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Conserved domains on  [gi|1659293175|emb|VME59165|]
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transcriptional regulator MutR [Streptococcus pneumoniae]

Protein Classification

RGG_Cterm family protein( domain architecture ID 10019825)

RGG_Cterm family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-287 1.25e-76

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


:

Pssm-ID: 273772  Cd Length: 220  Bit Score: 232.54  E-value: 1.25e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175  63 DKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQReqlekSKSSTTPLYFELNWILLQGLICQRDASYDMKQDDLDKVAD 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLS-----KISETKETYNRLNKAVIKARLHTLDHSYILSEEEVEFLTD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175 143 YLFKTEEWTMYELILFGNLYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFEAYTE 222
Cdd:TIGR01716  76 YLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLEKLE 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1659293175 223 KIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAMHIFDVLGLPEQVAYYQEHYEKFVKS 287
Cdd:TIGR01716 156 KILDPEDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
 
Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-287 1.25e-76

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


Pssm-ID: 273772  Cd Length: 220  Bit Score: 232.54  E-value: 1.25e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175  63 DKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQReqlekSKSSTTPLYFELNWILLQGLICQRDASYDMKQDDLDKVAD 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLS-----KISETKETYNRLNKAVIKARLHTLDHSYILSEEEVEFLTD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175 143 YLFKTEEWTMYELILFGNLYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFEAYTE 222
Cdd:TIGR01716  76 YLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLEKLE 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1659293175 223 KIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAMHIFDVLGLPEQVAYYQEHYEKFVKS 287
Cdd:TIGR01716 156 KILDPEDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
 
Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-287 1.25e-76

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


Pssm-ID: 273772  Cd Length: 220  Bit Score: 232.54  E-value: 1.25e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175  63 DKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQReqlekSKSSTTPLYFELNWILLQGLICQRDASYDMKQDDLDKVAD 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLS-----KISETKETYNRLNKAVIKARLHTLDHSYILSEEEVEFLTD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1659293175 143 YLFKTEEWTMYELILFGNLYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFEAYTE 222
Cdd:TIGR01716  76 YLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLEKLE 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1659293175 223 KIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAMHIFDVLGLPEQVAYYQEHYEKFVKS 287
Cdd:TIGR01716 156 KILDPEDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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