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Conserved domains on  [gi|1613408358|emb|VHG69840|]
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Protein dltB [Streptococcus pyogenes]

Protein Classification

D-alanyl-lipoteichoic acid biosynthesis protein DltB( domain architecture ID 10024434)

D-alanyl-lipoteichoic acid biosynthesis protein DltB is involved in the D-alanylation of lipoteichoic acid (LTA), which plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
12-408 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274974  Cd Length: 380  Bit Score: 532.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  12 EPYGNPIYFVYLILAFLPVIIGIFKQKRLSTYETLVSLVFILFMFGGDHYQqLVAFLFYLLWQIISVFAYQKYREKANSA 91
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKWQ-LIALILYVIWQTLLVKGYLAYRKKKNSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  92 GVFYLAIAMALFPLIWVKVAPLTGPSSqtLFSFLGISYLTFKSIGMIIEMRDGTLQEVRLPDFIRFMIFFPTFSSGPIDR 171
Cdd:TIGR04091  80 WVFYLAVFLSILPLVLVKVSPLFPLHS--LLGFLGISYLTFKAVQIIIEIRDGLIKEISLWDFLYFLLFFPTISSGPIDR 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 172 FRRFQEDYHKLPERDDYLAMLNKAVMYLMLGFLYKHIISYCLGGILLPLLENKALmvggyFNKETILVMYVYGLNLFFDF 251
Cdd:TIGR04091 158 SRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDAL-----FFWNLLGYMYAYSFYLFFDF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 252 AGYSMFAIGISYLLGIRTPENFNMSFLSASLKDFWNRWHMSLSFWFRDYVFMRLVHLLIKHKTFKNRNVTSGVAYLVNML 331
Cdd:TIGR04091 233 AGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKNRLTTSNVAYLINML 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1613408358 332 VMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRHRKKKglsplfqsrAFHVLCIVVTFHVVMFSLLLFSGFL 408
Cdd:TIGR04091 313 IMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNK---------WTKALSIFVTFHLVCFGFLIFSGFL 380
 
Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
12-408 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274974  Cd Length: 380  Bit Score: 532.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  12 EPYGNPIYFVYLILAFLPVIIGIFKQKRLSTYETLVSLVFILFMFGGDHYQqLVAFLFYLLWQIISVFAYQKYREKANSA 91
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKWQ-LIALILYVIWQTLLVKGYLAYRKKKNSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  92 GVFYLAIAMALFPLIWVKVAPLTGPSSqtLFSFLGISYLTFKSIGMIIEMRDGTLQEVRLPDFIRFMIFFPTFSSGPIDR 171
Cdd:TIGR04091  80 WVFYLAVFLSILPLVLVKVSPLFPLHS--LLGFLGISYLTFKAVQIIIEIRDGLIKEISLWDFLYFLLFFPTISSGPIDR 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 172 FRRFQEDYHKLPERDDYLAMLNKAVMYLMLGFLYKHIISYCLGGILLPLLENKALmvggyFNKETILVMYVYGLNLFFDF 251
Cdd:TIGR04091 158 SRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDAL-----FFWNLLGYMYAYSFYLFFDF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 252 AGYSMFAIGISYLLGIRTPENFNMSFLSASLKDFWNRWHMSLSFWFRDYVFMRLVHLLIKHKTFKNRNVTSGVAYLVNML 331
Cdd:TIGR04091 233 AGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKNRLTTSNVAYLINML 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1613408358 332 VMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRHRKKKglsplfqsrAFHVLCIVVTFHVVMFSLLLFSGFL 408
Cdd:TIGR04091 313 IMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNK---------WTKALSIFVTFHLVCFGFLIFSGFL 380
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
25-404 6.40e-49

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 172.71  E-value: 6.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  25 LAFLPVIIGIF----KQKRLSTYETLV-SLVFilFMFGGdhyqqlVAFLFYLLwqIISVFAY------QKYREKANSAGV 93
Cdd:COG1696     9 LLFLPIVLLLYwllpRSRRLRNLLLLVaSLFF--YAWWD------PRFLLLLL--LSTLVNYllglliERSRDKRRRKLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  94 FYLAIAMALFPLIWVKVAPLTGPSSQTLFSF-------------LGISYLTFKSIGMIIEMRDGTLQ-EVRLPDFIRFMI 159
Cdd:COG1696    79 LILGIVLNLGLLGFFKYFNFFLESLNALLGAletdlplldillpLGISFYTFQAISYLVDVYRGKIKpERNFLDYALFVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 160 FFPTFSSGPIDRFRRFQEDYHKLPERDdyLAMLNKAVMYLMLGFLYKHIISYCLGGILLPLLENKALMVGGyfnkETILV 239
Cdd:COG1696   159 FFPQLVAGPIVRAKDLLPQLRKRRTFD--YENFARGLRLFLLGLFKKVVIADNLAPYVDPVFDNPESLSGL----EAWLG 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 240 MYVYGLNLFFDFAGYSMFAIGISYLLGIRTPENFNMSFLSASLKDFWNRWHMSLSFWFRDYVFmrlvhllI------KHK 313
Cdd:COG1696   233 ALAYTLQIYFDFSGYSDMAIGLALLFGFRLPENFNSPYFARSITEFWRRWHISLSTWLRDYLY-------IplggnrKGK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 314 TFKNRNVtsgvayLVNMLVMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRhrkkkglsplfQSRAFHVLCIVVT 393
Cdd:COG1696   306 LRTYLNL------FITMLLGGLWHGAGWTFVIWGALHGLYLVLERLWRKLRLKLPR-----------LSRLGRLLGWLLT 368
                         410
                  ....*....|.
gi 1613408358 394 FHVVMFSLLLF 404
Cdd:COG1696   369 FLLVVFAWVFF 379
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
151-362 6.97e-06

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 47.82  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 151 LPDFIRFMIFFPTFSSGPIDRFRRFqEDYHKLPE-RDDYLAMLNKAVMYLML--GFLYKHIISYCLGGILLPLLENKALM 227
Cdd:pfam03062  81 LLEYLGYVFFYPGLLVGPIFSYSDY-MSFPRDPLfRWLYYVKRNLAPALGALflGLTYLILIQYLLSHLPDKDFSKFKFL 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 228 VGGYFNKETILVMYVYGLN----LFFDFAGYSmFAIGISYLLGIR-------TPENFNMSFLSA-SLKDFWNRWHMSLSF 295
Cdd:pfam03062 160 SYAFLLRFSVIMRILLGLLwlflLIFDFLGWL-FAEGEDILFGLGfngwdrvAPENIYRCWENAvSFSEFWRAWNIPVHK 238
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1613408358 296 WFRDYVFMRLVHLLIKHKTFknrnvtsgvAYLVNMLVMGFWHGLTWYYIAYGLFHGIGLIINDAWIR 362
Cdd:pfam03062 239 WLKRYVYKPLGKKGKLNKFL---------ATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRR 296
 
Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
12-408 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274974  Cd Length: 380  Bit Score: 532.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  12 EPYGNPIYFVYLILAFLPVIIGIFKQKRLSTYETLVSLVFILFMFGGDHYQqLVAFLFYLLWQIISVFAYQKYREKANSA 91
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKWQ-LIALILYVIWQTLLVKGYLAYRKKKNSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  92 GVFYLAIAMALFPLIWVKVAPLTGPSSqtLFSFLGISYLTFKSIGMIIEMRDGTLQEVRLPDFIRFMIFFPTFSSGPIDR 171
Cdd:TIGR04091  80 WVFYLAVFLSILPLVLVKVSPLFPLHS--LLGFLGISYLTFKAVQIIIEIRDGLIKEISLWDFLYFLLFFPTISSGPIDR 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 172 FRRFQEDYHKLPERDDYLAMLNKAVMYLMLGFLYKHIISYCLGGILLPLLENKALmvggyFNKETILVMYVYGLNLFFDF 251
Cdd:TIGR04091 158 SRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDAL-----FFWNLLGYMYAYSFYLFFDF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 252 AGYSMFAIGISYLLGIRTPENFNMSFLSASLKDFWNRWHMSLSFWFRDYVFMRLVHLLIKHKTFKNRNVTSGVAYLVNML 331
Cdd:TIGR04091 233 AGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKNRLTTSNVAYLINML 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1613408358 332 VMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRHRKKKglsplfqsrAFHVLCIVVTFHVVMFSLLLFSGFL 408
Cdd:TIGR04091 313 IMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNK---------WTKALSIFVTFHLVCFGFLIFSGFL 380
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
25-404 6.40e-49

