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Conserved domains on  [gi|1591723377|emb|VFS19042|]
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Invasion protein invB [Yokenella regensburgei]

Protein Classification

type III secretion system chaperone( domain architecture ID 13017824)

class I type III secretion system chaperone is required in the injection into host cells of effector proteins that are important for suppressing host defenses and establishing infection

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SC_IB_Spa15-like cd17035
Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This ...
 4-134 2.88e-36

Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This family includes type III secretion system (T3SS) chaperone proteins similar to Shigella flexneri Spa15, Salmonella enterica InvB, and similar proteins. In S. flexineri, which is a facultative intracellular pathogen that invades the colonic epithelium and causes bacillary dysentery, the T3SS allows injection of a number of effectors to ensure their stabilization prior to secretion. Spa15 is the chaperone for several TTS effectors, including IpaA, IpgB1, OspC3, OspB and OspD1. Effector IpgB that chaperone Spa15 is a mimic of the human Ras-like Rho guanosine triphosphatase RhoG, thus activating Rac1 guanosine triphosphatase and setting off membrane ruffling of the cell, assisting the internalization of Shigella. Also, Spa15 is a chaperone for secreted anti-activator OspD1 which is involved in the control of transcription by the type III secretion apparatus (T3SA) activity in Shigella flexneri.


:

Pssm-ID: 409319  Cd Length: 129  Bit Score: 120.77  E-value: 2.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591723377   4 DVVALLSTMLNDAGMADILDSDLSNHSTISLNMKDDiPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLNHNEe 83
Cdd:cd17035     1 DLAELVREALKELGCDDSIIGDLDNHSTITLDLKDL-PSINISTVDDRVWLWSQLPELTENLLSQNAARLLELLMEPVE- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1591723377  84 YFYTGQPCLYPVDGNIELRAQVKEKYLQAPDDFLSMLDNYLCILQEYRTVL 134
Cdd:cd17035    79 FFRTGQLQLGEGDGGLELKALLNPDALEDEEKFAEALEGFYERLEALSEAL 129
 
Name Accession Description Interval E-value
T3SC_IB_Spa15-like cd17035
Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This ...
 4-134 2.88e-36

Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This family includes type III secretion system (T3SS) chaperone proteins similar to Shigella flexneri Spa15, Salmonella enterica InvB, and similar proteins. In S. flexineri, which is a facultative intracellular pathogen that invades the colonic epithelium and causes bacillary dysentery, the T3SS allows injection of a number of effectors to ensure their stabilization prior to secretion. Spa15 is the chaperone for several TTS effectors, including IpaA, IpgB1, OspC3, OspB and OspD1. Effector IpgB that chaperone Spa15 is a mimic of the human Ras-like Rho guanosine triphosphatase RhoG, thus activating Rac1 guanosine triphosphatase and setting off membrane ruffling of the cell, assisting the internalization of Shigella. Also, Spa15 is a chaperone for secreted anti-activator OspD1 which is involved in the control of transcription by the type III secretion apparatus (T3SA) activity in Shigella flexneri.


Pssm-ID: 409319  Cd Length: 129  Bit Score: 120.77  E-value: 2.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591723377   4 DVVALLSTMLNDAGMADILDSDLSNHSTISLNMKDDiPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLNHNEe 83
Cdd:cd17035     1 DLAELVREALKELGCDDSIIGDLDNHSTITLDLKDL-PSINISTVDDRVWLWSQLPELTENLLSQNAARLLELLMEPVE- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1591723377  84 YFYTGQPCLYPVDGNIELRAQVKEKYLQAPDDFLSMLDNYLCILQEYRTVL 134
Cdd:cd17035    79 FFRTGQLQLGEGDGGLELKALLNPDALEDEEKFAEALEGFYERLEALSEAL 129
PRK15336 PRK15336
type III secretion system chaperone SpaK; Provisional
 1-134 1.61e-16

type III secretion system chaperone SpaK; Provisional


Pssm-ID: 185236  Cd Length: 135  Bit Score: 70.64  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591723377   1 MKYDVVALLSTMLNDAGMADILDSDLSNHSTISLNMkDDIPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLnH 80
Cdd:PRK15336    2 QHLDIAELVRSALEVSGCDPSLIGGIDSHSTIVLDL-FALPSICISVKDDDVWIWAQLGADSMVVLQQRAYEILMTIM-E 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1591723377  81 NEEYFYTGQPCLYPVDGNIELRAQVKEKYLQAPDDFLSMLDNYLCILQEY-RTVL 134
Cdd:PRK15336   80 GCHFARGGQLLLGEQNGELTLKALVHPDFLSDGEKFSTALNGFYNYLEVFsRSLM 134
Invas_SpaK pfam03519
Invasion protein B family;
25-101 3.77e-11

