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Conserved domains on  [gi|1577444730|emb|VFB05598|]
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Sodium/solute symporter [Corynebacterium striatum]

Protein Classification

sodium:solute symporter family protein( domain architecture ID 10183726)

sodium:solute symporter family protein may co-transport Na(+) with a variety of solutes such as sugars, amino acids, inorganic ions or vitamins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
13-508 0e+00

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


:

Pssm-ID: 271372  Cd Length: 496  Bit Score: 705.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIP 92
Cdd:cd11478     1 VDYLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVL 172
Cdd:cd11478    81 AMVFLGIVMMPFYYGSKVRSVPEYLKLRFNKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 173 SYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTW---PGTDISGFENPVWSVIGIVLG 249
Cdd:cd11478   161 AYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGPPGWNglsWGPQGSQSTNPMGVNLGLVFG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 LGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERA-EPNDAILLLMRDL 328
Cdd:cd11478   241 LGFVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGlDYNQALPYLMAKY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 329 LPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNFGNVMD 408
Cdd:cd11478   321 LPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVVGVLISIGTAYIASSFNNIMD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 409 YLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTdataSIFNLPGQGTAFVAAGVAFTVDII 488
Cdd:cd11478   401 YLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELG----LIVYHSDMAPNFYGAWWAFVVCFV 476
                         490       500
                  ....*....|....*....|
gi 1577444730 489 VSVIVTMFTQPKPDEELVGF 508
Cdd:cd11478   477 VTVLVSLLTKPKPEKELAGL 496
 
Name Accession Description Interval E-value
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
13-508 0e+00

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 705.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIP 92
Cdd:cd11478     1 VDYLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVL 172
Cdd:cd11478    81 AMVFLGIVMMPFYYGSKVRSVPEYLKLRFNKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 173 SYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTW---PGTDISGFENPVWSVIGIVLG 249
Cdd:cd11478   161 AYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGPPGWNglsWGPQGSQSTNPMGVNLGLVFG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 LGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERA-EPNDAILLLMRDL 328
Cdd:cd11478   241 LGFVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGlDYNQALPYLMAKY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 329 LPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNFGNVMD 408
Cdd:cd11478   321 LPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVVGVLISIGTAYIASSFNNIMD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 409 YLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTdataSIFNLPGQGTAFVAAGVAFTVDII 488
Cdd:cd11478   401 YLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELG----LIVYHSDMAPNFYGAWWAFVVCFV 476
                         490       500
                  ....*....|....*....|
gi 1577444730 489 VSVIVTMFTQPKPDEELVGF 508
Cdd:cd11478   477 VTVLVSLLTKPKPEKELAGL 496
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
11-454 1.32e-113

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 344.43  E-value: 1.32e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  11 TWVDYLLVALYFLFVLGIGWAA--KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWI 88
Cdd:COG4146     4 STLDYIVFLLYFLLVAGIGYWVsrKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  89 GAIpAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLI-AGVNLYLLATIVEALLGWPMWVALLVA 167
Cdd:COG4146    84 AAI-ALIILALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFVnLPSVLYAGALALNTIFGVPLWISVIGL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 168 GLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVG------GWQGLKDsvIAESHFHTWPGTDisgfeNPVW 241
Cdd:COG4146   163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGdgsvlaGWSALLK--VPPEKFNMIGPAD-----DPDL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 242 SVIGIVLGLgFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEEraePNDAI 321
Cdd:COG4146   236 PWLGIFTGM-PILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLDN---PDQAY 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 322 LLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQ 401
Cdd:COG4146   312 PTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAILIAPLIG 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1577444730 402 NFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFW 454
Cdd:COG4146   392 NADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILLK 444
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
46-446 1.06e-52

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 184.43  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  46 GRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAIPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGN-A 124
Cdd:TIGR00813   2 GRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYEL-GALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKrI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 125 AHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTII 204
Cdd:TIGR00813  81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 205 GLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSVIGIVLGL--GFVLSFGYWTtNFVEVQRAMASESISAARKTP 282
Cdd:TIGR00813 161 AFSEVGGLGTFVEKASQAAPTNPSPDDLYDFFRDPSTSDLPWGAGVfgLPHVALWYWT-NQVIVQRCLAAKSAKHAKKGC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 283 IIGAFPKMFVPFLVVIPGMVA-----SVSVADLMEERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFN 357
Cdd:TIGR00813 240 LISGVLKLLPMFGAVLPGLIAralytDIDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSAS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 358 TVISYDIWQTYVVKDREDDYYL-KFGRIATVVATGVAVFTAllAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTP 436
Cdd:TIGR00813 320 TVFTMDLYKKIIRPNASGEKKIvMRGRIAVLVAAVIAGFVA--AAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNA 397
                         410
                  ....*....|
gi 1577444730 437 HAGWSGLVAG 446
Cdd:TIGR00813 398 KGALAGMIAG 407
PRK10484 PRK10484
putative transporter; Provisional
19-551 5.29e-38

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 146.57  E-value: 5.29e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  19 ALYFLFVLGIGWAA--KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIpAMVF 96
Cdd:PRK10484    8 LGFTLLVAVISWWKtrKTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAI-ALII 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  97 LGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIA-GVNLYLLATIVEALLGWP----------MWVALL 165
Cdd:PRK10484   87 LALIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILFLIGYVVSFlPIVLYSGALALNSLFHVSellgisygaaIWLLVW 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 166 VAGLIVLSYITLGGLSA-AIYNEVLQFFVIVAALApLTIIGLNRVGG---WQGLKDSVIAES-HFHTwpgtdISGFENPV 240
Cdd:PRK10484  167 LIGIIGAIYAVFGGLKAvAVSDTINGIGLLIGGLL-VPVFGLIALGDgsfMQGLEQLTTVHPeKLNS-----IGGATDPV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 241 -WSVIgiVLGLgFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEeraEPND 319
Cdd:PRK10484  241 pFPTL--FTGL-ILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDGLP---NADM 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 320 AILLLMRDLLPNGLLGVAIAGLlasfmagMAANISAFN-------TVISYDIWQTYVVKDREDDYYLKFGRIATVVATGV 392
Cdd:PRK10484  315 AYPTLVNDVLPVPLVGFFAAVL-------FGAILSTFNgflnsasTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAII 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 393 AVFTALLAQNF-GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGtasaITFWYIATFtdatasifnLPG 471
Cdd:PRK10484  388 SMIVAPLIANApQGLYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFG----IILYIIINF---------VLK 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 472 QGTAFV-AAGVAFTVDIIVSVIVTMFtqpKPDEElvGFVSSVTPKdhfEDYTeknlPWyKQTVPLGVICLVIAVGLNVIF 550
Cdd:PRK10484  455 FDIHFLyVLAILFVINVVVMLIIGKI---KPRET--PFVLKDAFA---VDLT----PW-KYAKIASIGILLAMIGVYALF 521

                  .
gi 1577444730 551 A 551
Cdd:PRK10484  522 S 522
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
42-446 1.31e-30

