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Conserved domains on  [gi|2219611691|gb|UOH83841|]
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hypothetical protein LQV05_006579 [Cryptococcus neoformans]

Protein Classification

60S ribosomal export protein NMD3( domain architecture ID 10523188)

60S ribosomal export protein NMD3 acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
19-249 2.40e-96

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


:

Pssm-ID: 461505  Cd Length: 242  Bit Score: 293.43  E-value: 2.40e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  19 CADCGTVISSANGaGLCVGCLRNTVDITEGIPKeATLNFCRGCERFLsPPNTWVTVqPESRELLAICLKKIARP------ 92
Cdd:pfam04981   1 CCRCGRPIEPPIN-GLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLVSKglnvhe 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  93 ---LMKVRLIDASFIWTEPHSRRIKLKITIQKEV--LAHTVLQQTFVLTLVVHTGQCPSCTRLAAkNTWKASVQVRQK-- 165
Cdd:pfam04981  77 dveDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAG-GYWEAIVQVRQKre 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691 166 ---VTHKRTFLWLEQLILKHNAHKDTINIAEKRDGLDFFYSERNNAIKMCEFLAGVVPVRVKSSEQLISSDTHSNTSNYK 242
Cdd:pfam04981 156 lteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYR 235

                  ....*..
gi 2219611691 243 FTYSVEI 249
Cdd:pfam04981 236 FTYSVRI 242
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
19-249 2.40e-96

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 293.43  E-value: 2.40e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  19 CADCGTVISSANGaGLCVGCLRNTVDITEGIPKeATLNFCRGCERFLsPPNTWVTVqPESRELLAICLKKIARP------ 92
Cdd:pfam04981   1 CCRCGRPIEPPIN-GLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLVSKglnvhe 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  93 ---LMKVRLIDASFIWTEPHSRRIKLKITIQKEV--LAHTVLQQTFVLTLVVHTGQCPSCTRLAAkNTWKASVQVRQK-- 165
Cdd:pfam04981  77 dveDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAG-GYWEAIVQVRQKre 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691 166 ---VTHKRTFLWLEQLILKHNAHKDTINIAEKRDGLDFFYSERNNAIKMCEFLAGVVPVRVKSSEQLISSDTHSNTSNYK 242
Cdd:pfam04981 156 lteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYR 235

                  ....*..
gi 2219611691 243 FTYSVEI 249
Cdd:pfam04981 236 FTYSVRI 242
NMD3 COG1499
NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and ...
14-258 3.86e-09

NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441108  Cd Length: 352  Bit Score: 58.37  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  14 ESYILCADCGtvISSANG-AGLCVGCLRNTVDITEgIPKEATLNFCRGCERFLSPpNTWVTVQPESRELLAIclkKIARP 92
Cdd:COG1499     1 MSRGFCPRCG--REVEELvDGLCKDCYLEEFPLVD-APDRVEVTVCPRCGAVRRG-GRWVDPGAEDYEEVAI---EAVED 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  93 LMKVRLiDASFIWTEPHSR-----RIKLKITIQKEVLaHTVLQQTFVLTLVVHTGQCPSCTRLAAkNTWKASVQVRqkvT 167
Cdd:COG1499    74 ALKVHE-EAEDVEIEVEPEqldpnTIRVHVTVTGRVR-GEPVEEEVTVPVRIKREVCPRCSRIAG-GYYEAIVQVR---A 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691 168 HKRTF--------LWLEQLILKHNAHKD----TINIAEKRDGLDFFYSERNNAIKMCEFLAGVVPVRVKSSEQLISSDTH 235
Cdd:COG1499   148 DGRKPteeereeaEEIAEEVVDKLAKGDrlafITKVEELKEGLDIYLGSTKAGRKIARAIVEELGGSVSESPKLVGEDKD 227
                         250       260
                  ....*....|....*....|...
gi 2219611691 236 SNtSNYKFTYSVEIVPVCKDDLV 258
Cdd:COG1499   228 GK-EVYRVTYSVRLPEFRPGDIV 249
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
19-249 2.40e-96

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 293.43  E-value: 2.40e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  19 CADCGTVISSANGaGLCVGCLRNTVDITEGIPKeATLNFCRGCERFLsPPNTWVTVqPESRELLAICLKKIARP------ 92
Cdd:pfam04981   1 CCRCGRPIEPPIN-GLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLVSKglnvhe 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  93 ---LMKVRLIDASFIWTEPHSRRIKLKITIQKEV--LAHTVLQQTFVLTLVVHTGQCPSCTRLAAkNTWKASVQVRQK-- 165
Cdd:pfam04981  77 dveDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAG-GYWEAIVQVRQKre 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691 166 ---VTHKRTFLWLEQLILKHNAHKDTINIAEKRDGLDFFYSERNNAIKMCEFLAGVVPVRVKSSEQLISSDTHSNTSNYK 242
Cdd:pfam04981 156 lteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYR 235

                  ....*..
gi 2219611691 243 FTYSVEI 249
Cdd:pfam04981 236 FTYSVRI 242
NMD3 COG1499
NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and ...
14-258 3.86e-09

NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441108  Cd Length: 352  Bit Score: 58.37  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  14 ESYILCADCGtvISSANG-AGLCVGCLRNTVDITEgIPKEATLNFCRGCERFLSPpNTWVTVQPESRELLAIclkKIARP 92
Cdd:COG1499     1 MSRGFCPRCG--REVEELvDGLCKDCYLEEFPLVD-APDRVEVTVCPRCGAVRRG-GRWVDPGAEDYEEVAI---EAVED 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691  93 LMKVRLiDASFIWTEPHSR-----RIKLKITIQKEVLaHTVLQQTFVLTLVVHTGQCPSCTRLAAkNTWKASVQVRqkvT 167
Cdd:COG1499    74 ALKVHE-EAEDVEIEVEPEqldpnTIRVHVTVTGRVR-GEPVEEEVTVPVRIKREVCPRCSRIAG-GYYEAIVQVR---A 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2219611691 168 HKRTF--------LWLEQLILKHNAHKD----TINIAEKRDGLDFFYSERNNAIKMCEFLAGVVPVRVKSSEQLISSDTH 235
Cdd:COG1499   148 DGRKPteeereeaEEIAEEVVDKLAKGDrlafITKVEELKEGLDIYLGSTKAGRKIARAIVEELGGSVSESPKLVGEDKD 227
                         250       260
                  ....*....|....*....|...
gi 2219611691 236 SNtSNYKFTYSVEIVPVCKDDLV 258
Cdd:COG1499   228 GK-EVYRVTYSVRLPEFRPGDIV 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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