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Conserved domains on  [gi|1540040113|emb|VEH00070|]
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Multidrug export protein mepA [Slackia heliotrinireducens]

Protein Classification

MATE family efflux transporter( domain architecture ID 8282)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MATE_like super family cl09326
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
12-417 4.72e-85

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


The actual alignment was detected with superfamily member cd13143:

Pssm-ID: 447704 [Multi-domain]  Cd Length: 426  Bit Score: 267.45  E-value: 4.72e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  12 PQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQ 91
Cdd:cd13143     4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  92 FSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAA 171
Cdd:cd13143    84 FSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 172 GLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEMVSNIAMS 250
Cdd:cd13143   164 AVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLkLSLLRFKLSLKIIKEILALGFPSFLMQLSSS 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 251 LVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIA 330
Cdd:cd13143   244 VVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 331 TRVFARPLALVFVGYSEgLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLPTLFG 410
Cdd:cd13143   324 LLLFPEQIVSLFTDDPE-LIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFG 402

                  ....*..
gi 1540040113 411 ADGIWVS 417
Cdd:cd13143   403 LDGIWLA 409
 
Name Accession Description Interval E-value
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
12-417 4.72e-85

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 267.45  E-value: 4.72e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  12 PQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQ 91
Cdd:cd13143     4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  92 FSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAA 171
Cdd:cd13143    84 FSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 172 GLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEMVSNIAMS 250
Cdd:cd13143   164 AVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLkLSLLRFKLSLKIIKEILALGFPSFLMQLSSS 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 251 LVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIA 330
Cdd:cd13143   244 VVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 331 TRVFARPLALVFVGYSEgLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLPTLFG 410
Cdd:cd13143   324 LLLFPEQIVSLFTDDPE-LIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFG 402

                  ....*..
gi 1540040113 411 ADGIWVS 417
Cdd:cd13143   403 LDGIWLA 409
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
5-417 1.10e-66

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 219.63  E-value: 1.10e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113   5 MSRHFTLPQLIRFTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGD 84
Cdd:COG0534     1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVG-RLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  85 DARANRQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELG 164
Cdd:COG0534    80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 165 FGVTVAAGLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEM 243
Cdd:COG0534   160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLrLRLRDLRPDRKILKRILRIGLPAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 244 VSNIAMSLVSMAYNVQLLVYlGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSIC 323
Cdd:COG0534   240 LQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 324 GVAMFIATRVFARPLALVFVGySEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVF 403
Cdd:COG0534   319 GLLLALLLFLFPEPIIGLFTD-DPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
                         410
                  ....*....|....*
gi 1540040113 404 LLP-TLFGADGIWVS 417
Cdd:COG0534   398 LLAfLGLGLTGVWLA 412
vmrA PRK09575
MATE family efflux transporter;
13-417 2.48e-39

MATE family efflux transporter;


Pssm-ID: 236576 [Multi-domain]  Cd Length: 453  Bit Score: 147.45  E-value: 2.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  13 QLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQF 92
Cdd:PRK09575   13 TFWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRIL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  93 SLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAG 172
Cdd:PRK09575   93 TTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 173 LTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYF-ARPNKSFLRLGRTNMDWRMLGHACVNGSSEMVSNIAMSL 251
Cdd:PRK09575  173 LINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFfSSRANIRLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSF 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 252 VSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIAT 331
Cdd:PRK09575  253 VVALHNRLFMEYGSALTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLL 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 332 RVFARPLALVFVGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIfEIGAVFLLPTLFGA 411
Cdd:PRK09575  333 NLFPETMIALFNSGDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIGNMLI-QLPFLFILPKWLGV 411

                  ....*.
gi 1540040113 412 DGIWVS 417
Cdd:PRK09575  412 DGVWLA 417
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
20-359 2.83e-16

