|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-422 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 855.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 1 MFALADVNSFYASCERVFRPDLRGKPVVVLSNNDGCVIARSAEAKRLGIKMGTPWFQLKEAQFPEKLYVFSSNYELYASL 80
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 81 SNRVVALLEELSPRVEQYSIDECFLDARGIGQCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKEW-PQF 159
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 160 RGVLALSpdNPRRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGESCISLE 239
Cdd:PRK03609 161 GGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 240 EAPPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVNEPYYGNVATEKLNTPTRD 319
Cdd:PRK03609 239 EFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 320 TRDIIAAAVRSLDRIWLDGHRYAKAGIMLNDFSPNGVAQLNLFDDVQPRPHSDALMKVLDGIN-HSGLGKVWFAGRGIAP 398
Cdd:PRK03609 319 SRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIAQ 398
|
410 420
....*....|....*....|....
gi 2306678528 399 DWQMKREMLSPAYTTRWKELPVAR 422
Cdd:PRK03609 399 QWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-350 |
0e+00 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 511.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 3 ALADVNSFYASCERVFRPDLRGKPVVVLSNNDGCVIARSAEAKRLGIKMGTPWFQLKeaQFPEKL--YVFSSNYELYASL 80
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVP--DLLERHgvAVFSSNYALYGDM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 81 SNRVVALLEELSPRVEQYSIDECFLDARGIGQCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKEWPQFR 160
Cdd:cd01700 79 SRRIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 161 GVLALSPDNPRRtaKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGESCISLEE 240
Cdd:cd01700 159 GVVDLTDEEVRD--KLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 241 APPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVNEPYYGnvATEKLNTPTRDT 320
Cdd:cd01700 237 YPPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYS--ATNTLPYPTNDT 314
|
330 340 350
....*....|....*....|....*....|
gi 2306678528 321 RDIIAAAVRSLDRIWLDGHRYAKAGIMLND 350
Cdd:cd01700 315 REIVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-348 |
4.39e-129 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 375.64 E-value: 4.39e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 1 MFALADVNSFYASCERVFRPDLRGKPVVVLS-NNDGCVIARSAEAKRLGIKMGTPWFQLKeAQFPEkLYVFSSNYELYAS 79
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQAR-RLCPD-LVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 80 LSNRVVALLEELSPRVEQYSIDECFLDARGIGQCM-DLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKEwpq 158
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFgSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 159 fRGVLALSPDnprRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGESCISL 238
Cdd:COG0389 157 -DGLTVIPPG---EVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 239 EEAPPPKqQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVNEpyygnvATEKLNTPTR 318
Cdd:COG0389 233 EPRRPRK-SIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTT------RSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 2306678528 319 DTRDIIAAAVRSLDRIWLDGHRYAKAGIML 348
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-337 |
1.25e-59 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 197.36 E-value: 1.25e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNNDGCVIArSA--EAKRLGIKMGTPWFQLKEAqFPEkLYVFSSNYELYASLSNR 83
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVS-TAsyEARKFGVRSAMPIFQAKKL-CPN-LIFVPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIGQC-MDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKewPqfRGV 162
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLfGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNK--P--NGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 163 LALSPDNprrTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGESCISLEEAP 242
Cdd:cd03586 157 TVIPPED---VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 243 PPKqQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVnepyygNVATEKLNTPTRDTRD 322
Cdd:cd03586 234 ERK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFST------RTRSRTLPEPTDDAED 306
|
330
....*....|....*
gi 2306678528 323 IIAAAVRSLDRIWLD 337
Cdd:cd03586 307 IYELALELLEELLDG 321
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-383 |
4.01e-52 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 179.81 E-value: 4.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 4 LADVNSFYASCERVFRPDLRGKPVVVL---SNNDGCVIARSAEAKRLGIKMGTPwfqLKEAQ--FPEkLYVFSSNYELYA 78
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAER---LWEAQqkCPD-LVVVKPRMQRYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 79 SLSNRVVALLEELSPRVEQYSIDECFLDARGIGQCM-DLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSA--QWASKE 155
Cdd:PRK03103 83 DVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFgSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKKN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 156 wPQfrGVLALSPDNPRrtAKLLSLqPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGesc 235
Cdd:PRK03103 163 -PD--GLFTLDKEDVP--ADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANG--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 236 isLEEAPPPKQQIVCSRSFGQRIT------TYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVNEPYYGNVa 309
Cdd:PRK03103 234 --IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQM- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2306678528 310 teKLNTPTRDTRDIIAAAVRSLDRIWlDGHRYAKAGIMLNDFSPNGVAQLNLFDDvqpRPHSDALMKVLDGINH 383
Cdd:PRK03103 311 --TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGD---RERKRSLGYVMDDIKN 378
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-348 |
1.03e-51 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 176.78 E-value: 1.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNND--GCVIARSAEAKRLGIKMGTPWFQLKEAqFPEKLYVfSSNYELYASLSNR 83
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYGVKRGMPVREARKM-CPNLILV-PARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIGQCM-DLEDFGRQLRGHVLSGTG-LTIGVGCGATKTLAKSAQWASKewPQfrG 161
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLgLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK--PD--G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 162 VLALSPDN-PRRTAKLlslqPVEEIWGVGNRIAKKLHVMGITTALQLSLTNP-AFIRKNFNVVLERTVRELNGESCISLE 239
Cdd:cd00424 158 LTILDPEDlPGFLSKL----PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGIDDEPLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 240 EaPPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKT--SPFAVNEPYYGNVATEKLNTPt 317
Cdd:cd00424 234 P-PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTvdGRWSGHADIPSRSAPRPISTE- 311
|
330 340 350
....*....|....*....|....*....|.
