|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
47-356 |
1.70e-64 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 207.49 E-value: 1.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 47 MTLKKQIFNHELVSNGKISARGMADLRFESGEVIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELRDV 126
Cdd:COG0845 1 MKVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 127 ---------LISQGYpaddISQVPEETMK--LAKVKSGYDQSKSQYEMSKYNAEHATLTAPFDGVVANLFSKPYNLASTS 195
Cdd:COG0845 81 kaelerykaLLKKGA----VSQQELDQAKaaLDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 196 DVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGKLFSGMN 273
Cdd:COG0845 157 TPLFTIADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPAtRTVRVRAELpNPDGLLRPGMF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 274 VRVSVH-RSLGEQLVIPKSAVVLRSGKQVVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSGNINLAHEAPV 352
Cdd:COG0845 237 VRVRIVlGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKV 316
|
....
gi 2290489425 353 TIIE 356
Cdd:COG0845 317 RVVE 320
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
44-355 |
8.05e-44 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 153.62 E-value: 8.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 44 VSVMTLKKQIFNHELVSNGKISARGMADLRFESGEVIAHIWVKNGDRVRKGQKLAELD--KFKLDNQLSQSEDALKKSEL 121
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDddDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 122 ELRDV------------LISQgypADDISQVPEETMKLAKVKSgydqSKSQYEMSKYNAEHATLTAPFDGVVANLFSKPY 189
Cdd:TIGR01730 81 ELAQRsferaerlvkrnAVSQ---ADLDDAKAAVEAAQADLEA----AKASLASAQLNLRYTEIRAPFDGTIGRRLVEVG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 190 NLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGK 267
Cdd:TIGR01730 154 AYVTAGQTLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGtGTVRVRATFpNPDGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 268 LFSGMNVRVSVH-RSLGEQLVIPKSAVVLRSGKQVVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSGNINL 346
Cdd:TIGR01730 234 LLPGMFGRVTISlKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKL 313
|
....*....
gi 2290489425 347 AHEAPVTII 355
Cdd:TIGR01730 314 RDGAKVKVV 322
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
10-342 |
1.23e-12 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 68.20 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 10 LCLALTMLTACSGEEKESAS----EKGVETVLPDTKNEVSVMTlkkqifnhelvsnGKISARGMADLRFESGEVIAHIWV 85
Cdd:PRK09859 11 LLFCGAMLTACDDKSAENAAamtpEVGVVTLSPGSVNVLSELP-------------GRTVPYEVAEIRPQVGGIIIKRNF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 86 KNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELRDVLISQGYPA-----DDISQVPEETMK--LAKVKSGYDQSK 158
Cdd:PRK09859 78 IEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQAsllktNYVSRQDYDTARtqLNEAEANVTVAK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 159 SQYEMSKYNAEHATLTAPFDGVV--ANLFSKPYNLASTSDVFCTVIDMQGMEVDFT------------VLESELPLIKNG 224
Cdd:PRK09859 158 AAVEQATINLQYANVTSPITGVSgkSSVTVGALVTANQADSLVTVQRLDPIYVDLTqsvqdflrmkeeVASGQIKQVQGS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 225 DKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGKLFSGMNVRVSVHR-SLGEQLVIPKSAVVLRS-GKQ 300
Cdd:PRK09859 238 TPVQLNLENGKRYSQTGTLKFSDPTVDETtGSVTLRAIFpNPNGDLLPGMYVTALVDEgSRQNVLLVPQEGVTHNAqGKA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2290489425 301 VVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSG 342
Cdd:PRK09859 318 TALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSG 359
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
172-262 |
4.33e-09 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 53.52 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 172 TLTAPFDGVVANLFSKPYNLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVD 251
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVD 80
|
90
....*....|..
gi 2290489425 252 -DKGMVKVKARV 262
Cdd:pfam13437 81 pDTGVIPVRVSI 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
47-356 |
1.70e-64 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 207.49 E-value: 1.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 47 MTLKKQIFNHELVSNGKISARGMADLRFESGEVIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELRDV 126
Cdd:COG0845 1 MKVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 127 ---------LISQGYpaddISQVPEETMK--LAKVKSGYDQSKSQYEMSKYNAEHATLTAPFDGVVANLFSKPYNLASTS 195
Cdd:COG0845 81 kaelerykaLLKKGA----VSQQELDQAKaaLDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 196 DVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGKLFSGMN 273
Cdd:COG0845 157 TPLFTIADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPAtRTVRVRAELpNPDGLLRPGMF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 274 VRVSVH-RSLGEQLVIPKSAVVLRSGKQVVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSGNINLAHEAPV 352
Cdd:COG0845 237 VRVRIVlGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKV 316
|
....
