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Conserved domains on  [gi|1690422960|gb|TPD42921|]
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porin [Escherichia coli]

Protein Classification

porin( domain architecture ID 10447114)

outer membrane porin forms aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane, similar to Salmonella typhi major general diffusion porin OmpF

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Porin_1 pfam00267
Gram-negative porin;
29-365 6.13e-176

Gram-negative porin;


:

Pssm-ID: 395205  Cd Length: 335  Bit Score: 491.96  E-value: 6.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  29 KDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQgSSKDKTRLAFAGLKFG 108
Cdd:pfam00267   1 KDGNKLDLYGKVTGLHYFSDRDGSDGDDTYARIGFKGETQINDQLTGYGQWEYNVSVNGTEGA-STQWGTRLAFAGLKFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 109 DYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRSDFDNYT 188
Cdd:pfam00267  80 DFGSFDYGRNYGVLYDVGAWTDVLPEFGGDTTAQTDNFMTGRANGVATYRNPDFFGLVDGLNFALQYQGKNEDTPARNLT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 189 EGNGDGFGFSATYEYEG-FGIGATYAKSDRTDTQVNAGKVLPEVFASGKNAEVWAAGLKYDANNIYLATTYSETQNMTVF 267
Cdd:pfam00267 160 KSNGDGYGVSLNYDNGGgFGYGGAYARSDRTGDQKIEYYSIASLTGNGKKAEVWRLGGKYDANNIYLAAAYAQTRNATRY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 268 ADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDL-GVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDft 346
Cdd:pfam00267 240 GAMGFANKTQNTEVVAQYQFDFGLRPSISYAQSKGKDLeGAYGDNDLVKYVDVGATYYFNKNMSTYVDYKINLLDKGD-- 317
                         330
                  ....*....|....*....
gi 1690422960 347 kALGVSTDDIVAVGLVYQF 365
Cdd:pfam00267 318 -DLGINTDDAVAVGLRYQF 335
 
Name Accession Description Interval E-value
Porin_1 pfam00267
Gram-negative porin;
29-365 6.13e-176

Gram-negative porin;


Pssm-ID: 395205  Cd Length: 335  Bit Score: 491.96  E-value: 6.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  29 KDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQgSSKDKTRLAFAGLKFG 108
Cdd:pfam00267   1 KDGNKLDLYGKVTGLHYFSDRDGSDGDDTYARIGFKGETQINDQLTGYGQWEYNVSVNGTEGA-STQWGTRLAFAGLKFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 109 DYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRSDFDNYT 188
Cdd:pfam00267  80 DFGSFDYGRNYGVLYDVGAWTDVLPEFGGDTTAQTDNFMTGRANGVATYRNPDFFGLVDGLNFALQYQGKNEDTPARNLT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 189 EGNGDGFGFSATYEYEG-FGIGATYAKSDRTDTQVNAGKVLPEVFASGKNAEVWAAGLKYDANNIYLATTYSETQNMTVF 267
Cdd:pfam00267 160 KSNGDGYGVSLNYDNGGgFGYGGAYARSDRTGDQKIEYYSIASLTGNGKKAEVWRLGGKYDANNIYLAAAYAQTRNATRY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 268 ADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDL-GVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDft 346
Cdd:pfam00267 240 GAMGFANKTQNTEVVAQYQFDFGLRPSISYAQSKGKDLeGAYGDNDLVKYVDVGATYYFNKNMSTYVDYKINLLDKGD-- 317
                         330
                  ....*....|....*....
gi 1690422960 347 kALGVSTDDIVAVGLVYQF 365
Cdd:pfam00267 318 -DLGINTDDAVAVGLRYQF 335
PRK10554 PRK10554
outer membrane porin protein C; Provisional
16-365 1.09e-175

