NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2210635263|gb|UNO28914|]
View 

GntR family transcriptional regulator (plasmid) [Pseudomonas amygdali pv. aesculi]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GntR super family cl34361
DNA-binding transcriptional regulator, GntR family [Transcription];
30-92 1.35e-16

DNA-binding transcriptional regulator, GntR family [Transcription];


The actual alignment was detected with superfamily member COG1802:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 73.03  E-value: 1.35e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2210635263  30 REAIEEALRAAIMDGRLESGERLTQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVT 92
Cdd:COG1802    13 AEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
30-92 1.35e-16

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 73.03  E-value: 1.35e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2210635263  30 REAIEEALRAAIMDGRLESGERLTQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVT 92
Cdd:COG1802    13 AEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 31-92 1.73e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 66.32  E-value: 1.73e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2210635263  31 EAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVT 92
Cdd:cd07377     4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 29-91 1.43e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 1.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2210635263  29 PREAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRV 91
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
33-91 3.24e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 57.97  E-value: 3.24e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263   33 IEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRV 91
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11523 PRK11523
transcriptional regulator ExuR;
37-105 4.97e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 38.67  E-value: 4.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263  37 LRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVTNGQelPRHGHLPG 105
Cdd:PRK11523   17 LKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQ--PRHQQAAD 84
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
30-92 1.35e-16

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 73.03  E-value: 1.35e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2210635263  30 REAIEEALRAAIMDGRLESGERLTQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVT 92
Cdd:COG1802    13 AEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 31-92 1.73e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 66.32  E-value: 1.73e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2210635263  31 EAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVT 92
Cdd:cd07377     4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 29-91 1.43e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 1.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2210635263  29 PREAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRV 91
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
33-91 3.24e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 57.97  E-value: 3.24e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263   33 IEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRV 91
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
31-132 8.89e-11

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 57.64  E-value: 8.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263  31 EAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVTngqELPRHGHLPGLLRC 109
Cdd:COG2186    10 EQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR---EPSPWALLDPLALL 86

                          90       100
                  ....*....|....*....|....
gi 2210635263 110 VAERHTQLGDL-EAKVAFENEILR 132
Cdd:COG2186    87 LALDDASLRDLlEARLALEPEAAR 110
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
33-81 1.60e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 54.10  E-value: 1.60e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2210635263  33 IEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYI 81
Cdd:COG2188    10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLL 59
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 31-99 3.76e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 53.68  E-value: 3.76e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263  31 EAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVTNGQELPR 99
Cdd:COG1167    15 LQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPA 84
PRK11523 PRK11523
transcriptional regulator ExuR;
37-105 4.97e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 38.67  E-value: 4.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210635263  37 LRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVTNGQelPRHGHLPG 105
Cdd:PRK11523   17 LKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQ--PRHQQAAD 84
PRK09764 PRK09764
GntR family transcriptional regulator;
33-78 5.64e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 38.66  E-value: 5.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2210635263  33 IEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQ 78
Cdd:PRK09764   10 IADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQ 56
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
31-79 6.65e-04

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.46  E-value: 6.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2210635263  31 EAIEEALRAAIMDGRLESGERL-TQQAIADAFQVSRMPVREALRSLETQG 79
Cdd:PRK09464   13 DVIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKG 62
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 33-93 3.66e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.18  E-value: 3.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2210635263  33 IEEALRAAIMDGRLESGE------RLTQQAIADAFQVSRMPVREALRSLETQGYIATAYHKGYRVTN 93
Cdd:cd00092     1 AKERLASFLLNLSLRYGAgdlvqlPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVNP 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH