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Conserved domains on  [gi|1539694473|emb|VED58661|]
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antirepressor protein Cro (plasmid) [Klebsiella aerogenes]

Protein Classification

transcriptional regulator( domain architecture ID 10008341)

helix-turn-helix-type transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-70 3.69e-28

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


:

Pssm-ID: 443351  Cd Length: 68  Bit Score: 95.75  E-value: 3.69e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539694473  5 IKTAINIVGSQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATNGKVQAHQIRPDLP--KLFPS 70
Cdd:COG4197    1 LEKAIEALGSQSALARALGVSQQAVSQWLNGKRRVPAERCLAIERATGGAVTREELRPDLDwaYLWPE 68
 
Name Accession Description Interval E-value
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-70 3.69e-28

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 95.75  E-value: 3.69e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539694473  5 IKTAINIVGSQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATNGKVQAHQIRPDLP--KLFPS 70
Cdd:COG4197    1 LEKAIEALGSQSALARALGVSQQAVSQWLNGKRRVPAERCLAIERATGGAVTREELRPDLDwaYLWPE 68
YdaS_antitoxin pfam15943
Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT; YdaS_antitoxin is a family ...
 5-69 9.60e-26

Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT; YdaS_antitoxin is a family of putative bacterial antitoxins, neutralising the toxin YdaT, family pfam06254.


Pssm-ID: 435033  Cd Length: 65  Bit Score: 89.71  E-value: 9.60e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539694473  5 IKTAINIVGSQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATNGKVQAHQIRPDLPKLFP 69
Cdd:pfam15943  1 IKKAIEIVGGQKALAEALGVTQQAVSQWLHGKKGIPAEYCPAIERATSGKVTREELRPDVDWEFI 65
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-52 4.82e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.11  E-value: 4.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1539694473  14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATN 52
Cdd:smart00530 12 TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALG 50
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-52 1.19e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATN 52
Cdd:cd00093   14 TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALG 52
 
Name Accession Description Interval E-value
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-70 3.69e-28

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 95.75  E-value: 3.69e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539694473  5 IKTAINIVGSQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATNGKVQAHQIRPDLP--KLFPS 70
Cdd:COG4197    1 LEKAIEALGSQSALARALGVSQQAVSQWLNGKRRVPAERCLAIERATGGAVTREELRPDLDwaYLWPE 68
YdaS_antitoxin pfam15943
Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT; YdaS_antitoxin is a family ...
 5-69 9.60e-26

Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT; YdaS_antitoxin is a family of putative bacterial antitoxins, neutralising the toxin YdaT, family pfam06254.


Pssm-ID: 435033  Cd Length: 65  Bit Score: 89.71  E-value: 9.60e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539694473  5 IKTAINIVGSQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATNGKVQAHQIRPDLPKLFP 69
Cdd:pfam15943  1 IKKAIEIVGGQKALAEALGVTQQAVSQWLHGKKGIPAEYCPAIERATSGKVTREELRPDVDWEFI 65
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-52 4.82e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.11  E-value: 4.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1539694473  14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATN 52
Cdd:smart00530 12 TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALG 50
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-52 1.19e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATN 52
Cdd:cd00093   14 TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALG 52
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
14-50 1.60e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.13  E-value: 1.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNA 50
Cdd:COG1396   22 TQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKA 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 14-52 4.54e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.44  E-value: 4.54e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNATN 52
Cdd:pfam01381 11 SQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALG 49
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
14-50 2.27e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 32.90  E-value: 2.27e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPEHVNSIVNA 50
Cdd:COG1476   19 TQEELAELLGVSRQTISAIENGKYNPSLELALKIARA 55
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 14-42 4.13e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 32.47  E-value: 4.13e-03
                         10        20
                 ....*....|....*....|....*....
gi 1539694473 14 SQKKLGEACDVSQQAVYKWLHNKAKVSPE 42
Cdd:COG3093   24 SQTELAKALGVSRQRISEILNGKRAITAD 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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