|
Name |
Accession |
Description |
Interval |
E-value |
| TOPEUc |
smart00435 |
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ... |
1143-1520 |
0e+00 |
|
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras
Pssm-ID: 214661 [Multi-domain] Cd Length: 391 Bit Score: 665.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1143 LFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEK 1222
Cdd:smart00435 1 LFRGRGEHPKTGKLKRRIMPEDITINIGKDAPVPEPPPGHKWKEVRHDNTVTWLASWKENINGSIKYVFLAASSSLKGQS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1223 DWQKYETARRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEHINLYPKLD 1302
Cdd:smart00435 81 DRKKYEKARKLKKHIDKIRKDYTKDLKSKEMKVRQRATALYLIDKLALRAGNEKGE-DEADTVGCCSLRVEHVTLKPPNK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1303 dqeyvVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDLFDRLNTSILNKHLQELMDGLTAKVFRTYNASITLQ 1382
Cdd:smart00435 160 -----VIFDFLGKDSIRYYNEVEVDKQVFKNLKIFMKPKKPGDDLFDRLNTSKLNKHLKELMPGLTAKVFRTYNASITLQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1383 QQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMQNLQTKIDEKQKQL-------------SAARKQLK 1449
Cdd:smart00435 235 EQLKELTAKDGNVAEKILAYNRANREVAILCNHQRTVSKTHEKSMEKLQEKIKALKYQLkrlkkmillfemiSDLKRKLK 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1682042785 1450 AA------KAEHKASHDDKSKKAVEVKRKAVQRIEEQLMKLQVQATDREENKQIALGTSKLNYLDPRISVAWCKKFG 1520
Cdd:smart00435 315 SKferdneKLDAEVKEKKKEKKKEEKKKKQIERLEERIEKLEVQATDKEENKTVALGTSKINYIDPRITVAWCKKFD 391
|
|
| Topoisom_I_N |
pfam02919 |
Eukaryotic DNA topoisomerase I, DNA binding fragment; Topoisomerase I promotes the relaxation ... |
999-1212 |
2.48e-140 |
|
Eukaryotic DNA topoisomerase I, DNA binding fragment; Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. This family may be more than one structural domain.
Pssm-ID: 460746 Cd Length: 213 Bit Score: 429.59 E-value: 2.48e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMtsEEKSKIT 1078
Cdd:pfam02919 2 KWTTLEHNGVLFPPPYEPLPHNVKLKYDGKPVDLPPEAEEVATFYAAMLETDYAQNPVFNKNFFNDFRKVL--KEKGGIK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:pfam02919 80 DFEKCDFSPIYEYFEQEKEKKKAMSKEEKKALKEEKEKLEEPYGYCLVDGRKEKVGNFRVEPPGLFRGRGEHPKTGKLKK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIML 1212
Cdd:pfam02919 160 RVQPEDVTINIGKDAPVPEPPPGHKWKEVVHDNTVTWLASWKENINGQFKYVML 213
|
|
| Topoisomer_IB_N_htopoI_like |
cd03488 |
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA ... |
999-1213 |
2.05e-138 |
|
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). Topo I relaxes superhelical tension in duplex DNA by creating a single-strand nick, the broken strand can then rotate around the unbroken strand to remove DNA supercoils and, the nick is religated, liberating topo I. These enzymes regulate the topological changes that accompany DNA replication, transcription and other nuclear processes. Human topo I is the target of a diverse set of anticancer drugs including camptothecins (CPTs). CPTs bind to the topo I-DNA complex and inhibit religation of the single-strand nick, resulting in the accumulation of topo I-DNA adducts. This family may represent more than one structural domain.
Pssm-ID: 239570 Cd Length: 215 Bit Score: 424.44 E-value: 2.05e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSKIT 1078
Cdd:cd03488 1 KWTTLEHNGPVFAPPYEPLPKNVKFYYDGKPVKLSPEAEEVATFYAKMLEHDYATKEIFQKNFFKDFKKVMTKEEKVIIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:cd03488 81 DFSKCDFTQMFAYFKAQKEEKKAMSKEEKKAIKAEKEKLEEEYGFCILDGHKEKVGNFRIEPPGLFRGRGAHPKTGKLKR 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLN 1213
Cdd:cd03488 161 RIMPEDIIINIGKDAKVPEPPPGHKWKEVRHDNTVTWLASWTENINGSIKYVMLN 215
|
|
| Topoisom_I |
pfam01028 |
Eukaryotic DNA topoisomerase I, catalytic core; Topoisomerase I promotes the relaxation of DNA ... |
1215-1418 |
2.02e-132 |
|
Eukaryotic DNA topoisomerase I, catalytic core; Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination.
Pssm-ID: 460030 [Multi-domain] Cd Length: 198 Bit Score: 407.67 E-value: 2.02e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1215 SSRIKGEKDWQKYETARRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEH 1294
Cdd:pfam01028 1 SSKLKGESDWKKYEKARKLKKHIDKIREDYTKDLKSKDMKERQRATAVYLIDKLALRVGNEKDE-DEADTVGCCSLRVEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1295 INLYPKlddqeYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDLFDRLNTSILNKHLQELMDGLTAKVFRT 1374
Cdd:pfam01028 80 VKLHPP-----NTVEFDFLGKDSIRYYNTVEVDLQVFKNLKIFKKNKKPGDDLFDRLNTSKLNKYLKELMPGLTAKVFRT 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1682042785 1375 YNASITLQQQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRA 1418
Cdd:pfam01028 155 YNASITLQEQLKELVPKEGSVAEKLLAYNRANREVAILCNHQRS 198
|
|
| Topo_IB_C |
cd00659 |
DNA topoisomerase IB, C-terminal catalytic domain; Topoisomerase I promotes the relaxation of ... |
1221-1421 |
9.59e-96 |
|
DNA topoisomerase IB, C-terminal catalytic domain; Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of replication, transcription, and recombination. Unlike Topo IA enzymes, Topo IB enzymes do not require a single-stranded region of DNA or metal ions for their function. The type IB family of DNA topoisomerases includes eukaryotic nuclear topoisomerase I, topoisomerases of poxviruses, and bacterial versions of Topo IB. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their C-terminal catalytic domain and the overall reaction mechanism with tyrosine recombinases. The C-terminal catalytic domain in topoisomerases is linked to a divergent N-terminal domain that shows no sequence or structure similarity to the N-terminal domains of tyrosine recombinases.
Pssm-ID: 271176 [Multi-domain] Cd Length: 210 Bit Score: 307.28 E-value: 9.59e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1221 EKDWQKYETARRLKKCVDRIRNQYREDWKSKE-MRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEHINLYP 1299
Cdd:cd00659 1 ERDAKKFERARRLKKAIPKIRRRYRKDLKSKElMKERQLAVALYLIDKFALRVGNEKYE-EENDTVGCCTLRKEHVTLEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1300 klddqeYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLenKQPGDDLFD-----RLNTSILNKHLQELMDGLTAKVFRT 1374
Cdd:cd00659 80 ------NVVEFDFLGKDSIRYYNEVPVDPRVFKNLKIFM--KLPGDDLFDyvdvrRLNTSKLNAYLRELMGGLTAKDFRT 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1682042785 1375 YNASITLQQQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRAPPK 1421
Cdd:cd00659 152 YGASLTLQQQLKELTAPDSNIPAKKKVYNRANRAVAILCNHTPAVSK 198
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
181-731 |
6.28e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.12 E-value: 6.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 181 SSHSNNPSPIATAASincPTPSTNTNVST---VPNP----VTSGQIIP-ALTLSNSSSTQNQPSSAPKQSPSPKPITSAQ 252
Cdd:PHA03247 2545 SDDAGDPPPPLPPAA---PPAAPDRSVPPprpAPRPsepaVTSRARRPdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 253 HPHQWSPtmvavPNKNIRPQDIRQQTPVARTPQfitttpvfinpifQVPGGSVAPNTTVVPHSVTMMGpiqvsttniQLS 332
Cdd:PHA03247 2622 HAPDPPP-----PSPSPAANEPDPHPPPTVPPP-------------ERPRDDPAPGRVSRPRRARRLG---------RAA 2674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 333 AASSSTQlsvanMTSAQSTRNTVGqvqitSMTSTAPVGTQQPAQQIVPGAlkmdnqgevgsgqkTVPLVQQPPSRSVPSV 412
Cdd:PHA03247 2675 QASSPPQ-----RPRRRAARPTVG-----SLTSLADPPPPPPTPEPAPHA--------------LVSATPLPPGPAAARQ 2730
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 413 SAPfQPPLVSTPPCSSPGavnamrksPMSPVSTAQVKGKPAQAGvvvtatvdsqqSPADRPPQSTAGAVPPQVFHPPTS- 491
Cdd:PHA03247 2731 ASP-ALPAAPAPPAVPAG--------PATPGGPARPARPPTTAG-----------PPAPAPPAAPAAGPPRRLTRPAVAs 2790
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 492 -AALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTqivsqvsvpapssVSSSVKALPTQTTVATAVSVSSAPLLSTVV 570
Cdd:PHA03247 2791 lSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------LPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 571 PGQNSVKSNVPGTGPLQDVPPiTSPPVANLSGVPPSQSI----------------PAPLEPSLPSTAAPTEASQIAPESV 634