outer membrane porin protein C; Provisional


Pssm-ID: 182543  Cd Length: 355  Bit Score: 492.43  E-value: 1.09e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  16 LMAMSAQAAEIYNKDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQGSSk 95
Cdd:PRK10554    1 LVAGAANAAEIYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENENNS- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  96 dKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTqTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQY 175
Cdd:PRK10554   80 -WTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYG-SDNFMQQRGNGFATYRNTDFFGLVDGLNFALQY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 176 QGKNDRSDFDNYTEG-------NGDGFGFSATYEY-EGFGIGATYAKSDRTDTQVNAGkvlpeVFASGKNAEVWAAGLKY 247
Cdd:PRK10554  158 QGKNGSVSGEGMTNNgrgalrqNGDGYGGSLTYDYgEGFSIGAAISSSKRTDDQNNLA-----YIGNGDRAETYTGGLKY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 248 DANNIYLATTYSETQNMTVFADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLGV-----WGDQDLVKYVDVGAT 322
Cdd:PRK10554  233 DANNIYLAAQYTQTYNATRFGSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLGNingrnYGDQDILKYVDVGAT 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1690422960 323 YYFNKNMSTFVDYKINLLDKNDFTKALGVSTDDIVAVGLVYQF 365
Cdd:PRK10554  313 YYFNKNMSTYVDYKINLLDDNQFTRDAGINTDDIVALGLVYQF 355
OmpC COG3203
Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];
10-365 1.88e-74

Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442436 [Multi-domain]  Cd Length: 336  Bit Score: 233.74  E-value: 1.88e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  10 AVAASVLMAMSAQAAeiynkdsNKLDLYGKVNAKHYFSSNDA------DDGDTTYARLGFKGETQINDQLTGFGQWEYEF 83
Cdd:COG3203     4 ALAVAAALAGAAHAQ-------SSVTLYGRVDAGVEYVDNGGgsltrlTSGGDSGSRLGFKGSEDLGGGLKAIFQLESGF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  84 KGNRAESQGSSKDKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFG--GDTWTQTDVFMTQRATGVATYRNND 161
Cdd:COG3203    77 NADTGTSGGGGRLFGRQAYVGLKGDDFGTLTLGRQYTPLYDVVGAFDPFGDSGdaGNLAGDDNLAGTGRADNAIKYRSPN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 162 FfglvDGLNFAAQYQGKNDRSDFDnytegNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVnagkvlpevfASGKNAEVW 241
Cdd:COG3203   157 F----GGLTFGAQYSFGEDAGSSS-----NGRGYGAGLTYANGPLSLGAAYQQSNDAQGAT----------AGGDDADAW 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 242 AAGLKYDANNIYLATTYSETQNMTvfADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLgvwGDQDLVKYVDVGA 321
Cdd:COG3203   218 GLGASYDFGNLKLAAGYGQTKNDD--AGGAGNAKADGYELGASYPFGPALTLSASYGYTDAKDG---ADDDDANQYALGA 292
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1690422960 322 TYYFNKNMSTFVDYKINLLDKNDFTKALGVSTDDIVAVGLVYQF 365
Cdd:COG3203   293 DYALSKRTSLYAEYGYNDNDGNANFTAAAGDTDDGVAVGLRHKF 336
gram_neg_porins cd00342
Porins form aqueous channels for the diffusion of small hydrophillic molecules across the ...
32-365 8.23e-56

Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.


Pssm-ID: 238208 [Multi-domain]  Cd Length: 329  Bit Score: 185.65  E-value: 8.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  32 NKLDLYGKVNAKHYFSSNDADD-------GDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQGSSKDKTRLAFAG 104
Cdd:cd00342     1 SSVTLYGRIDAGVEYVNNAGGGgagqmtsGGNNGSRWGLRGSEDLGGGLKAIFQLESGFNLNTGALGQGGRLFGRQAYVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 105 LKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDT--WTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRs 182
Cdd:cd00342    81 LSSDTYGTLTLGRQYTPLYDVLGTTDPFGGSGGGSapGDGDNLAGTGRANNSVKYTSPFFGGLTFGAMYAFGNQAGSTS- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 183 dfdnytegNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVNAGkvlpevfASGKNAEVWAAGLKYDANNIYLATTYSETQ 262
Cdd:cd00342   160 --------NGRGYGAGLSYENGPLSLGAAYDQQRNGGGAAGGA-------AGATSQRAYGAGASYDFGGLKLGAGYTNTR 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 263 NMTVFADhfVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDlgVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDK 342
Cdd:cd00342   225 NDNGGGG--GSAKFNGYELGATYQLTPALRLGAAYYYTKDRN--DGGGDGKANQVALGADYALSKRTDLYAEYGYQKNSG 300
                         330       340
                  ....*....|....*....|....*....
gi 1690422960 343 NDFT------KALGVSTDDIVAVGLVYQF 365
Cdd:cd00342   301 GASTglagggGPSSGNNQDGVAVGIRHKF 329
 
Name Accession Description Interval E-value
Porin_1 pfam00267
Gram-negative porin;
29-365 6.13e-176