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 79.60  E-value: 2.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  20 PTIGMMLFMSLYVMVDGFFVSNWcGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFSLLVYAA 99
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 100 IVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGLTNIVVD 179
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 180 AVLI--ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLR-LGRTNMDWRMLGHACVNGSSEMVSNIAMSLVSMAY 256
Cdd:TIGR00797 160 YILIfgKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKwEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 257 NVqLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIATRVFAR 336
Cdd:TIGR00797 240 AL-LVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
                         330       340
                  ....*....|....*....|...
gi 1540040113 337 PLALVFVGYSEgLAELTVHAMLL 359
Cdd:TIGR00797 319 FIARLFTNDPE-VLELAAIYLIF 340
MatE pfam01554
MatE; The MatE domain
243-396 7.36e-12

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 63.35  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIAMSLVSMAYNVqLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:pfam01554   3 ALENLLQSLYSLIDTL-FVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLL 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1540040113 323 CGVAMFIATRVFARPLALVFvGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLI 396
Cdd:pfam01554  82 LSLPIALLVLLFSEPILSLF-GQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
 
Name Accession Description Interval E-value
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
12-417 4.72e-85

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 267.45  E-value: 4.72e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  12 PQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQ 91
Cdd:cd13143     4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  92 FSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAA 171
Cdd:cd13143    84 FSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 172 GLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEMVSNIAMS 250
Cdd:cd13143   164 AVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLkLSLLRFKLSLKIIKEILALGFPSFLMQLSSS 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 251 LVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIA 330
Cdd:cd13143   244 VVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 331 TRVFARPLALVFVGYSEgLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLPTLFG 410
Cdd:cd13143   324 LLLFPEQIVSLFTDDPE-LIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFG 402

                  ....*..
gi 1540040113 411 ADGIWVS 417
Cdd:cd13143   403 LDGIWLA 409
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
5-417 1.10e-66

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 219.63  E-value: 1.10e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113   5 MSRHFTLPQLIRFTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGD 84
Cdd:COG0534     1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVG-RLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  85 DARANRQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELG 164
Cdd:COG0534    80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 165 FGVTVAAGLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEM 243
Cdd:COG0534   160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLrLRLRDLRPDRKILKRILRIGLPAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 244 VSNIAMSLVSMAYNVQLLVYlGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSIC 323
Cdd:COG0534   240 LQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 324 GVAMFIATRVFARPLALVFVGySEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVF 403
Cdd:COG0534   319 GLLLALLLFLFPEPIIGLFTD-DPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
                         410
                  ....*....|....*
gi 1540040113 404 LLP-TLFGADGIWVS 417
Cdd:COG0534   398 LLAfLGLGLTGVWLA 412
vmrA PRK09575
MATE family efflux transporter;
13-417 2.48e-39

MATE family efflux transporter;


Pssm-ID: 236576 [Multi-domain]  Cd Length: 453  Bit Score: 147.45  E-value: 2.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  13 QLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQF 92
Cdd:PRK09575   13 TFWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRIL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  93 SLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAG 172
Cdd:PRK09575   93 TTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 173 LTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYF-ARPNKSFLRLGRTNMDWRMLGHACVNGSSEMVSNIAMSL 251
Cdd:PRK09575  173 LINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFfSSRANIRLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSF 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 252 VSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIAT 331
Cdd:PRK09575  253 VVALHNRLFMEYGSALTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLL 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 332 RVFARPLALVFVGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIfEIGAVFLLPTLFGA 411
Cdd:PRK09575  333 NLFPETMIALFNSGDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIGNMLI-QLPFLFILPKWLGV 411

                  ....*.
gi 1540040113 412 DGIWVS 417
Cdd:PRK09575  412 DGVWLA 417
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
11-417 1.84e-37

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 141.83  E-value: 1.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANR 90
Cdd:cd13138     2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  91 QFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVA 170
Cdd:cd13138    82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVII 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 171 AGLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEMVSNIAM 249
Cdd:cd13138   162 ACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFkLSLKDFRFDKEILKEILKIGLPSALQQSLV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 250 SLVSMAYNVQLLVYlGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFI 329
Cdd:cd13138   242 SISFLIINSIVNSY-GVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIIL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 330 ATRVFARPLALVFVGySEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLPTLF 409
Cdd:cd13138   321 LVFFFAPQLLGLFTS-DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLT 399
                         410
                  ....*....|
gi 1540040113 410 --GADGIWVS 417
Cdd:cd13138   400 glGLFGIWLA 409
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-417 5.27e-34