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 123.60  E-value: 1.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  42 FFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAIPAMVFLGIVMMPFYYGSKVRSVPEFMRRRF 121
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAI-GALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 122 GNAAHLV--NAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALA 199
Cdd:pfam00474  80 GGKRILVylSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 200 PLTIIGLNRVGGWQGLKDSV--IAESHFHTWPGTDISGFENPvwsVIGIVLGLGFVlsFGYwTTNFVEVQRAMASESISA 277
Cdd:pfam00474 160 ILMIIVFHEVGGYSSAVEKYmtADPNGVDLYTPDGLHILRDP---LTGLSLWPGLV--LGT-TGLPHILQRCLAAKDAKC 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 278 ARKTPIIGAfpkmfVPFLVVIPGMVASVSVADLM---------EERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAG 348
Cdd:pfam00474 234 IRCGVLILT-----PMFIIVMPGMISRGLFAIALaganpracgTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMST 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 349 MAANISAFNTVISYDIWQTYVVKDREDDYYL-KFGRIATVVATGVAVFTALLAQNfGNVMDYLQTLFGFFNAPLFATFIL 427
Cdd:pfam00474 309 LTSQLLSSSSAFTHDLYKNIRRKASATEKELvGRSRIIVLVVISLAILLAVQPAQ-MGIAFLVQLAFAGLGSAFLPVILL 387
                         410
                  ....*....|....*....
gi 1577444730 428 GMFWKRMTPHAGWSGLVAG 446
Cdd:pfam00474 388 AIFWKRVNEQGALWGMIIG 406
 
Name Accession Description Interval E-value
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
13-508 0e+00

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 705.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIP 92
Cdd:cd11478     1 VDYLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVL 172
Cdd:cd11478    81 AMVFLGIVMMPFYYGSKVRSVPEYLKLRFNKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 173 SYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTW---PGTDISGFENPVWSVIGIVLG 249
Cdd:cd11478   161 AYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGPPGWNglsWGPQGSQSTNPMGVNLGLVFG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 LGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERA-EPNDAILLLMRDL 328
Cdd:cd11478   241 LGFVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGlDYNQALPYLMAKY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 329 LPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNFGNVMD 408
Cdd:cd11478   321 LPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVVGVLISIGTAYIASSFNNIMD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 409 YLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTdataSIFNLPGQGTAFVAAGVAFTVDII 488
Cdd:cd11478   401 YLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELG----LIVYHSDMAPNFYGAWWAFVVCFV 476
                         490       500
                  ....*....|....*....|
gi 1577444730 489 VSVIVTMFTQPKPDEELVGF 508
Cdd:cd11478   477 VTVLVSLLTKPKPEKELAGL 496
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
11-454 1.32e-113

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 344.43  E-value: 1.32e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  11 TWVDYLLVALYFLFVLGIGWAA--KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWI 88
Cdd:COG4146     4 STLDYIVFLLYFLLVAGIGYWVsrKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  89 GAIpAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLI-AGVNLYLLATIVEALLGWPMWVALLVA 167
Cdd:COG4146    84 AAI-ALIILALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFVnLPSVLYAGALALNTIFGVPLWISVIGL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 168 GLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVG------GWQGLKDsvIAESHFHTWPGTDisgfeNPVW 241
Cdd:COG4146   163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGdgsvlaGWSALLK--VPPEKFNMIGPAD-----DPDL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 242 SVIGIVLGLgFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEEraePNDAI 321
Cdd:COG4146   236 PWLGIFTGM-PILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLDN---PDQAY 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 322 LLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQ 401
Cdd:COG4146   312 PTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAILIAPLIG 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1577444730 402 NFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFW 454
Cdd:COG4146   392 NADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILLK 444
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
11-509 3.47e-101

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 313.68  E-value: 3.47e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  11 TWVDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMhYFWIGA 90
Cdd:COG0591     2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSAL-WYALGY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  91 IPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLI 170
Cdd:COG0591    81 ALGALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 171 VLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFenpvwsviGIVLGL 250
Cdd:COG0591   161 VLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALPAPGLLSLFPGLGFTGW--------LAFLGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 251 GFVLSFGYWTTNFVeVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEerAEPNDAILLLMRDLLP 330
Cdd:COG0591   233 FLAIGLGYFGQPHI-VQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPL--ADPDLALPLLILELLP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 331 NGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNfgNVMDYL 410
Cdd:COG0591   310 PGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPS--SILDLV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 411 QTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTDATASIFnlpgqgtafvAAGVAFTVDIIVS 490
Cdd:COG0591   388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLGPFGWLY----------PILPGLLVSLLVF 457
                         490
                  ....*....|....*....
gi 1577444730 491 VIVTMFTQPKPDEELVGFV 509
Cdd:COG0591   458 VVVSLLTKPPSEEVLEEFD 476
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
15-551 1.08e-82

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 267.52  E-value: 1.08e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  15 YLLVALYFLFVLGIG-WAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIpA 93
Cdd:cd10329     1 IVIIAVYFVAVIAIGlWSSRKKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGNYEWNAAF-V 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  94 MVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLI-AGVNLYLLATIVEALLGWPMWVALLVAGLIVL 172
Cdd:cd10329    80 LLLLGWVFLPFYIRSGVSTMPEFLEKRFGGRSRVYLSVLSLILYVFTkISVDLYAGALVIKQLLGWDLYLSIIVLLVITA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 173 SYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVG-GWQGLKDSVIAESHFHTWPGTDISGFENPvwsviGIVLGLg 251
Cdd:cd10329   160 IYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGgGWSAYMAAIPSGTAFHLFRPPDDPDLPWP-----GLLLGY- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 252 FVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASV-------SVADLMEERAEPNDAILLL 324
Cdd:cd10329   234 PILGIWYWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARAlfpdlvaCVVPCGNGVGCSDIAYPTL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 325 MRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWqTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQ-NF 403
Cdd:cd10329   314 VTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIY-KRLRPEASEKELVRVGRIATLVVVVISILWAPIIQaQG 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 404 GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTDATASIFNLPGQGTAFVAAGVAF 483
Cdd:cd10329   393 GSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGEPDTRPAIIGGIHFLYFAFLLF 472
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1577444730 484 TVDIIVSVIVTMFTQPKPDEELVGFVSSVTPKDHFEdyTEKNLPWYKQTVPLGVICLVIAVGLNVIFA 551
Cdd:cd10329   473 VVSVIVTVIVSLLTPPPPAEKLAGLTWSTRLTKETS--TLERPPWYKNVRILAILLLALTIFLYGYFA 538
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
13-456 4.00e-62

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 210.87  E-value: 4.00e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIP 92
Cdd:cd10322     1 IDLIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVL 172
Cdd:cd10322    81 ALLLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 173 SYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVG--GWQGLKDSViAESHFHTWPGTDISgfenpvwsvIGIVLGL 250
Cdd:cd10322   161 LYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGggGFSALAAAL-PALLLALGPGGGLG---------WSTILSL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 251 GFVLSFGYWTTNFVeVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMeeraEPNDAILLLMRDLLP 330
Cdd:cd10322   231 ILLTGLGVLALPQV-FQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLE----NPDLALPTLINSLLP 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 331 NGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVatgVAVFTALLAQNFGNVMDYL 410
Cdd:cd10322   306 PGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVV---VGVLALLLALLPPSILLLL 382
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1577444730 411 QTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYI 456
Cdd:cd10322   383 SLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLL 428
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
14-458 3.38e-60