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAP-ARPPVRRLARPAVSRSTesfalppdqperppqpQAPPPPQPQPQPPPPPQPQPPPPPP 2936
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 635 QQEKSQEPVVTDKMGeditAGSEQGWAKKPIN--LVP-RATAEKPKGPSRRSSRaekEVEEEPSSGQRHQEEVRQTwnhd 711
Cdd:PHA03247 2937 PRPQPPLAPTTDPAG----AGEPSGAVPQPWLgaLVPgRVAVPRFRVPQPAPSR---EAPASSTPPLTGHSLSRVS---- 3005
|
570 580
....*....|....*....|
gi 1682042785 712 cSERSSLALKEVlPGRRPVS 731
Cdd:PHA03247 3006 -SWASSLALHEE-TDPPPVS 3023
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
144-511 |
4.93e-09 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.09 E-value: 4.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 144 FPVSTSSSNLQPPSVLTSHLSTNVNSNNSACLNQPPVSSHSNNPSPIATA-ASINCPT--PSTNTNVSTVPNPVTSGQII 220
Cdd:pfam05109 389 FDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGfAAPNTTTglPSSTHVPTNLTAPASTGPTV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 221 PALTLSNSSSTQNQPSSAPkQSPSPKPI---TSAQHPHQWSPT-MVAVPNKNirpqdirqqtPVARTPQFITTTPVFINP 296
Cdd:pfam05109 469 STADVTSPTPAGTTSGASP-VTPSPSPRdngTESKAPDMTSPTsAVTTPTPN----------ATSPTPAVTTPTPNATSP 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 297 IFqvpgGSVAPN---TTVVPHSVTMMGPIQVSTTNIQLSAASSSTQLSVANMTSAQSTRNTVG----QVQITSM----TS 365
Cdd:pfam05109 538 TL----GKTSPTsavTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGetspQANTTNHtlggTS 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 366 TAPVGTQQPAQqiVPGALKMDNQGEVGSGQKTVPL----VQQPPSRSVPSVSAPFQPPLVSTPPCsspGAVNAMRKSPMS 441
Cdd:pfam05109 614 STPVVTSPPKN--ATSAVTTGQHNITSSSTSSMSLrpssISETLSPSTSDNSTSHMPLLTSAHPT---GGENITQVTPAS 688
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1682042785 442 PVSTAQVKGKPA-QAGVVVTATVDSQQSPADRPPQ--STAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVT 511
Cdd:pfam05109 689 TSTHHVSTSSPApRPGTTSQASGPGNSSTSTKPGEvnVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANST 761
|
|
| Top1 |
COG3569 |
DNA topoisomerase IB [Replication, recombination and repair]; |
1223-1379 |
4.22e-07 |
|
DNA topoisomerase IB [Replication, recombination and repair];
Pssm-ID: 442790 Cd Length: 345 Bit Score: 54.02 E-value: 4.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1223 DWQ------KYETARRLKKCVDRIRNQYREDWKSKEMRiRQRAVALYF--IDKLALRAGNE---KEEGetadTVGCCSLR 1291
Cdd:COG3569 89 DWRevrdetKFDRLLAFGRALPRIRRRVARDLRRRGLP-REKVLAAVVrlLDRTLIRVGNEeyaRENG----SYGLTTLR 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1292 VEHInlypKLDDQEyvVEFDFLGKDSIRyyNRIPVEK----RVFKNLQlflenKQPGDDLF-----DRLNTSI----LNK 1358
Cdd:COG3569 164 KRHV----KVDGDT--VRFRFRGKSGKE--HEVTLRDrrlaRLVRRLQ-----DLPGQELFqyrdeDGERHPVdsgdVNA 230
|
170 180
....*....|....*....|..
gi 1682042785 1359 HLQELM-DGLTAKVFRTYNASI 1379
Cdd:COG3569 231 YLREITgEDFTAKDFRTWAGTV 252
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
226-575 |
1.41e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 46.46 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 226 SNSSSTQNQPSSAPKQSPSPKPITSAQHPHQWSPTMVAVPNKNIRPQDI-RQQTPVARTPQFITTTPVFIN------PIF 298
Cdd:cd22540 7 SPSEYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTpRKLVPIKPAPLPLGPGKNSIGflsakgNII 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 299 QVPGGSVAPNTTVVPHSVTMMGPIQV-------STTNIQLSAASSSTQLSVANMTSAQSTRNTVGQVQITSMTSTAPVGT 371
Cdd:cd22540 87 QLQGSQLSSSAPGGQQVFAIQNPTMIikgsqtrSSTNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 372 QQPAQQIVPGALKMDNQGeVGSGQKTVPLVQQPPSRSVPS-----VSAPFQPPLVSTPPCSSPGAVNA-MRKSPMSPVST 445
Cdd:cd22540 167 AHKPVPIKPAPLQTSNTN-SASLQVPGNVIKLQSGGNVALtlpvnNLVGTQDGATQLQLAAAPSKPSKkIRKKSAQAAQP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 446 AQVKGKPAQAgVVVTATVDS----------QQSPADRPPQSTAgavPPQVFHPPTSAAL-QTEAPAPRTTAAQSnVTLPA 514
Cdd:cd22540 246 AVTVAEQVET-VLIETTADNiiqagnnlliVQSPGTGQPAVLQ---QVQVLQPKQEQQVvQIPQQALRVVQAAS-ATLPT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1682042785 515 V------SFSIPIQVAVPTQIVSQVSVPAPSSVSSSVK--ALPTQTTVATAVSVSSAPLLSTVVPGQNS 575
Cdd:cd22540 321 VpqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEApaATATPSSSTSTVQQQVTANNGTGTSKPNY 389
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOPEUc |
smart00435 |
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ... |
1143-1520 |
0e+00 |
|
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras
Pssm-ID: 214661 [Multi-domain] Cd Length: 391 Bit Score: 665.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1143 LFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEK 1222
Cdd:smart00435 1 LFRGRGEHPKTGKLKRRIMPEDITINIGKDAPVPEPPPGHKWKEVRHDNTVTWLASWKENINGSIKYVFLAASSSLKGQS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1223 DWQKYETARRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEHINLYPKLD 1302
Cdd:smart00435 81 DRKKYEKARKLKKHIDKIRKDYTKDLKSKEMKVRQRATALYLIDKLALRAGNEKGE-DEADTVGCCSLRVEHVTLKPPNK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1303 dqeyvVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDLFDRLNTSILNKHLQELMDGLTAKVFRTYNASITLQ 1382
Cdd:smart00435 160 -----VIFDFLGKDSIRYYNEVEVDKQVFKNLKIFMKPKKPGDDLFDRLNTSKLNKHLKELMPGLTAKVFRTYNASITLQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1383 QQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMQNLQTKIDEKQKQL-------------SAARKQLK 1449
Cdd:smart00435 235 EQLKELTAKDGNVAEKILAYNRANREVAILCNHQRTVSKTHEKSMEKLQEKIKALKYQLkrlkkmillfemiSDLKRKLK 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1682042785 1450 AA------KAEHKASHDDKSKKAVEVKRKAVQRIEEQLMKLQVQATDREENKQIALGTSKLNYLDPRISVAWCKKFG 1520
Cdd:smart00435 315 SKferdneKLDAEVKEKKKEKKKEEKKKKQIERLEERIEKLEVQATDKEENKTVALGTSKINYIDPRITVAWCKKFD 391
|
|
| Topoisom_I_N |
pfam02919 |
Eukaryotic DNA topoisomerase I, DNA binding fragment; Topoisomerase I promotes the relaxation ... |
999-1212 |
2.48e-140 |
|
Eukaryotic DNA topoisomerase I, DNA binding fragment; Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. This family may be more than one structural domain.
Pssm-ID: 460746 Cd Length: 213 Bit Score: 429.59 E-value: 2.48e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMtsEEKSKIT 1078
Cdd:pfam02919 2 KWTTLEHNGVLFPPPYEPLPHNVKLKYDGKPVDLPPEAEEVATFYAAMLETDYAQNPVFNKNFFNDFRKVL--KEKGGIK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:pfam02919 80 DFEKCDFSPIYEYFEQEKEKKKAMSKEEKKALKEEKEKLEEPYGYCLVDGRKEKVGNFRVEPPGLFRGRGEHPKTGKLKK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIML 1212
Cdd:pfam02919 160 RVQPEDVTINIGKDAPVPEPPPGHKWKEVVHDNTVTWLASWKENINGQFKYVML 213
|
|
| Topoisomer_IB_N_htopoI_like |
cd03488 |
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA ... |
999-1213 |
2.05e-138 |
|
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). Topo I relaxes superhelical tension in duplex DNA by creating a single-strand nick, the broken strand can then rotate around the unbroken strand to remove DNA supercoils and, the nick is religated, liberating topo I. These enzymes regulate the topological changes that accompany DNA replication, transcription and other nuclear processes. Human topo I is the target of a diverse set of anticancer drugs including camptothecins (CPTs). CPTs bind to the topo I-DNA complex and inhibit religation of the single-strand nick, resulting in the accumulation of topo I-DNA adducts. This family may represent more than one structural domain.
Pssm-ID: 239570 Cd Length: 215 Bit Score: 424.44 E-value: 2.05e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSKIT 1078
Cdd:cd03488 1 KWTTLEHNGPVFAPPYEPLPKNVKFYYDGKPVKLSPEAEEVATFYAKMLEHDYATKEIFQKNFFKDFKKVMTKEEKVIIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:cd03488 81 DFSKCDFTQMFAYFKAQKEEKKAMSKEEKKAIKAEKEKLEEEYGFCILDGHKEKVGNFRIEPPGLFRGRGAHPKTGKLKR 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLN 1213
Cdd:cd03488 161 RIMPEDIIINIGKDAKVPEPPPGHKWKEVRHDNTVTWLASWTENINGSIKYVMLN 215
|
|
| Topoisom_I |
pfam01028 |
Eukaryotic DNA topoisomerase I, catalytic core; Topoisomerase I promotes the relaxation of DNA ... |
1215-1418 |
2.02e-132 |
|
Eukaryotic DNA topoisomerase I, catalytic core; Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination.