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 132.36  E-value: 5.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANR 90
Cdd:cd13144     7 LRLLLTMSIPAMISMLFQALYNIVDSIFVA-RLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  91 QFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVA 170
Cdd:cd13144    86 AANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 171 AGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNK-SFLRLGRTNMDWRMLGHACVNGSSEMVS 245
Cdd:cd13144   166 GAIINIILDPILIfglfGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKdVQPDLRLFRPSLRIIKEIYAVGLPSIIM 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 246 NIAMSLVSMAYNVQLLVYlGESGVAAYGVIMYV-GMAFVAVFmGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICG 324
Cdd:cd13144   246 QAISSVMVFGLNKILAGF-GPTAVAVFGIYFKLqSFVFMPVF-GLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIM 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 325 VAMFIATRVFARPLALVFVGySEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFL 404
Cdd:cd13144   324 LAGGLLFQLFPDQLLGLFNA-SEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWL 402
                         410
                  ....*....|...
gi 1540040113 405 LPTLFGADGIWVS 417
Cdd:cd13144   403 LAKMFGLNGVWWS 415
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
19-415 1.59e-32

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 127.83  E-value: 1.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  19 LPTIGMMLFMSLYVMVDGFFVSNWcGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFSLLVYA 98
Cdd:cd12082     2 APLLLSMLLQTLYNLVDTFFLGRL-LGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  99 AIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGLTNIVV 178
Cdd:cd12082    81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 179 DAVLIALL---DFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLRLGRTN-MDWRMLGHACVNGSSEMVSNIAMSLVSM 254
Cdd:cd12082   161 DPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLkPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 255 AYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIATRVF 334
Cdd:cd12082   241 IIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 335 ARPLALVFVGYSEGLaELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLPTL-FGADG 413
Cdd:cd12082   321 PEPILSLFTNDPEFL-ELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLgLGLYG 399

                  ..
gi 1540040113 414 IW 415
Cdd:cd12082   400 IW 401
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
14-416 5.98e-32

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 126.50  E-value: 5.98e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  14 LIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFS 93
Cdd:cd13147    11 IIKLSIPMIIAMLLQTLYNLVDAIWVAG-LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  94 LLVYAAIVAGAAFAALGVLLLRPLLVALGAqGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGL 173
Cdd:cd13147    90 HSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 174 TNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLRLGRTNM--DWRMLGHACVNGSSEMVSNIAMSL 251
Cdd:cd13147   169 LNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDTYVSLSLKNFkfDKKIVKDILKVGIPASLEQLIMSV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 252 VSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIAT 331
Cdd:cd13147   249 LMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILI 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 332 RVFARPLALVF--VGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLL--PT 407
Cdd:cd13147   329 FIFAPQIAYLFtySEESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAYLFaiVL 408

                  ....*....
gi 1540040113 408 LFGADGIWV 416
Cdd:cd13147   409 GLGLFGVWW 417
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
13-417 5.80e-27

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 112.22  E-value: 5.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  13 QLIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQF 92
Cdd:cd13137     2 RIWSLAWPVILENLLQTLVGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  93 SLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAG 172
Cdd:cd13137    81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 173 LTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNGSSEMVSNI 247
Cdd:cd13137   161 VLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIkISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 248 AMSLVSMAYNVqLLVYLGESGVAAYGVIMYV-GMAFVAVFmGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVA 326
Cdd:cd13137   241 LRSLGFLVLLA-IVASYGTAALAAYQIGLRIeSLAFMPGF-GFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 327 MFIATRVFARPLALVFVGYSEgLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLLP 406
Cdd:cd13137   319 LGLLLFIFAPPLASLFTPDPE-VIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLG 397
                         410
                  ....*....|...
gi 1540040113 407 TLF--GADGIWVS 417
Cdd:cd13137   398 FVLglGLTGIWLA 410
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-414 3.75e-26