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 206.30  E-value: 3.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFwIGAIPA 93
Cdd:cd11494     2 DWIVLVGYLLGILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYY-FGLPLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  94 MVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVLS 173
Cdd:cd11494    81 MIFLCITFVPVFYKLKVYTAYEYLERRFGLKTRLLTSILFLISRGLATGVTIYAPAIILSTILGWSLWLTILLIGGITII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 174 YITLGGLSAAIYNEVLQFFVIVAAL--APLTIIGLNRVGGWQGLKDSVIAEsHFHTWpGTDISGFE-NPVWS-VIGivlg 249
Cdd:cd11494   161 YTVLGGIKAVIWTDVIQMVIIWAGLfiAFGLLLKLLPVGFVDALLVAGKSG-RLNAL-DFSFDLSDtYTFWSgLIG---- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 lGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMV---------ASVSVADLMEERAEPNDA 320
Cdd:cd11494   235 -GFFLYLSYFGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvfvfyqfnpFPVSFNPAEDETKDTNYI 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 321 ILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLA 400
Cdd:cd11494   314 FLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALFA 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1577444730 401 QNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIAT 458
Cdd:cd11494   394 GLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIVLWLFPD 451
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
13-516 3.07e-59

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 204.35  E-value: 3.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSI-DFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAI 91
Cdd:cd11477     1 LDWLVIALYFLLMLGIGLWFSKRASKSTsDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFlGIVMMPFYYGSKVRSVPEFM----RRRFGNAAHLVNAISFAVAQLLIAGVNLYLLAT-IVEALLGWPMWVALLV 166
Cdd:cd11477    81 AGLIG-AFVFARRWRRLRVLTDGEFPeeryGGRYGAPLRQFYAVYFALLSNVDILAWVFLAAIkVSAVFGPWDPWLTILI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSVIGI 246
Cdd:cd11477   160 LGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQLPEGHLDLFGSGLGASGFYITFFFILFF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 247 vlglgFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEPNDAILLLMR 326
Cdd:cd11477   240 -----GWYPLSYSGGGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDLDDPEADFELAYPMMIK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 327 DLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNFGNV 406
Cdd:cd11477   315 EYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALASDSIGGA 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 407 MDYLQTLFGFFNAPLfatfILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTDATASifnlpgqgtAFVAAGVAFTVD 486
Cdd:cd11477   395 FWIVLALGAGLGGPL----ILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPED---------FLFSFLVPVLLS 461
                         490       500       510
                  ....*....|....*....|....*....|
gi 1577444730 487 IIVSVIVTMFTQPKPDEELVGFVSSVTPKD 516
Cdd:cd11477   462 LVVWLAVTLLTPPTDEETLVAFYKKVRPWG 491
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
16-550 1.93e-55

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 194.83  E-value: 1.93e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  16 LLVALYFLFVLGIG-WAAKAR---VSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAI 91
Cdd:cd10325     1 VIFIVYVILIIGLGlWVSREKkggEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASYEWMAAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 pAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAIsFAVaqLLIAGVNL----YLLATIVEALLGWPMWVALLVA 167
Cdd:cd10325    81 -TLIIVAKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAV-FWL--LLYVFVNLtsvlYLGALAIETITGIPLTYSIIGL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 168 GLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGG----WQGLKDSVI-AESHFHTW--PGTDISGFENPV 240
Cdd:cd10325   157 ALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGgegvFAGFTLLAAeAPEHFHMIldKSNPEDAYKDLP 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 241 WsvIGIVLGLGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERA----E 316
Cdd:cd10325   237 G--IAVLLGGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNLLLPAAtgieK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 317 PNDAILLLMRdLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFT 396
Cdd:cd10325   315 PDQAYPWLLR-NLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAALI 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 397 ALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIAtftdatasiFNLPGQgtaf 476
Cdd:cd10325   394 APPLLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKFLL---------PELPFL---- 460
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1577444730 477 VAAGVAFTVDIIVSVIVTMFTqPKPDEELVGFVSSvtpKDHFEDYTEKNLpwykqtvpLGVICLVIAVGLNVIF 550
Cdd:cd10325   461 DRMGYVFFICVVLIVLVSLLT-PKGKDDPKAIEID---PDMFKTSPSFNL--------GAVGVLAILAALYVVF 522
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
46-446 1.06e-52

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 184.43  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  46 GRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAIPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGN-A 124
Cdd:TIGR00813   2 GRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYEL-GALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKrI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 125 AHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTII 204
Cdd:TIGR00813  81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 205 GLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSVIGIVLGL--GFVLSFGYWTtNFVEVQRAMASESISAARKTP 282
Cdd:TIGR00813 161 AFSEVGGLGTFVEKASQAAPTNPSPDDLYDFFRDPSTSDLPWGAGVfgLPHVALWYWT-NQVIVQRCLAAKSAKHAKKGC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 283 IIGAFPKMFVPFLVVIPGMVA-----SVSVADLMEERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFN 357
Cdd:TIGR00813 240 LISGVLKLLPMFGAVLPGLIAralytDIDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSAS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 358 TVISYDIWQTYVVKDREDDYYL-KFGRIATVVATGVAVFTAllAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTP 436
Cdd:TIGR00813 320 TVFTMDLYKKIIRPNASGEKKIvMRGRIAVLVAAVIAGFVA--AAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNA 397
                         410
                  ....*....|
gi 1577444730 437 HAGWSGLVAG 446
Cdd:TIGR00813 398 KGALAGMIAG 407
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
14-506 8.53e-47

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 172.81  E-value: 8.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAAKARVSSSI--DFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAI 91
Cdd:cd11488     1 DIAVVVVYFVFVLAVGIWSSIRASRGTvgGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEW-NAA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLV--NAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGL 169
Cdd:cd11488    80 WVLIALGWIFVPVYIAAGVVTMPEYLKKRFGGQRIRIymSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTD--------ISGFENPVW 241
Cdd:cd11488   160 VTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNTTchlprsdaFHIFRDPVT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 242 SVI---GIVLGLGfVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVA------SVSVADLME 312
Cdd:cd11488   240 GDIpwpGLIFGLT-VLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISralfpdEVGCVDPDE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 313 -------ERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLkFGR-- 383
Cdd:cd11488   319 cqkicgaKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQELMV-VGRvf 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 384 IATVVATGVAVFTALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAIT-----FWYIAT 458
Cdd:cd11488   398 ILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVrmimeFVYGAP 477
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1577444730 459 FTDATASIFNLPGQGTAFVAAGVAFTVDIIVSVIVTMFTQPKPDEELV 506
Cdd:cd11488   478 SCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLV 525
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
13-452 8.90e-47

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 172.82  E-value: 8.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSI--DFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGA 90
Cdd:cd11489     3 ADIIVIGVYFALNVAVGIWSSCRVSRNTvsGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEW-NA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  91 IPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAA--HLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAG 168
Cdd:cd11489    82 TYALLALAWVFVPVYISSGIVTMPEYLQRRFGGERirMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLML 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 169 LIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDS--------VIAESHFHTWPGTDISGFENPV 240
Cdd:cd11489   162 VVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAylqavpskIIPNTTCHLPRADAMHLFRDPV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 241 -----WSviGIVLGLGFVLSFgYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLM---- 311
Cdd:cd11489   242 tgdlpWT--GMTFGLTIMATW-YWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVacvd 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 312 ---------EERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLkFG 382
Cdd:cd11489   319 peeclrvcgAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLL-VG 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1577444730 383 RIATVVATGVAV--FTALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAIT 452
Cdd:cd11489   398 RLVTVILVGVSVvwIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLT 469
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
11-482 1.96e-45