Gram-negative porin;


Pssm-ID: 395205  Cd Length: 335  Bit Score: 491.96  E-value: 6.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  29 KDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQgSSKDKTRLAFAGLKFG 108
Cdd:pfam00267   1 KDGNKLDLYGKVTGLHYFSDRDGSDGDDTYARIGFKGETQINDQLTGYGQWEYNVSVNGTEGA-STQWGTRLAFAGLKFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 109 DYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRSDFDNYT 188
Cdd:pfam00267  80 DFGSFDYGRNYGVLYDVGAWTDVLPEFGGDTTAQTDNFMTGRANGVATYRNPDFFGLVDGLNFALQYQGKNEDTPARNLT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 189 EGNGDGFGFSATYEYEG-FGIGATYAKSDRTDTQVNAGKVLPEVFASGKNAEVWAAGLKYDANNIYLATTYSETQNMTVF 267
Cdd:pfam00267 160 KSNGDGYGVSLNYDNGGgFGYGGAYARSDRTGDQKIEYYSIASLTGNGKKAEVWRLGGKYDANNIYLAAAYAQTRNATRY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 268 ADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDL-GVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDft 346
Cdd:pfam00267 240 GAMGFANKTQNTEVVAQYQFDFGLRPSISYAQSKGKDLeGAYGDNDLVKYVDVGATYYFNKNMSTYVDYKINLLDKGD-- 317
                         330
                  ....*....|....*....
gi 1690422960 347 kALGVSTDDIVAVGLVYQF 365
Cdd:pfam00267 318 -DLGINTDDAVAVGLRYQF 335
PRK10554 PRK10554
outer membrane porin protein C; Provisional
16-365 1.09e-175

outer membrane porin protein C; Provisional


Pssm-ID: 182543  Cd Length: 355  Bit Score: 492.43  E-value: 1.09e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  16 LMAMSAQAAEIYNKDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQGSSk 95
Cdd:PRK10554    1 LVAGAANAAEIYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENENNS- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  96 dKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTqTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQY 175
Cdd:PRK10554   80 -WTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYG-SDNFMQQRGNGFATYRNTDFFGLVDGLNFALQY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 176 QGKNDRSDFDNYTEG-------NGDGFGFSATYEY-EGFGIGATYAKSDRTDTQVNAGkvlpeVFASGKNAEVWAAGLKY 247
Cdd:PRK10554  158 QGKNGSVSGEGMTNNgrgalrqNGDGYGGSLTYDYgEGFSIGAAISSSKRTDDQNNLA-----YIGNGDRAETYTGGLKY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 248 DANNIYLATTYSETQNMTVFADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLGV-----WGDQDLVKYVDVGAT 322
Cdd:PRK10554  233 DANNIYLAAQYTQTYNATRFGSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLGNingrnYGDQDILKYVDVGAT 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1690422960 323 YYFNKNMSTFVDYKINLLDKNDFTKALGVSTDDIVAVGLVYQF 365
Cdd:PRK10554  313 YYFNKNMSTYVDYKINLLDDNQFTRDAGINTDDIVALGLVYQF 355
PRK10159 PRK10159
phosphoporin PhoE;
1-365 1.19e-164

phosphoporin PhoE;


Pssm-ID: 182275  Cd Length: 351  Bit Score: 464.02  E-value: 1.19e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960   1 MKKLTVAIsaVAASVLMAMSAQAAEIYNKDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWE 80
Cdd:PRK10159    1 MKKSTLAL--VVMGIVASASVQAAEVYNKDGNKLDVYGKVKAMHYMSDNDSKDGDQSYIRFGFKGETQINDQLTGYGRWE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  81 YEFKGNRAESQGSSKdKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNN 160
Cdd:PRK10159   79 AEFAGNKAESDTAQQ-KTRLAFAGLKYKDLGSFDYGRNLGALYDVEAWTDMFPEFGGDSSAQTDNFMTKRASGLATYRNT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 161 DFFGLVDGLNFAAQYQGKNDRSDfdnYTEGNGDGFGFSATYEYEG--FGIGATYAKSDRTDTQVNAGKvlpevfASGKNA 238
Cdd:PRK10159  158 DFFGVIDGLNLTLQYQGKNENRD---VKKQNGDGFGTSLTYDFGGsdFAISGAYTNSDRTNEQNLQSR------GTGKRA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 239 EVWAAGLKYDANNIYLATTYSETQNMTVFADHFvANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLGVWGDQDLVKYVD 318
Cdd:PRK10159  229 EAWATGLKYDANNIYLATFYSETRKMTPISGGF-ANKTQNFEAVAQYQFDFGLRPSLGYVLSKGKDIEGIGDEDLVNYID 307
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1690422960 319 VGATYYFNKNMSTFVDYKINLLDKNDftkALGVSTDDIVAVGLVYQF 365
Cdd:PRK10159  308 VGATYYFNKNMSAFVDYKINQLDSDN---KLNINNDDIVAVGMTYQF 351
PRK10002 PRK10002
porin OmpF;
1-365 3.25e-147

porin OmpF;