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 110.09  E-value: 3.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANR 90
Cdd:cd13149     8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGK-LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKR 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  91 QFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVA 170
Cdd:cd13149    87 LATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 171 AGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNK----SFLRLGRTNMDWRMLGHACVNGSSE 242
Cdd:cd13149   167 AALVNVILDPILIfgfgPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRlidfSEPSLKALFRSWKDILSIGIPAALS 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIamslVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:cd13149   247 NILTP----LSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 323 CGVAMFIATRVFARPLALVFVGYSEgLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAV 402
Cdd:cd13149   323 YGAILGIVLALFAGWLASLFSAEPE-VIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLA 401
                         410
                  ....*....|..
gi 1540040113 403 FLLPTLFGADGI 414
Cdd:cd13149   402 YVGSHLLGFAGV 413
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-417 6.69e-21

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 94.57  E-value: 6.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWcGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANR 90
Cdd:cd13142    10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRL-GADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  91 QFS-LLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTV 169
Cdd:cd13142    89 VAGqTFSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMF 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 170 AAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIpLVYFARPNKSFLRLGRTNM--DWRMLGHACVNGsseM 243
Cdd:cd13142   169 GSVLLNVILDPLLIfgigPFPGLGVAGAALATVISRGIAAVI-GLYLLFKGRVGLKISLRDLkpDWEWLKKIFRIG---L 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 244 VSNIAMSLVSMAYNVQ--LLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVS 321
Cdd:cd13142   245 PSSIEQSARALGFTVMtaLVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIF 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 322 ICGVAMFIATRVFARPLALVFVGYSEGLAElTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGA 401
Cdd:cd13142   325 LILVIGGVLAFLFAEPIVRVFINDPEVIKE-GADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPL 403
                         410
                  ....*....|....*...
gi 1540040113 402 VFLL--PTLFGADGIWVS 417
Cdd:cd13142   404 AYLLayVLGLGVTGIWIA 421
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
9-376 2.68e-18

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 86.81  E-value: 2.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113   9 FTLPQLIRFTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARA 88
Cdd:cd13133     2 GGYREILKIALPLVLSMLSQTVMGFTDRAFLG-RLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  89 NRQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVT 168
Cdd:cd13133    81 GRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVAN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 169 VAAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPN--KSFLRLGRTNMDWRMLGHACVNGSSE 242
Cdd:cd13133   161 LVMVVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKnrRRFGLRRAWRFDRELLRRILRLGLPS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVsNIAMSLVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:cd13133   241 GL-QFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALA 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1540040113 323 CGVAMFIATRVFARPLALVFVGYSEG--LAELTVHAMLLYSASLLIVGFNM-YGSAL 376
Cdd:cd13133   320 YMLLLGILFLLFPELLLSIFTPGADFalIAELAVPLLRFVAAYILFDALALvFAGAL 376
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
20-359 2.83e-16

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 79.60  E-value: 2.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  20 PTIGMMLFMSLYVMVDGFFVSNWcGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFSLLVYAA 99
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 100 IVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGLTNIVVD 179
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 180 AVLI--ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLR-LGRTNMDWRMLGHACVNGSSEMVSNIAMSLVSMAY 256
Cdd:TIGR00797 160 YILIfgKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKwEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 257 NVqLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMFIATRVFAR 336
Cdd:TIGR00797 240 AL-LVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
                         330       340
                  ....*....|....*....|...
gi 1540040113 337 PLALVFVGYSEgLAELTVHAMLL 359
Cdd:TIGR00797 319 FIARLFTNDPE-VLELAAIYLIF 340
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
13-417 5.92e-15

