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Conserved domains on  [gi|2318961058|gb|UYJ17965|]
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MAG: Holliday junction branch migration DNA helicase RuvB [Veillonellaceae bacterium]

Protein Classification

Holliday junction branch migration DNA helicase RuvB( domain architecture ID 11455025)

Holliday junction branch migration DNA helicase RuvB is an ATPase that forms a complex with RuvA; the helicase RuvAB mediates the Holliday junction migration by localized denaturation and reannealing

EC:  3.6.4.12
Gene Symbol:  ruvB
Gene Ontology:  GO:0003677|GO:0005524|GO:0009378
PubMed:  11478862|7625278

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
7-328 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


:

Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 619.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   7 RIVSTEESSKDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVT 86
Cdd:COG2255     6 RLSSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRIT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  87 SGPAIARPGELAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGS 166
Cdd:COG2255    86 SGPAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 167 LSAPLRDRFLINHHMEFYEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNS-AITAEI 245
Cdd:COG2255   166 LTSPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDgVITLEI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 246 ASEAMEALHVDDIGLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYD 325
Cdd:COG2255   246 ADAALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYE 325

                  ...
gi 2318961058 326 HIG 328
Cdd:COG2255   326 HLG 328
 
Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
7-328 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 619.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   7 RIVSTEESSKDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVT 86
Cdd:COG2255     6 RLSSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRIT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  87 SGPAIARPGELAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGS 166
Cdd:COG2255    86 SGPAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 167 LSAPLRDRFLINHHMEFYEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNS-AITAEI 245
Cdd:COG2255   166 LTSPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDgVITLEI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 246 ASEAMEALHVDDIGLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYD 325
Cdd:COG2255   246 ADAALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYE 325

                  ...
gi 2318961058 326 HIG 328
Cdd:COG2255   326 HLG 328
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
7-328 0e+00

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 589.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   7 RIVSTEESS--KDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFK 84
Cdd:PRK00080    1 RLVSPETLEeeEDEIERSLRPKSLDEFIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  85 VTSGPAIARPGELAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRP 164
Cdd:PRK00080   81 ITSGPALEKPGDLAAILTNLEEGDVLFIDEIHRLSPVVEEILYPAMEDFRLDIMIGKGPAARSIRLDLPPFTLIGATTRA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 165 GSLSAPLRDRFLINHHMEFYEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIK-NSAITA 243
Cdd:PRK00080  161 GLLTSPLRDRFGIVQRLEFYTVEELEKIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKgDGVITK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 244 EIASEAMEALHVDDIGLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAA 323
Cdd:PRK00080  241 EIADKALDMLGVDELGLDEMDRKYLRTIIEKFGGGPVGLDTLAAALGEERDTIEDVYEPYLIQQGFIQRTPRGRVATPKA 320

                  ....*
gi 2318961058 324 YDHIG 328
Cdd:PRK00080  321 YEHLG 325
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
26-328 4.46e-170

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 475.25  E-value: 4.46e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  26 QRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGELAAILTTLQ 105
Cdd:TIGR00635   1 KLLAEFIGQEKVKEQLQLFIEAAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKPGDLAAILTNLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 EHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGSLSAPLRDRFLINHHMEFYE 185
Cdd:TIGR00635  81 EGDVLFIDEIHRLSPAVEELLYPAMEDFRLDIVIGKGPSARSVRLDLPPFTLVGATTRAGMLTSPLRDRFGIILRLEFYT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 186 PDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNSA-ITAEIASEAMEALHVDDIGLDDLD 264
Cdd:TIGR00635 161 VEELAEIVSRSAGLLNVEIEPEAALEIARRSRGTPRIANRLLRRVRDFAQVRGQKiINRDIALKALEMLMIDELGLDEID 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2318961058 265 NEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYDHIG 328
Cdd:TIGR00635 241 RKLLSVLIEQFQGGPVGLKTLAAALGEDADTIEDVYEPYLLQIGFLQRTPRGRIATELAYEHLG 304
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
23-181 3.92e-110

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 317.52  E-value: 3.92e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGELAAILT 102
Cdd:pfam05496   1 LRPRTLDEYIGQEKVKENLKIFIEAAKQRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERPGDLAAILT 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2318961058 103 TLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGSLSAPLRDRFLINHHM 181
Cdd:pfam05496  81 NLEPGDVLFIDEIHRLNRAVEEILYPAMEDFRLDIVIGKGPSARSIRLDLPPFTLVGATTRAGLLTSPLRDRFGIVLRL 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
32-177 6.09e-16

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 74.10  E-value: 6.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  32 IGQTAFKNNLKVYIEAAKGRgesldHVLLYGPPGLGKTTMAKIIANELGSQ---FKVTSGPAIARPGELAAILTTLQ--- 105
Cdd:cd00009     1 VGQEEAIEALREALELPPPK-----NLLLYGPPGTGKTTLARAIANELFRPgapFLYLNASDLLEGLVVAELFGHFLvrl 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 --------EHDVLFIDEIHRLNRSVEEILYSAMEDFaldlvmgkgtgaTSVRINLAPFTLIGATTRP--GSLSAPLRDRF 175
Cdd:cd00009    76 lfelaekaKPGVLFIDEIDSLSRGAQNALLRVLETL------------NDLRIDRENVRVIGATNRPllGDLDRALYDRL 143

                  ..
gi 2318961058 176 LI 177
Cdd:cd00009   144 DI 145
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
57-175 1.20e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 56.23  E-value: 1.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   57 HVLLYGPPGLGKTTMAKIIANELGSQFK----------------------VTSGPAIARPGELAAILTTL---QEHDVLF 111
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGgviyidgedileevldqllliiVGGKKASGSGELRLRLALALarkLKPDVLI 83
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2318961058  112 IDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGatsvrinlapFTLIGATTRPG-SLSAPLRDRF 175
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEKN----------LTVILTTNDEKdLGPALLRRRF 138
 
Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
7-328 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 619.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   7 RIVSTEESSKDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVT 86
Cdd:COG2255     6 RLSSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRIT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  87 SGPAIARPGELAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGS 166
Cdd:COG2255    86 SGPAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 167 LSAPLRDRFLINHHMEFYEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNS-AITAEI 245
Cdd:COG2255   166 LTSPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDgVITLEI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 246 ASEAMEALHVDDIGLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYD 325
Cdd:COG2255   246 ADAALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYE 325

                  ...
gi 2318961058 326 HIG 328
Cdd:COG2255   326 HLG 328
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
7-328 0e+00

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 589.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   7 RIVSTEESS--KDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFK 84
Cdd:PRK00080    1 RLVSPETLEeeEDEIERSLRPKSLDEFIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  85 VTSGPAIARPGELAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRP 164
Cdd:PRK00080   81 ITSGPALEKPGDLAAILTNLEEGDVLFIDEIHRLSPVVEEILYPAMEDFRLDIMIGKGPAARSIRLDLPPFTLIGATTRA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 165 GSLSAPLRDRFLINHHMEFYEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIK-NSAITA 243
Cdd:PRK00080  161 GLLTSPLRDRFGIVQRLEFYTVEELEKIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKgDGVITK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 244 EIASEAMEALHVDDIGLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAA 323
Cdd:PRK00080  241 EIADKALDMLGVDELGLDEMDRKYLRTIIEKFGGGPVGLDTLAAALGEERDTIEDVYEPYLIQQGFIQRTPRGRVATPKA 320

