFTPFIAAALVTFSGGSWhsvALYLTAGC-LLSALTALLMKKHP 437
Cdd:COG0738 323 LALDGLG---KRTAAAVSAVlIMGIVGGAIGPPLIGFLADAFGLRA---AFLVPLVCyLLILLLALALKRKR 388
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
67-226 |
5.04e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 51.65 E-value: 5.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 67 ATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWApvLLVFLRAVQGFAVGGEWGGAA 146
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 147 LLSVENAPQGKKAFYSSGVQVGYGVGlLLSTGLVSLISSLTSDQQF----------------LSWGWRLPFLFSVVLVLI 210
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGFG-ILAGAIVALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALL 216
|
170
....*....|....*.
gi 1790608800 211 ALWIRNGMAESQEFEA 226
Cdd:TIGR00887 217 ALYFRLTIPETPRYTA 232
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
67-185 |
7.27e-07 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 50.81 E-value: 7.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 67 ATFGVGFLFrplGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwaPVLLVFlRAVQGFAVGGEWGGAA 146
Cdd:cd17379 40 SSLNLGFLI---GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY-------PWFLIF-RFLQGLFGKGGWMTGY 108
|
90 100 110
....*....|....*....|....*....|....*....
gi 1790608800 147 LLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISS 185
Cdd:cd17379 109 VLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPH 147
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
67-351 |
2.96e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 67 ATFGVGFLfrpLGGIIFGHFGDRLGRKRMLMmtvWMMGIATACIGLLPSFNQIGWWAPvllvfLRAVQGFAVGGEWGGAA 146
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFA---AGAAITAVSVLLLALTDSPWVWFL-----LRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 147 LLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTSdqqflswgwrLPFLFSVVLVLIALWIrNGMAESQEFEA 226
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA----------LPFLIAAVLLLLALVP-LLLTRRAAPEI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 227 QQSQdnapqmkkRLPVVEALLRHPGAFLLIIALRLCE--LLTMYIVTAFALNYSTQNLGLPrelflnIGLLVGGLSCLTI 304
Cdd:cd17477 176 EEAE--------SISLRRLLRIAPLALLGAFVAGFLEgaFYSLLPLYGLRLGLSVAQAALL------LAAFVLGGLLLQW 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1790608800 305 PcFAWLADRFGRRRIYITGALIGTLSGFPFFMALESQSVFWILFFAL 351
Cdd:cd17477 242 P-LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW 287
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
171-439 |
3.03e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 49.23 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 171 VGLLLSTGLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIR-NGMAESQEFEAQQSQDNAPQmKKRLPVVEALLRH 249
Cdd:pfam13347 145 GGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITaAGTKERVSMRSKEDTGQKEA-GSLLDMLKEVFRN 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 250 PgAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRElFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIgTL 329
Cdd:pfam13347 224 R-AFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA-ASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALI-TI 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 330 SGFPFFMALESQSVfWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSG---AGVGYQVASVV---GGGFTPFIAAA 403
Cdd:pfam13347 301 AGFALALLLGPNNT-LLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGkrrEGTFFAMWSFIsklATGVGLGVSGL 379
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1790608800 404 LVTFSGGSWHSVA-----------LYLTAGCLLSALTALLMKKHPVD 439
Cdd:pfam13347 380 LLSAFGYNAGDSVqspqavtairlLYAVLPAVLFLVALLLLYFYPLD 426
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
40-353 |
5.83e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.39 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 40 YGITAALVFNREFFpQIGPAMGTLAAFAtFGVGFLfrpLGGIIFGHFGDRLGRKRMLM--MTVWmmGIATACIGLLPSFn 117
Cdd:cd17328 16 FTIAGVLPDIQSDF-LIDDSLAGLLQTV-FIISYM---VLSPIFGYLGDRYNRKWILAvgILIW--SAATLLSSFAPNF- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 118 qigWWapvlLVFLRAVQGFavgGEWGGAAL---LSVENAPQGKK----AFYSSGVQVGYGVGLLLStglvSLISSLTSDQ 190
Cdd:cd17328 88 ---WQ----LLLFRALVGI---GEASYSPIaptIIADLFPKEKRtralGVFYFAIPLGSGLGYVVG----GLVAQATGGW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 191 QflsWGWRLPFLFSVVLVLIALWI----RNGMAESQEFEAQQSQDNAPQMKkrlpvveALLRHPgAFLLIIALRLCELLT 266
Cdd:cd17328 154 R---WAFRVTGVLGVLLAILLLLFvrepPRGAAEGGVMAKSTATSFLADLK-------ALAKNP-SFILSTLGFTAVSFV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 267 MYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLT----IPCFAWLADRFGRR--RIYITGALIGTLSGFPF-FMALE 339
Cdd:cd17328 223 TGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKtpRADPLVCAVGLLAAAPFlFLALV 302
|
330
....*....|....