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 166.56  E-value: 1.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  11 TWVDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGveYGFQTMHYFWIGA 90
Cdd:cd11495     2 GWLDYLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKA--YATDWNYFVGSLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  91 IPAMVFLGI-VMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGL 169
Cdd:cd11495    80 IIIAAPLAAyFFVPFFRRLNVTSAYEYLEKRFGPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILMGV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFV-IVAALAPLTIIGLNRVGGWQGLKDsvIAESHFHTWPGTDISGFENPvwsVIGIVL 248
Cdd:cd11495   160 LCIIYTVLGGIEAVIWTDVIQGVVlLGGALLCLIILLFSIPGGFGEVFD--IAIANGKFSLGDFSFSLTES---TIWVIF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 249 GLGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASV---SVADLMEErAEPNDAIL-LL 324
Cdd:cd11495   235 IGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVfyqQHPELLPA-GINGDAVFpYF 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 325 MRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYvVKDREDDYYLKFGRIATVVATGVAVFTAL--LAQN 402
Cdd:cd11495   314 IVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRL-SPDPSDKQYLKVARLITLLVGLLGTLVALylANAG 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 403 FGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTasAITFWYIATFTDATASIFNLPGQGTAFVAAGVA 482
Cdd:cd11495   393 VKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSI--IVIFWISLLYTPIHFFLYSVIGTLVCFVVGYVV 470
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
14-505 2.67e-44

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 166.26  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIG-WAAKARVSSSID-FFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAI 91
Cdd:cd11486     2 DISVIVIYFVVVLAVGvWAMVSTNRGTVGgFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEW-NAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLV--NAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGL 169
Cdd:cd11486    81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVylSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVI-------------AESHFHTWPGTDISGF 236
Cdd:cd11486   161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMtaipsvigtgnstSQEKCYTPRADSFHIF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 237 ENPV-----WSviGIVLGLGfVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLM 311
Cdd:cd11486   241 RDPItgdlpWP--GLLFGLS-ILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEI 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 312 -------------EERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYY 378
Cdd:cd11486   318 acvvpdeckavcgTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELM 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 379 LKfGRIATVVATGVAVFTALLAQNF--GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITfWYI 456
Cdd:cd11486   398 IA-GRLFMLVLIGISIAWVPIVQSAqsGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLA-RMI 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1577444730 457 ATFTDATASIFNLPGQGTAFVA------AGVAFTVDIIVSVIVTMFTQPKPDEEL 505
Cdd:cd11486   476 TEFAYGTGSCVNPSNCPTIICGvhylyfAIILFGISCILILSISLMTKPIPDVHL 530
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
14-516 1.30e-41

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 158.15  E-value: 1.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIG-WAAKARVSSSID-FFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAI 91
Cdd:cd11490     1 DIVVLVLYFLFVLAVGlWSMWKTKRSTVKgYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVfLGIVMMPFYYGSKVRSVPEFMRRRFGNAAhlvNAISFAVAQLLI-----AGVNLYLLATIVEALLGWPMWVALLV 166
Cdd:cd11490    81 MVLV-LAWLFLPIYIASRVTTMPEYLKKRFGGKR---IQIFLAVLYLFIyiftkISVDMYAGAVFIQQALQWDLYLAVVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKdsviaESHFHTWPGTDISG----------- 235
Cdd:cd11490   157 LLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALL-----EKYFQAIPSIRSPNstcgipredaf 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 236 --FENPVWSVI---GIVLGLGfVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADL 310
Cdd:cd11490   232 hiFRDPVTSDLpwpGVLLGMS-IPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQ 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 311 MeERAEP--------------NDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTyvVKDREDD 376
Cdd:cd11490   311 V-ACADPevckeicgnpsgcsDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRH--IRPRASE 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 377 YYLKF-GRIATVVATGVAVFTALLAQ--NFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAIT- 452
Cdd:cd11490   388 WELMIvGRVFVLVLVVVSILWIPLVQasQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTr 467
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1577444730 453 ----FWYIATFTDATASIFNLPGQGTAFVAAGVAFTVDIIVSVIVTMFTQPkPDEELVGFVSSVTPKD 516
Cdd:cd11490   468 mvldFIYVTPQCDQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLATEP-PSKEMISRLTWFTRFD 534
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
14-446 5.76e-41

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 156.23  E-value: 5.76e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAAKARVSSSI--DFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAI 91
Cdd:cd11487     2 DISVIAAYFLLVIGVGLWSMCRTNRGTvgGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEW-NAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNA--AHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGL 169
Cdd:cd11487    81 FVVLLLGWLFVPVYLTAGVITMPQYLKKRFGGQriRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISG-------------- 235
Cdd:cd11487   161 ITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSEDPAVGnissscyrprpdsy 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 236 --FENPVWSVI---GIVLGLGFVLSFgYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASV----S 306
Cdd:cd11487   241 hlLRDPVTGDLpwpALILGLTIVSSW-YWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVlypdE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 307 VADLMEERAE---------PNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDY 377
Cdd:cd11487   320 VACVEPSVCLrvcgtevgcSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKEL 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1577444730 378 YLkFGRIATV--VATGVAVFTALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAG 446
Cdd:cd11487   400 LL-VGRVWVVciVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGG 469
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
14-504 2.34e-40

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 154.64  E-value: 2.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAA--KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFqTMHYFWIGAI 91
Cdd:cd11491     1 DIAVVALYFILVMCIGIYAmwKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGF-AVGAFEFNAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGnaAHLVNaISFAVAQLLI-----AGVNLYLLATIVEALLGWPMWVAL-L 165
Cdd:cd11491    80 ILLQLLGWVFIPVYIRSGVYTLPEYLSKRFG--GHRIQ-VYLAALSLILyiftkISVNLYSGALFIQEALGWNLYVSIiL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 166 VAGLIVLSYITlGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHT----------------WP 229
Cdd:cd11491   157 LLGLTALLTVT-GGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVTsilltynlsntnsccvHP 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 230 GTD-ISGFENPVWSVI---GIVLGLGFVlSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASV 305
Cdd:cd11491   236 KKDaFKLLRDPTDEDVpwpGFILGQTPA-SIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRI 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 306 SVADLM-------------EERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKD 372
Cdd:cd11491   315 LFPDDIacinpehcmqvcgSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKA 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 373 REDDYYLkFGRIATVVATGVAVFTALLAQNF--GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASA 450
Cdd:cd11491   395 SSRELMI-VGRIFVAVMVVISIAWIPVIQEMqgGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLG 473
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1577444730 451 -----ITFWYIATFTDATASIFNLPGQGTAFVAAGVAFTVDIIVSVIVTMFTQPKPDEE 504
Cdd:cd11491   474 avrliLAFAYRAPECGQPDNRPGIIKDIHYMYFATALFWITGLITVIVSLLTPPPTKEN 532
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
13-501 1.28e-39

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 150.06  E-value: 1.28e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHY-FWIGAi 91
Cdd:cd11479     1 LDYGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLvVAIGL- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 pAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIV 171
Cdd:cd11479    80 -GILALSLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGGIV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 172 LSYITLGGLSAAIYNEVLQFFVIVAAL-APLTIIGLNRVGGWQGLKDSVIAeSHFhtwpgtDISGFENPVWSVIGIVLGL 250
Cdd:cd11479   159 VLYSVLGGMWSITLTDIIQFVIKTIGIfLLLLPLALSKAGGLSGLQEKLPA-SYF------DLTSIGWDTIVTYFLLYFF 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 251 GFVLSFGYWttnfvevQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLmeerAEPNDAILLLMRDLLP 330
Cdd:cd11479   232 GILIGQDIW-------QRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPDL----ANPQNAFATMAQEVLP 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 331 NGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQnfgNVMDYL 410
Cdd:cd11479   301 VGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVN---DVVAAL 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 411 QTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIaTFTDATASIFnlpgqgTAFVAAGVAFtvdiivs 490
Cdd:cd11479   378 TIAYAILVGGLLVPILGGLFWKRATGAGALASMVAGSVVVLAGMAV-DGLLANTPIY------YGLAVSLVAF------- 443
                         490
                  ....*....|.
gi 1577444730 491 VIVTMFTQPKP 501
Cdd:cd11479   444 VAVSLLTRPTP 454
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
21-459 2.98e-38