                  ....*
gi 2318961058 324 YDHIG 328
Cdd:PRK00080  321 YEHLG 325
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
26-328 4.46e-170

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 475.25  E-value: 4.46e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  26 QRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGELAAILTTLQ 105
Cdd:TIGR00635   1 KLLAEFIGQEKVKEQLQLFIEAAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKPGDLAAILTNLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 EHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGSLSAPLRDRFLINHHMEFYE 185
Cdd:TIGR00635  81 EGDVLFIDEIHRLSPAVEELLYPAMEDFRLDIVIGKGPSARSVRLDLPPFTLVGATTRAGMLTSPLRDRFGIILRLEFYT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 186 PDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNSA-ITAEIASEAMEALHVDDIGLDDLD 264
Cdd:TIGR00635 161 VEELAEIVSRSAGLLNVEIEPEAALEIARRSRGTPRIANRLLRRVRDFAQVRGQKiINRDIALKALEMLMIDELGLDEID 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2318961058 265 NEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYDHIG 328
Cdd:TIGR00635 241 RKLLSVLIEQFQGGPVGLKTLAAALGEDADTIEDVYEPYLLQIGFLQRTPRGRIATELAYEHLG 304
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
23-181 3.92e-110

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 317.52  E-value: 3.92e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGELAAILT 102
Cdd:pfam05496   1 LRPRTLDEYIGQEKVKENLKIFIEAAKQRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERPGDLAAILT 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2318961058 103 TLQEHDVLFIDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGATSVRINLAPFTLIGATTRPGSLSAPLRDRFLINHHM 181
Cdd:pfam05496  81 NLEPGDVLFIDEIHRLNRAVEEILYPAMEDFRLDIVIGKGPSARSIRLDLPPFTLVGATTRAGLLTSPLRDRFGIVLRL 159
AAA_lid_4 pfam17864
RuvB AAA lid domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes ...
184-256 3.41e-38

RuvB AAA lid domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This entry contains the AAA lid domain that is found to the C-terminus of the AAA domain.


Pssm-ID: 380039 [Multi-domain]  Cd Length: 74  Bit Score: 130.63  E-value: 3.41e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2318961058 184 YEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIK-NSAITAEIASEAMEALHVD 256
Cdd:pfam17864   1 YSVEELELIVKRSARILGVEIDEEGAAEIARRSRGTPRIANRLLRRVRDFAQVKgDGRITLEIADAALDLLEVD 74
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
23-250 2.15e-28

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 114.03  E-value: 2.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQT---AFKNNLKVYIEAAKgrgesLDHVLLYGPPGLGKTTMAKIIANELGSQFK----VTSG-----PA 90
Cdd:PRK13342    6 MRPKTLDEVVGQEhllGPGKPLRRMIEAGR-----LSSMILWGPPGTGKTTLARIIAGATDAPFEalsaVTSGvkdlrEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  91 IARpgelAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDfaldlvmgkGTgatsvrinlapFTLIGATTR-PG-SLS 168
Cdd:PRK13342   81 IEE----ARQRRSAGRRTILFIDEIHRFNKAQQDALLPHVED---------GT-----------ITLIGATTEnPSfEVN 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 169 APLRDRFLInhhMEFY--EPDELKHIITRA---AGILNIEIEESGAAEIARRSRGTPRIANRLLkrirDFAQIKNSAITA 243
Cdd:PRK13342  137 PALLSRAQV---FELKplSEEDIEQLLKRAledKERGLVELDDEALDALARLANGDARRALNLL----ELAALGVDSITL 209

                  ....*..
gi 2318961058 244 EIASEAM 250
Cdd:PRK13342  210 ELLEEAL 216
RuvB_C pfam05491
RuvB C-terminal winged helix domain; The RuvB protein makes up part of the RuvABC revolvasome ...
259-328 5.05e-27

RuvB C-terminal winged helix domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family consists of the C-terminal region of the RuvB protein which is thought to be helicase DNA-binding domain.


Pssm-ID: 398896 [Multi-domain]  Cd Length: 72  Bit Score: 101.48  E-value: 5.05e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 259 GLDDLDNEILKCIIYKFNGGPVGVDTISAAVSEERNTIEDVCEPYLMQIGFISRTPRGRIAMKAAYDHIG 328
Cdd:pfam05491   3 GLDELDINYLKTLYENFKGGPVGLDTLAAILGEDKDTIEDVIEPYLLRLGLIERTSRGRIITPKGYKYLK 72
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
23-250 4.84e-26

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 107.83  E-value: 4.84e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQTAF--KNN-LKVYIEAakGRGESLdhvLLYGPPGLGKTTMAKIIANELGSQFK----VTSG-----PA 90
Cdd:COG2256    19 MRPRTLDEVVGQEHLlgPGKpLRRAIEA--GRLSSM---ILWGPPGTGKTTLARLIANATDAEFValsaVTSGvkdirEV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  91 IARpgelAAILTTLQEHDVLFIDEIHRLNRSVEEILYSAMEDfaldlvmgkGTgatsvrinlapFTLIGATTR-PG-SLS 168
Cdd:COG2256    94 IEE----ARERRAYGRRTILFVDEIHRFNKAQQDALLPHVED---------GT-----------ITLIGATTEnPSfEVN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 169 APLRDRFLInhhMEFY--EPDELKHIITRAA-------GILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNS 239
Cdd:COG2256   150 SALLSRCRV---FVLKplSEEDLEQLLERALadderglGGYKLELDDEALEALARLADGDARRALNALELAVLSAPPDGV 226
                         250
                  ....*....|..
gi 2318961058 240 A-ITAEIASEAM 250
Cdd:COG2256   227 IeITLELVEEAL 238
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
58-175 1.39e-25

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 99.59  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI------ARPGELAAILTTLQEH--DVLFIDEIHRLNRS-------- 121
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELvskyvgESEKRLRELFEAAKKLapCVIFIDEIDALAGSrgsggdse 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058 122 ---VEEILYSAMEDFaldlvmgkgtgatsvRINLAPFTLIGATTRPGSLSAPLRDRF 175
Cdd:pfam00004  81 srrVVNQLLTELDGF---------------TSSNSKVIVIAATNRPDKLDPALLGRF 122
PRK13341 PRK13341
AAA family ATPase;
23-287 4.08e-16

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 79.33  E-value: 4.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQTAF---KNNLKVYIEAakGRGESLdhvLLYGPPGLGKTTMAKIIANELGSQFKVTSGpAIARPGELAA 99
Cdd:PRK13341   22 LRPRTLEEFVGQDHIlgeGRLLRRAIKA--DRVGSL---ILYGPPGVGKTTLARIIANHTRAHFSSLNA-VLAGVKDLRA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 100 ILTTLQE----HD---VLFIDEIHRLNRSVEEILYSAMEdfaldlvmgKGTgatsvrinlapFTLIGATTR-------PG 165
Cdd:PRK13341   96 EVDRAKErlerHGkrtILFIDEVHRFNKAQQDALLPWVE---------NGT-----------ITLIGATTEnpyfevnKA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 166 SLSaplRDRFLinhHMEFYEPDELKHIITRA-------AGILNIEIEESGAAEIARRSRGTPRianRLLKrirdfaqikn 238
Cdd:PRK13341  156 LVS---RSRLF---RLKSLSDEDLHQLLKRAlqdkergYGDRKVDLEPEAEKHLVDVANGDAR---SLLN---------- 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2318961058 239 saiTAEIASEAMEAlhvDDIGLDDLDNEIL------KCIIYKfNGGPVGVDTISA 287
Cdd:PRK13341  217 ---ALELAVESTPP---DEDGLIDITLAIAeesiqqRAVLYD-KEGDAHFDTISA 264
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
32-177 6.09e-16

