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Conserved domains on  [gi|1613363895|emb|VGJ85519|]
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transposase [Klebsiella quasipneumoniae]

Protein Classification

transposase( domain architecture ID 1750097)

IS5 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0032196
PubMed:  20215432|30454069

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS5_2 super family cl41331
IS5 family transposase;
6-86 2.77e-26

IS5 family transposase;


The actual alignment was detected with superfamily member NF033579:

Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 97.74  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613363895   6 PRKGAGYWPGEYAdRNRAVANQRMTGsNARWKWTTDYNRRSIAETAMYRVKQLFGGSLTLRDYDGQVAEAMALVRALNKM 85
Cdd:NF033579  209 PRKNARLWKEGKA-RNAAIREIRRLG-RELWKKWSGYHRRSLVETAFSRLKRLLGERLRARNFDRQVREVKLKVAVLNKF 286


                  .
gi 1613363895  86 T 86
Cdd:NF033579  287 T 287
 
Name Accession Description Interval E-value
transpos_IS5_2 NF033579
IS5 family transposase;
6-86 2.77e-26

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 97.74  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613363895   6 PRKGAGYWPGEYAdRNRAVANQRMTGsNARWKWTTDYNRRSIAETAMYRVKQLFGGSLTLRDYDGQVAEAMALVRALNKM 85
Cdd:NF033579  209 PRKNARLWKEGKA-RNAAIREIRRLG-RELWKKWSGYHRRSLVETAFSRLKRLLGERLRARNFDRQVREVKLKVAVLNKF 286


                  .
gi 1613363895  86 T 86
Cdd:NF033579  287 T 287
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 6-83 9.99e-04

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 36.07  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613363895   6 PRKGAGYWPGEYADRNRAVANQRMTGSNARWKWTTD------------YNRRSIAETAMYRVKQLFGG-SLTLRDYDGQV 72
Cdd:pfam01609 106 LKKNAKLIDDKRRGRLRKHGKLKILTKVDKLKGRVNstllsaetlaelYRRRWQIERVFKWLKRVFGLdRLRYRGLNAVE 185

                          90
                  ....*....|.
gi 1613363895  73 AEAMALVRALN 83
Cdd:pfam01609 186 AELLLLALAYN 196
 
Name Accession Description Interval E-value
transpos_IS5_2 NF033579
IS5 family transposase;
6-86 2.77e-26

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 97.74  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613363895   6 PRKGAGYWPGEYAdRNRAVANQRMTGsNARWKWTTDYNRRSIAETAMYRVKQLFGGSLTLRDYDGQVAEAMALVRALNKM 85
Cdd:NF033579  209 PRKNARLWKEGKA-RNAAIREIRRLG-RELWKKWSGYHRRSLVETAFSRLKRLLGERLRARNFDRQVREVKLKVAVLNKF 286


                  .
gi 1613363895  86 T 86
Cdd:NF033579  287 T 287
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 6-83 9.99e-04

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 36.07  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613363895   6 PRKGAGYWPGEYADRNRAVANQRMTGSNARWKWTTD------------YNRRSIAETAMYRVKQLFGG-SLTLRDYDGQV 72
Cdd:pfam01609 106 LKKNAKLIDDKRRGRLRKHGKLKILTKVDKLKGRVNstllsaetlaelYRRRWQIERVFKWLKRVFGLdRLRYRGLNAVE 185

                          90
                  ....*....|.
gi 1613363895  73 AEAMALVRALN 83
Cdd:pfam01609 186 AELLLLALAYN 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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