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 76.45  E-value: 5.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  13 QLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAypiPMILGTLGFMFG---TGGSAIVAKTRGEGDDARAN 89
Cdd:cd13136     4 EILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALG---TTIFNTLFWLFGflrMGTTGLVAQALGAGDREEAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  90 RQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTV 169
Cdd:cd13136    81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 170 AAGLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYFARP-NKSFLRLGRTNMDWRMLGHACVNGSSEMVSNIA 248
Cdd:cd13136   161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRvRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 249 MsLVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICGVAMF 328
Cdd:cd13136   241 L-LAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 329 IATRVFARPLALVFVGYSEGLAELTVHAMLLYSASLL-IVGFNMYGSAL----FTALGNGLVSAIISFvrtlifeIGAVF 403
Cdd:cd13136   320 LLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIgALAFVLDGIFIgatdTRYLRNSMLVSLAVF-------LPLLF 392
                         410
                  ....*....|....
gi 1540040113 404 LLPTLFGADGIWVS 417
Cdd:cd13136   393 LLVPLWGNHGLWLA 406
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
10-417 3.02e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 74.48  E-value: 3.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  10 TLPQLIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARAN 89
Cdd:cd13140     3 ILKTLLRLALPIMGTSFIQMAYNLTDMFWVGR-LGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEAR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  90 R--QFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQgEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGV 167
Cdd:cd13140    82 KyaRNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDA-EVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 168 TVAAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLRLG-RTNMDWRMLGHACVNGSSE 242
Cdd:cd13140   161 NAIGLVLNIILDPLLIfgfgPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRiLKRPDRKYIKEILKLGLPV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIAMSLVSMAYNvQLLVYLGESGVAAYGVimyvGMAFVAV-FM---GYVFGSSPLMSFQYGANNRIEMRSLFRKSLL 318
Cdd:cd13140   241 ALQSILFALISMILA-RIIASFGPVAIAAQKV----GSQIESIsWMtaeGFSTALAAFVGQNYGAGKYDRIRKGYKTALK 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 319 FVSICGVAMFIATRVFARPLALVFVGYSEGLAELTVHAMLLySASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFE 398
Cdd:cd13140   316 IASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRIL-GFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNGLRI 394
                         410
                  ....*....|....*....
gi 1540040113 399 IGAVFLLPTLFGADGIWVS 417
Cdd:cd13140   395 PLALLLSPTGLGLNGIWWA 413
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-410 4.44e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 73.97  E-value: 4.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVS--NWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARA 88
Cdd:cd13146     7 SPLLIRLALPILIGQLFQLLYNITDTIWISmiDPSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKEL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  89 NRQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVT 168
Cdd:cd13146    87 DQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAM 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 169 VAAGLTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYF-ARPNKSFLRLGRTNMDWRMLGHACVNGSSEMVSNI 247
Cdd:cd13146   167 LIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFlIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLLQL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 248 AMSLVSMAYNvQLLVYLGESGVAAYgvIMYVGMAFVAVFMGYVFGSSPL--MSFQYGANNRIEMRSLFRKSLLfVSICGV 325
Cdd:cd13146   247 ISSISFLIYN-RIIIDIDPVAMTAF--TLVGRLDQFILIPIFAISSALLtiAGQNWGRGNYDRMLQILMTAVI-LGIVVV 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 326 AMFIATRVFARPLALVFVGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVFLL 405
Cdd:cd13146   323 LVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLL 402

                  ....*
gi 1540040113 406 PTLFG 410
Cdd:cd13146   403 AYVFG 407
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
22-417 8.66e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 73.03  E-value: 8.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  22 IGMMLFM---SLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFSLLVYA 98
Cdd:cd13139    21 IPMVLEMvmeSLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  99 AIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGLTNIVV 178
Cdd:cd13139   100 GVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIIL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 179 DAVLIALL----DFGVVGAAIGTIAGEAVGGIIPLVYFARpNKSFLRLGRTNMD------WRMLGHAcVNGSSEMVsnIA 248
Cdd:cd13139   180 DPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFK-GKGRIQIRRRHLKldwaiiKKIIKIA-VGGILQFL--IA 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 249 MSlvSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANN--RIEmRSLFRK---SLLFVSIC 323
Cdd:cd13139   256 SS--SWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQpdRAE-KSVWRAgkyNMVFLGIV 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 324 GVAMFIatrvFARPLALVFVGySEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFEIGAVF 403
Cdd:cd13139   333 SLVFFL----FAEPLVSFFTT-DPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAY 407
                         410
                  ....*....|....*.
gi 1540040113 404 LL--PTLFGADGIWVS 417
Cdd:cd13139   408 LLarHLNLGPKGVFIA 423
MATE_like_13 cd13141
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
14-404 3.34e-13