gi 1790608800 340 SQSVFWILFFALML 353
Cdd:cd17328 303 LALSNLLLAWVLLF 316
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-437 |
9.03e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 9.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 256 IIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFF 335
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 336 MAlesqSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGgsWHSV 415
Cdd:pfam07690 81 FA----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFG--WRAA 153
|
170 180
....*....|....*....|..
gi 1790608800 416 ALYLTAGCLLSALTALLMKKHP 437
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPP 175
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
78-222 |
1.41e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.80 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGK 157
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1790608800 158 KAFYSSGVQVGYGVGLLLSTgLVSLISSLTSdqqflSWGWRLPFLFSVVLVLIALWIRNGMAESQ 222
Cdd:cd17315 121 RGALGTLNQLMITFGILLAY-LLGLALSLSP-----PGWWRLMFALAAVPALLQLLLMFFLPESR 179
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
82-434 |
1.63e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.80 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 82 IFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwaPVLLVFlRAVQGFAVGGEWGGAALLSVENAPQ---GKK 158
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL-------PVLIAG-RALQGIGGAVFPLAFALVREEFPPErvpVAQ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 159 AFYSSGVQVGYGVGLLLSTGLVslissltsdqQFLSWGWRLPFLFSVVLVLIALwirngmaesqefeaqqsqdnAPQMKK 238
Cdd:cd17504 122 GILSATFGIGAGIGLPLGGWIV----------QHLGWRWIFWTAAPVAVLLAAL--------------------VPLIDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 239 RlpvveaLLRHPGAFLLIIALrlceLLTMyiVTAFALNYSTQNLG-LPRELFLNIGLLVGGLSCLTI--------PCFAW 309
Cdd:cd17504 172 R------LLRRRNVLLANITA----LLAG--FGMFMVFQLLPQLLqLPTPTGFGLGITEAGLLLLPGalvmliagPLAGR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 310 LADRFGRRRIYITGALIGTLSGfpFFMALESQSVFWI--------LFFALMLANIAHDMVVCVQQPMFTELFGASY--RY 379
Cdd:cd17504 240 LIARVGPRRVLLIGLVISAVGL--LLLALLHSSLWALvvallligIGLGLAFASLPNIVVESVPPDRTGIATGMNTvlRT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1790608800 380 SGAGVGYQVASVVGGGFTPFIAAALVTfSGGSWHSVALYLTAGCLLSALTALLMK 434
Cdd:cd17504 318 IGSAIGPAIAGAILTTYTVSITSGGVP-TEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
69-433 |
1.96e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 69 FGVGFLFRPLGGIIFGHFGDRLGRKRML--MMTVWmmGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAA 146
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLavSMLLW--SLFTALTGFATSL--------TSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 147 LLSVENAPQGKKA----FYSSGVQVGYGVGLLLSTGLVSLissltsdqqflsWGWRLPFLFSVVLVLIALWIrngmaesq 222
Cdd:cd17319 114 KALAEWFPARERGratgLFNSGAPLGAAIGPPLSGWLLLL------------FGWRWAFIIEGLLGLLLAVL-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 223 efeaqqsqdnapqmkkrlpvveALLRHPgAFLLIIALRLCELLTMYIVTAFALNYSTQNLGLPRE---LFLNIGLLVGGL 299
Cdd:cd17319 174 ----------------------WWFYLR-QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKqvgLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 300 SCLTIPcfaWLADRF--GRRRIYITGALIGTLSGFPFFMALESqsvFWILFFALMLANIAHDMVVCVQQPMFTELFGASY 377
Cdd:cd17319 231 GMILGG---RLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTS---PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1790608800 378 RYSGAGVgYQVASVVGGGFTPFIAAALVTFSgGSWHSVALYLTAGCLLSALTALLM 433
Cdd:cd17319 305 AATAGGL-INSGGNLGGFVAPLLIGYLVDAT-GSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
78-219 |
2.00e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 46.26 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwaPVLLVFlRAVQGFAVGGEWGGAALLSVENAPQGK 157