gi 2306678528 318 rdTRDIIAAAVRSLDRIWLDGHRYAKAGIML 348
Cdd:cd00424 312 --DGELLHALDKLWRALLDDKGPRRLRRLGV 340
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-149 |
1.88e-41 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 143.87 E-value: 1.88e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNN-DGCVIARSAEAKRLGIKMGTPWFQLKEAqFPEkLYVFSSNYELYASLSNRV 84
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKL-CPN-LIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2306678528 85 VALLEEL-SPRVEQYSIDECFLDARGIGQCMDLE-DFGRQLRGHVLSGTGLTIGVGCGATKTLAKSA 149
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEeALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-337 |
6.12e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 148.63 E-value: 6.12e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNND-----GCVIARSAEAKRLGIKMGTPwfqLKEA--QFPEKLYVfSSNYELYA 78
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFGVRAGMP---LRTAarRCPDAVFL-PSDPAAYD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 79 SLSNRVVALLEELSPRVEQYSIDECFLDARgigqCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKEwpq 158
Cdd:PRK03352 87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD----TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP--- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 159 fRGVLALSPDNprrTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFN-------VVLERTVreln 231
Cdd:PRK03352 160 -AGVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGG---- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 232 GESCISlEEAPPPKqqivcSRS----FGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFavnepyYGN 307
Cdd:PRK03352 232 GDTEVS-AEPWVPR-----SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTR 299
|
330 340 350
....*....|....*....|....*....|
gi 2306678528 308 VATEKLNTPTRDTRDIIAAAVRSLDRIWLD 337
Cdd:PRK03352 300 TKIRKLPEPTTDPDVIEAAALDVLDRFELD 329
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-333 |
1.76e-35 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 135.83 E-value: 1.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVV--LSNNdGCVIARSAEAKRLGIKMGTPWFQLKeAQFPEKLYVFSSNYELYASLSNR 83
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEARVFGARSAMPMHQAR-RLVGNGAVVLPPRFVVYRAASRR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIG--QCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKewPQfrG 161
Cdd:PRK03348 89 VFDTLRELSPVVEQLSFDEAFVEPAELAgaSAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAK--PD--G 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 162 VLALSPDNPRRtakLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIrknfnvvlertVRELNGESCISL--- 238
Cdd:PRK03348 165 IRVVPPGEERE---LLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEV-----------ANLLGATVGPALhrl 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 239 ----------EEAppPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVnepyygNV 308
Cdd:PRK03348 231 argiddrpvaERA--EAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFST------LT 302
|
330 340
....*....|....*....|....*
gi 2306678528 309 ATEKLNTPTRDTRDIIAAAVRSLDR 333
Cdd:PRK03348 303 RSATLPYATDDAAVLAATARRLLLD 327
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-381 |
2.99e-35 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 134.34 E-value: 2.99e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 5 ADVNSFYASCERVFRPDLRGKPVVVlsnNDGCVIARSAEAKRLGIKMGTPWFQLKeAQFPEKLYVfSSNYELYASLSNRV 84
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQAR-RLCPQAVVV-PPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 85 VALLEELSPRVEQYSIDECFLDARGIGQCMDL-EDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKewPQfrGVL 163
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--PD--GLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 164 ALSPDnpRRTAKLLSLqPVEEIWGVGNRIAKKLHVMGITTALQL---------SLTNPAFIRKNFNVVLERTVRELnges 234
Cdd:PRK03858 160 VVPPD--RELAFLHPL-PVRRLWGVGPVTAAKLRAHGITTVGDVaelpesalvSLLGPAAGRHLHALAHNRDPRRV---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 235 cisleEAPPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAvnepyygnVATEK-- 312