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240546 [Multi-domain]  Cd Length: 443  Bit Score: 71.19  E-value: 3.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  14 LIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFS 93
Cdd:cd13141    13 IISMALPIAIGMIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFN 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  94 LLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYampLVMGVPATVLQYLFQEL---LVTAGKPELGFGVTVA 170
Cdd:cd13141    92 QSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTY---LYWFIPSLALQFILTVLgaaLRGTGIVKPFMVIQIL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 171 AGLTNIVVDAVLIA----LLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF---LRLGRTNMD-WRMLGHACVNGSSE 242
Cdd:cd13141   169 AVLLNIILAPILITgwgtGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLrldLALWRPDLPtWKRLLKIGLPSGGE 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MvsniAMSLVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:cd13141   249 F----LLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTA 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 323 cgvAMFIATRVFARPLALVFVGYSEGLAELTVHAMLLYSASLLIV--GFNMYGSALFTALGNGLVSAIISFVRTLIFEIG 400
Cdd:cd13141   325 ---LMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVaaGLVFTCSGMFQALGNTWPSLLSSASRLLTFALP 401

                  ....
gi 1540040113 401 AVFL 404
Cdd:cd13141   402 VIWL 405
MatE pfam01554
MatE; The MatE domain
243-396 7.36e-12

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 63.35  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIAMSLVSMAYNVqLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:pfam01554   3 ALENLLQSLYSLIDTL-FVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLL 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1540040113 323 CGVAMFIATRVFARPLALVFvGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLI 396
Cdd:pfam01554  82 LSLPIALLVLLFSEPILSLF-GQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-417 2.89e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 65.31  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIR-FTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARAN 89
Cdd:cd13145     7 IPKLIRkLAIPASVGFFFNTMFNVVDTFFAG-KISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKAR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  90 RQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTV 169
Cdd:cd13145    86 RYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 170 AAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAvGGIIPLVYFARPNKSFLRLGRTNM--DWRMLGHACVNGSSEM 243
Cdd:cd13145   166 IGFFLNIILDPLFIfgggGIPAMGVSGIALATIISQF-IGMFYLLYKVRKSGIISGCRLRDFipRLDVYKEILKQGFPAS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 244 VSNIAMSLVSmaYNVQLLV-YLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLF-VS 321
Cdd:cd13145   245 LNMMTIGLGI--FVITYFVgQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYgFV 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 322 ICGVAMFIAtRVFARPLALVFVGYSE----GLAELTVHAMLLYSASLLivgfNMYGSALfTALGNGLVSAIISFVRTLIF 397
Cdd:cd13145   323 IMVVATVFL-LFFAEPLMSLFTNDPAviaiGAGYLRIDALIFYAYVVL----FISVSVL-QGLKRPIFALWIGLYRQLVG 396
                         410       420
                  ....*....|....*....|..
gi 1540040113 398 EIGAVFLLPTLFGAD--GIWVS 417
Cdd:cd13145   397 PALVFWLLVNVLGLGvtGIWWG 418
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
10-342 9.17e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 60.59  E-value: 9.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  10 TLPQLIRFTLPTIGMMLFMSLYVMVDGFFVSnWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARAN 89
Cdd:cd13134     1 FKLSLFALAWPIFIELLLQMLLGTIDTFMLS-RYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKAR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  90 RQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTV 169
Cdd:cd13134    80 QIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 170 AAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLRL----GRTNMDWRMLGHACVNGSS 241
Cdd:cd13134   160 IMNILNIVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLkdlrPFPKKLLKKILKIGLPSAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 242 EMVS-NIAMSLVSMAYNvqllvYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFV 320
Cdd:cd13134   240 EELSyNLSQTVITAFIA-----RLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIG 314
                         330       340
                  ....*....|....*....|..
gi 1540040113 321 SICGVAMFIATRVFARPLALVF 342
Cdd:cd13134   315 LLVSLAVALLLALFREPILGLF 336
MatE pfam01554
MatE; The MatE domain
20-181 9.67e-10