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 146.53  E-value: 2.98e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  21 YFLFVLGIGWAA-----KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMhyFW-IGAIPAM 94
Cdd:cd10328     1 FLLFTALVALISwyktrGDDLSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVM--AWeVTAAIAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  95 VFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIA-GVNLYLLATI------VEALLGWPMWVALLVA 167
Cdd:cd10328    79 IILALVFLPRYLKGGITTIPEFLEERYDETTRRIVSILFLLGYVVILlPIVLYSGALAlnslfdVSELLGISYFQALWLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 168 ----GLIVLSYITLGGLSA-AIYNEVLQFFVIVAALApLTIIGLNRVGG---WQGLKDSVIAE-SHFhtwpgTDISGFEN 238
Cdd:cd10328   159 vwliGIIGAIYAIFGGLKAvAVSDTINGVGLLIGGLL-IPILGLIALGDgsfLAGLDTLLTAHpEKL-----NAIGGADS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 239 PV-WSVIgiVLGLGFVLSFgYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEp 317
Cdd:cd10328   233 PVpFSTL--FTGMLLVNLF-YWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGDGLENADM- 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 318 ndAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTA 397
Cdd:cd10328   309 --AYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISMIIA 386
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1577444730 398 LLAQNFGN-VMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGtasaITFWYIATF 459
Cdd:cd10328   387 PFIAYAPEgLFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFG----VILYALLQF 445
PRK10484 PRK10484
putative transporter; Provisional
19-551 5.29e-38

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 146.57  E-value: 5.29e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  19 ALYFLFVLGIGWAA--KARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIpAMVF 96
Cdd:PRK10484    8 LGFTLLVAVISWWKtrKTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAI-ALII 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  97 LGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIA-GVNLYLLATIVEALLGWP----------MWVALL 165
Cdd:PRK10484   87 LALIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILFLIGYVVSFlPIVLYSGALALNSLFHVSellgisygaaIWLLVW 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 166 VAGLIVLSYITLGGLSA-AIYNEVLQFFVIVAALApLTIIGLNRVGG---WQGLKDSVIAES-HFHTwpgtdISGFENPV 240
Cdd:PRK10484  167 LIGIIGAIYAVFGGLKAvAVSDTINGIGLLIGGLL-VPVFGLIALGDgsfMQGLEQLTTVHPeKLNS-----IGGATDPV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 241 -WSVIgiVLGLgFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEeraEPND 319
Cdd:PRK10484  241 pFPTL--FTGL-ILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDGLP---NADM 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 320 AILLLMRDLLPNGLLGVAIAGLlasfmagMAANISAFN-------TVISYDIWQTYVVKDREDDYYLKFGRIATVVATGV 392
Cdd:PRK10484  315 AYPTLVNDVLPVPLVGFFAAVL-------FGAILSTFNgflnsasTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAII 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 393 AVFTALLAQNF-GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGtasaITFWYIATFtdatasifnLPG 471
Cdd:PRK10484  388 SMIVAPLIANApQGLYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFG----IILYIIINF---------VLK 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 472 QGTAFV-AAGVAFTVDIIVSVIVTMFtqpKPDEElvGFVSSVTPKdhfEDYTeknlPWyKQTVPLGVICLVIAVGLNVIF 550
Cdd:PRK10484  455 FDIHFLyVLAILFVINVVVMLIIGKI---KPRET--PFVLKDAFA---VDLT----PW-KYAKIASIGILLAMIGVYALF 521

                  .
gi 1577444730 551 A 551
Cdd:PRK10484  522 S 522
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
14-461 1.76e-37

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 144.24  E-value: 1.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHyFWIGAIPA 93
Cdd:cd10326     1 DWAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQ-MVLGFLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  94 MVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYL----LATIVEALLGWPMWVALLVAGL 169
Cdd:cd10326    80 YLIIAFVLLPLYYRLNLTSIYEYLEDRFGVSSRKTGAVFFLLSRILGAGIRLYLvalvLQQFLFDSLGIPFWLTVLITGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSvigIVLG 249
Cdd:cd10326   160 LIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAAGESGYSRIFNFDDDNSRRTFWK---QFLG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 lGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGmVASVSVADLMEERAEPNDAILLLMR--- 326
Cdd:cd10326   237 -GIFITIAMTGLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLG-VLLYTYAQKNGIALPAKDSDQLFPYfal 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 327 DLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDI--WQTYVVKDREDDYYLKFGRIATVVatgVAVFTALLAQNFG 404
Cdd:cd10326   315 NGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDIlnRFKRKSEKKSERKYVHIAFSLTFV---LGILVFGSASNSG 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1577444730 405 NVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAG--WSGLVAGTASAITFWYIATFTD 461
Cdd:cd10326   392 SLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDKWvpLVGLLAPVLSYLLVSNSEGFFG 450
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
14-446 5.02e-37

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 143.12  E-value: 5.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIgmSANGVEYGfQTMHY--FWIGAI 91
Cdd:cd11493     1 DLAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFL--SIPGLAYG-GDLTFlqLALGYI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 PAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGW-----PMWVALLV 166
Cdd:cd11493    78 LGRIIVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVTFLVTRLLADGVRLFAAAIPVSMILGAdgvalSYIASILI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFV-IVAALAPLTIIGLNRVGGWQGLkdsVIAESHFH-TWPGTDISGFENP--VWS 242
Cdd:cd11493   158 ISVVTLLYTYFGGIRAVVWTDVIQLVVyIGGAVAALAYLLGALPADWLQI---AAAAGKFHlFDLSDLILGLTSPytFWA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 243 VIgivLGlGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASV--SVADLMEERAEPNDA 320
Cdd:cd11493   235 AI---IG-GALLSMASHGTDQLMVQRLLACRNLRDAQKALIGSGVVVFPQFALFLLIGLLLYVyyGGASLAALGLGSPDE 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 321 IL--LLMRDLlPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTAL 398
Cdd:cd11493   311 VFpyFIVHEL-PAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTLVWAVVLVGIAL 389
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1577444730 399 LAQNFGN-VMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAG 446
Cdd:cd11493   390 LFQYTDQpVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVG 438
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
19-490 4.03e-36

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 140.34  E-value: 4.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  19 ALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQtmhYFWI------GAIP 92
Cdd:cd11475     5 IVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLS---AIWIaiglilGAYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISfavAQLLIAGVNLYLLATIV------EALLGWPMWVALLV 166
Cdd:cd11475    82 NWLFVAKRLRRYTEKNDSITLPDYLENRFRDKSKLLRILS---ALIILIFFTIYAAAQLVaggklfESLFGIDYSTGLLI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAE--SHFHTWPGTDISGFenpvwsVI 244
Cdd:cd11475   159 GAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIdpGLLSPFGGDLGAGG------LL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 245 GIVLGLGFvlSFGYWTTNFVeVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEpnDAILLL 324
Cdd:cd11475   233 AIISLLAW--GLGYFGQPHI-LVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPDGLLGDPE--TVFPVL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 325 MRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQnfG 404
Cdd:cd11475   308 AQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALNPP--S 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 405 NVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAItFWYIATFTdatasIFNLPGQGTAFVAAGVAFt 484
Cdd:cd11475   386 SVFSLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVV-VWKLLGLG-----IFGLYEIVPGFLASLLAI- 458