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 74.10  E-value: 6.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  32 IGQTAFKNNLKVYIEAAKGRgesldHVLLYGPPGLGKTTMAKIIANELGSQ---FKVTSGPAIARPGELAAILTTLQ--- 105
Cdd:cd00009     1 VGQEEAIEALREALELPPPK-----NLLLYGPPGTGKTTLARAIANELFRPgapFLYLNASDLLEGLVVAELFGHFLvrl 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 --------EHDVLFIDEIHRLNRSVEEILYSAMEDFaldlvmgkgtgaTSVRINLAPFTLIGATTRP--GSLSAPLRDRF 175
Cdd:cd00009    76 lfelaekaKPGVLFIDEIDSLSRGAQNALLRVLETL------------NDLRIDRENVRVIGATNRPllGDLDRALYDRL 143

                  ..
gi 2318961058 176 LI 177
Cdd:cd00009   144 DI 145
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
23-256 3.16e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 73.02  E-value: 3.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  23 LRPQRLDDYIGQTAFKNNLKVYIEAAKGRGESLD--------HVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP 94
Cdd:COG0464   151 LREAILDDLGGLEEVKEELRELVALPLKRPELREeyglppprGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSK 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  95 --GE----LAAILTTLQEHD--VLFIDEIHRL------------NRSVEEILySAMEDFALDLVmgkgtgatsvrinlap 154
Cdd:COG0464   231 yvGEteknLREVFDKARGLApcVLFIDEADALagkrgevgdgvgRRVVNTLL-TEMEELRSDVV---------------- 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 155 ftLIGATTRPGSLSAPLRDRFliNHHMEF--YEPDELKHIITRAAGILNIEiEESGAAEIARRSRG-TPR-IANRLLKRI 230
Cdd:COG0464   294 --VIAATNRPDLLDPALLRRF--DEIIFFplPDAEERLEIFRIHLRKRPLD-EDVDLEELAEATEGlSGAdIRNVVRRAA 368
                         250       260
                  ....*....|....*....|....*.
gi 2318961058 231 RDFAQIKNSAITAEIASEAMEALHVD 256
Cdd:COG0464   369 LQALRLGREPVTTEDLLEALEREDIF 394
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
58-172 1.57e-13

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 67.70  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI--ARPGE----LAAILTTLQEH--DVLFIDEIHrlnrsveeilysa 129
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvsKYLGEseknLREIFEEARSHapSIIFIDEID------------- 103
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2318961058 130 medfALDLVMGKGTGATSVRINLAPFTL------------IGATTRPGSLSAPLR 172
Cdd:cd19503   104 ----ALAPKREEDQREVERRVVAQLLTLmdgmssrgkvvvIAATNRPDAIDPALR 154
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
57-175 6.17e-12

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 62.31  E-value: 6.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIA-------------------NELGSQFKVTSGPAIARPGELaaiLTTLQEHDVLFIDEIHR 117
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsnrpvfyvqltrdtteEDLFGRRNIDPGGASWVDGPL---VRAAREGEIAVLDEINR 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2318961058 118 LNRSVEEILYSAMEDFALDLVMGKGTgatsVRINLAPFTLIGATTRPG----SLSAPLRDRF 175
Cdd:pfam07728  78 ANPDVLNSLLSLLDERRLLLPDGGEL----VKAAPDGFRLIATMNPLDrglnELSPALRSRF 135
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
58-269 1.57e-11

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 64.26  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTL----QEHD--VLFIDEI-------------H 116
Cdd:COG1222   115 VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKyiGEGARNVREVfelaREKApsIIFIDEIdaiaarrtddgtsG 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 117 RLNRSVEEILySAMEDFaldlvmgkgTGATSVRInlapftlIGATTRPGSL-SAPLRD-RFliNHHMEFYEPDE--LKHI 192
Cdd:COG1222   195 EVQRTVNQLL-AELDGF---------ESRGDVLI-------IAATNRPDLLdPALLRPgRF--DRVIEVPLPDEeaREEI 255
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058 193 ITRAAGILNIEiEESGAAEIARRSRGTprianrllkrirDFAQIKnsAITAEIASEAMEAlHVDDIGLDDLDNEILK 269
Cdd:COG1222   256 LKIHLRDMPLA-DDVDLDKLAKLTEGF------------SGADLK--AIVTEAGMFAIRE-GRDTVTMEDLEKAIEK 316
44 PHA02544
clamp loader, small subunit; Provisional
18-253 2.12e-11

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 63.86  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  18 AWQTSLRPQRLDDYIGQTAFKNNLKVYIEaaKGRgesLDHVLLYGP-PGLGKTTMAKIIANELGSQFKVTSGpAIARPG- 95
Cdd:PHA02544   10 MWEQKYRPSTIDECILPAADKETFKSIVK--KGR---IPNMLLHSPsPGTGKTTVAKALCNEVGAEVLFVNG-SDCRIDf 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  96 ------ELAAILTTLQEHDVLFIDEIHRLNRS-VEEILYSAMEDFALDLvmgkgtgatsvrinlapfTLIGATTRPGSLS 168
Cdd:PHA02544   84 vrnrltRFASTVSLTGGGKVIIIDEFDRLGLAdAQRHLRSFMEAYSKNC------------------SFIITANNKNGII 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 169 APLRDRFLInhhMEFYEPDE------LKHIITRAAGIL---NIEIEESGAAEIARRSRGTPRianRLLKRIRDFA---QI 236
Cdd:PHA02544  146 EPLRSRCRV---IDFGVPTKeeqiemMKQMIVRCKGILeaeGVEVDMKVLAALVKKNFPDFR---RTINELQRYAstgKI 219
                         250
                  ....*....|....*..
gi 2318961058 237 kNSAITAEIASEAMEAL 253
Cdd:PHA02544  220 -DAGILSEVTNSDIDDV 235
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
58-175 3.05e-11

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 61.14  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPG------ELAAILTTLQEHD--VLFIDEIHRLNRSVEEILYSA 129
Cdd:cd19481    29 ILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYvgesekNLRKIFERARRLApcILFIDEIDAIGRKRDSSGESG 108
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2318961058 130 MEDFAL--DLVMGKGTGATSvrinlaPFTLIGATTRPGSL-SAPLR-DRF 175
Cdd:cd19481   109 ELRRVLnqLLTELDGVNSRS------KVLVIAATNRPDLLdPALLRpGRF 152
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
57-237 3.27e-11