gi 2290489425 353 TIIE 356
Cdd:COG0845 317 RVVE 320
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
44-355 |
8.05e-44 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 153.62 E-value: 8.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 44 VSVMTLKKQIFNHELVSNGKISARGMADLRFESGEVIAHIWVKNGDRVRKGQKLAELD--KFKLDNQLSQSEDALKKSEL 121
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDddDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 122 ELRDV------------LISQgypADDISQVPEETMKLAKVKSgydqSKSQYEMSKYNAEHATLTAPFDGVVANLFSKPY 189
Cdd:TIGR01730 81 ELAQRsferaerlvkrnAVSQ---ADLDDAKAAVEAAQADLEA----AKASLASAQLNLRYTEIRAPFDGTIGRRLVEVG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 190 NLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGK 267
Cdd:TIGR01730 154 AYVTAGQTLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGtGTVRVRATFpNPDGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 268 LFSGMNVRVSVH-RSLGEQLVIPKSAVVLRSGKQVVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSGNINL 346
Cdd:TIGR01730 234 LLPGMFGRVTISlKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKL 313
|
....*....
gi 2290489425 347 AHEAPVTII 355
Cdd:TIGR01730 314 RDGAKVKVV 322
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
55-279 |
7.77e-24 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 100.12 E-value: 7.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 55 NHELVSNGKISARgMADLRFESGEVIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELRDVLISQGYPA 134
Cdd:COG1566 32 DEPVTADGRVEAR-VVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEAQLARLEAELGAEA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 135 D------DISQVpEETMKLAK---------VKSG------YDQSKSQYEMSK---------------------------- 165
Cdd:COG1566 111 EiaaaeaQLAAA-QAQLDLAQreleryqalYKKGavsqqeLDEARAALDAAQaqleaaqaqlaqaqaglreeeelaaaqa 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 166 -------------YNAEHATLTAPFDGVVANLFSKPYNLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPY 232
Cdd:COG1566 190 qvaqaeaalaqaeLNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVPETDLGRVKPGQPVEVRVD 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 233 SDAATVHEGSISEINPLVD-----------DKGMVKVKARVNGA--GKLFSGMNVRVSVH 279
Cdd:COG1566 270 AYPDRVFEGKVTSISPGAGftsppknatgnVVQRYPVRIRLDNPdpEPLRPGMSATVEID 329
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
10-342 |
1.23e-12 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 68.20 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 10 LCLALTMLTACSGEEKESAS----EKGVETVLPDTKNEVSVMTlkkqifnhelvsnGKISARGMADLRFESGEVIAHIWV 85
Cdd:PRK09859 11 LLFCGAMLTACDDKSAENAAamtpEVGVVTLSPGSVNVLSELP-------------GRTVPYEVAEIRPQVGGIIIKRNF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 86 KNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELRDVLISQGYPA-----DDISQVPEETMK--LAKVKSGYDQSK 158
Cdd:PRK09859 78 IEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQAsllktNYVSRQDYDTARtqLNEAEANVTVAK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 159 SQYEMSKYNAEHATLTAPFDGVV--ANLFSKPYNLASTSDVFCTVIDMQGMEVDFT------------VLESELPLIKNG 224
Cdd:PRK09859 158 AAVEQATINLQYANVTSPITGVSgkSSVTVGALVTANQADSLVTVQRLDPIYVDLTqsvqdflrmkeeVASGQIKQVQGS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 225 DKVVIKPYSDAATVHEGSISEINPLVDDK-GMVKVKARV-NGAGKLFSGMNVRVSVHR-SLGEQLVIPKSAVVLRS-GKQ 300
Cdd:PRK09859 238 TPVQLNLENGKRYSQTGTLKFSDPTVDETtGSVTLRAIFpNPNGDLLPGMYVTALVDEgSRQNVLLVPQEGVTHNAqGKA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2290489425 301 VVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGDTVIVSG 342
Cdd:PRK09859 318 TALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSG 359
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
44-356 |
1.14e-11 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 65.58 E-value: 1.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 44 VSVMTLKKQIFNHELVSNGKISARGMADLRFE-SGEVIAhIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELE 122
Cdd:PRK11556 62 VQAATATEQAVPRYLTGLGTVTAANTVTVRSRvDGQLMA-LHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 123 L----RDV----------LISQGYPADDISQVPEETMKLAKVKSGYDQSKSQYEMSKynaehatLTAPFDGVVANLFSKP 188
Cdd:PRK11556 141 LanarRDLaryqqlaktnLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSR-------ITAPISGRVGLKQVDV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 189 YNLASTSDVFCTVIDMQGMEVD--FTVLESELPLI----KNGDKVVIKPY--SDAATVHEGSISEINPLVD-DKGMVKVK 259
Cdd:PRK11556 214 GNQISSGDTTGIVVITQTHPIDlvFTLPESDIATVvqaqKAGKPLVVEAWdrTNSKKLSEGTLLSLDNQIDaTTGTIKLK 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 260 ARV-NGAGKLFSG--MNVRVSVHrSLGEQLVIPKSAVVLRSGKQVVFTLKDGKMAQWNYIHTALENADSYSVADGLTEGD 336
Cdd:PRK11556 294 ARFnNQDDALFPNqfVNARMLVD-TLQNAVVIPTAALQMGNEGHFVWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGD 372
|
330 340
....*....|....*....|
gi 2290489425 337 TVIVSGNINLAHEAPVTIIE 356
Cdd:PRK11556 373 RVVTDGIDRLTEGAKVEVVE 392
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
172-262 |
4.33e-09 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 53.52 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 172 TLTAPFDGVVANLFSKPYNLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVD 251
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVD 80
|
90
....*....|..