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 172.71  E-value: 6.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  25 LAFLPVIIGIF----KQKRLSTYETLV-SLVFilFMFGGdhyqqlVAFLFYLLwqIISVFAY------QKYREKANSAGV 93
Cdd:COG1696     9 LLFLPIVLLLYwllpRSRRLRNLLLLVaSLFF--YAWWD------PRFLLLLL--LSTLVNYllglliERSRDKRRRKLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358  94 FYLAIAMALFPLIWVKVAPLTGPSSQTLFSF-------------LGISYLTFKSIGMIIEMRDGTLQ-EVRLPDFIRFMI 159
Cdd:COG1696    79 LILGIVLNLGLLGFFKYFNFFLESLNALLGAletdlplldillpLGISFYTFQAISYLVDVYRGKIKpERNFLDYALFVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 160 FFPTFSSGPIDRFRRFQEDYHKLPERDdyLAMLNKAVMYLMLGFLYKHIISYCLGGILLPLLENKALMVGGyfnkETILV 239
Cdd:COG1696   159 FFPQLVAGPIVRAKDLLPQLRKRRTFD--YENFARGLRLFLLGLFKKVVIADNLAPYVDPVFDNPESLSGL----EAWLG 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 240 MYVYGLNLFFDFAGYSMFAIGISYLLGIRTPENFNMSFLSASLKDFWNRWHMSLSFWFRDYVFmrlvhllI------KHK 313
Cdd:COG1696   233 ALAYTLQIYFDFSGYSDMAIGLALLFGFRLPENFNSPYFARSITEFWRRWHISLSTWLRDYLY-------IplggnrKGK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 314 TFKNRNVtsgvayLVNMLVMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRhrkkkglsplfQSRAFHVLCIVVT 393
Cdd:COG1696   306 LRTYLNL------FITMLLGGLWHGAGWTFVIWGALHGLYLVLERLWRKLRLKLPR-----------LSRLGRLLGWLLT 368
                         410
                  ....*....|.
gi 1613408358 394 FHVVMFSLLLF 404
Cdd:COG1696   369 FLLVVFAWVFF 379
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
151-362 6.97e-06

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 47.82  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 151 LPDFIRFMIFFPTFSSGPIDRFRRFqEDYHKLPE-RDDYLAMLNKAVMYLML--GFLYKHIISYCLGGILLPLLENKALM 227
Cdd:pfam03062  81 LLEYLGYVFFYPGLLVGPIFSYSDY-MSFPRDPLfRWLYYVKRNLAPALGALflGLTYLILIQYLLSHLPDKDFSKFKFL 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613408358 228 VGGYFNKETILVMYVYGLN----LFFDFAGYSmFAIGISYLLGIR-------TPENFNMSFLSA-SLKDFWNRWHMSLSF 295
Cdd:pfam03062 160 SYAFLLRFSVIMRILLGLLwlflLIFDFLGWL-FAEGEDILFGLGfngwdrvAPENIYRCWENAvSFSEFWRAWNIPVHK 238
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1613408358 296 WFRDYVFMRLVHLLIKHKTFknrnvtsgvAYLVNMLVMGFWHGLTWYYIAYGLFHGIGLIINDAWIR 362
Cdd:pfam03062 239 WLKRYVYKPLGKKGKLNKFL---------ATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRR 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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