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 63.26  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELGSQFK---VTSG--PA------IA---------RPGelaAILTTlqehdVLFIDEIH 116
Cdd:COG0714    33 HLLLEGVPGVGKTTLAKALARALGLPFIriqFTPDllPSdilgtyIYdqqtgefefRPG---PLFAN-----VLLADEIN 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 117 RLNRSVEEILYSAMED---------FALD---LVMgkgtgATSvriNlaPFTLIGatTRPgsLSAPLRDRFLINHHMEFY 184
Cdd:COG0714   105 RAPPKTQSALLEAMEErqvtipggtYKLPepfLVI-----ATQ---N--PIEQEG--TYP--LPEAQLDRFLLKLYIGYP 170
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2318961058 185 EPDELKHIITRAAGILNIEI-------EESGAAEIARRSRGTPRIAN---RLLKRIRDFAQIK 237
Cdd:COG0714   171 DAEEEREILRRHTGRHLAEVepvlspeELLALQELVRQVHVSEAVLDyivDLVRATREHPDLR 233
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
42-172 3.96e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 61.08  E-value: 3.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  42 KVYIEAAKGrgesldhVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GE----LAAILTTLQEH--DVLFID 113
Cdd:TIGR01243 206 HLGIEPPKG-------VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKyyGEseerLREIFKEAEENapSIIFID 278
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2318961058 114 EIHRLNRSVEEILYSAMEDFA---LDLVMG-KGTGATSVrinlapftlIGATTRPGSLSAPLR 172
Cdd:TIGR01243 279 EIDAIAPKREEVTGEVEKRVVaqlLTLMDGlKGRGRVIV---------IGATNRPDALDPALR 332
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
28-249 8.61e-10

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 58.36  E-value: 8.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  28 LDDYIGQTAFKNNLKV------YIEAAKGRGESLD-HVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI--ARPGELA 98
Cdd:COG1223     1 LDDVVGQEEAKKKLKLiikelrRRENLRKFGLWPPrKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLigSYLGETA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  99 AILTTLQEHD-----VLFIDEIHRL-------------NRSVEEILySAMEDFALDLVmgkgtgatsvrinlapftLIGA 160
Cdd:COG1223    81 RNLRKLFDFArrapcVIFFDEFDAIakdrgdqndvgevKRVVNALL-QELDGLPSGSV------------------VIAA 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 161 TTRPGSLSAPLRDRFliNHHMEFYEPD--ELKHIITRAAGILNIEIEESgAAEIARRSRG-TPRIANRLLKRIRDFAQI- 236
Cdd:COG1223   142 TNHPELLDSALWRRF--DEVIEFPLPDkeERKEILELNLKKFPLPFELD-LKKLAKKLEGlSGADIEKVLKTALKKAILe 218
                         250
                  ....*....|...
gi 2318961058 237 KNSAITAEIASEA 249
Cdd:COG1223   219 DREKVTKEDLEEA 231
rfc PRK00440
replication factor C small subunit; Reviewed
24-79 9.59e-10

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 59.12  E-value: 9.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAakgrgESLDHVLLYGPPGLGKTTMAKIIANEL 79
Cdd:PRK00440   12 RPRTLDEIVGQEEIVERLKSYVKE-----KNMPHLLFAGPPGTGKTTAALALAREL 62
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
57-175 1.20e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 56.23  E-value: 1.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058   57 HVLLYGPPGLGKTTMAKIIANELGSQFK----------------------VTSGPAIARPGELAAILTTL---QEHDVLF 111
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGgviyidgedileevldqllliiVGGKKASGSGELRLRLALALarkLKPDVLI 83
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2318961058  112 IDEIHRLNRSVEEILYSAMEDFALDLVMGKGTGatsvrinlapFTLIGATTRPG-SLSAPLRDRF 175
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEKN----------LTVILTTNDEKdLGPALLRRRF 138
PRK04195 PRK04195
replication factor C large subunit; Provisional
24-80 4.18e-09

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 57.62  E-value: 4.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAAKgRGESLDHVLLYGPPGLGKTTMAKIIANELG 80
Cdd:PRK04195    9 RPKTLSDVVGNEKAKEQLREWIESWL-KGKPKKALLLYGPPGVGKTSLAHALANDYG 64
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
58-172 4.64e-09

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 55.10  E-value: 4.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIAR--PGELAAILTTLQEHD------VLFIDEI-----------HRL 118
Cdd:cd19518    37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSgvSGESEEKIRELFDQAisnapcIVFIDEIdaitpkresaqREM 116
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2318961058 119 NRSVEEILYSAMEdfalDLVMGKGTGatsvrinlAPFTLIGATTRPGSLSAPLR 172
Cdd:cd19518   117 ERRIVSQLLTCMD----ELNNEKTAG--------GPVLVIGATNRPDSLDPALR 158
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
58-175 6.95e-09

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 54.28  E-value: 6.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQF-KVTSGPAIARP-GE----------LAAILTTlqehDVLFIDEIHRL--NRSVE 123
Cdd:cd19509    35 ILLYGPPGTGKTLLARAVASESGSTFfSISASSLVSKWvGEsekivralfaLARELQP----SIIFIDEIDSLlsERGSG 110
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2318961058 124 EILYSAM--EDF--ALDLVMGKGTGATSVrinlapftlIGATTRPGSLSAPLRDRF 175
Cdd:cd19509   111 EHEASRRvkTEFlvQMDGVLNKPEDRVLV---------LGATNRPWELDEAFLRRF 157
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
42-172 8.53e-09

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 53.98  E-value: 8.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  42 KVYIEAAKGrgesldhVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GE----LAAILTTLQEH--DVLFID 113
Cdd:cd19519    28 AIGIKPPRG-------ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKlaGEsesnLRKAFEEAEKNapAIIFID 100
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058 114 EI-------HRLNRSVEEILYSAMedfaLDLVMG-KGTGATSVrinlapftlIGATTRPGSLSAPLR 172
Cdd:cd19519   101 EIdaiapkrEKTHGEVERRIVSQL----LTLMDGlKQRAHVIV---------MAATNRPNSIDPALR 154
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
44-226 5.93e-08

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 53.25  E-value: 5.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  44 YIEAAKGRGESLdhVLLYGPPGLGKTTMAKIIANELGSQFKV------TSGP-----AIA-------RPGELAAILTTLQ 105
Cdd:COG3267    34 RLEYALAQGGGF--VVLTGEVGTGKTTLLRRLLERLPDDVKVayipnpQLSPaellrAIAdelglepKGASKADLLRQLQ 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 EH----------DVLFIDEIHRLNRSV-EEI-LYSAME---DFALDLVMgkgTGATSVRINLAPFTLigattrpgslsAP 170
Cdd:COG3267   112 EFllelaaagrrVVLIIDEAQNLPPETlEELrLLSNLEtdsRKLLQIVL---VGQPELRERLARPEL-----------RQ 177
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 171 LRDRFLINHHMEFYEPDELKHIIT---RAAGILNIEI-EESGAAEIARRSRGTPRIANRL 226
Cdd:COG3267   178 LRQRITARYHLRPLDREETAAYIEhrlKVAGGEGDPLfTPEAIEAIYRASGGIPRLINNL 237
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
58-176 6.11e-08

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 51.81  E-value: 6.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTT------LQEHDVLFIDEIHRL--NRSVEEILY 127
Cdd:cd19523    36 ILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKwaGEGEKILQAsflaarCRQPSVLFISDLDALlsSQDDEASPV 115
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2318961058 128 SAME-DFALDLVMGKGTGATSVRInlapftlIGATTRPGSLSAPLRDRFL 176
Cdd:cd19523   116 GRLQvELLAQLDGVLGSGEDGVLV-------VCTTSKPEEIDESLRRYFS 158
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
48-320 7.31e-08