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 57.19  E-value: 9.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  20 PTIGMMLFMSLYVMVDGFFVSNWcGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQFSLLVYAA 99
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHL-GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 100 IVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAGLTNIVVD 179
Cdd:pfam01554  80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159

                  ..
gi 1540040113 180 AV 181
Cdd:pfam01554 160 YL 161
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
11-232 3.75e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 55.36  E-value: 3.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  11 LPQLIRFTLPTIGMMLFMSLYVMVDGFFVSNwCGQTALAAVNFAYPIPMILGTLGF-MFGTGGSAIVAKTRGEGDDARAN 89
Cdd:cd13148    11 LPTLLRLALPNILALLVQTLVGLAETYFVGQ-LGTDALAGVALVFPLLMLTQMMSNgAMGGGVSSAIARALGAGDRERAE 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  90 RQFSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTV 169
Cdd:cd13148    90 ALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTL 169
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540040113 170 AAGLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRML 232
Cdd:cd13148   170 VGAVVQIPLSPGLIlgwgPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLrLRLRALRLERRLF 237
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
13-212 2.67e-07

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 52.71  E-value: 2.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  13 QLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMFGTGGSAIVAKTRGEGDDARANRQF 92
Cdd:cd12082   220 RLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRIT 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  93 SLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAAG 172
Cdd:cd12082   300 WVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSY 379
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1540040113 173 LTNIVVDAVLIALLDFGVVGAAIGTIAGEAVGGIIPLVYF 212
Cdd:cd12082   380 WVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
MATE_MurJ_like cd13123
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
165-414 1.47e-05

MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240528 [Multi-domain]  Cd Length: 420  Bit Score: 47.06  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 165 FGVTVAAG-LTNIVVDAVLIAL---LDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTN---------MDWR 230
Cdd:cd13123   145 FFAPALAPvLLNLVIIAGLLLLaplFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFrPRLDFRDpgvrrvlklMLPA 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 231 MLGHACVNGSSEMVSNIAMSL----VSMAYNVQLLVYLgesgvaAYGVImyvGMAFVAVFMgyvfgssPLMSFQYGANNR 306
Cdd:cd13123   225 LLGVSVSQINLLVDTILASFLpegsISALYYADRLYQL------PLGIF---GVAIATALL-------PRLSRLAAAGDL 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 307 IEMRSLFRKSLLFVSICGVAMFIATRVFARPLALVFVGY---SEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNG 383
Cdd:cd13123   289 DEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERgafTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDT 368
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1540040113 384 LVSAIISFVrTLIFEIGAVFLLPTLFGADGI 414
Cdd:cd13123   369 KTPVKIAVI-AVAVNILLNLLLIKPLGHVGL 398
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
243-414 1.90e-05

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 46.48  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIAMSLVSMAYNVQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSI 322
Cdd:COG2244   183 LLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLL 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 323 CGVAMFIATRVFARPLALVFVG--YSEGlaeltVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLIFeIG 400
Cdd:COG2244   263 LGLPLALGLALLAPPLLSLLFGpeYAEA-----APVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLN-LV 336
                         170
                  ....*....|....
gi 1540040113 401 AVFLLPTLFGADGI 414
Cdd:COG2244   337 LNLLLIPRYGLVGA 350
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
165-414 2.11e-05