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF-------PIYCVF-RFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1790608800 158 KAFYSSGVQVGYGVGLLLSTGLVSLIssltSDQQFLSWGWRLPFLFS---------VVLVLIALWIRNGMA 219
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAI----RDWRWLQLAVSLPFFIFflyswwfprITFCLSLVWFSTSFA 186
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
78-439 |
2.24e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.40 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGewGGAALLSVENAPQGK 157
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAV--GNVLLPGLIKRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 158 K-----AFYSSGVQVGYGVGLLLSTGLVSlissltsdqqflSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQSQDN 232
Cdd:COG2807 138 RvglmtGLYTAAMGLGAALAAGLTVPLAA------------ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 233 APqmkkrlpvVEALLRHPGAFLLIIALRLCeLLTMYIVTAFALNYSTQnLGLPRE---LFLNIGLLVGGLSCLTIPcfaW 309
Cdd:COG2807 206 AS--------LRSLWRSPLAWLLTLFFGLQ-SLLYYAVVAWLPPILRD-AGLSAAtagLLLSLFQLAGIPGSLLVP---L 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 310 LADRFGRRRIYITGALIGTLSGFPFFMALESQS-VFWILFFALMLANIahdMVVCvqqPMFTELFGASYRYSGAGVGY-Q 387
Cdd:COG2807 273 LADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLpWLWAVLLGLGQGGL---FPLA---LTLIGLRARTPAEAAALSGMaQ 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1790608800 388 VASVVGGGFTPFIAAALVTFSgGSWHSVALYLTAGCLLSALTALLMKKHPVD 439
Cdd:COG2807 347 SVGYLLAALGPLLVGALHDAT-GSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-214 |
2.49e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 60 MGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVG 139
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--------WLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1790608800 140 GEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSltsdqqflSWGWRLPFLFSVVLVLIALWI 214
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD--------AFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
78-433 |
4.15e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.64 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEwGGAALLSVENAPQGK 157
Cdd:cd17320 49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAG-SVVARAIVRDLYSGA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 158 KAFYSSGVqvgygvgLLLSTGLVSLISSLTSDQQFLSWGWRLPFLF-----SVVLVLIALWIRngmaesqefEAQQSQDN 232
Cdd:cd17320 120 ELAKIFSL-------LMMILAIAPALAPLLGGLLLLFFGWRAIFVFlallgLLLLLLVLLFLP---------ETLPEEKR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 233 APQMKKRLPVVEALLRHPG--AFLLIIALRLCELLTMYIVTAFALnysTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWL 310
Cdd:cd17320 184 KPLLSSLLRAYKRVLKNRRflGYALALGLSFAGLFAYLAAAPFIY---IEQLGLSPAQFGLLFALNAIALILGSLLNGRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 311 ADRFGRRRIYITGALIGTLSGFPFF-MALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGasyrySGAGVgyqvA 389
Cdd:cd17320 261 VRRFGPRRLLRLGLLLLLAAALVLLlAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-----HVAGT----A 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1790608800 390 SVVGGGFTPFIAAALVTFSGGSWHSVALYLTAGCLLSALTALLM 433
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
77-214 |
6.07e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.97 E-value: 6.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 77 PLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGAALLSVENAPQG 156
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1790608800 157 KKAFYSSGVQVGYGVGLLLSTGLVSLIssltSDQQFLSWGWRLPFLFSVVLVLIALWI 214
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGLAYAI----RDWRLLQLVVSVPFFLFFLYSWWLPKR 174
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