Pssm-ID: 460030 [Multi-domain] Cd Length: 198 Bit Score: 407.67 E-value: 2.02e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1215 SSRIKGEKDWQKYETARRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEH 1294
Cdd:pfam01028 1 SSKLKGESDWKKYEKARKLKKHIDKIREDYTKDLKSKDMKERQRATAVYLIDKLALRVGNEKDE-DEADTVGCCSLRVEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1295 INLYPKlddqeYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDLFDRLNTSILNKHLQELMDGLTAKVFRT 1374
Cdd:pfam01028 80 VKLHPP-----NTVEFDFLGKDSIRYYNTVEVDLQVFKNLKIFKKNKKPGDDLFDRLNTSKLNKYLKELMPGLTAKVFRT 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1682042785 1375 YNASITLQQQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRA 1418
Cdd:pfam01028 155 YNASITLQEQLKELVPKEGSVAEKLLAYNRANREVAILCNHQRS 198
|
|
| Topoisomer_IB_N |
cd00660 |
Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) ... |
999-1213 |
8.91e-132 |
|
Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). Topo I relaxes superhelical tension in duplex DNA by creating a single-strand nick, the broken strand can then rotate around the unbroken strand to remove DNA supercoils and, the nick is religated, liberating topo I. These enzymes regulate the topological changes that accompany DNA replication, transcription and other nuclear processes. Human topo I is the target of a diverse set of anticancer drugs including camptothecins (CPTs). CPTs bind to the topo I-DNA complex and inhibit re-ligation of the single-strand nick, resulting in the accumulation of topo I-DNA adducts. In addition to differences in structure and some biochemical properties, Trypanosomatid parasite topo I differ from human topo I in their sensitivity to CPTs and other classical topo I inhibitors. Trypanosomatid topos I play putative roles in organizing the kinetoplast DNA network unique to these parasites. This family may represent more than one structural domain.
Pssm-ID: 238356 Cd Length: 215 Bit Score: 406.65 E-value: 8.91e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSKIT 1078
Cdd:cd00660 1 KWTTLEHNGVIFPPPYEPLPKNVKFYYDGKPVKLPPEAEEVATFFAVMLETDYATKEVFRKNFFKDFRKILTKEEKHIIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:cd00660 81 KLSKCDFTPIYQYFEEEKEKKKAMSKEEKKAIKEEKEKLEEPYGYCLVDGHKEKVGNFRIEPPGLFRGRGEHPKMGKLKR 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLN 1213
Cdd:cd00660 161 RIMPEDITINIGKDAPVPEPPAGHKWKEVRHDNTVTWLASWKENINGQFKYVMLA 215
|
|
| Topo_IB_C |
cd00659 |
DNA topoisomerase IB, C-terminal catalytic domain; Topoisomerase I promotes the relaxation of ... |
1221-1421 |
9.59e-96 |
|
DNA topoisomerase IB, C-terminal catalytic domain; Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of replication, transcription, and recombination. Unlike Topo IA enzymes, Topo IB enzymes do not require a single-stranded region of DNA or metal ions for their function. The type IB family of DNA topoisomerases includes eukaryotic nuclear topoisomerase I, topoisomerases of poxviruses, and bacterial versions of Topo IB. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their C-terminal catalytic domain and the overall reaction mechanism with tyrosine recombinases. The C-terminal catalytic domain in topoisomerases is linked to a divergent N-terminal domain that shows no sequence or structure similarity to the N-terminal domains of tyrosine recombinases.
Pssm-ID: 271176 [Multi-domain] Cd Length: 210 Bit Score: 307.28 E-value: 9.59e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1221 EKDWQKYETARRLKKCVDRIRNQYREDWKSKE-MRIRQRAVALYFIDKLALRAGNEKEEgETADTVGCCSLRVEHINLYP 1299
Cdd:cd00659 1 ERDAKKFERARRLKKAIPKIRRRYRKDLKSKElMKERQLAVALYLIDKFALRVGNEKYE-EENDTVGCCTLRKEHVTLEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1300 klddqeYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLenKQPGDDLFD-----RLNTSILNKHLQELMDGLTAKVFRT 1374
Cdd:cd00659 80 ------NVVEFDFLGKDSIRYYNEVPVDPRVFKNLKIFM--KLPGDDLFDyvdvrRLNTSKLNAYLRELMGGLTAKDFRT 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1682042785 1375 YNASITLQQQLKELSCSDDSVPAKILSYNRANRAVAILCNHQRAPPK 1421
Cdd:cd00659 152 YGASLTLQQQLKELTAPDSNIPAKKKVYNRANRAVAILCNHTPAVSK 198
|
|
| Topoisomer_IB_N_LdtopoI_like |
cd03489 |
Topoisomer_IB_N_LdtopoI_like: N-terminal DNA binding fragment found in eukaryotic DNA ... |
999-1212 |
4.08e-71 |
|
Topoisomer_IB_N_LdtopoI_like: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). Topo I relaxes superhelical tension in duplex DNA by creating a single-strand nick, the broken strand can then rotate around the unbroken strand to remove DNA supercoils and, the nick is religated, liberating topo I. These enzymes regulate the topological changes that accompany DNA replication, transcription and other nuclear processes. Human topo I is the target of a diverse set of anticancer drugs including camptothecins (CPTs). CPTs bind to the topo I-DNA complex and inhibit re-ligation of the single-strand nick, resulting in the accumulation of topo I-DNA adducts. In addition to differences in structure and some biochemical properties, Trypanosomatid parasite topo I differ from human topo I in their sensitivity to CPTs and other classical topo I inhibitors. Trypanosomatid topo I play putative roles in organizing the kinetoplast DNA network unique to these parasites. This family may represent more than one structural domain.
Pssm-ID: 239571 Cd Length: 212 Bit Score: 237.08 E-value: 4.08e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYEPlpDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRkEMTSEEKSKIT 1078
Cdd:cd03489 1 RWTTLVHNGVLFPPPYKP--HGIPILYNGQPFDMTPEEEEVATMFAVMKEHDYYRKEVFRRNFFESWR-EILDKRHHPIR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1079 DLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKR 1158
Cdd:cd03489 78 KLELCDFTPIYEWHLREKEKKKSRTKEEKKALKEEKDKEAEPYMWCVWDGVKEQVANFRVEPPGLFRGRGEHPKMGKLKK 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1682042785 1159 RIRPEDIIINCSKDSKHPKPPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIML 1212
Cdd:cd03489 158 RIQPEDITINIGKGAPIPECPAGHKWKEVKHDNTVTWLAMWRDPIAGNFKYVML 211
|
|
| Topoisomer_IB_N_1 |
cd03490 |
Topoisomer_IB_N_1: A subgroup of the N-terminal DNA binding fragment found in eukaryotic DNA ... |
999-1213 |
8.79e-58 |
|
Topoisomer_IB_N_1: A subgroup of the N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB. Topo IB proteins include the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). Topo I relaxes superhelical tension in duplex DNA by creating a single-strand nick, the broken strand can then rotate around the unbroken strand to remove DNA supercoils and, the nick is religated, liberating topo I. These enzymes regulate the topological changes that accompany DNA replication, transcription and other nuclear processes. Human topo I is the target of a diverse set of anticancer drugs including camptothecins (CPTs). CPTs bind to the topo I-DNA complex and inhibit religation of the single-strand nick, resulting in the accumulation of topo I-DNA adducts. In addition to differences in structure and some biochemical properties, Trypanosomatid parasite topos I differ from human topo I in their sensitivity to CPTs and other classical topo I inhibitors. Trypanosomatid topos I have putative roles in organizing the kinetoplast DNA network unique to these parasites. This family may represent more than one structural domain.
Pssm-ID: 239572 Cd Length: 217 Bit Score: 198.97 E-value: 8.79e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 999 KWRFLEHKGPVFAPPYepLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEK-SKI 1077
Cdd:cd03490 1 QWKYLEHNGMIFTPPY--VPHNVPIMYKGETIHLPPNLEEIATYWAQSMGTNYETKEKFCKNFWKVFVNSFEKDHKfIRR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1078 TDLNKCNFAGMNEYFKAQSEARKQMSKEEKQKIKEdnERILQEYGF--CIMDNHKERIGNFRIEPPGLFRGRGDHPKMGM 1155
Cdd:cd03490 79 CKLSDADFSLIKNHLEEEKEKKKNLNKEEKEAKKK--ERAKREYPFnyALVDWIREKVSSNKLEPPGLFKGRGEHPKQGL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1682042785 1156 LKRRIRPEDIIINCSKDSKHPKPP---PGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLN 1213
Cdd:cd03490 157 LKSRIFPEDVILNISKDAPVPKVTnfmEGHSWKDIYHDNSVTWLAYYKDSINDQFKYMFLS 217
|
|
| Topo_C_assoc |
pfam14370 |
C-terminal topoisomerase domain; This domain is found at the C-terminal of topoisomerase and ... |
1478-1546 |
1.45e-37 |
|
C-terminal topoisomerase domain; This domain is found at the C-terminal of topoisomerase and other similar enzymes.