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 53.27  E-value: 7.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  48 AKGRGESLDHVLLYGPPGLGKTTMAKIIANELGSQFK------VTSG-------PAIaRPGELAAILTTLQEHDVLFIDE 114
Cdd:COG0593    27 AEWPGKAYNPLFLYGGVGLGKTHLLHAIGNEALENNPgarvvyLTAEeftndfiNAI-RNNTIEEFKEKYRSVDVLLIDD 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 115 IHRL---NRSVEEILYsamedfALDLVMGKGTgatsvRInlapftLIGATTRPGSLS---APLRDRF---LInHHMEfyE 185
Cdd:COG0593   106 IQFLagkEATQEEFFH------TFNALREAGK-----QI------VLTSDRPPKELPgleERLRSRLewgLV-VDIQ--P 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 186 PD-ELK-HIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAQIKNSAITAEIASEAmealhvddigLDDL 263
Cdd:COG0593   166 PDlETRiAILRKKAADRGLELPDEVLEYLARRIERNVRELEGALNRLDAYALLTGRPITLELAREV----------LKDL 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2318961058 264 DNEILKciiykfnggPVGVDTISAAVSEERN-TIEDVCEPylmqigfiSRT-----PRgRIAM 320
Cdd:COG0593   236 LRAQKK---------EITIEDIQKAVAEYFGvSVADLLSK--------SRTreiarPR-QIAM 280
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
58-115 1.18e-07

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 50.74  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GEL-AAILTTLQEHD-----VLFIDEI 115
Cdd:cd19511    30 VLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKyvGESeRAVREIFQKARqaapcIIFFDEI 95
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
58-175 4.63e-07

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 49.09  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQ-FKVTSGPAIAR-PGELAAILTTL----QEH--DVLFIDEIHRLNRSVEEILYSA 129
Cdd:cd19521    43 ILLYGPPGTGKSYLAKAVATEANSTfFSVSSSDLVSKwMGESEKLVKQLfamaRENkpSIIFIDEVDSLCGTRGEGESEA 122
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2318961058 130 MEDFALD-LVMGKGTGATSVRInlapfTLIGATTRPGSLSAPLRDRF 175
Cdd:cd19521   123 SRRIKTElLVQMNGVGNDSQGV-----LVLGATNIPWQLDSAIRRRF 164
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
42-115 5.02e-07

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 49.26  E-value: 5.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  42 KVYIEAAKGrgesldhVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTL----QEHD--VLFID 113
Cdd:cd19502    31 ELGIEPPKG-------VLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKyiGEGARLVRELfemaREKApsIIFID 103

                  ..
gi 2318961058 114 EI 115
Cdd:cd19502   104 EI 105
PRK04132 PRK04132
replication factor C small subunit; Provisional
19-77 7.16e-07

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 50.99  E-value: 7.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2318961058  19 WQTSLRPQRLDDYIGQTAFKNNLKVYIEAAkgrgeSLDHVLLYGPPGLGK--TTMAKIIAN 77
Cdd:PRK04132    9 WVEKYRPQRLDDIVGQEHIVKRLKHYVKTG-----SMPHLLFAGPPGVGKclTGDTKVIAN 64
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
58-175 1.14e-06

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 48.45  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTL------QEHDVLFIDEIHRLNRSVEEILYSA 129
Cdd:cd19525    58 ILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKwvGEGEKMVRALfsvarcKQPAVIFIDEIDSLLSQRGEGEHES 137
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2318961058 130 MEDFALD-LVMGKG-TGATSVRInlapfTLIGATTRPGSLSAPLRDRF 175
Cdd:cd19525   138 SRRIKTEfLVQLDGaTTSSEDRI-----LVVGATNRPQEIDEAARRRL 180
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
58-91 1.27e-06

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 47.88  E-value: 1.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI 91
Cdd:cd19529    30 ILLYGPPGTGKTLLAKAVATESNANFISVKGPEL 63
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
58-164 1.40e-06

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 47.48  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELA-AILTTLQEHD-----VLFIDEIHRLNRSVEEILYSA 129
Cdd:cd19530    33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKyvGESErAVRQVFQRARasapcVIFFDEVDALVPKRGDGGSWA 112
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2318961058 130 MEDFALDLV--MGKGTGATSVRInlapftlIGATTRP 164
Cdd:cd19530   113 SERVVNQLLteMDGLEERSNVFV-------IAATNRP 142
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
16-268 1.50e-06

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 49.22  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  16 KDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAkgrgeSLDHVLLYGPPGLGKTTMAKIIANEL-------------GSQ 82
Cdd:PRK12402    2 APLWTEKYRPALLEDILGQDEVVERLSRAVDSP-----NLPHLLVQGPPGSGKTAAVRALARELygdpwennftefnVAD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  83 FKVTSGPAIARPGELAAILTTLQEHDVLFIDEIhrlNRSVEEilYSAM-------------------EDF--ALDLVMGK 141
Cdd:PRK12402   77 FFDQGKKYLVEDPRFAHFLGTDKRIRSSKIDNF---KHVLKE--YASYrplsadyktilldnaealrEDAqqALRRIMEQ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 142 GTGATSvrinlapftLIGATTRPGSLSAPLRDRFLinhHMEFYEP--DELKHIITRAAGILNIEIEESGAAEIARRSRGT 219
Cdd:PRK12402  152 YSRTCR---------FIIATRQPSKLIPPIRSRCL---PLFFRAPtdDELVDVLESIAEAEGVDYDDDGLELIAYYAGGD 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2318961058 220 PRIANRLLKrirdFAQIKNSAITAEIASEAMEalhvdDIGLDDLDNEIL 268
Cdd:PRK12402  220 LRKAILTLQ----TAALAAGEITMEAAYEALG-----DVGTDEVIESLL 259
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
58-171 1.67e-06

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 47.50  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTLQEHD------VLFIDEIHRL--NRSVEEILY 127
Cdd:cd19528    30 VLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMwfGESEANVRDIFDKAraaapcVLFFDELDSIakARGGNIGDA 109
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2318961058 128 SAMEDFALDLVMGKGTGATSVRinlaPFTLIGATTRPGSLSAPL 171
Cdd:cd19528   110 GGAADRVINQILTEMDGMNTKK----NVFIIGATNRPDIIDPAI 149
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
42-115 1.68e-06

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 49.45  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  42 KVYIEAAKGrgesldhVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTL----QEHD--VLFID 113
Cdd:PRK03992  159 EVGIEPPKG-------VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKfiGEGARLVRELfelaREKApsIIFID 231

                  ..
gi 2318961058 114 EI 115
Cdd:PRK03992  232 EI 233
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
24-244 1.73e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 49.77  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAAKgrgesLDHVLLY-GPPGLGKTTMAKIIANELGSQfkvtSGPAIARPGELAAI-- 100
Cdd:PRK06647   11 RPRDFNSLEGQDFVVETLKHSIESNK-----IANAYIFsGPRGVGKTSSARAFARCLNCV----NGPTPMPCGECSSCks 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 101 LTTLQEHDVLFIDEIHrlNRSV-------EEILY----SAMEDFALDLVMGKGTGATSV---RINLAP--FTLIGATTRP 164
Cdd:PRK06647   82 IDNDNSLDVIEIDGAS--NTSVqdvrqikEEIMFppasSRYRVYIIDEVHMLSNSAFNAllkTIEEPPpyIVFIFATTEV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 165 GSLSAPLRDRFlinHHMEF--YEPDELKHIITRAAGILNIEIEESGAAEIARRSRGTPRIANRLLKRIRDFAqikNSAIT 242
Cdd:PRK06647  160 HKLPATIKSRC---QHFNFrlLSLEKIYNMLKKVCLEDQIKYEDEALKWIAYKSTGSVRDAYTLFDQVVSFS---DSDIT 233