Cdd:PRK03858 233 -----ETGRRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFT--------RATRSht 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2306678528 313 LNTPTRDTRDIIAAAVRSLDRIW-LDGHRyakaGIMLNDFS-----PNGVAQLNL-FDdvqPRPHSDALMKVLDGI 381
Cdd:PRK03858 300 LPRPTASTATLLAAARDLVAAAApLIAER----GLTLVGFAvsnldDDGAQQLELpFG---LRRPGSALDAALDAV 368
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-382 |
8.86e-35 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 133.23 E-value: 8.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSN---NDGCVIARSAEAKRLGIKMGTPWFQLKEaQFPEkLYVFSSNYELYASLSN 82
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAKR-LCPQ-LIVRRPNFDRYREASR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 83 RVVALLEELSPRVEQYSIDECFLDARGIGQCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQwaskEWPQFRGV 162
Cdd:PRK01810 89 QMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLGI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 163 LALspdNPRRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGEscislEEAP 242
Cdd:PRK01810 165 TVL---RKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DDRP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 243 PPKQQIVCSRSFG------QRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAvnepyygNVA-TEKLNT 315
Cdd:PRK01810 237 VDPEAIYQFKSVGnsttlsHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR-------TITrSKTLKN 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2306678528 316 PTRDTRDIIAAAVRSLDRIWlDGHRYAKAGIMLNDFS--PNGVAQLNLF---DDVQPRPhsdaLMKVLDGIN 382
Cdd:PRK01810 310 PIWEKRDIFQAASRLFKQHW-NGDPVRLLGVTATDLEwkTEAVKQLDLFsfeEDAKEEP----LLAVIDQIN 376
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-362 |
6.93e-34 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 129.45 E-value: 6.93e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVV--LSNNdGCVIARSAEAKRLGIKMGTPWFQLKEaQFPEKLYVfSSNYELYASLSNR 83
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYGVHSAMPVFMAKK-RCPHGIFL-PVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIGQcmDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQwaskEWPQFRGVL 163
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 164 ALSPDnprRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTA---LQLSLTNPAFIRKNFNVVLERTVRELNGESCISLEE 240
Cdd:PRK14133 160 IITED---MIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIedlLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 241 apppKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVnepyygNVATEKLNTPTRDT 320
Cdd:PRK14133 237 ----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQT------HTKSKTLNDYIRDK 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2306678528 321 RDIIAAAVRSLDRIWLDghRYAK-AGIMLNDFSPNGVAQLNLF 362
Cdd:PRK14133 307 EEIYNVACEILEHINIK--EPIRlIGLSVSNLSENKIEQLSFL 347
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-355 |
2.75e-27 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 104.56 E-value: 2.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 245 KQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAvnepyyGNVATEKLNTPTRDTRDII 324
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR------TITRSVTLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|.
gi 2306678528 325 AAAVRSLDRIWlDGHRYAKAGIMLNDFSPNG 355
Cdd:pfam11799 75 RAALRLLRRLY-RGRPVRLLGVSLSNLVPEG 104
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-201 |
8.14e-24 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 101.40 E-value: 8.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 1 MFALADVNSFYASCERVFRPDLRGKPVVVL-----SNNDGCVIARSAEAKRLGIKMGTPWFQLKEAqFPEKLYVfSSNYE 75
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLGIKAGMPIVEAKKI-LPNAVYL-PMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 76 LYASLSNRVVALLEELSPRVEQYSIDECFLD-ARGIGQCMDLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAqwASK 154
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDiSDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIA--ADM 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2306678528 155 EWPQFRGVLalspdNPRRTAKLLSLQPVEEIWGVGNRIAKKLHVMGI 201
Cdd:PRK01216 158 AKPNGIKVI-----DDEEVKRFINELDIADIPGIGDITAEKLKKLGV 199
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
374-421 |
2.32e-21 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 86.38 E-value: 2.32e-21