Pssm-ID: 464154 [Multi-domain] Cd Length: 68 Bit Score: 135.39 E-value: 1.45e-37
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1682042785 1478 EEQLMKLQVQATDREENKQIALGTSKLNYLDPRISVAWCKKFGIPIEKIYNKTQREKFAWAIDmAEKDF 1546
Cdd:pfam14370 1 KERIKKLELQLKDKEENKTVALGTSKINYIDPRITVAWCKKHDVPIEKIFSKTLREKFPWAMD-VDPDW 68
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
181-731 |
6.28e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.12 E-value: 6.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 181 SSHSNNPSPIATAASincPTPSTNTNVST---VPNP----VTSGQIIP-ALTLSNSSSTQNQPSSAPKQSPSPKPITSAQ 252
Cdd:PHA03247 2545 SDDAGDPPPPLPPAA---PPAAPDRSVPPprpAPRPsepaVTSRARRPdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 253 HPHQWSPtmvavPNKNIRPQDIRQQTPVARTPQfitttpvfinpifQVPGGSVAPNTTVVPHSVTMMGpiqvsttniQLS 332
Cdd:PHA03247 2622 HAPDPPP-----PSPSPAANEPDPHPPPTVPPP-------------ERPRDDPAPGRVSRPRRARRLG---------RAA 2674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 333 AASSSTQlsvanMTSAQSTRNTVGqvqitSMTSTAPVGTQQPAQQIVPGAlkmdnqgevgsgqkTVPLVQQPPSRSVPSV 412
Cdd:PHA03247 2675 QASSPPQ-----RPRRRAARPTVG-----SLTSLADPPPPPPTPEPAPHA--------------LVSATPLPPGPAAARQ 2730
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 413 SAPfQPPLVSTPPCSSPGavnamrksPMSPVSTAQVKGKPAQAGvvvtatvdsqqSPADRPPQSTAGAVPPQVFHPPTS- 491
Cdd:PHA03247 2731 ASP-ALPAAPAPPAVPAG--------PATPGGPARPARPPTTAG-----------PPAPAPPAAPAAGPPRRLTRPAVAs 2790
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 492 -AALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTqivsqvsvpapssVSSSVKALPTQTTVATAVSVSSAPLLSTVV 570
Cdd:PHA03247 2791 lSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------LPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 571 PGQNSVKSNVPGTGPLQDVPPiTSPPVANLSGVPPSQSI----------------PAPLEPSLPSTAAPTEASQIAPESV 634
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAP-ARPPVRRLARPAVSRSTesfalppdqperppqpQAPPPPQPQPQPPPPPQPQPPPPPP 2936
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 635 QQEKSQEPVVTDKMGeditAGSEQGWAKKPIN--LVP-RATAEKPKGPSRRSSRaekEVEEEPSSGQRHQEEVRQTwnhd 711
Cdd:PHA03247 2937 PRPQPPLAPTTDPAG----AGEPSGAVPQPWLgaLVPgRVAVPRFRVPQPAPSR---EAPASSTPPLTGHSLSRVS---- 3005
|
570 580
....*....|....*....|
gi 1682042785 712 cSERSSLALKEVlPGRRPVS 731
Cdd:PHA03247 3006 -SWASSLALHEE-TDPPPVS 3023
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
144-511 |
4.93e-09 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.09 E-value: 4.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 144 FPVSTSSSNLQPPSVLTSHLSTNVNSNNSACLNQPPVSSHSNNPSPIATA-ASINCPT--PSTNTNVSTVPNPVTSGQII 220
Cdd:pfam05109 389 FDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGfAAPNTTTglPSSTHVPTNLTAPASTGPTV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 221 PALTLSNSSSTQNQPSSAPkQSPSPKPI---TSAQHPHQWSPT-MVAVPNKNirpqdirqqtPVARTPQFITTTPVFINP 296
Cdd:pfam05109 469 STADVTSPTPAGTTSGASP-VTPSPSPRdngTESKAPDMTSPTsAVTTPTPN----------ATSPTPAVTTPTPNATSP 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 297 IFqvpgGSVAPN---TTVVPHSVTMMGPIQVSTTNIQLSAASSSTQLSVANMTSAQSTRNTVG----QVQITSM----TS 365
Cdd:pfam05109 538 TL----GKTSPTsavTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGetspQANTTNHtlggTS 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 366 TAPVGTQQPAQqiVPGALKMDNQGEVGSGQKTVPL----VQQPPSRSVPSVSAPFQPPLVSTPPCsspGAVNAMRKSPMS 441
Cdd:pfam05109 614 STPVVTSPPKN--ATSAVTTGQHNITSSSTSSMSLrpssISETLSPSTSDNSTSHMPLLTSAHPT---GGENITQVTPAS 688
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1682042785 442 PVSTAQVKGKPA-QAGVVVTATVDSQQSPADRPPQ--STAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVT 511
Cdd:pfam05109 689 TSTHHVSTSSPApRPGTTSQASGPGNSSTSTKPGEvnVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANST 761
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
117-503 |
1.36e-08 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 59.20 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 117 NSKNTDMPTSVSTTITTNELEAKAKPVFPVS----TSSSNLQPPSVLTSHLSTNVNsnnsacLNQPPVSSHSnnpspiAT 192
Cdd:pfam17823 41 NASGDAVPRADNKSSEQ*NFCAATAAPAPVTltkgTSAAHLNSTEVTAEHTPHGTD------LSEPATREGA------AD 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 193 AASINCPTPSTNTNVSTVPNPVTSGqiIPALTLSNSSSTQNQPSSAPKQSPSPKPITSAQHPHQWSPTmvavpnknirPQ 272
Cdd:pfam17823 109 GAASRALAAAASSSPSSAAQSLPAA--IAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPA----------PR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 273 DIRQQTPVARTPQFITTTPVfinpifqvpGGSVAPNTTVVPHSvtmmgPIQVSTTNIQLSAASSSTQlSVANMTSAQSTR 352
Cdd:pfam17823 177 TAASSTTAASSTTAASSAPT---------TAASSAPATLTPAR-----GISTAATATGHPAAGTALA-AVGNSSPAAGTV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 353 NTVgqvqiTSMTSTAPVGTQQPAQQIVPGALKMDNQGEvgsgqktvPLVQQP-PSRSVPSVSAPFQPPLVSTPPCSSPGA 431
Cdd:pfam17823 242 TAA-----VGTVTPAALATLAAAAGTVASAAGTINMGD--------PHARRLsPAKHMPSDTMARNPAAPMGAQAQGPII 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 432 --------VNAMRKSPMSPVSTAQVKGKPAQAGVVVTATVDSQQSPADRPpqsTAGAVPPqvfhPPTSAALQTEAPAPRT 503
Cdd:pfam17823 309 qvstdqpvHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP---SASPVPV----LHTSMIPEVEATSPTT 381
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
309-684 |
5.22e-08 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 57.28 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 309 TTVVPHSVTMMGPIQVSTTNiqlSAASSSTQLSVANMTSAQSTRNTVGQVQITSMTSTAPVGTQQPAQQIVPGALKMDNQ 388
Cdd:pfam17823 63 ATAAPAPVTLTKGTSAAHLN---STEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 389 GEVGSGQKTVPlvqqppsrSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVVTATVdsqqS 468
Cdd:pfam17823 140 EAFSAPRAAAC--------RANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATL----T 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 469 PADRPPQSTAGAVPPQVfhPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQivsqvsvpapssvsssvkal 548
Cdd:pfam17823 208 PARGISTAATATGHPAA--GTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS-------------------- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 549 pTQTTVATAVSVSSAPLLSTVVPGQNSVKSNVPGTGPLQDVPPI---TSPPVANLSGVPPSQSIPAPLEPSLPSTAAPTE 625
Cdd:pfam17823 266 -AAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIqvsTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTN 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1682042785 626 ASQIAPESVQQEK---SQEPVVTDKMGEDITAGS----------EQGWAKKPINLVPRATAEKPK------GPSRRSS 684
Cdd:pfam17823 345 LAVVTTTKAQAKEpsaSPVPVLHTSMIPEVEATSpttqpspllpTQGAAGPGILLAPEQVATEATagtasaGPTPRSS 422
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
304-627 |
1.43e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.46 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 304 SVAPNTTVVPHSVTMMGPIQVSTTniqlSAASSSTQLSVaNMTSAQSTRNTVGQVQITSMTstaPVGTQQPAQQIVPGAL 383
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPNTT----TGLPSSTHVPT-NLTAPASTGPTVSTADVTSPT---PAGTTSGASPVTPSPS 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 384 KMDNQGEVGSGQKTVPL--VQQP---PSRSVPSVSAPF----QPPLVSTPPCSSPGAVNAMRKSPM------SPVSTAQV 448
Cdd:pfam05109 494 PRDNGTESKAPDMTSPTsaVTTPtpnATSPTPAVTTPTpnatSPTLGKTSPTSAVTTPTPNATSPTpavttpTPNATIPT 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 449 KGKPAQAGVVVTATVDS------QQSPADRPPQSTAGAVP--PQVFHPPTSA-ALQTEAPAPRTTAAQSNVTLPAVSFSI 519
Cdd:pfam05109 574 LGKTSPTSAVTTPTPNAtsptvgETSPQANTTNHTLGGTSstPVVTSPPKNAtSAVTTGQHNITSSSTSSMSLRPSSISE 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 520 PIQVAVPTQIVSQV---SVPAPSSVSSSVKALPTQTTVATAVSVSSAPLlstvvPGQNSVKSNvPGTGPLQdvppiTSPP 596
Cdd:pfam05109 654 TLSPSTSDNSTSHMpllTSAHPTGGENITQVTPASTSTHHVSTSSPAPR-----PGTTSQASG-PGNSSTS-----TKPG 722
|
330 340 350
....*....|....*....|....*....|.