                  ..
gi 2318961058 243 AE 244
Cdd:PRK06647  234 LE 235
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
58-174 3.23e-06

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 46.65  E-value: 3.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GE---LAAILTTLQ---EHDVLFIDEIHRLNRSVEEILYSA 129
Cdd:cd19520    38 VLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKwyGEsqkLVAAVFSLAsklQPSIIFIDEIDSFLRQRSSTDHEA 117
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2318961058 130 MEDFALDLVM---GKGTGATSVRInlapftLIGATTRPGSLSAPLRDR 174
Cdd:cd19520   118 TAMMKAEFMSlwdGLSTDGNCRVI------VMGATNRPQDLDEAILRR 159
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
58-175 4.44e-06

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 46.52  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTLQEH------DVLFIDEI------------HR 117
Cdd:cd19522    36 VLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKyrGESEKLVRLLFEMarfyapTTIFIDEIdsicsrrgtseeHE 115
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2318961058 118 LNRSVEEILYSAMedfalDLVMGKGTGATSVRINLapftLIGATTRPGSLSAPLRDRF 175
Cdd:cd19522   116 ASRRVKSELLVQM-----DGVGGASENDDPSKMVM----VLAATNFPWDIDEALRRRL 164
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
28-175 6.27e-06

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 46.37  E-value: 6.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  28 LDDYIGQTAFKNNLKVyieAAKGRgeslDHVLLYGPPGLGKTTMAKII--------------------ANELGSQFKVTS 87
Cdd:pfam01078   2 LADVKGQEQAKRALEI---AAAGG----HNLLMIGPPGSGKTMLAKRLpgilpplteaealevtaihsVAGLGGDGGLIR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  88 ------------------GPAIARPGELaailtTLQEHDVLFIDEIHRLNRSVEEILYSAMEDFaldlvmgkgtgatSVR 149
Cdd:pfam01078  75 rrpfraphhsasaaalvgGGSIPRPGEI-----SLAHNGVLFLDELPEFKRRVLESLRQPLEDG-------------EIT 136
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058 150 IN--------LAPFTLIGAT---------------TRP--------GSLSAPLRDRF 175
Cdd:pfam01078 137 ISrarakvtfPARFQLVAAMnpcpcgylgdpnkrcRCSprqirrylSRLSGPLLDRI 193
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
57-175 7.47e-06

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 45.21  E-value: 7.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGE--LAAI------LTTLQEHDVLFIDEI-----HRLNRSVE 123
Cdd:cd19512    24 NILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRegVTAIhkvfdwANTSRRGLLLFVDEAdaflrKRSTEKIS 103
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2318961058 124 EILYSAMEDFALDlvmgkgTGATSVRinlapFTLIGATTRPGSLSAPLRDRF 175
Cdd:cd19512   104 EDLRAALNAFLYR------TGEQSNK-----FMLVLASNQPEQFDWAINDRI 144
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
57-252 9.77e-06

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 46.51  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGEL-------------------------------AAILTTLQ 105
Cdd:COG0470    20 ALLLHGPPGIGKTTLALALARDLLCENPEGGKACGQCHSRLmaagnhpdllelnpeeksdqigidqirelgeFLSLTPLE 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 106 -EHDVLFIDEIHRLNRSVEEILYSAMEDFAldlvmgKGTgatsvrinlaPFTLIgaTTRPGSLSAPLRDR-FLInhhmEF 183
Cdd:COG0470   100 gGRKVVIIDEADAMNEAAANALLKTLEEPP------KNT----------PFILI--ANDPSRLLPTIRSRcQVI----RF 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058 184 YEPDElkhiiTRAAGILNIE-IEESGAAEIARRSRGTPRIANRLLKR-------IRDFAQIKNSAITAEIASEAMEA 252
Cdd:COG0470   158 RPPSE-----EEALAWLREEgVDEDALEAILRLAGGDPRAAINLLQAlagrkelLEDLAALLSRDRALELLDALLKA 229
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
58-171 1.34e-05

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 46.82  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP--GELAAILTTLQEHD------VLFIDEIHRLNRSVEEILYSA 129
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKwvGESEKAIREIFRKArqaapaIIFFDEIDAIAPARGARFDTS 569
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2318961058 130 MEDFALDLVMGKGTGAtsvrINLAPFTLIGATTRPGSLSAPL 171
Cdd:TIGR01243 570 VTDRIVNQLLTEMDGI----QELSNVVVIAATNRPDILDPAL 607
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
57-84 2.14e-05

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 43.70  E-value: 2.14e-05
                          10        20
                  ....*....|....*....|....*...
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELGSQFK 84
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFR 28
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
58-150 3.61e-05

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 42.21  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARPGELaAILTTLQEHDVLFIDEIHRLNRSVEE-ILYSAMEDFALD 136
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPKDSVYSRNPDD-DFWDGYTGQPVVIIDDFGQNPDGPDEaELIRLVSSTPYP 79
                          90
                  ....*....|....*...
gi 2318961058 137 LVM----GKGTGATSVRI 150
Cdd:pfam00910  80 PPMaaleEKGTPFTSKFV 97
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
58-121 4.43e-05

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 43.38  E-value: 4.43e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI---------ARPGELaaiLTTLQEHD--VLFIDEIHRLNRS 121
Cdd:cd19501    40 VLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFvemfvgvgaSRVRDL---FEQAKKNApcIVFIDEIDAVGRK 111
dnaX_nterm TIGR02397
DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ ...
24-76 6.78e-05

DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274111 [Multi-domain]  Cd Length: 355  Bit Score: 44.09  E-value: 6.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2318961058  24 RPQRLDDYIGQ----TAFKNNLKvyieaaKGRgesLDHV-LLYGPPGLGKTTMAKIIA 76
Cdd:TIGR02397   9 RPQTFEDVIGQehivQTLKNAIK------NGR---IAHAyLFSGPRGTGKTSIARIFA 57
ftsH CHL00176
cell division protein; Validated
58-115 1.29e-04

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 43.89  E-value: 1.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANEL--------GSQF-KVTSGPAIARPGELaaiLTTLQEHD--VLFIDEI 115
Cdd:CHL00176  219 VLLVGPPGTGKTLLAKAIAGEAevpffsisGSEFvEMFVGVGAARVRDL---FKKAKENSpcIVFIDEI 284
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
58-172 1.65e-04

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 41.73  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQ-----FKVTSGPAIARP--GELAAILTTLQEH------DVLFIDEIHRL---NRS 121
Cdd:cd19517    37 VLFHGPPGTGKTLMARALAAECSKGgqkvsFFMRKGADCLSKwvGEAERQLRLLFEEayrmqpSIIFFDEIDGLapvRSS 116
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2318961058 122 VEEILYSAMEDFALDLVMGKGTGATSVrinlapftLIGATTRPGSLSAPLR 172
Cdd:cd19517   117 KQEQIHASIVSTLLALMDGLDNRGQVV--------VIGATNRPDALDPALR 159
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
24-79 1.98e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 42.94  E-value: 1.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAakgrgESLDHVLLY-GPPGLGKTTMAKIIANEL 79
Cdd:PRK14970   12 RPQTFDDVVGQSHITNTLLNAIEN-----NHLAQALLFcGPRGVGKTTCARILARKI 63
PRK07133 PRK07133
DNA polymerase III subunits gamma and tau; Validated
18-84 2.71e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235943 [Multi-domain]  Cd Length: 725  Bit Score: 42.88  E-value: 2.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2318961058  18 AWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKgrgesLDHVLLY-GPPGLGKTTMAKIIANELGSQFK 84
Cdd:PRK07133    7 ALYRKYRPKTFDDIVGQDHIVQTLKNIIKSNK-----ISHAYLFsGPRGTGKTSVAKIFANALNCSHK 69
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
58-115 2.74e-04