Invasion protein B family;


Pssm-ID: 427345  Cd Length: 78  Bit Score: 55.17  E-value: 3.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1591723377  25 DLSNHSTISLNMkDDIPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLnhneeyfytgQPCLYPVDGNIEL 101
Cdd:pfam03519   9 NLDSHSTIALDL-DDMPSINISLVDDDVWLWANLTEPSDVKLQQRAYNLLKLLL----------EGCSYSRGGLLEL 74
 
Name Accession Description Interval E-value
T3SC_IB_Spa15-like cd17035
Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This ...
 4-134 2.88e-36

Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15; This family includes type III secretion system (T3SS) chaperone proteins similar to Shigella flexneri Spa15, Salmonella enterica InvB, and similar proteins. In S. flexineri, which is a facultative intracellular pathogen that invades the colonic epithelium and causes bacillary dysentery, the T3SS allows injection of a number of effectors to ensure their stabilization prior to secretion. Spa15 is the chaperone for several TTS effectors, including IpaA, IpgB1, OspC3, OspB and OspD1. Effector IpgB that chaperone Spa15 is a mimic of the human Ras-like Rho guanosine triphosphatase RhoG, thus activating Rac1 guanosine triphosphatase and setting off membrane ruffling of the cell, assisting the internalization of Shigella. Also, Spa15 is a chaperone for secreted anti-activator OspD1 which is involved in the control of transcription by the type III secretion apparatus (T3SA) activity in Shigella flexneri.


Pssm-ID: 409319  Cd Length: 129  Bit Score: 120.77  E-value: 2.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591723377   4 DVVALLSTMLNDAGMADILDSDLSNHSTISLNMKDDiPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLNHNEe 83
Cdd:cd17035     1 DLAELVREALKELGCDDSIIGDLDNHSTITLDLKDL-PSINISTVDDRVWLWSQLPELTENLLSQNAARLLELLMEPVE- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1591723377  84 YFYTGQPCLYPVDGNIELRAQVKEKYLQAPDDFLSMLDNYLCILQEYRTVL 134
Cdd:cd17035    79 FFRTGQLQLGEGDGGLELKALLNPDALEDEEKFAEALEGFYERLEALSEAL 129
PRK15336 PRK15336
type III secretion system chaperone SpaK; Provisional
 1-134 1.61e-16

type III secretion system chaperone SpaK; Provisional


Pssm-ID: 185236  Cd Length: 135  Bit Score: 70.64  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591723377   1 MKYDVVALLSTMLNDAGMADILDSDLSNHSTISLNMkDDIPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLnH 80
Cdd:PRK15336    2 QHLDIAELVRSALEVSGCDPSLIGGIDSHSTIVLDL-FALPSICISVKDDDVWIWAQLGADSMVVLQQRAYEILMTIM-E 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1591723377  81 NEEYFYTGQPCLYPVDGNIELRAQVKEKYLQAPDDFLSMLDNYLCILQEY-RTVL 134
Cdd:PRK15336   80 GCHFARGGQLLLGEQNGELTLKALVHPDFLSDGEKFSTALNGFYNYLEVFsRSLM 134
Invas_SpaK pfam03519
Invasion protein B family;
25-101 3.77e-11

Invasion protein B family;


Pssm-ID: 427345  Cd Length: 78  Bit Score: 55.17  E-value: 3.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1591723377  25 DLSNHSTISLNMkDDIPTIHVRSEDDEVWVWAKIVEQAPASLSYCSTSLLPLMLnhneeyfytgQPCLYPVDGNIEL 101
Cdd:pfam03519   9 NLDSHSTIALDL-DDMPSINISLVDDDVWLWANLTEPSDVKLQQRAYNLLKLLL----------EGCSYSRGGLLEL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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