78-433 |
1.31e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWApVLLVFLRAVQgfavggEWGGAALLSVENAPQGK 157
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGFGGGLF------EPASEAMIADVTTPENR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 158 KAFYSS---GVQVGYGVGLLLSTGLVSLISSLTsdqqFLswgwrLPFLFSVVLVLIALWIRNgmaESQEFEAQQSQDNAP 234
Cdd:cd17329 123 TRAFSLlywAINLGVAIGPLLGGLLLLYSFRLL----FL-----AAAVLFLLAALVLLFLLP---ETRPKRRAAEKTEIL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 235 QMKKRlpvveaLLRHPGAFLLIIALRLCELLTMYIVTAFALnYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRF 314
Cdd:cd17329 191 RGYKI------VLRDRAFLLFLLASFLISLIYFQLESTLPV-YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERF 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 315 GRRRIYITGALIGTLSgfpfFMALESQSVFWILFFALMLANIAHDMVVCVQQPMFTELFGASYR--YSGAgvgYQVASVV 392
Cdd:cd17329 264 RLRKILMIGILLFAIG----FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRgsYMGF---YALAWGL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1790608800 393 GGGFTPFIAAALVTFSGGSWhsVALYLTAGCLLSALTALLM 433
Cdd:cd17329 337 GRAIGPLVGGLLLDLLGPGL--PWLILAALGLIAAALLLGL 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
81-411 |
1.75e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 81 IIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSfnqigwwaPVLLVFLRAVQGFavggewGGAALLSVENA------P 154
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGI------GAAAIMPASLAliaatfP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 155 QGKK----AFYSSGVQVGYGVGLLLSTGLVSLissltsdqqflsWGWRLPFLFSVVLVLIALWIrnGMAESqefeaqqsq 230
Cdd:cd17321 115 GERRgralGLWGAVVGIGAALGPLLGGLLLEL------------FGWRWIFLINVPIGLVALLL--ARTFS--------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 231 dnapqmkkrlpvveallrhpGAFLLIIALRLCELLTMYIVTAF---ALNYSTQNLGLpRELFLNIGLLVGGlscltiPCF 307
Cdd:cd17321 172 --------------------GAVLAAFLLGAALGGLLFLLPLYlqgVLGYSPLQAGL-ALLPLALAMLVAA------PLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 308 AWLADRFGRRRIYITGALIGTLsGFPFFMALESQSVFWILFFALMLANIAhdmVVCVQQPMFTE-LFGASYRYSGAGVG- 385
Cdd:cd17321 225 GRLADRFGPRLVLVAGLLLTAV-GLLLLALLGADSSVWLLLPGLVLLGLG---LGLFATPLTNAaLSSVPKEKAGAASGi 300
|
330 340
....*....|....*....|....*.
gi 1790608800 386 YQVASVVGGGFTPFIAAALVTFSGGS 411
Cdd:cd17321 301 LNTARQLGGALGVALLGALLTAGLSA 326
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
84-354 |
2.41e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 84 GHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKK----A 159
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRgaamG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 160 FYSSGVQVGYGVGLLLSTGLVSlissltsdqqflSWGWRLPFLFSVVLVLIALWIrngmaesqefeaqqsqdnapqmkkr 239
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTD------------NLSWRWIFYINLPIGILALLL------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 240 LPVVE-ALLRHPG---AFLLIIALRLCELLTMYIVTafalNYSTQNLGLPRelfLNIGLLV---GGLSCLTIPCFAWLAD 312
Cdd:cd17503 167 APLLDlRLFKDRNftlGLLLSFLLGLGLFGAMFLLP----LYLQNVLGYSA---FESGLVLapgGLASAILSPLVGRLLD 239
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1790608800 313 RFGRRRIYITGALIGTLSGFPFFMALESQSVFWILFFALMLA 354
Cdd:cd17503 240 KFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRG 281
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
268-439 |
2.85e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 268 YIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMAlesqSVFWIL 347
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA----PSFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 348 FFALMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGGSWHSVALYLTAGCLLSA 427
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAA 166
|
170
....*....|..