gi 2290489425 252 -DKGMVKVKARV 262
Cdd:pfam13437 81 pDTGVIPVRVSI 92
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
76-341 |
2.73e-08 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 54.78 E-value: 2.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 76 SGEvIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALK---------KSELELRDVLIS--------QGYPADDIS 138
Cdd:PRK11578 69 SGQ-LKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMelraqrqqaEAELKLARVTLSrqqrlaktQAVSQQDLD 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 139 QVPEE-TMKLAKV---KSGYDQSKSQYEMSKYNAEHATLTAPFDGVVAN---LFSKPYNLASTSDVFCTVIDMQGMEVDF 211
Cdd:PRK11578 148 TAATElAVKQAQIgtiDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQittLQGQTVIAAQQAPNILTLADMSTMLVKA 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 212 TVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPL---VDDKGMVKVKARV-NGAGKLFSGMNVRVSVH-RSLGEQL 286
Cdd:PRK11578 228 QVSEADVIHLKPGQKAWFTVLGDPLTRYEGVLKDILPTpekVNDAIFYYARFEVpNPNGLLRLDMTAQVHIQlTDVKNVL 307
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290489425 287 VIPKSAVvlrsGKQV------VFTLKDGKMAQWNYIHTALENADSySVADGLTEGDTVIVS 341
Cdd:PRK11578 308 TIPLSAL----GDPVgdnrykVKLLRNGETREREVTIGARNDTDV-EIVKGLEAGDEVIIG 363
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
57-278 |
1.57e-07 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 52.43 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 57 ELVSNGKISARGMAD-LRFESGEVIAHIWVKNGDRVRKGQKLAELDK-------FKLDNQLSQSEDALKKSELELR---- 124
Cdd:pfam00529 7 GVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPtdyqaalDSAEAQLAKAQAQVARLQAELDrlqa 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 125 ---DVLISQGYPADDISQVPEETMKLAKVKSGYDQSKSQY---------------------------------------- 161
Cdd:pfam00529 87 lesELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLarrrvlapiggisreslvtagalvaqaqanllatvaqldq 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 162 ----------------------------------EMSKYNAEHATLTAPFDGVVANLFSKPY-NLASTSDVFCTVIDMQG 206
Cdd:pfam00529 167 iyvqitqsaaenqaevrselsgaqlqiaeaeaelKLAKLDLERTEIRAPVDGTVAFLSVTVDgGTVSAGLRLMFVVPEDN 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2290489425 207 MEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLVDDKGMVKVKARVNGAGKlfsgMNVRVSV 278
Cdd:pfam00529 247 LLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPY----YPLRIGL 314
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
88-274 |
2.04e-07 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 50.97 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 88 GDRVRKGQKLAELDKFKLDN------QLSQSEDALKKSELEL--RDVLISQGYPADDISQVpeetmklakVKSGydqsKS 159
Cdd:pfam16576 39 GDPVKKGQPLAELYSPELVAaqqeylLALRSGDALSKSELLRaaRQRLRLLGMPEAQIAEL---------ERTG----KV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 160 QYEMskynaehaTLTAPFDGVVANL------FSKP----YNLASTSDVFctvidmqgmeVDFTVLESELPLIKNGDKVVI 229
Cdd:pfam16576 106 QPTV--------TVYAPISGVVTELnvregmYVQPgdtlFTIADLSTVW----------VEADVPEQDLALVKVGQPAEV 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2290489425 230 KPYSDAATVHEGSISEINPLVDDKGMVkVKARV---NGAGKLFSGMNV 274