gi 1682042785 597 VANLSGVPPSQSIPAPLEPSLPSTAAPTEAS 627
Cdd:pfam05109 723 EVNVTKGTPPKNATSPQAPSGQKTAVPTVTS 753
|
|
| Top1 |
COG3569 |
DNA topoisomerase IB [Replication, recombination and repair]; |
1223-1379 |
4.22e-07 |
|
DNA topoisomerase IB [Replication, recombination and repair];
Pssm-ID: 442790 Cd Length: 345 Bit Score: 54.02 E-value: 4.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1223 DWQ------KYETARRLKKCVDRIRNQYREDWKSKEMRiRQRAVALYF--IDKLALRAGNE---KEEGetadTVGCCSLR 1291
Cdd:COG3569 89 DWRevrdetKFDRLLAFGRALPRIRRRVARDLRRRGLP-REKVLAAVVrlLDRTLIRVGNEeyaRENG----SYGLTTLR 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1292 VEHInlypKLDDQEyvVEFDFLGKDSIRyyNRIPVEK----RVFKNLQlflenKQPGDDLF-----DRLNTSI----LNK 1358
Cdd:COG3569 164 KRHV----KVDGDT--VRFRFRGKSGKE--HEVTLRDrrlaRLVRRLQ-----DLPGQELFqyrdeDGERHPVdsgdVNA 230
|
170 180
....*....|....*....|..
gi 1682042785 1359 HLQELM-DGLTAKVFRTYNASI 1379
Cdd:COG3569 231 YLREITgEDFTAKDFRTWAGTV 252
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
396-588 |
1.37e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 52.96 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 396 KTVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGA----VNAMRKSPMSPVSTAQVKGKPAQAGVVVTATvdsqqSPAD 471
Cdd:PRK12323 378 AAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAaaarAVAAAPARRSPAPEALAAARQASARGPGGAP-----APAP 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 472 RPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVT---------LPAVSFSIPIQVAVPTQIVSQVSVPAPSSVS 542
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPAdddpppweeLPPEFASPAPAQPDAAPAGWVAESIPDPATA 532
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1682042785 543 SSVKALPTQTTVATAVSVSSAPLLSTVVPGQNSVKSNVPGTGPLQD 588
Cdd:PRK12323 533 DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
16-512 |
2.80e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 52.23 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 16 PLRDLSAPRMASPRFPAPQqgkpdleNQTGTSDRQQVHTAPGQDSGISPTQRSAP-TSLNQLLDNAAMQNVPLRPVQSST 94
Cdd:pfam05109 425 PESTTTSPTLNTTGFAAPN-------TTTGLPSSTHVPTNLTAPASTGPTVSTADvTSPTPAGTTSGASPVTPSPSPRDN 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 95 GRDGLGKD--SPKSVLDTErqvignSKNTDMPTSVSTTITTNELE---AKAKPVFPVSTSSSNLQPPsvlTSHLSTNVNS 169
Cdd:pfam05109 498 GTESKAPDmtSPTSAVTTP------TPNATSPTPAVTTPTPNATSptlGKTSPTSAVTTPTPNATSP---TPAVTTPTPN 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 170 NNSACLNQPPVSSHSNNPSPIATAASINCPTPSTNTnvstvpnpvtsgqiipaltlsnSSSTQNQPSSAPKQSPSPKPIT 249
Cdd:pfam05109 569 ATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANT----------------------TNHTLGGTSSTPVVTSPPKNAT 626
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 250 SAQHPHQWSPTMVAVPNKNIRPQDIRQQTPVARTPQFITTTPVFINPifQVPGGsvapnttvvpHSVTMMGPIQVSTTNI 329
Cdd:pfam05109 627 SAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSA--HPTGG----------ENITQVTPASTSTHHV 694
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 330 QLSA-ASSSTQLSVANMTSAQSTRNTVGQVQITSmtSTAPVGTQQPaqqivpgalkmdnqgEVGSGQKTvplvqqppsrS 408
Cdd:pfam05109 695 STSSpAPRPGTTSQASGPGNSSTSTKPGEVNVTK--GTPPKNATSP---------------QAPSGQKT----------A 747
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 409 VPSVSapfqpplvstppcSSPGAVNAMRKSPMSPVSTAQVKGKP-AQAGVVVTATVDSQQSPADRPPQSTAGAVPPQVFH 487
Cdd:pfam05109 748 VPTVT-------------STGGKANSTTGGKHTTGHGARTSTEPtTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRWTFT 814
|
490 500
....*....|....*....|....*.
gi 1682042785 488 PPTSAALQTEAPAPRTTAAQ-SNVTL 512
Cdd:pfam05109 815 SPPVTTAQATVPVPPTSQPRfSNLSM 840
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
404-684 |
3.18e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 51.84 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 404 PPSRSVPS-VSAPFQP-PLVSTPPCSSPGAVNAMR-KSPMSPVSTAQVKGKPAQA------GVVVTATVDSQQSPADRPP 474
Cdd:pfam05109 449 PSSTHVPTnLTAPASTgPTVSTADVTSPTPAGTTSgASPVTPSPSPRDNGTESKApdmtspTSAVTTPTPNATSPTPAVT 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 475 QSTAGAVPPQVFHPPTSAALQTeaPAPRTTAAQSNVTLPAVSFSIPiqvavptqivsqvsvpapssvsSSVKALPTqTTV 554
Cdd:pfam05109 529 TPTPNATSPTLGKTSPTSAVTT--PTPNATSPTPAVTTPTPNATIP----------------------TLGKTSPT-SAV 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 555 ATAVSVSSAPLLSTVVPGQNSVKSNVPGTgplQDVPPITSPPVANLSGVPPSQSIPAPLEPSLPSTAAPTEASQIAPESV 634
Cdd:pfam05109 584 TTPTPNATSPTVGETSPQANTTNHTLGGT---SSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTS 660
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1682042785 635 QQEKSQEPVVTDKM---GEDITAGSEQGWAKKPINL---VPR-ATAEKPKGPSRRSS 684
Cdd:pfam05109 661 DNSTSHMPLLTSAHptgGENITQVTPASTSTHHVSTsspAPRpGTTSQASGPGNSST 717
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
469-637 |
4.30e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.39 E-value: 4.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 469 PADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSSSVKAL 548
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 549 PTQTTVATAVSVSSAPLLSTVVPGQNSvksnVPGTGPLQDVPPITSPPVANLSGVPPSQSIPAPLEPSLPSTA----APT 624
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADS----GSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsredAPA 523
|
170
....*....|...
gi 1682042785 625 EASQIAPESVQQE 637
Cdd:PRK07003 524 AAAPPAPEARPPT 536
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
474-643 |
1.14e-05 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 50.10 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 474 PQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQvsvpapssvsssvkalPTQTT 553
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPA----------------PVAAP 429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 554 VATAVSVSSAPLLSTVVPGQNSvksnvpgtgPLQDVPPITSPPVANLSGVPPSQSIPAPLEPSLPSTAAPTEASQIAPES 633
Cdd:PRK14951 430 AAAAPAAAPAAAPAAVALAPAP---------PAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHAT 500
|
170
....*....|
gi 1682042785 634 VQQEKSQEPV 643
Cdd:PRK14951 501 VQQLAAAEAI 510
|
|
| PRK14949 |
PRK14949 |
DNA polymerase III subunits gamma and tau; Provisional |
332-565 |
1.55e-05 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237863 [Multi-domain] Cd Length: 944 Bit Score: 49.72 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 332 SAASSSTQLSVANMTSAQSTRNT-VGQVQITSMTSTAPVGT--QQPAQQIVPGA-----------LKMDNQGEvGSGQKT 397
Cdd:PRK14949 561 SESYNALSDDEQHSANVQSAQSAaEAQPSSQSLSPISAVTTaaASLADDDILDAvlaardsllsdLDALSPKE-GDGKKS 639
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 398 VPLVQQ--PPSRSVPSVSapfqpplvSTPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVVTATVDSQQS-PADRPP 474
Cdd:PRK14949 640 SADRKPktPPSRAPPASL--------SKPASSPDASQTSASFDLDPDFELATHQSVPEAALASGSAPAPPPVPdPYDRPP 711
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 475 QSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFsipiQVAVPTQIVSQVSVPAPSSVSSSVKALPTQTTV 554
Cdd:PRK14949 712 WEEAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATH----QPQVQAEAQSPASTTALTQTSSEVQDTELNLVL 787
|
250
....*....|.