gi 1790608800 428 LTALLMKKHPVD 439
Cdd:cd06174 167 ILLLLVVPDPPE 178
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
78-210 |
3.17e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 42.72 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapvLLVFLRAVQGFAVGGEWGGAALLSVENAPQGK 157
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1790608800 158 KAFYSSGVQVGYGVGLLLSTglvsLISSLTSDqqfLSWGWRLPFLFSVVLVLI 210
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGY----VSGYAFAD---VVGGWRYMYGLAAPPALL 171
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
68-333 |
6.53e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 6.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 68 TFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigWWapvlLVFLRAVQGFaVGGEWGGAAL 147
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNV----WQ----LLILRLLQGV-FSGYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 148 LSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSLTsdqqflswGWRLPFLF-SVVLVLIALWIRNGMAEsqEFEA 226
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF--------GIRNVFFItGGLLFLAFLLTLFFVKE--DFKP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 227 QQSQdnapQMKKRLPVVEALLRHPGAFLLIIALRLCEL--------LTMYIVTafaLNYSTQNLGLPRELFLNIgllVGG 298
Cdd:cd17391 182 VEKK----KMVSTKEVWNSVPNPSLLISLFVTTFIIQLanqsiepiLTLYIRQ---LMGDASNLAFISGLVFSA---TGV 251
|
250 260 270
....*....|....*....|....*....|....*
gi 1790608800 299 LSCLTIPCFAWLADRFGRRRIYITGALIGTLSGFP 333
Cdd:cd17391 252 SSLLSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
292-437 |
1.12e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 292 IGLLVGGLS---CLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMAlesqSVFWILFFALMLANIAHDMVVCVQQPM 368
Cdd:cd17325 33 IGLIVAAYAlaqLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA----TSYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1790608800 369 FTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGgsWHSVALYLTAGCLLSALTALLMKKHP 437
Cdd:cd17325 109 IADIAPPEERGRAMGI-FSSAIGLGFLIGPLLGGLLADALG--YRAPFLVCAALALLALVLALLLLPEP 174
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
78-408 |
1.20e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.01 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 78 LGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNqigwwapvLLVFLRAVQGFAVGGEWGGAALLSVENAPQGK 157
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT--------IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 158 KAFYSSGVQVGYGVGLLLSTGLVSLISSLTSDQQFLSWGWRLPFLFSVVLVLIALWIRNGMAESQEFEAQQsqdnapqmk 237
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSK--------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 238 krlpvveallrhpGAFLLIIALRLCeLLTMYIVTAFALNYST---QNLGLPRE--LFLNIGllVGGLSCLTIPCFAWLAD 312
Cdd:cd17359 194 -------------GKPILIIGIGLA-IFQQFVGINVIFYYGPeifQNAGFSENaaLLQTIG--IGVVNVIFTIIAILLVD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 313 RFGRRRIYITGALIGTLS----GFPFFMALESQSVFWILFFALMLANIAHDMVVC-VQQPMFTELFGASYRYSGAGVgyq 387
Cdd:cd17359 258 KVGRKPLLLIGSIGMAISllliGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGpVTWVLLSEIFPNRIRGLAMGI--- 334
|
330 340
....*....|....*....|.
