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Conserved domains on  [gi|1707683983|gb|TSA72986|]
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carboxymuconolactone decarboxylase family protein [Salmonella enterica subsp. enterica serovar Typhimurium]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-143 1.94e-48

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 152.34  E-value: 1.94e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  12 SPEVYSALVQAKNAL-EKSTLDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWRVSHHFSEQECAAL 90
Cdd:COG2128     2 SPELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707683983  91 AWAESVTHIAeTHAEDNIYLPLLDHFSAREISDLTFAIGLMNCFNRLAIGMRM 143
Cdd:COG2128    82 AFAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGT 133
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-143 1.94e-48

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 152.34  E-value: 1.94e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  12 SPEVYSALVQAKNAL-EKSTLDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWRVSHHFSEQECAAL 90
Cdd:COG2128     2 SPELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707683983  91 AWAESVTHIAeTHAEDNIYLPLLDHFSAREISDLTFAIGLMNCFNRLAIGMRM 143
Cdd:COG2128    82 AFAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGT 133
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 13-94 3.09e-20

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 78.89  E-value: 3.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  13 PEVYSALVQ-AKNALEKSTLDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWRVSHHFSEQECAALA 91
Cdd:pfam02627   1 PELLAALTAlAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ...
gi 1707683983  92 WAE 94
Cdd:pfam02627  81 AAE 83
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 31-77 4.22e-13

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 59.69  E-value: 4.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1707683983  31 LDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWR 77
Cdd:TIGR00778   3 LDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
PRK15052 PRK15052
tagatose-bisphosphate aldolase subunit GatZ;
43-128 7.63e-03

tagatose-bisphosphate aldolase subunit GatZ;


Pssm-ID: 237889  Cd Length: 421  Bit Score: 35.21  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  43 VSQINGCAFCLEMHSKALRKAGVNQAKLDALA-----GWRVSH----HFSEQECAAL-AWAESVTHIAETHAED----NI 108
Cdd:PRK15052  187 VTRVEDAANTLRTHQKAFIARGLTEALTRVIAivvqpGVEFDHsniiHYQPQEAQALsAWIENTPMVYEAHSTDyqtrQA 266

                          90       100
                  ....*....|....*....|..
gi 1707683983 109 YLPLL-DHFSAREISD-LTFAI 128
Cdd:PRK15052  267 YRELVrDHFAILKVGPaLTFAL 288
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-143 1.94e-48

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 152.34  E-value: 1.94e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  12 SPEVYSALVQAKNAL-EKSTLDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWRVSHHFSEQECAAL 90
Cdd:COG2128     2 SPELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707683983  91 AWAESVTHIAeTHAEDNIYLPLLDHFSAREISDLTFAIGLMNCFNRLAIGMRM 143
Cdd:COG2128    82 AFAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGT 133
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 13-94 3.09e-20

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 78.89  E-value: 3.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  13 PEVYSALVQ-AKNALEKSTLDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWRVSHHFSEQECAALA 91
Cdd:pfam02627   1 PELLAALTAlAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ...
gi 1707683983  92 WAE 94
Cdd:pfam02627  81 AAE 83
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 31-77 4.22e-13

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 59.69  E-value: 4.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1707683983  31 LDPTLMELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDALAGWR 77
Cdd:TIGR00778   3 LDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 6-142 1.45e-08

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 50.87  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983   6 QPYYELSPEVYSALV-QAKNALEKSTLDPTLM-----------ELIYLRVSQINGCAFCLEMHSKALRKAGVNQAKLDAL 73
Cdd:TIGR01926  23 EEKTGFVPNVFRALAhDPEALRARTAYFNDLMlgegglsraerELIAVVVSRANGCVYCAAVHGAALRQLSGDPDLADAV 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707683983  74 AgwrVSHH---FSEQECAALAWAESVTHIAETHAEDNIYlPLLDH-FSAREISDLTFAIGLMNCFNRL--AIGMR 142
Cdd:TIGR01926 103 A---VNFRdadLSPRERAMLDFAVKLTATPAKVNEADFA-ALRAAgFSDLDILDLIHSVAFFNWANRLmlALGEP 173
PRK15052 PRK15052
tagatose-bisphosphate aldolase subunit GatZ;
43-128 7.63e-03

tagatose-bisphosphate aldolase subunit GatZ;


Pssm-ID: 237889  Cd Length: 421  Bit Score: 35.21  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707683983  43 VSQINGCAFCLEMHSKALRKAGVNQAKLDALA-----GWRVSH----HFSEQECAAL-AWAESVTHIAETHAED----NI 108
Cdd:PRK15052  187 VTRVEDAANTLRTHQKAFIARGLTEALTRVIAivvqpGVEFDHsniiHYQPQEAQALsAWIENTPMVYEAHSTDyqtrQA 266

                          90       100
                  ....*....|....*....|..
gi 1707683983 109 YLPLL-DHFSAREISD-LTFAI 128
Cdd:PRK15052  267 YRELVrDHFAILKVGPaLTFAL 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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