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 46.68  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 165 FGVTVAAG-LTNIVVDAVLIAL---LDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSF-LRLGRTNMDWRMLGHACVNg 239
Cdd:COG0728   152 FAAPALAPvLLNLVIIAGLLLLaplFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLrPRFDLRDPGVRRVLKLMLP- 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 240 sseMVSNIAMSLVSMAYNVQLLVYLGESGVAAYgvimYVGMAFVAVFMGyVFGSS------PLMSFQYGANNRIEMRSLF 313
Cdd:COG0728   231 ---ALLGVSVSQINLLVDTILASFLPEGSVSAL----YYADRLYQLPLG-LFGVAigtallPRLSRAAAAGDLEEFRRTL 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 314 RKSLLFVSICGVAMFIATRVFARPLALVFVGY---SEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIIS 390
Cdd:COG0728   303 SRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERgafTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIA 382
                         250       260
                  ....*....|....*....|....
gi 1540040113 391 FVrTLIFEIGAVFLLPTLFGADGI 414
Cdd:COG0728   383 VI-AVVVNIVLNLLLVPPLGHAGL 405
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
12-384 9.32e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 44.59  E-value: 9.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  12 PQLIRFTLPTIGMMLFMSLYVMVDGFFVSNWCGQTALAAVNFAYPIPMILGTLGFMfGTGGSAIVAKTRGEGDDARANRQ 91
Cdd:cd13135     1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSI-SIGFTILGSQSVGAKDIKRINDY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113  92 FSLLVYAAIVAGAAFAALGVLLLRPLLVALGAQGEMLDLCMVYAMPLVMGVPATVLQYLFQELLVTAGKPELGFGVTVAA 171
Cdd:cd13135    80 AISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 172 GLTNIVVDAVLI----ALLDFGVVGAAIGTIAGEAVGGIIPLVYFARPNKSFLRLGRTNMD---WRMLGHACVNGSSEMV 244
Cdd:cd13135   160 NLLNVILDYVLIfgnfGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLkanIRPYKFTIKLGLPLGG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 245 SNIAMSLVSMAYNvQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRKSLLFVSICG 324
Cdd:cd13135   240 EEFLWNIGNLAVI-RILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIY 318
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 325 VAMFIATRVFARPLALVFVGYSEGLAELTVHamllysasLLIVGFNMYGSALFTALGNGL 384
Cdd:cd13135   319 IAAAIVFLAFPYKILSLFTNDPELINYSIPY--------LIFIIIILFFKSINIVYGFAI 370
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
243-396 1.14e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 44.24  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 243 MVSNIAMSLVSMAYNVQLLVYLGESG---VAAYGVIMYVGMAFVAVFMGYVFGSSPLMSFQYGANNRIEMRSLFRkSLLF 319
Cdd:cd12082     1 AAPLLLSMLLQTLYNLVDTFFLGRLLgdaLAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLV-QSIV 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1540040113 320 VSICGVAMFIATRVFARPLALVFVGYSEGLAELTVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVRTLI 396
Cdd:cd12082    80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLL 156
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
180-413 3.58e-03

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 39.45  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 180 AVLIALLDFGVVGAAIGTIAGEAVGGIIpLVYFARPNKSFLRLGRTNMDW--RMLGHacvnGSSEMVSNIAMSLVSMAYN 257
Cdd:cd13128   156 ALILVLLGGGLIGFALAYLIASVLSAIL-LLYIYRKKILLPKFFSFDLKLakELLRF----SIPLALSGIFSLIYTRIDT 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540040113 258 VQLLVYLGESGVAAYGVIMYVGMAFVAVFMGYVFGSSPLMSfQYGANNRIEMRSLFRKSLLFVSICGVAMFIATRVFARP 337
Cdd:cd13128   231 IMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRIS-ELYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEP 309
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540040113 338 LALVFVG--YSEGlaeltVHAMLLYSASLLIVGFNMYGSALFTALGNGLVSAIISFVrTLIFEIGAVFLLPTLFGADG 413
Cdd:cd13128   310 IITLLFGeeYLPA-----ALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI-GALLNVILNLLLIPKYGIIG 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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