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2306678528 374 LMKVLDGINHS-GLGKVWFAGRGIAPDWQMKREMLSPAYTTRWKELPVA 421
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-368 |
1.47e-20 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 93.07 E-value: 1.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNNDG-----CVIARSAeakrlGIKMGTPWFQLKEAqFPEKLyVFSSNYELYASL 80
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARIH-----GVRSAMPMFKALKL-CPDAV-VIKPDMEKYVRV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 81 SNRVVALLEELSPRVEQYSIDECFLD----AR--GIGQCMDLEDFGRQLRGHVlsgtGLTIGVGCGATKTLAKSAQWASK 154
Cdd:PRK02794 115 GREVRAMMQALTPLVEPLSIDEAFLDlsgtERlhGAPPAVVLARFARRVEREI----GITVSVGLSYNKFLAKIASDLDK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 155 ewPqfRGVLALSPDNprrTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGES 234
Cdd:PRK02794 191 --P--RGFSVIGRAE---ALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGID 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 235 CISLEEAPPPKqQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPFAVnepyygNVATEKLN 314
Cdd:PRK02794 264 DRKVSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRL------RTRRRTLE 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2306678528 315 TPTRDTRDIIAAAVRSLDRIwLDGHRYAKAGIMLNDFSPNGVAQL-NLFDDVQPR 368
Cdd:PRK02794 337 DPTQLADRIFRTARELLEKE-TDGTAFRLIGIGVSDLSPADEADPpDLLDPQATR 390
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-295 |
4.67e-20 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 91.22 E-value: 4.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSN-NDGCVIAR-SAEAKRLGIKMGTpWFQLKEAQFPEkLYVFSSNYELYASLSNR 83
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAVCHGkGPNSEIAScNYEARSYGIKNGM-WVGQAKKLCPQ-LVTLPYDFEAYEEVSLT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIGQCM--DLEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKewPQfrG 161
Cdd:cd01701 131 FYEILASYTDNIEAVSCDEALIDITSLLEETyeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK--PD--G 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 162 VLALSPDNprrTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLtnpafiRKNFNVVLERTVRELNGESCISL--- 238
Cdd:cd01701 207 QYHLSAEK---VEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLEL------RSKTKEKLQKVLGPKTGEKLYDYcrg 277
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2306678528 239 -----EEAPPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKT 295
Cdd:cd01701 278 iddrpVTGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLMK 339
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-219 |
6.22e-12 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 66.30 E-value: 6.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 10 FYASCERVFRPDLRGKPVVVLSNND--GCVIARSAEAKRLGIK--MGTpwfqlKEAQ--FPEKLYVfSSNYELYASLSNR 83
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGrrGVISTCNYEARKFGVRsaMPT-----AQALklCPDLIFV-PGRFDVYKEVSRQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 84 VVALLEELSPRVEQYSIDECFLDARGIGQCMdledfG------RQLRGHVLSGTGLTIGVGCGATKTLAKSaqwASkEW- 156
Cdd:PRK02406 78 IREIFRRYTDLIEPLSLDEAYLDVTDNKLCI-----GsatliaQEIRQDIFEELGLTASAGVAPNKFLAKI---AS-DWn 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2306678528 157 -P--QFrgVlaLSPDNPrrTAKLLSLqPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNF 219
Cdd:PRK02406 149 kPngLF--V--ITPEEV--DAFLATL-PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHF 207
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-266 |
1.08e-10 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 62.72 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 3 ALADVNSFYASCERVFRPDLRGKPVVVLSNNDgcVIARSAEAKRLGIKMG-----------------TPWFQLKEAQFPE 65
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAARAFGVTRFmtideakkkcpdlilahVATYKKGEDEADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 66 KLYVFSSNY----ELYASLSNRVVALLEELSPRVEQYSIDECFLDargIGQCMDLEdfgrqLRGHVLSGTGLTIGVGCGA 141
Cdd:cd01702 79 HENPSPARHkvslDPYRRASRKILNILKRFGDVVEKASIDEAYLD---LGSRIVEE-----IRQQVYDELGYTCSAGIAH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 142 TKTLAKSAQWASKewpqfrgvlalsPDN-----PRRTAKLLSLQPVEEIWGVGNRIAKKL-HVMGITTALQLSLTN--PA 213