gi 1682042785 555 ATAVSVSSAPL 565
Cdd:PRK14949 788 LSSGSITGHPL 798
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
105-493 |
2.50e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 49.00 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 105 KSVLDTERQVIGNSKNTDMPTSVSTTITTneleAKAKPVFPVSTSSSNLQPPSVLTSHLSTNVNSNNSACLNQPPVSSHS 184
Cdd:pfam03154 164 QQILQTQPPVLQAQSGAASPPSPPPPGTT----QAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 185 NN-PSPIATAASINCPTPSTNTNVSTVPNPVTSGQIIPAltlsnSSSTQNQPSSAPKQSPS---------------PKPI 248
Cdd:pfam03154 240 QRlPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPM-----PHSLQTGPSHMQHPVPPqpfpltpqssqsqvpPGPS 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 249 TSAQHPHQWSPTMVAVPNKNIRPQDIRQQtPVARTPQFIT-TTPVFINPIFQVPggsvAPNTTVVPHSVTMMGPIQVSTT 327
Cdd:pfam03154 315 PAAPGQSQQRIHTPPSQSQLQSQQPPREQ-PLPPAPLSMPhIKPPPTTPIPQLP----NPQSHKHPPHLSGPSPFQMNSN 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 328 NIQLSAASSSTQLSVANMTSAQSTRNTV---GQvQITSMTSTAPVGTQqpAQQIVPGALKMDNQGEVGSGQKTVPLVQQP 404
Cdd:pfam03154 390 LPPPPALKPLSSLSTHHPPSAHPPPLQLmpqSQ-QLPPPPAQPPVLTQ--SQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 405 psrSVPSVSAPFQPPlvSTPPCSSPGAVNAMRksPMSPVSTAQVKGKPAQAGVVVTAT------VDSQQSPADRPPQSTA 478
Cdd:pfam03154 467 ---FVPGGPPPITPP--SGPPTSTSSAMPGIQ--PPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRS 539
|
410
....*....|....*
gi 1682042785 479 GAVPPQVFHPPTSAA 493
Cdd:pfam03154 540 PSPEPTVVNTPSHAS 554
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
191-734 |
3.17e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 48.61 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 191 ATAASINCPTPSTNTNVSTVPNPVTSGQIIPALTLSNSSSTQNQPSSAPKQSPSPKPITSAQH-PHQWSPTMVAVPNKNI 269
Cdd:pfam03154 143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSvPPQGSPATSQPPNQTQ 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 270 R---PQDIRQQTPVARTPQFITTTPvfinPIFQVPGGSVAPNTTVVPH-SVTMMGPIQVSTTNIQlsAASSSTQLSVANM 345
Cdd:pfam03154 223 StaaPHTLIQQTPTLHPQRLPSPHP----PLQPMTQPPPPSQVSPQPLpQPSLHGQMPPMPHSLQ--TGPSHMQHPVPPQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 346 TSAQSTRNTVGQVQITSMTStAPVGTQQ----PAQQIVPGALKMDNQGEVGSGQKTVPLVQQPPSRSVPSVSAP---FQP 418
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPA-APGQSQQrihtPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPqshKHP 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 419 PLVSTPpcsSPGAVNAMRKSP--MSPVSTAQVKGKPAQAGVVVTATVDSQQ--SPADRPPQSTAGAV--PPQVFHPPTSA 492
Cdd:pfam03154 376 PHLSGP---SPFQMNSNLPPPpaLKPLSSLSTHHPPSAHPPPLQLMPQSQQlpPPPAQPPVLTQSQSlpPPAASHPPTSG 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 493 AlqteAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSqvsvpapssvssSVKALPTQTTVATAVSVSSAPLLSTVVPG 572
Cdd:pfam03154 453 L----HQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSS------------AMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 573 QNsVKSNvpgtgPLQDVPPITSPPvanlsgvPPSQSiPAPlEPSLPSTaaPTEASQIAPESVQQEKSQEPVVTDKMGEDI 652
Cdd:pfam03154 517 VQ-IKEE-----ALDEAEEPESPP-------PPPRS-PSP-EPTVVNT--PSHASQSARFYKHLDRGYNSCARTDLYFMP 579
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 653 TAGSEqgWAKKpinlvpRATA-EKPKGPSRRSSRAEKEVEEEpssgqRHQEEVRQTWNHDCSERSSLALKEVLPGRRPVS 731
Cdd:pfam03154 580 LAGSK--LAKK------REEAlEKAKREAEQKAREEKEREKE-----KEKEREREREREREAERAAKASSSSHEGRMGDP 646
|
...
gi 1682042785 732 QLS 734
Cdd:pfam03154 647 QLA 649
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
380-644 |
4.76e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 48.03 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 380 PGALKMDNQGEvgsgqkTVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVV 459
Cdd:pfam17823 35 NGAGKQNASGD------AVPRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREGAAD 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 460 TATVDSQQSPADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPS 539
Cdd:pfam17823 109 GAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASST 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 540 SVSSSVKALPTQTTVATAVSVS--SAPLLSTVVPGQNSVKSNVPGTGPL-----QDVPPITSPPVANL---------SGV 603
Cdd:pfam17823 189 TAASSAPTTAASSAPATLTPARgiSTAATATGHPAAGTALAAVGNSSPAagtvtAAVGTVTPAALATLaaaagtvasAAG 268
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1682042785 604 PPSQSIPAPLEPSlPSTAAPTEASQIAPESVQQEKSQEPVV 644
Cdd:pfam17823 269 TINMGDPHARRLS-PAKHMPSDTMARNPAAPMGAQAQGPII 308
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
31-508 |
9.59e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.24 E-value: 9.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 31 PAPQQGKPDLENQTGTSDRQQVHTAPGQDSGIS-----PTQRSAPTSLNQLLDNAAMQNVPLRP----------VQSSTG 95
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASsppqrPRRRAARPTVGSLTSLADPPPPPPTPepaphalvsaTPLPPG 2724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 96 RDGLGKDSPKSVLDTERQVIGNSKNTDM-PTSVSTTITTNELEAKAKPVFPVSTSSSNLQPPSVLTSHLSTNVNSNNSAC 174
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAGPATPGgPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 175 LNQPPVSSHSNNPSPIATAASINCPTPSTNTnvsTVPNPVTSGQIIPALTLSNSSSTQNQPS-SAPKQSPSPKPITSAQH 253
Cdd:PHA03247 2805 ADPPAAVLAPAAALPPAASPAGPLPPPTSAQ---PTAPPPPPGPPPPSLPLGGSVAPGGDVRrRPPSRSPAAKPAAPARP 2881
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 254 PHQW--SPTMVAVPNKNIRPQDIRQQTPVARTPQFITTTPvfinPIFQVPGGSVAPNTTVVPhsvtmmgpiqvsttniql 331
Cdd:PHA03247 2882 PVRRlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP----QPPPPPQPQPPPPPPPRP------------------ 2939
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 332 saassstqlsvanmtsaqstrntvgQVQITSMTSTAPVGTQQpaqqivpGALKMDNQGEVGSGQKTVPLVQQPPSRSVPS 411
Cdd:PHA03247 2940 -------------------------QPPLAPTTDPAGAGEPS-------GAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 412 VSAPFQPPLV--STPPCSSPGAVNAMRKSPMS-PVSTAQVKGKPAQagvvvTATVDSQQSPADRPPQSTAGAVPPQvfhP 488
Cdd:PHA03247 2988 APASSTPPLTghSLSRVSSWASSLALHEETDPpPVSLKQTLWPPDD-----TEDSDADSLFDSDSERSDLEALDPL---P 3059
|
490 500
....*....|....*....|
gi 1682042785 489 PTSAALQTEAPAPRTTAAQS 508
Cdd:PHA03247 3060 PEPHDPFAHEPDPATPEAGA 3079
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
213-591 |
1.06e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.98 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 213 PVTSGQIIPALTLSNSSSTQNQPSSAPKQSPSPK------PITSAqhPHQWSPTMVAVPNKNIRPQDIRQQTPVARTPQF 286
Cdd:PHA03378 576 PLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPttqshiPETSA--PRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQ 653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 287 ittTPvfinpifQVPGGSVAPNTTVVPHSvtmmgPIQVSTTNiqlSAASSSTQLSVANMT--SAQSTRNTVGQVQITSMT 364
Cdd:PHA03378 654 ---PP-------QVEITPYKPTWTQIGHI-----PYQPSPTG---ANTMLPIQWAPGTMQppPRAPTPMRPPAAPPGRAQ 715
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 365 STAPVGTQQPAQQIVPGALKMdnqgevgsgQKTVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSPMSPVS 444
Cdd:PHA03378 716 RPAAATGRARPPAAAPGRARP---------PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAP 786
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 445 TAQVKGKPA-----QAG----VVVTATVDSQQSPADRP-PQSTAGAVP---PQVFHPPTSAALQTEAPAPRTTAAQSNVT 511
Cdd:PHA03378 787 QQRPRGAPTpqpppQAGptsmQLMPRAAPGQQGPTKQIlRQLLTGGVKrgrPSLKKPAALERQAAAGPTPSPGSGTSDKI 866
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 512 LPAVSFSIPiqVAVPTQivsqvsvpapssvsssvkaLPTQTTVATAVSVSSAPLLSTVVPGQNsvksNVPGTGPLQDVPP 591
Cdd:PHA03378 867 VQAPVFYPP--VLQPIQ-------------------VMRQLGSVRAAAASTVTQAPTEYTGER----RGVGPMHPTDIPP 921
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
399-658 |
1.12e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.98 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 399 PLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSP--MSPVSTAQVKGKPAQAGVVVTATVDSQQSPAdRPPQS 476
Cdd:PHA03378 691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPgrARPPAAAPGRARPPAAAPGRARPPAAAPGRA-RPPAA 769
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 477 TAGAV----PPQVfhPPTSAALQTEAPAPrTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSSSVKALPTQT 552
Cdd:PHA03378 770 APGAPtpqpPPQA--PPAPQQRPRGAPTP-QPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAAL 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 553 TVATAVSVSSAPLLSTvvpGQNSVKSNV---PGTGPLQDVPPITSPPVANLSGVP--PSQ-------SIPAPLEPSLPST 620
Cdd:PHA03378 847 ERQAAAGPTPSPGSGT---SDKIVQAPVfypPVLQPIQVMRQLGSVRAAAASTVTqaPTEytgerrgVGPMHPTDIPPSK 923
|
250 260 270
....*....|....*....|....*....|....*...