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 42.45  E-value: 2.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQF-KVTSGPAIAR-----PGELAAILTTLQEH--DVLFIDEI 115
Cdd:PTZ00361  220 VILYGPPGTGKTLLAKAVANETSATFlRVVGSELIQKylgdgPKLVRELFRVAEENapSIVFIDEI 285
COG2842 COG2842
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ...
58-251 3.40e-04

Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];


Pssm-ID: 442090 [Multi-domain]  Cd Length: 254  Bit Score: 41.48  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPA---------IA----------RPGEL-AAILTTLQEHD-VLFIDEIH 116
Cdd:COG2842    53 GVVYGESGVGKTTAAREYANRNPNVIYVTASPSwtskelleeLAeelgipappgTIADLrDRILERLAGTGrLLIIDEAD 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 117 RLNRSVEEILySAMEDfaldlvmgkGTGatsvrinlAPFTLIGATTRPGSLS--APLRDRFLINHHMEFYEPDELKHIIT 194
Cdd:COG2842   133 HLKPKALEEL-RDIHD---------ETG--------VGVVLIGMERLPAKLKryEQLYSRIGFWVEFKPLSLEDVRALAE 194
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2318961058 195 RAAGILNIEIeesgAAEIARRSRGTPRIANRLLKRIRDFAQIKN-SAITAEIASEAME 251
Cdd:COG2842   195 AWGELTDPDL----LELLHRITRGNLRRLDRTLRLAARAAKRNGlTKITLDHVRAAAL 248
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
24-89 4.73e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 41.72  E-value: 4.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  24 RPQRLDDYIGQTafknnlkvYIEAAKGRGESLDHV----LLYGPPGLGKTTMAKIIANELGSQFKVTSGP 89
Cdd:PRK14961   11 RPQYFRDIIGQK--------HIVTAISNGLSLGRIhhawLLSGTRGVGKTTIARLLAKSLNCQNGITSNP 72
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
58-89 5.40e-04

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 40.19  E-value: 5.40e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGP 89
Cdd:cd19527    29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGP 60
PRK06835 PRK06835
DNA replication protein DnaC; Validated
29-79 5.43e-04

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 41.42  E-value: 5.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058  29 DDYIGQTAFKNNLKV------YIEAAKGRGESLdhvLLYGPPGLGKTTMAKIIANEL 79
Cdd:PRK06835  154 DDDEPLSPRKNMEKIlekcknFIENFDKNNENL---LFYGNTGTGKTFLSNCIAKEL 207
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
58-174 5.90e-04

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 41.29  E-value: 5.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANE--------LGSQF---KVTSGPAIARPgelaaILTTLQEH--DVLFIDEIHRL------ 118
Cdd:PTZ00454  182 VLLYGPPGTGKTMLAKAVAHHttatfirvVGSEFvqkYLGEGPRMVRD-----VFRLARENapSIIFIDEVDSIatkrfd 256
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2318961058 119 -----NRSVEEIL---YSAMEDFALDlvmgkgtgaTSVRINLA---PFTLIGATTRPGSLSA----PLRDR 174
Cdd:PTZ00454  257 aqtgaDREVQRILlelLNQMDGFDQT---------TNVKVIMAtnrADTLDPALLRPGRLDRkiefPLPDR 318
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
24-124 6.54e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 41.57  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  24 RPQRLDDYIGQtafkNNLKVYIEAAKGRGEsLDHVLLY-GPPGLGKTTMAKIIANELGSQFKVTSGPAiarpgELAAILT 102
Cdd:PRK14960   10 RPRNFNELVGQ----NHVSRALSSALERGR-LHHAYLFtGTRGVGKTTIARILAKCLNCETGVTSTPC-----EVCATCK 79
                          90       100
                  ....*....|....*....|....*
gi 2318961058 103 TLQEHDvlFID--EIHRLNRS-VEE 124
Cdd:PRK14960   80 AVNEGR--FIDliEIDAASRTkVED 102
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
51-256 6.56e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 41.37  E-value: 6.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  51 RGESLDHVLLYGPPGLGKTTMAKIIANEL---------------------GSQFKVTS--------GPAIARPG----EL 97
Cdd:COG1474    47 RGERPSNVLIYGPTGTGKTAVAKYVLEELeeeaeergvdvrvvyvncrqaSTRYRVLSrileelgsGEDIPSTGlstdEL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  98 -AAILTTLQEHD---VLFIDEIHRL-NRSVEEILYS---AMEDFaldlvmgkgtgaTSVRInlapfTLIGATTRPG---S 166
Cdd:COG1474   127 fDRLYEALDERDgvlVVVLDEIDYLvDDEGDDLLYQllrANEEL------------EGARV-----GVIGISNDLEfleN 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 167 LSAPLRDRFLINhHMEF--YEPDELKHIIT-RAA-----GILNIE-IEEsgAAEIARRSRGTPRIANRLLKRIRDFAQIK 237
Cdd:COG1474   190 LDPRVKSSLGEE-EIVFppYDADELRDILEdRAElafydGVLSDEvIPL--IAALAAQEHGDARKAIDLLRVAGEIAERE 266
                         250       260
                  ....*....|....*....|
gi 2318961058 238 NS-AITAEIASEAMEALHVD 256
Cdd:COG1474   267 GSdRVTEEHVREAREKIERD 286
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
58-91 6.88e-04

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 40.17  E-value: 6.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANEL-GSQFKVTSGPAI 91
Cdd:cd19504    38 ILLYGPPGTGKTLMARQIGKMLnAREPKIVNGPEI 72
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
24-76 7.65e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 7.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIeaAKGRgesLDHVLLY-GPPGLGKTTMAKIIA 76
Cdd:PRK14950   11 RSQTFAELVGQEHVVQTLRNAI--AEGR---VAHAYLFtGPRGVGKTSTARILA 59
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
58-91 9.85e-04