Pssm-ID: 236639  Cd Length: 362  Bit Score: 420.44  E-value: 3.25e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960   1 MKKLTVAIsaVAASVLMAMSAQAAEIYNKDSNKLDLYGKVNAKHYFSSNDAD-----DGDTTYARLGFKGETQINDQLTG 75
Cdd:PRK10002    2 MKRNILAV--IVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNGEnsyggNGDMTYARLGFKGETQINSDLTG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  76 FGQWEYEFKGNRAE-SQGSSKDKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTwTQTDVFMTQRATGV 154
Cdd:PRK10002   80 YGQWEYNFQGNNSEgADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDT-AYSDDFFVGRVGGV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 155 ATYRNNDFFGLVDGLNFAAQYQGKNDRsdfDNYTEGNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVNAgkvlpeVFAS 234
Cdd:PRK10002  159 ATYRNSNFFGLVDGLNFAVQYLGKNER---DTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQ------PLGN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 235 GKNAEVWAAGLKYDANNIYLATTYSETQNMTVFADHFV-----ANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLGVWG 309
Cdd:PRK10002  230 GKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTntsgfANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIG 309
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1690422960 310 DQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDftkALGVSTDDIVAVGLVYQF 365
Cdd:PRK10002  310 DVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDN---KLGVGSDDTVAVGIVYQF 362
OmpC COG3203
Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];
10-365 1.88e-74

Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442436 [Multi-domain]  Cd Length: 336  Bit Score: 233.74  E-value: 1.88e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  10 AVAASVLMAMSAQAAeiynkdsNKLDLYGKVNAKHYFSSNDA------DDGDTTYARLGFKGETQINDQLTGFGQWEYEF 83
Cdd:COG3203     4 ALAVAAALAGAAHAQ-------SSVTLYGRVDAGVEYVDNGGgsltrlTSGGDSGSRLGFKGSEDLGGGLKAIFQLESGF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  84 KGNRAESQGSSKDKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFG--GDTWTQTDVFMTQRATGVATYRNND 161
Cdd:COG3203    77 NADTGTSGGGGRLFGRQAYVGLKGDDFGTLTLGRQYTPLYDVVGAFDPFGDSGdaGNLAGDDNLAGTGRADNAIKYRSPN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 162 FfglvDGLNFAAQYQGKNDRSDFDnytegNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVnagkvlpevfASGKNAEVW 241
Cdd:COG3203   157 F----GGLTFGAQYSFGEDAGSSS-----NGRGYGAGLTYANGPLSLGAAYQQSNDAQGAT----------AGGDDADAW 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 242 AAGLKYDANNIYLATTYSETQNMTvfADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLgvwGDQDLVKYVDVGA 321
Cdd:COG3203   218 GLGASYDFGNLKLAAGYGQTKNDD--AGGAGNAKADGYELGASYPFGPALTLSASYGYTDAKDG---ADDDDANQYALGA 292
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1690422960 322 TYYFNKNMSTFVDYKINLLDKNDFTKALGVSTDDIVAVGLVYQF 365
Cdd:COG3203   293 DYALSKRTSLYAEYGYNDNDGNANFTAAAGDTDDGVAVGLRHKF 336
gram_neg_porins cd00342
Porins form aqueous channels for the diffusion of small hydrophillic molecules across the ...
32-365 8.23e-56

Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.