gi 1682042785 621 AAPTEASqIAPESVQQEKSQEPVVtdkMGEDITAGSEQ 658
Cdd:PHA03378 924 RAKTDAY-VESQPPHGGQSHSFSV---IWENVSQGQQQ 957
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
226-575 |
1.41e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 46.46 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 226 SNSSSTQNQPSSAPKQSPSPKPITSAQHPHQWSPTMVAVPNKNIRPQDI-RQQTPVARTPQFITTTPVFIN------PIF 298
Cdd:cd22540 7 SPSEYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTpRKLVPIKPAPLPLGPGKNSIGflsakgNII 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 299 QVPGGSVAPNTTVVPHSVTMMGPIQV-------STTNIQLSAASSSTQLSVANMTSAQSTRNTVGQVQITSMTSTAPVGT 371
Cdd:cd22540 87 QLQGSQLSSSAPGGQQVFAIQNPTMIikgsqtrSSTNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 372 QQPAQQIVPGALKMDNQGeVGSGQKTVPLVQQPPSRSVPS-----VSAPFQPPLVSTPPCSSPGAVNA-MRKSPMSPVST 445
Cdd:cd22540 167 AHKPVPIKPAPLQTSNTN-SASLQVPGNVIKLQSGGNVALtlpvnNLVGTQDGATQLQLAAAPSKPSKkIRKKSAQAAQP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 446 AQVKGKPAQAgVVVTATVDS----------QQSPADRPPQSTAgavPPQVFHPPTSAAL-QTEAPAPRTTAAQSnVTLPA 514
Cdd:cd22540 246 AVTVAEQVET-VLIETTADNiiqagnnlliVQSPGTGQPAVLQ---QVQVLQPKQEQQVvQIPQQALRVVQAAS-ATLPT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1682042785 515 V------SFSIPIQVAVPTQIVSQVSVPAPSSVSSSVK--ALPTQTTVATAVSVSSAPLLSTVVPGQNS 575
Cdd:cd22540 321 VpqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEApaATATPSSSTSTVQQQVTANNGTGTSKPNY 389
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
145-522 |
1.60e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 46.07 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 145 PVSTSSSNLQPPSVLTSHLSTNVNSNNSAclnQPPVSShsnnPSPIAtaasincPTPSTNTNVSTVPNPVTSGQIIPALT 224
Cdd:cd22540 14 PAASTTQDSQPSPLALLAATCSKIGPPAV---EAAVTP----PAPPQ-------PTPRKLVPIKPAPLPLGPGKNSIGFL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 225 LSNSSSTQNQPSSAPKQSPSPKPITSAQHPHQWSPTMVAVPNKNIRPQDIRQ-----QTPVARTPQFITTT------PVF 293
Cdd:cd22540 80 SAKGNIIQLQGSQLSSSAPGGQQVFAIQNPTMIIKGSQTRSSTNQQYQISPQiqaagQINNSGQIQIIPGTnqaiitPVQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 294 INPIFQVPGGSVAPNTTVVPHSVTMMGPIQVSTTNIQLSAASSSTQLSVANMTsaQSTRNTVGQVQITSMTSTAPVGTQQ 373
Cdd:cd22540 160 VLQQPQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGGNVALTLPVNNL--VGTQDGATQLQLAAAPSKPSKKIRK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 374 PAQQIVPGALKMDNQGEVGSGQKTVP---------LVQQPPSRSVPSVSAPFQ-------PPLVSTPPCSSPGAVNAMRK 437
Cdd:cd22540 238 KSAQAAQPAVTVAEQVETVLIETTADniiqagnnlLIVQSPGTGQPAVLQQVQvlqpkqeQQVVQIPQQALRVVQAASAT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 438 SPMSPVSTAQ----VKGKPAQAGVVVTA------TVDSQQSPAD-RPPQSTAGAVPPQVFH------PPTSAALQTEAPA 500
Cdd:cd22540 318 LPTVPQKPLQniqiQNSEPTPTQVYIKTpsgevqTVLLQEAPAAtATPSSSTSTVQQQVTAnngtgtSKPNYNVRKERTL 397
|
410 420
....*....|....*....|..
gi 1682042785 501 PRTTAAQSNVTLPAVSFSIPIQ 522
Cdd:cd22540 398 PKIAPAGGIISLNAAQLAAAAQ 419
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
400-638 |
1.66e-04 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 46.14 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 400 LVQQPPSRSVPSVS-APFQPPLVSTPPCSSPGAVNAMRksPMSPVSTAQVKGKPAQAGVVVTATVDSQQsPADRPPQSTA 478
Cdd:PRK12727 50 LVQRALETARSDTPaTAAAPAPAPQAPTKPAAPVHAPL--KLSANANMSQRQRVASAAEDMIAAMALRQ-PVSVPRQAPA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 479 GAvppqvfhpPTSAalqTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSssvkALPTQTTVATA- 557
Cdd:PRK12727 127 AA--------PVRA---ASIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRA----PVQAPVVAAPAp 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 558 VSVSSAPLLSTVVPGQNSVKSNVPGTGPLQDVPPITSPPVAnlsgVPPSQSIPAPlepslPSTAAPTEASQIAPESVQQE 637
Cdd:PRK12727 192 VPAIAAALAAHAAYAQDDDEQLDDDGFDLDDALPQILPPAA----LPPIVVAPAA-----PAALAAVAAAAPAPQNDEEL 262
|
.
gi 1682042785 638 K 638
Cdd:PRK12727 263 K 263
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
389-711 |
1.75e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.13 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 389 GEVGSGQKTVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSPMSP-----VSTAQVKGKPAQAGVVVTATV 463
Cdd:PRK07764 395 AAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNApaggaPSPPPAAAPSAQPAPAPAAAP 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 464 DSQQSPADRPPQSTAGAVPPQvfhPPTSAAlqteAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSS 543
Cdd:PRK07764 475 EPTAAPAPAPPAAPAPAAAPA---APAAPA----APAGADDAATLRERWPEILAAVPKRSRKTWAILLPEATVLGVRGDT 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 544 SVKALPTQTTVATAVSVSSAPLLSTVVPGQ--NSVKSN-VPGTGPLQDVPPITSPPVANLSGVPPSQ--SIPAPLEPSLP 618
Cdd:PRK07764 548 LVLGFSTGGLARRFASPGNAEVLVTALAEElgGDWQVEaVVGPAPGAAGGEGPPAPASSGPPEEAARpaAPAAPAAPAAP 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 619 STA-APTEASQIAPESVQQEKSQEPVVTDKMGEDITAGSeQGWAKKPINLVPRATAEKPKGPSRRSSRAEKEVEEEP-SS 696
Cdd:PRK07764 628 APAgAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG-DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPaPA 706
|
330
....*....|....*
gi 1682042785 697 GQRHQEEVRQTWNHD 711
Cdd:PRK07764 707 ATPPAGQADDPAAQP 721
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
391-642 |
4.55e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.84 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 391 VGSGQKTVPLVQQPPSRSVPS--VSAPFQPPLVSTPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVVTATVDSQQS 468
Cdd:PRK07003 362 VTGGGAPGGGVPARVAGAVPApgARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDD 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 469 PADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSSSVKAL 548
Cdd:PRK07003 442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 549 PtqttvatAVSVSSAPLLSTVVPGQNSVKSNVPGTGPLQDV--------------------PPITSPPVANLSGVP-PSQ 607
Cdd:PRK07003 522 P-------AAAAPPAPEARPPTPAAAAPAARAGGAAAALDVlrnagmrvssdrgaraaaaaKPAAAPAAAPKPAAPrVAV 594
|
250 260 270
....*....|....*....|....*....|....*
gi 1682042785 608 SIPAPLEPSLPSTAAPTEASQiAPESVQQEKSQEP 642
Cdd:PRK07003 595 QVPTPRARAATGDAPPNGAAR-AEQAAESRGAPPP 628
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
221-508 |
6.67e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 221 PALTlSNSSSTQNQPSSAPKQSPSPKPITSAQHPHQWSPTMVAVPNKNIRPqdIRQQTPVARTPQFITTTPVFINPifqV 300
Cdd:PRK07003 360 PAVT-GGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAA--LAPKAAAAAAATRAEAPPAAPAP---P 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 301 PGGSVAPNTTVVPHSVTMMGPIQVSTTNIQLSAASSSTQLSVANMTSAQSTRNTVGQVQITSMTSTAPVGTQQPAQQIVP 380
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 381 GAlkmdnqgevgsgqktVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNA---MRKSPMSpVSTAQVKGKPAQAgv 457
Cdd:PRK07003 514 AA---------------ASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAldvLRNAGMR-VSSDRGARAAAAA-- 575
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1682042785 458 vvtatvdsqqSPADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQS 508
Cdd:PRK07003 576 ----------KPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARA 616
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
402-622 |
8.11e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 402 QQPPSRSVPSVSAPF---QPPLVSTPPCSSPGAVNAMrkSPMSPVSTAQVKGKPAQAGVVVTATVDSQQSPADRPPQSTA 478
Cdd:PRK12323 372 AGPATAAAAPVAQPApaaAAPAAAAPAPAAPPAAPAA--APAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 479 gavppqvfhpPTSAALQTEAPAPRTTAAQSnVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVsssvkaLPTQTTVATAV 558
Cdd:PRK12323 450 ----------PAPAPAAAPAAAARPAAAGP-RPVAAAAAAAPARAAPAAAPAPADDDPPPWEE------LPPEFASPAPA 512
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1682042785 559 SVSSAPllstvvPGQNSVKSNVPGTGPLQDVPPiTSPPVANLSGVPPSQSIPAPLEPSLPSTAA 622
Cdd:PRK12323 513 QPDAAP------AGWVAESIPDPATADPDDAFE-TLAPAPAAAPAPRAAAATEPVVAPRPPRAS 569
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
378-501 |
1.66e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 41.91 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 378 IVPGAL---KMDNQGEVGSgqktVPLVQQPPSRSVPSVSAPFQPPLVSTPPcssPGAVNAMRKSPM--SPVSTAQVKGKP 452
Cdd:PRK11633 22 VLPGLLdgqKKHYQDEFAA----IPLVPKPGDRDEPDMMPAATQALPTQPP---EGAAEAVRAGDAaaPSLDPATVAPPN 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1682042785 453 AQAGV--VVTATVDSQQSPADRPPQSTAGAVPPQVFHPPTSAALQTEAPAP 501
Cdd:PRK11633 95 TPVEPepAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAP 145
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
424-532 |
2.28e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 424 PPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGV--VVTATVDSQQSPADRPPqstAGAVPPQVFHPPTSAALQTEAPAP 501
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAapAPAAAPAAAASAPAAPP---AAAPPAPVAAPAAAAPAAAPAAAP 442
|
90 100 110
....*....|....*....|....*....|...