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 39.33  E-value: 9.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAI 91
Cdd:cd19526    30 ILLYGPPGCGKTLLASAIASECGLNFISVKGPEL 63
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
15-237 1.31e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 40.45  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  15 SKDAWQTSLRPQRLDDYIGQTAFKNNLKVYIEAAKgrgesLDHVLLY-GPPGLGKTTMAKIIANELGSQFKVTSGP---- 89
Cdd:PRK14957    2 SYQALARKYRPQSFAEVAGQQHALNSLVHALETQK-----VHHAYLFtGTRGVGKTTLGRLLAKCLNCKTGVTAEPcnkc 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  90 ------------------AIARPG--ELAAILTTLQ------EHDVLFIDEIHRLNRSVEEILYSAMEDfaldlvmgkgt 143
Cdd:PRK14957   77 encvainnnsfidlieidAASRTGveETKEILDNIQympsqgRYKVYLIDEVHMLSKQSFNALLKTLEE----------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 144 gatsvrinlAP--FTLIGATTRPGSLSAPLRDRfLINHHMEFYE----PDELKHIITRAagilNIEIEESGAAEIARRSR 217
Cdd:PRK14957  146 ---------PPeyVKFILATTDYHKIPVTILSR-CIQLHLKHISqadiKDQLKIILAKE----NINSDEQSLEYIAYHAK 211
                         250       260
                  ....*....|....*....|....*..
gi 2318961058 218 GTPRIANRLLKRIRDF-------AQIK 237
Cdd:PRK14957  212 GSLRDALSLLDQAISFcggelkqAQIK 238
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
21-227 1.38e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 40.17  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  21 TSLRPQRLDDYIGQ----TAFKNNLKvyieaaKGRgesLDHV-LLYGPPGLGKTTMAKIIANELGSQFKVTSGP------ 89
Cdd:COG2812     2 SYQVPQTFDDVVGQehvvRTLKNALA------SGR---LAHAyLFTGPRGVGKTTLARILAKALNCENGPTGEPcgeces 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  90 --AIARPGelaailttlqeH-DVLFIDEiHRLNRSVEEIlysamedfaLDLVMgkgtgatsvRINLAPF----------- 155
Cdd:COG2812    73 crAIAAGS-----------HpDVIEIDA-EASNIGVDDI---------RELIE---------KVSYAPVegrykvyiide 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058 156 --------------TL---------IGATTRPGSLSAPLRDRfliNHHMEFY--EPDELKHIITRAAGILNIEIEESGAA 210
Cdd:COG2812   123 ahmltteafnallkTLeeppphvvfILATTEPQKLLPTILSR---CQRFDFRrlPPEEIAEHLAKIAEREGIEIEPEALA 199
                         250
                  ....*....|....*..
gi 2318961058 211 EIARRSRGTPRIANRLL 227
Cdd:COG2812   200 LIARAADGSMRDALSLL 216
PLN03025 PLN03025
replication factor C subunit; Provisional
19-84 1.60e-03

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 39.71  E-value: 1.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058  19 WQTSLRPQRLDDYIGQTAFKNNLKVYieaakGRGESLDHVLLYGPPGLGKTTMAKIIANE-LGSQFK 84
Cdd:PLN03025    3 WVEKYRPTKLDDIVGNEDAVSRLQVI-----ARDGNMPNLILSGPPGTGKTTSILALAHElLGPNYK 64
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
24-125 1.64e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 40.21  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEaaKGRgesLDHVLLY-GPPGLGKTTMAKIIANELGsqfkvTSGPAIARPGELAAILT 102
Cdd:PRK14963    9 RPITFDEVVGQEHVKEVLLAALR--QGR---LGHAYLFsGPRGVGKTTTARLIAMAVN-----CSGEDPKPCGECESCLA 78
                          90       100
                  ....*....|....*....|....*
gi 2318961058 103 TLQ-EH-DVLFIDEIHrlNRSVEEI 125
Cdd:PRK14963   79 VRRgAHpDVLEIDAAS--NNSVEDV 101
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
59-80 1.95e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 38.49  E-value: 1.95e-03
                          10        20
                  ....*....|....*....|..
gi 2318961058  59 LLYGPPGLGKTTMAKIIANELG 80
Cdd:cd19510    27 LLYGPPGTGKSSFIAALAGELD 48
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
58-131 2.05e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.75  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGS---------QF---------------KVTSGPAIARPGELAAILTTLQEHD----V 109
Cdd:COG1401   224 VILAGPPGTGKTYLARRLAEALGGedngriefvQFhpswsyedfllgyrpSLDEGKYEPTPGIFLRFCLKAEKNPdkpyV 303
                          90       100
                  ....*....|....*....|....*.
gi 2318961058 110 LFIDEIhrlNRS-VEEI---LYSAME 131
Cdd:COG1401   304 LIIDEI---NRAnVEKYfgeLLSLLE 326
NTPase_1 pfam03266
NTPase; This domain is found across all species from bacteria to human, and the function was ...
57-128 2.24e-03

NTPase; This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteriztic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.


Pssm-ID: 460869  Cd Length: 168  Bit Score: 38.38  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELGSQ--------------------FKV----------------TSGPAIARPG----- 95
Cdd:pfam03266   1 RIFITGPPGVGKTTLVLKVAELLKSSgvkvggfytpevreggrrigFKIvdlasgeegwlarvgaVSGPRVGKYVvnves 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2318961058  96 --ELA--AILTTLQEHDVLFIDEI-------HRLNRSVEEILYS 128
Cdd:pfam03266  81 feEIAvpALRRALEEADLIIIDEIgpmelksKKFREAVREVLDS 124
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
58-118 2.92e-03

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 37.91  E-value: 2.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVTSGPAIARP----GE-----LAAILTTLQEhDVLFIDEIHRL 118
Cdd:cd19524    36 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKyvgeGEklvraLFAVARELQP-SIIFIDEVDSL 104
AAA_22 pfam13401
AAA domain;
57-128 2.96e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.32  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  57 HVLLYGPPGLGKTTMAKIIANELG----SQFKVT-----------------SGPAIARPGELAAILTTLQEH-------D 108
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPevrdSVVFVDlpsgtspkdllrallraLGLPLSGRLSKEELLAALQQLllalavaV 86
                          90       100
                  ....*....|....*....|
gi 2318961058 109 VLFIDEIHRLNRSVEEILYS 128
Cdd:pfam13401  87 VLIIDEAQHLSLEALEELRD 106
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
24-76 2.97e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 39.47  E-value: 2.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAAKgrgesLDHVLLY-GPPGLGKTTMAKIIA 76
Cdd:PRK05563   11 RPQTFEDVVGQEHITKTLKNAIKQGK-----ISHAYLFsGPRGTGKTSAAKIFA 59
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
59-83 3.17e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 37.92  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|....*
gi 2318961058  59 LLYGPPGLGKTTMAKIIANELGSQF 83
Cdd:cd19500    41 CLVGPPGVGKTSLGKSIARALGRKF 65
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
24-89 3.39e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.34  E-value: 3.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2318961058  24 RPQRLDDYIGQTAFKNNLKVYIEAakGRgesLDHVLLY-GPPGLGKTTMAKIIANELGSQFKVTSGP 89
Cdd:PRK14965   11 RPQTFSDLTGQEHVSRTLQNAIDT--GR---VAHAFLFtGARGVGKTSTARILAKALNCEQGLTAEP 72
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
58-120 3.90e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 38.77  E-value: 3.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGSQFKVT------SGPAIARPGE-LAAILTTLQEHDVLFIDEIHRLNR 120
Cdd:COG1373    23 VVITGPRQVGKTTLLKQLAKELENILYINlddprlRALAEEDPDDlLEALKELYPGKTYLFLDEIQRVPE 92
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
58-99 5.72e-03

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 37.02  E-value: 5.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANELGsqFKVTSGPAIARpgELAA 99
Cdd:TIGR02173   3 ITISGPPGSGKTTVAKILAEKLS--LKLISAGDIFR--ELAA 40
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
58-78 8.86e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 37.71  E-value: 8.86e-03
                          10        20
                  ....*....|....*....|.
gi 2318961058  58 VLLYGPPGLGKTTMAKIIANE 78
Cdd:COG0465   178 VLLVGPPGTGKTLLAKAVAGE 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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