                  ....*.
gi 1577444730 485 vdIIVS 490
Cdd:cd11475   459 --VVVS 462
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
13-454 1.50e-34

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 136.85  E-value: 1.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIG----WAAKaRVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQtmhYFWI 88
Cdd:cd11492     1 VDYVVFVAMLLISAAIGiyfgFFGG-KQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQ---YWLI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  89 gaIPAMVFLGIVM----MPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVAL 164
Cdd:cd11492    77 --VIAYVLVGPITayifLPVFYNLQLTSVYEYLELRFNRRVRLLASFLFILQMLLYLPIVIYAPALALSQVTGINLHIII 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 165 LVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGG----WQglkdsVIAESHFHTWPGTDISGFE-NP 239
Cdd:cd11492   155 LVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGfsevWE-----IAEEGGRLEFFNFDPDPTVrHT 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 240 VWSVigiVLGLGFvlsfgYWTTNF----VEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVAD---LME 312
Cdd:cd11492   230 FWSL---VIGGTF-----TWLSLYgvnqTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVIYAKYHDcdpLTA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 313 ERAEPNDAIL-LLMRDLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVA 389
Cdd:cd11492   302 GLIKKPDQLLpYFVMDVLGHlpGLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPFFKKKLSERQATNIMKLLVVVF 381
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1577444730 390 TGVAVFTALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFwkrmTPHAGWSGLVAGTAS--AITFW 454
Cdd:cd11492   382 GLLCIGLAFLVEKLGGVLQLSLSIFGITGGPLLGIFTLGMF----FPWANSKGALVGLLVglIFMLW 444
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
42-446 1.31e-30

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 123.60  E-value: 1.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  42 FFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWiGAIPAMVFLGIVMMPFYYGSKVRSVPEFMRRRF 121
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAI-GALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 122 GNAAHLV--NAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALA 199
Cdd:pfam00474  80 GGKRILVylSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 200 PLTIIGLNRVGGWQGLKDSV--IAESHFHTWPGTDISGFENPvwsVIGIVLGLGFVlsFGYwTTNFVEVQRAMASESISA 277
Cdd:pfam00474 160 ILMIIVFHEVGGYSSAVEKYmtADPNGVDLYTPDGLHILRDP---LTGLSLWPGLV--LGT-TGLPHILQRCLAAKDAKC 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 278 ARKTPIIGAfpkmfVPFLVVIPGMVASVSVADLM---------EERAEPNDAILLLMRDLLPNGLLGVAIAGLLASFMAG 348
Cdd:pfam00474 234 IRCGVLILT-----PMFIIVMPGMISRGLFAIALaganpracgTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMST 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 349 MAANISAFNTVISYDIWQTYVVKDREDDYYL-KFGRIATVVATGVAVFTALLAQNfGNVMDYLQTLFGFFNAPLFATFIL 427
Cdd:pfam00474 309 LTSQLLSSSSAFTHDLYKNIRRKASATEKELvGRSRIIVLVVISLAILLAVQPAQ-MGIAFLVQLAFAGLGSAFLPVILL 387
                         410
                  ....*....|....*....
gi 1577444730 428 GMFWKRMTPHAGWSGLVAG 446
Cdd:pfam00474 388 AIFWKRVNEQGALWGMIIG 406
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
16-494 1.35e-29

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 121.92  E-value: 1.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  16 LLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQT-MHYFWIGAIPAM 94
Cdd:cd11476     9 ALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGpFWYASGATLQIL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  95 VF--LGIVM---MPfyygsKVRSVPEFMRRRFGNAAHLVnAISFAVAQLLIAGVNLYL-LATIVEALLGWPMWVALLVAG 168
Cdd:cd11476    89 LFapLAIRIkrlAP-----NAHTLLEIVRARYGTAAHLV-FLVFALFTNVIVLAMLLLgGSAVVNALTGMPIVAASFLIP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 169 LIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGL--NRVGGWQGLKDSVIAESHFHTWPGTDISG--FENP---VW 241
Cdd:cd11476   163 LGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYtsSDIGSPSKVYDLLQEAAPDLPVEGNQGSYltFKSKaglIF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 242 SVIGIVLGLGFV-LSFGYWttnfvevQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEPNDA 320
Cdd:cd11476   243 GIINIVGNFGTVfLDQGYW-------QRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGLNPTFEEVSAGLV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 321 ILLLMRDLLPNGLlgvAIAGLLASFMA---GMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVAtgvAVFTA 397
Cdd:cd11476   316 LPYVAAALLGKGG---AAAVLVLLFMAvtsTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGF---GLFMG 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 398 LLAQNF---GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWYIATFTDATASIFNLPGQGT 474
Cdd:cd11476   390 GLAVGLnyiGISLGWLLLFMGILIGSAVFPVALGLYWRRQTGTAAVVSPIAGLVAGLAVWLVTAKSYYGEVNVDTTGGNY 469
                         490       500
                  ....*....|....*....|.
gi 1577444730 475 AFVAAG-VAFTVDIIVSVIVT 494
Cdd:cd11476   470 PMLAGNlVALFSPAIVSVLLS 490
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
16-491 4.16e-27

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 114.52  E-value: 4.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  16 LLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHY--FWIGAIPA 93
Cdd:cd11480     2 GLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYaiGWTGGYVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  94 MVFLgivMMPFYYGSKVRSVPEFMRRRFG-NAAHLVNAIS-------FAVAQLLIAGVnlyllatIVEALLGWPMWVALL 165
Cdd:cd11480    82 LLLL---VAEPLRNFGKYTVPDFLGARLGsRPVRLVAAVStlvisffYLVAQMVGAGL-------LLSLLLGIPYEVGVV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 166 VAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGG------WQGLKDSVIAESHFHTWPGTDISGFENP 239
Cdd:cd11480   152 VVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGnplgagPGLLGLAAAAASGAGEAYLAPGLLLTDP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 240 vWSVIGIVLGLGF-------VLSfgywttnfvevqRAMASESISAARK---------------TPIIGAFPKMFVPFLVV 297
Cdd:cd11480   232 -LDVISLTLALMLgtaglphVLM------------RFYTVPDARAARKsvvwalgfiglfyllAPALGFGARALVGPDVI 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 298 IPGMVASVSVAdlmeeraePNDAILLL-MRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDD 376
Cdd:cd11480   299 GAPIAGELDGG--------GDMAVLLLpEIAGLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPGASER 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 377 YYLKFGRIATVVATGVAVFTALLAQNfGNVMdYLQTL-FGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITFWY 455
Cdd:cd11480   371 REVRVARIAAVVVGVIAILLALLFPP-QNVA-FLVALaFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIV 448
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1577444730 456 IATFTDATASIFNLPG---QGTAFVAAGVAFTVDIIVSV 491
Cdd:cd11480   449 LSPAVSGAPPGHDFAGfplTNPGLVSVPLGFLVAIVVSL 487
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
16-496 6.91e-27