Cdd:pfam16576 168 TLPALPGKTFEGKVDYIYPTLDPKTRT-VRVRIelpNPDGRLKPGMFA 214
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
172-353 |
3.92e-06 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 48.33 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 172 TLTAPFDGVVANL-FSKPYNLASTSdvfcTVIDMQGME---VDFTVLESELPLIKNGDKVVIK-PYSDAATVHegsISEI 246
Cdd:PRK09783 211 TLKAPIDGVITAFdLRAGMNIAKDN----VVAKIQGMDpvwVTAAIPESIAWLVKDASQFTLTvPARPDKTFT---IRKW 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 247 N--PLVDDKG-MVKVKARVNGA-GKLFSGMNVRVSVHRSLGEQLVIPKSAVVLRSGKQVVFTL-KDGKMAQwNYIHTALE 321
Cdd:PRK09783 284 TllPSVDAATrTLQLRLEVDNAdEALKPGMNAWLQLNTASEPMLLIPSQALIDTGSEQRVITVdADGRFVP-KRVAVFQE 362
|
170 180 190
....*....|....*....|....*....|..
gi 2290489425 322 NADSYSVADGLTEGDTVIVSGNINLAHEAPVT 353
Cdd:PRK09783 363 SQGVTAIRSGLAEGEKVVSSGLFLIDSEANIS 394
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
79-117 |
1.06e-04 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 39.35 E-value: 1.06e-04
10 20 30
....*....|....*....|....*....|....*....
gi 2290489425 79 VIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALK 117
Cdd:pfam13533 12 KVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
108-298 |
4.35e-04 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 41.94 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 108 QLSQSEDALKKSELELRDVLISQGYPADDISQVPEEtmkLAKVksgyDQSKSQYEMSKYNAEHATLTAPFDGVVANLFSK 187
Cdd:PRK10476 153 QVDQARTAQRDAEVSLNQALLQAQAAAAAVGGVDAL---VAQR----AAREAALAIAELHLEDTTVRAPFDGRVVGLKVS 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 188 PYNLASTSDVFCTVIDMQGMEVDFTVLESELPLIKNGDKVVIKPYSDAATVHEGSISEINPLV--DDKGMV-----KVKA 260
Cdd:PRK10476 226 VGEFAAPMQPIFTLIDTDHWYAIANFRETDLKNIRVGDCATVYSMIDRGRPFEGKVDSIGWGVlpDDGGNVprglpYVPR 305
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2290489425 261 RVN--GAGKLFSgmnVRVSVHRSLGEQLVIPKSAVV-LRSG 298
Cdd:PRK10476 306 SINwvRVAQRFP---VRIMLDKPDPELFRIGASAVVeLRPG 343
|
|
| type_I_hlyD |
TIGR01843 |
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ... |
76-175 |
2.49e-03 |
|
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 130902 [Multi-domain] Cd Length: 423 Bit Score: 39.61 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 76 SGEVIAHIWVKNGDRVRKGQKLAELD-------KFKLDNQLSQSE------DALKKSEL--ELRDVLISQGYPADDiSQV 140
Cdd:TIGR01843 50 EGGIVREILVREGDRVKAGQVLVELDatdveadAAELESQVLRLEaevarlRAEADSQAaiEFPDDLLSAEDPAVP-ELI 128
|
90 100 110
....*....|....*....|....*....|....*..
gi 2290489425 141 PEETMKLAKVKSGYDQSKSQY--EMSKYNAEHATLTA 175
Cdd:TIGR01843 129 KGQQSLFESRKSTLRAQLELIlaQIKQLEAELAGLQA 165
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
71-162 |
5.20e-03 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 38.40 E-value: 5.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290489425 71 DLRFESGEVIAHIWVKNGDRVRKGQKLAELDKFKLDNQLSQSEDALKKSELELrdVLISQGYPADDISQVPEEtmkLAKV 150
Cdd:PRK03598 45 NLGFRVGGRLASLAVDEGDAVKAGQVLGELDAAPYENALMQAKANVSVAQAQL--DLMLAGYRDEEIAQARAA---VKQA 119
|
90
....*....|..
gi 2290489425 151 KSGYDQSKSQYE 162
Cdd:PRK03598 120 QAAYDYAQNFYN 131
|
|
| |