gi 1790608800 388 vasvvgGGFTPFIAAALVTFS 408
Cdd:cd17359 335 ------AVFFLWIANFLVSLT 349
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
289-404 |
1.47e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.41 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 289 FLNIGLLVGGLScltipcFAWLADRFGRRRIYITGALIGTLSGfpFFMALeSQSVFWILFFALMLANIAHD--MVVCVqq 366
Cdd:cd17379 41 SLNLGFLIGSIV------IGYLADRFGRKVCFLISILGNGVSG--VLMAF-SPNYPWFLIFRFLQGLFGKGgwMTGYV-- 109
|
90 100 110
....*....|....*....|....*....|....*...
gi 1790608800 367 pMFTELFGASYRYSgAGVGYQVASVVGGGFTPFIAAAL 404
Cdd:cd17379 110 -LVTEFVGSKYRRT-VGIVYQMFFTLGLLILPGIAYFI 145
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
81-219 |
1.76e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 81 IIFGHFGDRLGRKRMLMmtvWMMGIATACIGLLPSFNQIGWWApvlLVFLRAVQGFAVGGEWGGAALLSVENAPQGKKAF 160
Cdd:cd17318 74 IPGGYLAEKYGAKRVLG---YSILITALLTLLTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1790608800 161 YSSGVQVGYGVGLLLSTGLVSLISSltsdqqflSWGWrlPFLF----SVVLVLIALWIRNGMA 219
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCE--------SLGW--PSIFyifgGLGLLWCLLWFFLVLP 200
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
89-363 |
1.78e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 89 RLGRKRML--MMTVWmmGIATACIGLLPSFNQigwwapvlLVFLRAVQGFAVGGEWGG-AALLSV--ENAPQGKK-AFYS 162
Cdd:cd17327 67 RFPPSKWLsvFIVLW--GLLTLLTAAVKNFGG--------LIALRFFLGLFESGVFPGfILYLGMwyKREEQAKRiAFFY 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 163 SGVQVGYGVGLLLSTGLVSLISSLTsdqqfLSwGWRLPFLF-----SVVLVLIALWIRNGMAES-----QEFE-----AQ 227
Cdd:cd17327 137 AAAGLGSIFGGLLAYGVFKILGVGG-----LA-GWRWLFIIeglitIIIGLVIFFWLPDNPSKAwflteEEKElaverLR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 228 QSQDNAPQMKKRLPVVEALLRHPGAFLLIIALRLCELlTMYIVTAFAL---------NYSTQNLGLPrelflnigllVGG 298
Cdd:cd17327 211 ANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQI-TNNGISNFLPlilkslgfySLQTNLLSVP----------IGA 279
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1790608800 299 LSCLTIPCFAWLADRFGRRRIYITGALIGTLSGfpFFMALESQSVFWILFFALMLANIAHDMVVC 363
Cdd:cd17327 280 LGAVSLLIAALLSDRFKKRGLFAIFACVLALVG--SIILLAAPNPPGAYFAAYILGGGSYAGFPI 342
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-428 |
3.22e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 63 LAAFATFGVGFLFRPLGGIIfghfGDRLGRKRMLMMTVWMMGIATacIGLLPSFNqigwwaPVLLVFLRAVQGFAVGGEW 142
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRL----LDRFGRKRLLLIGLLIFALAT--LLYLLATS------VALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 143 GGAALLSVENAPQGKKA----FYSSGVQVGYGVGLLLSTGLVSLissltsdqqflsWGWRLPFLFSVVLVLIALWIRNGM 218
Cdd:cd17489 103 TAAATLVADIIPPSRRGegigYYGLATTLAMALGPALGLFLYQH------------LGFAVLFIVAAVLALLALLLVFLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 219 AEsQEFEAQQSQDNAPQMKKRLPVVEALLrhPGAFLLIIALRLCELLTMYIVTAFALNYStqnlglprelflNIGL---L 295
Cdd:cd17489 171 KD-PPPVAAEEAEAGTRAFRRLVEKKVLP--PALILFLASIAYGAISTFLPLYAAERGIS------------NAGLfftV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 296 VGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSgfpfFMALESQSVFWILFFALMLANIAHDMVvcvqQPMFTELFGA 375
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG----LLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQALAVD 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1790608800 376 SYRYSGAGVG---YQVASVVGGGFTPFIAAALVTFSGgswHSVALYLTAGCLLSAL 428
Cdd:cd17489 308 LVPPHRRGAAngtFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLAAVVVLLAL 360
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
66-212 |
3.89e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.63 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 66 FATFGVGFLFrplGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFnqigwwapVLLVFLRAVQGFAVGGEWGGA 145
Cdd:TIGR00880 4 LAGYALGQLI---YSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNI--------TVLIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1790608800 146 ALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSltsdqqflSWGWRLPFLFSVVLVLIAL 212
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQ--------FLGWRAPFLFLAILALAAF 131
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
261-364 |
4.36e-03 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 39.38 E-value: 4.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 261 LCELLTMYIVTAFALNYSTQNLGLPR--ELFLNIGLLVGGLscLTIPCFAWLADRFGRRRIYITGALIGTLSGFPFFMAl 338
Cdd:PRK09848 238 LCVLISTFAVSASSLFYVRYVLNDTGlfTVLVLVQNLVGTV--ASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWV- 314
|
90 100
....*....|....*....|....*.
