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Conserved domains on  [gi|1704008290|gb|TRH13930|]
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DNA-binding transcriptional activator BglJ [Salmonella enterica subsp. enterica serovar Senftenberg]

Protein Classification

DNA-binding transcriptional activator BglJ( domain architecture ID 11485358)

DNA-binding transcriptional activator BglJ is a crytic transcriptional activator that acts independently of transcription factor LeuO.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-224 2.33e-134

DNA-binding transcriptional activator BglJ; Provisional


:

Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 375.62  E-value: 2.33e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  18 MSTIGIKGLFDAMPDCRHTLHIFSKPSAFYKSALKTPFSAVIFSLSALRTERRTGLSSLTELAINYPHMRRLVIADDDAE 97
Cdd:PRK11475    1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  98 ARLISALSPLPLDGVISKASPLDVLQDALFTSLNSARRTTERTDNLWELHQNCMLSPTEREILRFMSNGYSMPQIAVQLE 177
Cdd:PRK11475   81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1704008290 178 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLYLRAGDGTALQHRV 224
Cdd:PRK11475  161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNVLHPV 207
 
Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-224 2.33e-134

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 375.62  E-value: 2.33e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  18 MSTIGIKGLFDAMPDCRHTLHIFSKPSAFYKSALKTPFSAVIFSLSALRTERRTGLSSLTELAINYPHMRRLVIADDDAE 97
Cdd:PRK11475    1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  98 ARLISALSPLPLDGVISKASPLDVLQDALFTSLNSARRTTERTDNLWELHQNCMLSPTEREILRFMSNGYSMPQIAVQLE 177
Cdd:PRK11475   81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1704008290 178 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLYLRAGDGTALQHRV 224
Cdd:PRK11475  161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNVLHPV 207
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 152-206 1.03e-14

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 66.02  E-value: 1.03e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 152-206 2.27e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 65.24  E-value: 2.27e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290  152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 151-206 7.81e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 60.29  E-value: 7.81e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1704008290 151 MLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:COG2197    69 LLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLA 124
GerE pfam00196
Bacterial regulatory proteins, luxR family;
152-206 2.44e-11

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 57.21  E-value: 2.44e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
 
Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-224 2.33e-134

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 375.62  E-value: 2.33e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  18 MSTIGIKGLFDAMPDCRHTLHIFSKPSAFYKSALKTPFSAVIFSLSALRTERRTGLSSLTELAINYPHMRRLVIADDDAE 97
Cdd:PRK11475    1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  98 ARLISALSPLPLDGVISKASPLDVLQDALFTSLNSARRTTERTDNLWELHQNCMLSPTEREILRFMSNGYSMPQIAVQLE 177
Cdd:PRK11475   81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1704008290 178 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLYLRAGDGTALQHRV 224
Cdd:PRK11475  161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNVLHPV 207
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 152-206 1.03e-14

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 66.02  E-value: 1.03e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 152-206 2.27e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 65.24  E-value: 2.27e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290  152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 82-204 3.39e-12

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 63.31  E-value: 3.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  82 NYPHMRRLVIADDDAEArLISALSPLPLDGVISKASPLDVLQDALfTSLNSARR-TTERTDNLWEL-----HQNCMLSPT 155
Cdd:PRK10840   77 HFPSLSIIVLTMNNNPA-ILSAVLDLDIEGIVLKQGAPTDLPKAL-AALQKGKKfTPESVSRLLEKisaggYGDKRLSPK 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1704008290 156 EREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLD 204
Cdd:PRK10840  155 ESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLN 203
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 151-206 7.81e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 60.29  E-value: 7.81e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1704008290 151 MLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:COG2197    69 LLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLA 124
GerE pfam00196
Bacterial regulatory proteins, luxR family;
152-206 2.44e-11

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 57.21  E-value: 2.44e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
59-206 3.78e-10

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 57.07  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  59 IFSLSALRTERRTGLSSLTELAINYPHMRRLVIADDDAEARLISALSPLPLDGVISKASPLDVLQDALFTSLNSARRTTE 138
Cdd:COG2771    35 LLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALL 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1704008290 139 RTDNLWELHQNCMLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:COG2771   115 LAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALA 182
PRK15369 PRK15369
two component system response regulator;
72-203 8.09e-09

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 53.54  E-value: 8.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290  72 GLSSLTELAINYPHMRRLVIADDDAEARLISALSPLPLdGVISKASPLDVLQDALFT----------SLNSARRTTERTD 141
Cdd:PRK15369   64 GLDVIPQLHQRWPAMNILVLTARQEEHMASRTLAAGAL-GYVLKKSPQQILLAAIQTvavgkryidpALNREAILALLNA 142

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1704008290 142 nlwELHQNCMLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLL 203
Cdd:PRK15369  143 ---DDTNPPLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 152-215 1.08e-07

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 47.65  E-value: 1.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLldaadILLYLRAG 215
Cdd:COG5905    13 LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQA-----VVWALRLG 71
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
147-206 2.46e-07

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 49.49  E-value: 2.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290 147 HQNCMLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 206
Cdd:PRK09935  145 STDTVLSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYA 204
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 120-215 5.94e-07

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 48.17  E-value: 5.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704008290 120 DVLQDALFTSLNSARRTTERTDNLWELHQNC-MLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSS 198
Cdd:COG4566   105 QALLDAVRRALARDRARRAERARRAELRARLaSLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARS 184

                          90
                  ....*....|....*..
gi 1704008290 199 DAGLldaadILLYLRAG 215
Cdd:COG4566   185 LAEL-----VRLALALG 196
PRK10360 PRK10360
transcriptional regulator UhpA;
152-202 1.85e-05

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 43.81  E-value: 1.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1704008290 152 LSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGL 202
Cdd:PRK10360  138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
161-213 1.30e-03

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 38.53  E-value: 1.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1704008290 161 RFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLYLR 213
Cdd:COG2909   132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 120-198 2.37e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 37.70  E-value: 2.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1704008290 120 DVLQDALFTSLNSARRTTERTDNLwelhqncmLSPTEREILRFMSNGYSMPQIAVQLERNIKTIRAHKFNVMSKLGVSS 198
Cdd:PRK10651  132 EALTPVLAASLRANRATTERDVNQ--------LTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKS 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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