Pssm-ID: 238208 [Multi-domain]  Cd Length: 329  Bit Score: 185.65  E-value: 8.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  32 NKLDLYGKVNAKHYFSSNDADD-------GDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQGSSKDKTRLAFAG 104
Cdd:cd00342     1 SSVTLYGRIDAGVEYVNNAGGGgagqmtsGGNNGSRWGLRGSEDLGGGLKAIFQLESGFNLNTGALGQGGRLFGRQAYVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 105 LKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDT--WTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRs 182
Cdd:cd00342    81 LSSDTYGTLTLGRQYTPLYDVLGTTDPFGGSGGGSapGDGDNLAGTGRANNSVKYTSPFFGGLTFGAMYAFGNQAGSTS- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 183 dfdnytegNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVNAGkvlpevfASGKNAEVWAAGLKYDANNIYLATTYSETQ 262
Cdd:cd00342   160 --------NGRGYGAGLSYENGPLSLGAAYDQQRNGGGAAGGA-------AGATSQRAYGAGASYDFGGLKLGAGYTNTR 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 263 NMTVFADhfVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDlgVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDK 342
Cdd:cd00342   225 NDNGGGG--GSAKFNGYELGATYQLTPALRLGAAYYYTKDRN--DGGGDGKANQVALGADYALSKRTDLYAEYGYQKNSG 300
                         330       340
                  ....*....|....*....|....*....
gi 1690422960 343 NDFT------KALGVSTDDIVAVGLVYQF 365
Cdd:cd00342   301 GASTglagggGPSSGNNQDGVAVGIRHKF 329
OM_channels cd01345
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
152-354 8.10e-39

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


Pssm-ID: 238655 [Multi-domain]  Cd Length: 253  Bit Score: 139.10  E-value: 8.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 152 TGVATYRNNDFFGLVDGLNFAAQYQGKNDRSDFDNYTEGN-------GDGFGFSATYE-YEGFGIGATYAKSDRTDtQVN 223
Cdd:cd01345     8 NPVLNIRQGLGQTPDDDLTLK*GYARANKAPSLYQTNPGNddakaetSDGKEIGLEFKrDGGWLAGVTYARNDYTN-KIE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 224 AGKVLPEVFASGK-----------NAEVWAAGLKYDAN-NIYLATTYSETQNMTVFADHFVANKAQNFEAVAQYQFDFGL 291
Cdd:cd01345    87 AGYVAVGQNAVGTdlyqwdnvpkaVVEGLEGSLNVPVSeTV*WTNNYTY*LKSENKTTRLSIIPEYTLNVTLSWQAREDL 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1690422960 292 RPSVAYLQSKGKDLGVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDFTKALGVSTD 354
Cdd:cd01345   167 S*QVTYTWYKKQQPKKYKEIDPYSIVGLSATWDVTKNVSLTGGYDNLFDKRLWRAGNAQTTGD 229
Porin_4 pfam13609
Gram-negative porin;
10-335 1.88e-09

Gram-negative porin;


Pssm-ID: 433346 [Multi-domain]  Cd Length: 311  Bit Score: 58.22  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  10 AVAASVLMAMSAQAAEiynkdsnKLDLYGKVNAKHYFSSNDADDGDTTYA-------RLGFKGETQINDQLTGFGQWEYE 82
Cdd:pfam13609   1 ALAALAAAAGAAAAQS-------SVTLYGSADAGVGYVNGGAAGAGADGEtgldsnsRIGFGGSEELDNGLGFGASFELE 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960  83 fkgnrAESQGSSKDKTRLAFAGLKfGDYGSIDYGRNYGVAYDigAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNND- 161
Cdd:pfam13609  74 -----AGFNGAGGFNNRQAYVGLS-GGFGTVTLGRQDGAFDE--AGVDYDFDGGSLGDSGYDGSGLSGSAGFDGRDSNSi 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 162 --FFGLVDGLNFAAQY-----QGKNDRSDFDNYTEGNGDGFGFSATYEYEGFGIGATYAKSDRTDtqvnagkvlpevfaS 234
Cdd:pfam13609 146 iyYSPKFGGFTAGASYafgedGNTNGNNGGVAGDSNDTDGYGLGAGYDFGGVGFSVAAAYQQTDN--------------E 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690422960 235 GKNAEVWAAGLKYDANNIYLATTYSETQNmtvfADHFVANKAQNFEAVAQYQFDfGLRPSVAYLQSKGKDlgvwGDQDLV 314
Cdd:pfam13609 212 GGDQDAWGLGASYSLGAFTLGASYADIDD----DGAAAGADDNGYGVGATYTVG-ALTVGAAYGRYDDAG----GGDADA 282
                         330       340
                  ....*....|....*....|.
gi 1690422960 315 KYVDVGATYYFNKNMSTFVDY 335
Cdd:pfam13609 283 TQYGLGADYNLSKRTTLYAEY 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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