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 113.77  E-value: 6.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  16 LLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQtmhyfWIGAIP--- 92
Cdd:cd11474     2 IGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLG-----GVAQDPfgy 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 --AMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLI 170
Cdd:cd11474    77 alCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILISAAI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 171 VLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLkdSVIAESHFHTWPGTDISGFENPVWSVIgIVLGL 250
Cdd:cd11474   157 VLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIA--SAAAAGKLRFFPWLGTKSDWLIWIDAW-LTLGL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 251 GFVLSFGYwttnfveVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEPNDAILL--LMRDL 328
Cdd:cd11474   234 GSIPQQDV-------FQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEEDAQLILplLLQYL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 329 LPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVatgVAVFTALLAQNFGNVMD 408
Cdd:cd11474   307 TPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVV---FGAIATLMALTVESIYG 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 409 YLQTLFGFFNAPLFATFILGMFWKRmtphAGWSGLVAGTASAITFWYIATFTDATASIFNLPGqgtaFVAAGVAFTVDII 488
Cdd:cd11474   384 LVELASDLVLVGLFVPLLAGLYWKR----ANTYGALAAIIVGLVLRLLGGELLLGLPADIPPQ----LQGFPFSTLAMVI 455

                  ....*...
gi 1577444730 489 VSVIVTMF 496
Cdd:cd11474   456 GSLLPLAV 463
ActP COG4147
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
1-508 1.13e-23

Na+(or H+)/acetate symporter ActP [Energy production and conversion];


Pssm-ID: 443318  Cd Length: 526  Bit Score: 104.47  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730   1 MEPSVLRLDATWVDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGF 80
Cdd:COG4147     1 MLALLEQLGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  81 QTMHYF--WIGAIPAMVFLgivMMPFYYGSKVRSVPEFMRRRFG-NAAHLVNAIS-------FAVAQLLIAGVnlyllat 150
Cdd:COG4147    81 DGLIYSigWLVGYVLLLLL---LAEYLRNFGKFTVPDFLGDRFYsRPARLVAAIStlvvsffYLIAQMVGAGV------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 151 IVEALLGWPMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHtwpG 230
Cdd:COG4147   151 LISLLLGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPLLAKAAEVHDL---G 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 231 TDISGFENPVWSVIGIVLgLGFVLSFGywT-------TNFVEVQRAmasesiSAARK---------------TPIIGAFP 288
Cdd:COG4147   228 AAYLEPGGLVKSPLDFIS-LGLALMLG--TaglphilMRFFTVPDA------KEARKsvgwalgfiglfyltAPALGFGA 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 289 KMFVpflvviPGMVASVSVADLMEERAEPNDAILLLMRDL-LPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQT 367
Cdd:COG4147   299 RALV------GPLPEWFDTGLIGAADGGGNMAVLALAEIAgGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYAN 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 368 YVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNfGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGT 447
Cdd:COG4147   373 VIKGKATEKEELRVARIAAVVIGVVAILLGINAPP-QNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGL 451
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1577444730 448 ASAIT--FWYIATFTDATASIFnLPGQGTAFVAAGVAFtvdiIVSVIVTMFTQPKPDEELVGF 508
Cdd:COG4147   452 ISALVliVLSPFVWVLGVDAAL-FPLENPGLVSMPLGF----LVAIVVSLLTPEPPAEDQELV 509
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
13-454 1.08e-22

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 101.49  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIGW---AAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSAN----GVEYGFQTMHY 85
Cdd:cd11504     4 ADYVVFSLLLVISAGIGLyyaCTGGKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSEsytfGTQYWFLGCSY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  86 FWIGAIPAMVFLgivmmPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALL 165
Cdd:cd11504    84 FLGLLIPAHVFI-----PVFYRLELTSAYEYLELRFNKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 166 VAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGwqglkdsvIAESHFHTWPGTDISGFE-NPVWSVI 244
Cdd:cd11504   159 AMGVVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAGG--------IARVWRVAAESDRIDGFNlSPDPTIR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 245 GIVLGLGF---VLSFGYWTTNFVEVQRAMASESISAARKTpiigafpkmfvpFLVVIPGMVASVSVADLM---------- 311
Cdd:cd11504   231 HTFWTLVVggvFNMLALYGVNQAQVQRYLSSRTEKQAKRS------------CYLVFPGQQLSLCIGCLCglvmfaryhe 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 312 ------EERAEPNDAILLLMRDLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYvVKDREDDYYLKFGR 383
Cdd:cd11504   299 cdplknGIVARSDQLVPYFVMDVLDGlpGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPK-FPDMTEERATLLSK 377
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1577444730 384 IATVVATGVAVFTALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTasAITFW 454
Cdd:cd11504   378 GLAVGYGLLCLLMAYLASTMGQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGL--FMAFW 446
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
13-448 5.21e-21

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 96.45  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  13 VDYLLVALYFLFVLGIG-WAAKAR--VSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMhYFWIG 89
Cdd:cd11503     1 WDYGVFAAMLLVSTGIGlFVGLARggQRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFL-WMCLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  90 AIPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGL 169
Cdd:cd11503    80 QLLNSLMTAVLFMPVFYRLGITSTYQYLEMRFSRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 170 IVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDsvIAESHFHTWPGtDISGFENPVWSVIGIVLG 249
Cdd:cd11503   160 ICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLE--IAQNHSRINFM-DFDPDPRRRYTFWTFVVG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 250 lGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVAD----LMEERAEPNDAILLLM 325
Cdd:cd11503   237 -GTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLVNQVGLCLIVSSAATCGIVMFVYYSNcdplLIGRISAPDQYMPYLV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 326 RDLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVFTALLAQNF 403
Cdd:cd11503   316 LDIFEDlpGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLPTIAPRKLVFISKGLSLIYGSACITVAALSSLLG 395
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1577444730 404 GNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTA 448
Cdd:cd11503   396 GGVLQGSFTVMGVISGPLLGAFALGMFLPACNTPGVFSGLAVGLA 440
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
14-454 1.21e-17

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 86.10  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIG--WAAKAR-VSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSAN----GVEYGFQTMHYF 86
Cdd:cd11505     8 DYVVFAAMLFISAGIGiyYAFAGGgQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEvyrfGASFLIFAFAYL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  87 WIGAIPAMVFLgivmmPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLV 166
Cdd:cd11505    88 FVVLISSEVFL-----PVFYRLGITSTYEYLELRFNKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSvigI 246
Cdd:cd11505   163 TGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILNDSYNGSRLNFWDFDPNPLRRHTFWT---I 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 247 VLGLGFVLSfGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAE----PNDAIL 322
Cdd:cd11505   240 TVGGTFTWT-GIYGVNQSQVQRYISCKTRFQAKLSLYFNLLGLWAILVCAVFSGLAMYSHYKDCDPWTAKivsaPDQLMP 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 323 LLMRDLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYV--VKDREDDYYLK-FGRIATVVATGVAVFTA 397
Cdd:cd11505   319 YLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFrsLSEKLSSWISKgLSLLYGAMCIGMAVAAS 398
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1577444730 398 LLaqnfGNVMDYLQTLFGFFNAPLFATFILGMfwkrMTPHAGWSGLVAG--TASAITFW 454
Cdd:cd11505   399 LM----GGLLQAALSIFGMVGGPLLGLFSLGI----LFPFVNSKGALGGllTGFAISLW 449
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
14-454 3.29e-16