gi 1790608800 339 eSQSVFWILFFALMLANIAHDMVVCV 364
Cdd:PRK09848 315 -SVWSLPVALVALAIASIGQGVTMTV 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
60-177 |
4.58e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 60 MGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMMTVWMMGIATACIGLLPSFNQIGWWAPVLLVFlravqGFAVG 139
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-----GFGFG 306
|
90 100 110
....*....|....*....|....*....|....*...
gi 1790608800 140 GEWGGAALLSVENAPQGKKAFYSSGVQVGYGVGLLLST 177
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
255-432 |
4.82e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 255 LIIALRLCELLTMYIVTAFALNYSTQNLGlPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRIYITGALIGTLSgfpF 334
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG---S 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 335 FMALESQSVFWILfFALMLANIAHDMVVCVqQPMFTELFGASYRYSGAGVGYqVASVVGGGFTPFIAAALVTFSGGSWHS 414
Cdd:cd06179 77 IVAGTAKSVNMLI-GGQALIGIGAGTQGLG-AAVASELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAGWRW 153
|
170
....*....|....*...
gi 1790608800 415 VaLYLTAGclLSALTALL 432
Cdd:cd06179 154 I-FYINAI--FNALALIL 168
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
34-409 |
5.32e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 34 WYDFLLYGITAALVfnreffPQIGPAMGTLAAFATFGVGFLF------RPLGGIIFGHFGDRLGRKRMLMMTVWMMGIAT 107
Cdd:cd17333 2 YISFFSNGLTDALL------GILGPSLEEAFNLNVADVSVIFssqnagYLIGSLLAGFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 108 ACIGLLPSFnqigWWAPVLLVFLRAVQGFAVGGewggaALLSVENAPQGKKAFYSSGVQVGYGVGLLLSTGLVSLISSlt 187
Cdd:cd17333 76 ALIFATPSI----YLFVVLMFLAGLGAGILDTG-----ANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLT-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 188 sdqQFLSWGWRLPFLFSVVLVLIALWIRngmaeSQEFEAQQSQDNAPQMKKRLPVVEALLRHPGAFLLIIALrLCELLTM 267
Cdd:cd17333 145 ---SELSWSWAYLIIGLIYLLLAILILL-----TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL-FLYVGAE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1790608800 268 YIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRR---IYITGALIG--TLSGFPFFMALESQS 342
Cdd:cd17333 216 TAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTllvLSGSGALLGllILLLAPTLVVGLVAT 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1790608800 343 VFWILFFALMLANIAHDMVVCVQQpmftelfgasyrYSGAGVGYQVAS-VVGGGFTPFIAAALVTFSG 409
Cdd:cd17333 296 ALLGLFMAALFPTILSLGISNLPY------------AKGKGTSVLLAAgSIGGAIIPFIMGFIAEAVG 351
|
|
| |