Cdd:cd01702 151 NKMLAKLASGMNK------------PNAqtilrNDAVASFLSSLPITSIRGLGGKLGEEIiDLLGLPTEGDVAGFRssES 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2306678528 214 FIRKNFNVVLERTV-RELNGESCISLEEAPPPKqQIVCSRSFGQRITTYEEMRQ 266
Cdd:cd01702 219 DLQEHFGEKLGEWLyNLLRGIDHEPVKPRPLPK-SMGSSKNFPGKTALSTEDVQ 271
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-280 |
4.33e-09 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 57.87 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVLSNNdgCVIARSAEAKRLGIK--MgtpwfQLKEAQ--FPEKLYVFSSNYELYASLS 81
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY--IVVTCNYEARRLGVKklM-----SIKDAKeiCPDLVLVNGEDLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 82 NRVVALLEELSP--RVEQYSIDECFldargigqcMDLED--------FGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQW 151
Cdd:cd01703 77 KKVYRLLRSYSWndRVERLGFDENF---------MDVTEmrllvashIAYEMRERIENELGLTCCAGIASNKLLAKLVGS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 152 ASKEWPQfrgvLALSPDNPRRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTA--LQLSLTNPAFIRKNFNVVLE----- 224
Cdd:cd01703 148 VNKPNQQ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVrdLQEFSNRNRQTVGAAPSLLElllmv 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2306678528 225 ---------RTVRELNGESCISLEEAPPPKQQIVCSRSFGQriTTYEEMRQAVCQYAERAAEKLR 280
Cdd:cd01703 224 kefgegigqRIWKLLFGRDTSPVKPASDFPQQISIEDSYKK--CSLEEIREARNKIEELLASLLE 286
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
15-291 |
7.50e-09 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 57.01 E-value: 7.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 15 ERVFR--PDLRGKPVVVLS-NNDGCVIARSAEAKRLGIKMGTPwfqLKEAQ--FPEkLYVFSSNYELYASLSNRVVALLE 89
Cdd:cd03468 11 DALLRnrPADDEAPLAVVErKKAGRILACNAAARAAGVRPGMP---LAEALalCPN-LQVVEYDPEADARALQELALWLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 90 ELSPRVEQYSIDECFLDARGIGQCMDLED-FGRQLRGHvLSGTGLTIGVGCGATKTLAKsaqWASKewpqFRGVLALSPD 168
Cdd:cd03468 87 RFTPLVALDGPDGLLLDVTGCLHLFGGEDaLAASLRAA-LATLGLSARAGIADTPGAAW---LLAR----AGGGRGVLRR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 169 NPRRTAKLLSLQPVEEIWGVGNRIAKKLHVMGITTALQLSLTNPAFIRKNFNVVLERTVRELNGE--SCISLEEAPPPKQ 246
Cdd:cd03468 159 EALAAALVLLAPLPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpEPLLFSPPPPAFD 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2306678528 247 QIVcSRSFGQRITtyEEMRQAVCQYAERAAEKLRGERQYCRHISI 291
Cdd:cd03468 239 FRL-ELQLEEPIA--RGLLFPLRRLLEQLCAFLALRGLGARRLSL 280
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-298 |
1.21e-07 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 53.87 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 6 DVNSFYASCERVFRPDLRGKPVVVlsnndGCVIARSAE---AKRLGIKMGTPWF-QLKeaqFPEKLYVFSSNYELYASLS 81
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAI-----GTMTMLQTAnyvARGRGIRQGMPGFlALK---ICPNLLILPPDFDAYNEES 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 82 NRVVALLEELSPRVEQYSIDECFLDARGIGQCMD----LEDFGRQLRGHVLSGTGLTIGVGCGATKTLAKSAQWASKewP 157
Cdd:PTZ00205 211 NTVRRIVAEYDPNYISFGLDELTLEVSAYIERFEgtktAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINK--P 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2306678528 158 QFRGVLALSPDNPRRT-AKLLSLQPVEeiwGVGNRIAKKLHVMGITT-------ALQLSLTnpaFIRKNFNVVLERTV-- 227
Cdd:PTZ00205 289 NGQHDLNLHTRGDVMTyVRDLGLRSVP---GVGKVTEALLKGLGITTlsdiynrRVELCYI---LHNNLFRFLLGASIgi 362
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2306678528 228 -------RELNGESCislEEAP-PPKQQIVCSRSFgQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISIFIKTSPF 298
Cdd:PTZ00205 363 mqwpdaaTAANTENC---EGATgGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY 437
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
181-201 |
1.10e-03 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.22 E-value: 1.10e-03
|
| H3TH |
COG3743 |
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain ... |
185-217 |
1.75e-03 |
|
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain [Replication, recombination and repair];
Pssm-ID: 442957 [Multi-domain] Cd Length: 92 Bit Score: 37.21 E-value: 1.75e-03
10 20 30
....*....|....*....|....*....|...
gi 2306678528 185 IWGVGNRIAKKLHVMGITTALQLSLTNPAFIRK 217
Cdd:COG3743 28 IKGIGPKIEKKLNELGIFTFAQIAAWTPEDIAW 60
|
|
| |