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 81.43  E-value: 3.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIGWA---AKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYG--FQT--MHYF 86
Cdd:cd11519     8 DYVVFAGMLLISAGIGIYyafAGGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGaiFSIfaFTYA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  87 WIGAIPAMVFLgivmmPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLV 166
Cdd:cd11519    88 IVVVISAEVFL-----PVFYRLGITSTYEYLELRFNKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGAVVA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSvigI 246
Cdd:cd11519   163 TGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILNDSYYGGRLNFWDFDPNPLQRHTFWT---I 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 247 VLGlGFVLSFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVAD----LMEERAEPNDAIL 322
Cdd:cd11519   240 VIG-GTFTWTSIYGVNQSQVQRYISCKTRFQAKMSLYVNLVGLWAILSCAVLSGLAMYSIYKDcdpwTAKDVSAPDQLMP 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 323 LLMRDLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDY-YLKFGriATVVATGVAVFTALL 399
Cdd:cd11519   319 YLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQLsWISMG--MSVFYGALCIGMAGL 396
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1577444730 400 AQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTasAITFW 454
Cdd:cd11519   397 ASLMGALLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGF--AISLW 449
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
18-501 1.31e-15

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 79.17  E-value: 1.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  18 VALYFLFVLGIG-WAAKARVSSSIDF----FLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFWIGAIP 92
Cdd:cd10327     5 IIIYLVILLGIGfYARRSKKRRSGDFleeyFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQVPT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  93 AMVFLGIVMMPFYYGSK---VRSVPEFMRRRFGNAAhLVNAISFAVAQLLIAGVNLYLL--ATIVEALLGWPMWVALLVA 167
Cdd:cd10327    85 GFLTLGVLGKKFAIIARkinAVTIIDYLRARYNSKA-LVVLSSLALIVFFIAAMVAQFIggARLLEAVTGLSYVTGLLIF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 168 GLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGG----WQGLKDS---VIAESHFHTWPGTDISGFenpv 240
Cdd:cd10327   164 GLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGmeaiMATLAEIdpnLLTPFGPGFLSPPYILSF---- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 241 WSVIGI-VLGLGFVlsfgywttnfveVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLmeerAEPND 319
Cdd:cd10327   240 WVLVGFgVIGLPQT------------AVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLPDL----EVPDK 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 320 AILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDrEDDYYLKFGRIATVVATGVAVFTALL 399
Cdd:cd10327   304 VIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKE-KKTSEKKVKRISLIITIILGLLVFLL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 400 AQNFGNVMDYLQTL-FGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTAS--AITFWYIAtftdatasIFNLPGQGTAF 476
Cdd:cd10327   383 AINPPDLIVWLNLFaFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSyiLITYLKIK--------ILGLHPIVPSL 454
                         490       500
                  ....*....|....*....|....*
gi 1577444730 477 VAAGVAFtvdiivsVIVTMFTQPKP 501
Cdd:cd10327   455 LLSLIAF-------IIVSLATKKPD 472
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
14-454 1.41e-14

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 76.43  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  14 DYLLVALYFLFVLGIG--WAAKAR-VSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGfQTMHYFWIGA 90
Cdd:cd11520     8 DYVVFAGLFLVSSGIGvfFAIKERkKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFG-ASFVLFFIAY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  91 IPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIAGVNLYLLATIVEALLGWPMWVALLVAGLI 170
Cdd:cd11520    87 TFVIIFTSELFLPVFYRSGITSTYEYLELRFNKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 171 VLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFHTWPGTDISGFENPVWSvigIVLGL 250
Cdd:cd11520   167 CTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGGFTNVWETAYNGSRLNIFDFDVDPLRRHTFWT---ITVGG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 251 GFVLsFGYWTTNFVEVQRAMASESISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAE----PNDAILLLMR 326
Cdd:cd11520   244 TFTW-LGIYGVNQSTIQRCISCKTEKHAKLALYLNLLGLWIILVCAVFSGLIMYSHYKDCDPWTSGfisaPDQLMPYFVM 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 327 DLLPN--GLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYV--VKDREDDYYLKfgriATVVATGVAVFT-ALLAQ 401
Cdd:cd11520   323 EIFSTmpGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFphLSEKLSTWISK----GLCILFGVMCTSmAVAAS 398
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1577444730 402 NFGNVMDYLQTLFGFFNAPLFATFILGMFWkrmtPHAGWSGLVAGTASAIT--FW 454
Cdd:cd11520   399 LMGGVVQAALSIHGMCGGPMLGLFTLGIVF----PFVNWKGALGGLLTGITlsFW 449
PRK12488 PRK12488
cation/acetate symporter;
12-453 1.29e-07

cation/acetate symporter;


Pssm-ID: 237114 [Multi-domain]  Cd Length: 549  Bit Score: 54.42  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  12 WVDYLLVALYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANLGAVEIIGMSANGVEYGFQTMHYFwIGai 91
Cdd:PRK12488   32 WTAIGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYA-LG-- 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  92 pamVFLGIVMMPFYYGSKVRSVPEFM-------------RRRFGNAAHLVNAISFAVAQLLIAGvnlyllaTIVEALLGW 158
Cdd:PRK12488  109 ---VLAGWPIILFLIAERLRNLGKYTfadvvsyrlaqgpVRLTAAFGTLTVVLMYLVAQMVGAG-------KLIELLFGI 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 159 PMWVALLVAGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAESHFH----TWPGTDIS 234
Cdd:PRK12488  179 SYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVHAKgqaiLAPGGLLS 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 235 gfeNPVwSVIGIVLGLGFVLS-FGYWTTNFVEVQRAMASESiSAARKTPIIGAFpkmFVPFLVVIPGMVASVSVADLMEE 313
Cdd:PRK12488  259 ---NPI-DAISLGLGMMFGTAgLPHILMRFFTVSDAREARK-SVLYATGFIGYF---YLLIIVVGFGAIVMVGTEPSYRD 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 314 RAEP-----NDAILLLMRDLLPNGLLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYY-LKFGRIATV 387
Cdd:PRK12488  331 AGGKiigggNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGQASEAQeMRVSKIATL 410
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1577444730 388 VATGVAVFTALLAQNFgNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITF 453
Cdd:PRK12488  411 GIGLLAVVLGLMFESQ-NIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSAVVL 475
PRK15419 PRK15419
sodium/proline symporter PutP;
20-453 3.42e-04

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 43.47  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  20 LYFLFVLGIGWAAKARVSSSIDFFLSGRGLPAWVTGLAFVSANL---------GAVEIIGMSANGVEYGFQtmhyfwIGA 90
Cdd:PRK15419   13 VYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMsgwllmglpGAVFLSGISESWIAIGLT------LGA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730  91 -IPAMVFLGIVMMPFYYGSKVRSVPEFMRRRFGNAAHLVNAISFAVAQLLIA---GVNLYLLATIVEALLGWPMWVALLV 166
Cdd:PRK15419   87 wINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTiycASGIVAGARLFESTFGMSYETALWA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 167 AGLIVLSYITLGGLSAAIYNEVLQFFVIVAALAPLTIIGLNRVGGWQGLKDSVIAEShfhtwpgtdisgFENpvwsvIGI 246
Cdd:PRK15419  167 GAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKS------------IEN-----VDM 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 247 VLGLGFV--LSFGYWTTNFVE----VQRAMASES---ISAARKTPIIGAFPKMFVPFLVVIPGMVASVSVADLMEERAEP 317
Cdd:PRK15419  230 LKGLNFVaiISLMGWGLGYFGqphiLARFMAADShhsIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAVAGAVNQN 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577444730 318 NDAILLLMRDLLPNG-LLGVAIAGLLASFMAGMAANISAFNTVISYDIWQTYVVKDREDDYYLKFGRIATVVATGVAVft 396
Cdd:PRK15419  310 AERVFIELAQILFNPwIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAI-- 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1577444730 397 ALLAQNFGNVMDYLQTLFGFFNAPLFATFILGMFWKRMTPHAGWSGLVAGTASAITF 453
Cdd:PRK15419  388 ALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVW 444
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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