gi 1682042785 502 RTTAAQSNVTLPAVS--FSIPIQVAVPTQIVSQ 532
Cdd:PRK14951 443 AAVALAPAPPAQAAPetVAIPVRVAPEPAVASA 475
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
422-516 |
2.39e-03 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 41.94 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 422 STPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVVTATVDSQQSPAdrPPQSTAGAVPPQVFHPPTSAALQTEAPAP 501
Cdd:PRK10856 161 SVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAV--VAPSQANVDTAATPAPAAPATPDGAAPLP 238
|
90
....*....|....*
gi 1682042785 502 rttAAQSNVTLPAVS 516
Cdd:PRK10856 239 ---TDQAGVSTPAAD 250
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
367-651 |
3.04e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 367 APVGTQQPAqqiVPGAL-----KMDNQGEVGSGQKTVPLVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRkspms 441
Cdd:PRK07003 367 APGGGVPAR---VAGAVpapgaRAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR----- 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 442 pVSTAQVKGKPAQAGVVVTATVDSQ-QSPADRPPQSTAGAVPPQVFHPPTSAAlqteAPAPRTTAAQSNVTLPAVSFSIP 520
Cdd:PRK07003 439 -GDDAADGDAPVPAKANARASADSRcDERDAQPPADSGSASAPASDAPPDAAF----EPAPRAAAPSAATPAAVPDARAP 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 521 IQVAVPTQIVSQVSVPAPSSVSSSVKALPTQ--TTVATAVSVssaplLSTVVPGQNSVKSNVPGTGPLQDVPPITSPPVA 598
Cdd:PRK07003 514 AAASREDAPAAAAPPAPEARPPTPAAAAPAAraGGAAAALDV-----LRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPA 588
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1682042785 599 nlsgvPPSQSIPAPlEPSLPSTAAPTEASQIAPESVQQEKSQEPVVTDKMGED 651
Cdd:PRK07003 589 -----APRVAVQVP-TPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPD 635
|
|
| FliJ |
pfam02050 |
Flagellar FliJ protein; |
1421-1497 |
3.21e-03 |
|
Flagellar FliJ protein;
Pssm-ID: 426581 [Multi-domain] Cd Length: 123 Bit Score: 39.19 E-value: 3.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1682042785 1421 KTFEKSMQNLQTKIDEKQKQLSAARKQLKAAKAEHKAshddkskkaVEVKRKAVQRIEEQLMKLQVQATDREENKQI 1497
Cdd:pfam02050 48 RNYQAFISQLDEAIAQQQQELAQAEAQVEKAREEWQE---------ARQERKSLEKLREREKKEERKEQNRREQKQL 115
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
386-639 |
3.24e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.47 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 386 DNQGEVGSGQKTVP---LVQQPPSRSVPSVSAPFQPPLVSTPPCSSPGAVNAMRKSPMSPVSTAQVKGKPAQAGVVVTAT 462
Cdd:PHA03307 157 ASPAAVASDAASSRqaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 463 VD---SQQSPADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQSNvtlPAVSFSIPIQVAVPtqivsqvsvpaps 539
Cdd:PHA03307 237 SDsssSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAS---SSSSPRERSPSPSP------------- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 540 sVSSSVKALPTQTTVATAVSVSSAPLLSTVVPGQNSVKSNVPGTGPLQDVPPITSPPVANLSGVPPSQSIPAPLEPSLPS 619
Cdd:PHA03307 301 -SSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPA 379
|
250 260
....*....|....*....|....*
gi 1682042785 620 TAAPTEAS-----QIAPESVQQEKS 639
Cdd:PHA03307 380 ASAGRPTRrraraAVAGRARRRDAT 404
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
399-686 |
3.25e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 399 PLVQQPPSRSVPSVSAPFQPPLVSTPPcsSPGAVNAmrksPMSPVSTAQVKGKPAQA----------GVVVTATVDSQQS 468
Cdd:PHA03247 2478 PVYRRPAEARFPFAAGAAPDPGGGGPP--DPDAPPA----PSRLAPAILPDEPVGEPvhprmltwirGLEELASDDAGDP 2551
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 469 ----PADRPPQSTAGAVPPQVFHP-PTSAALQTEAPAPRTTAAQSNVTLP----------AVSFSIPIQVAVPTQIVSQV 533
Cdd:PHA03247 2552 ppplPPAAPPAAPDRSVPPPRPAPrPSEPAVTSRARRPDAPPQSARPRAPvddrgdprgpAPPSPLPPDTHAPDPPPPSP 2631
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 534 SVPAPSSVSSSVKALPTQTTVATAVSVSSAPLLSTVVPGQNSVKSNVPGTGPLQDVPPITSPPVANLSGVPPSQSIPAP- 612
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPa 2711
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 613 ---LEPSLPSTAAPTEASQIAPESvqqekSQEPVVTDKMGEDITAGSEQGWAKKPINLVPRATA---EKPKGPSRRSSRA 686
Cdd:PHA03247 2712 phaLVSATPLPPGPAAARQASPAL-----PAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaAPAAGPPRRLTRP 2786
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
452-646 |
3.65e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 452 PAQAGVVVTATVDSQQSPADRPPQSTAGAVPPQVFHPPTSAALQTEAPAPRTTAAQ--------SNVTLPAVSFSIPIQV 523
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEalaaarqaSARGPGGAPAPAPAPA 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 524 AVPTQIVSQVSVPAPSSVSSSVKALPTQTTVATAVSVSSAPLLSTVVPGQNSVKSNVP-GTGPLQDVPPITSPPVANLSG 602
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQpDAAPAGWVAESIPDPATADPD 535
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1682042785 603 VPPSQSIPAPLEPSLPSTAAPTEaSQIAPESVQQEKSQEPVVTD 646
Cdd:PRK12323 536 DAFETLAPAPAAAPAPRAAAATE-PVVAPRPPRASASGLPDMFD 578
|
|
| MscS_porin |
pfam12795 |
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ... |
1380-1511 |
4.25e-03 |
|
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.
Pssm-ID: 432790 [Multi-domain] Cd Length: 238 Bit Score: 40.75 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1380 TLQQQLKELSCSDDSVPAKILSY-------NRANRAVAILCNHQRAPpKTFEKSMQNLQTKIDEKQKQLSAARKQLKAAK 1452
Cdd:pfam12795 55 ELRQELAALQAKAEAAPKEILASlsleeleQRLLQTSAQLQELQNQL-AQLNSQLIELQTRPERAQQQLSEARQRLQQIR 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1682042785 1453 AEHKASHDdkSKKAVEVKRKAVQRIEEQLMKLQVQATDRE---ENKQIALGTSKLNYLDPRI 1511
Cdd:pfam12795 134 NRLNGPAP--PGEPLSEAQRWALQAELAALKAQIDMLEQEllsNNNRQDLLKARRDLLTLRI 193
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
374-595 |
4.73e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.45 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 374 PAQQIVPgalKMDNQGEVGSGQKTVPLVQQPPSrsVPSVSAPFQPPLVSTPPCSsPGAVNAMRKSPMSPVSTAQVKGKPA 453
Cdd:PLN03209 324 PSQRVPP---KESDAADGPKPVPTKPVTPEAPS--PPIEEEPPQPKAVVPRPLS-PYTAYEDLKPPTSPIPTPPSSSPAS 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 454 QA---GVVVTATVDSQQSPAD-----------------------------RPPQSTAGAVPPQVFHPPTSAALQTEAPAP 501
Cdd:PLN03209 398 SKsvdAVAKPAEPDVVPSPGSasnvpevepaqveakktrplspyaryedlKPPTSPSPTAPTGVSPSVSSTSSVPAVPDT 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 502 RTTAAQSNVTLPAVSFSIPIQvavPTQIVSQVSVPAPSSVSSSVKALPTQTTVATAVSVSSAPLLSTVVPGQNSvksnVP 581
Cdd:PLN03209 478 APATAATDAAAPPPANMRPLS---PYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHA----QP 550
|
250 260
....*....|....*....|
gi 1682042785 582 GTGPL------QDVPPITSP 595
Cdd:PLN03209 551 KPRPLspytmyEDLKPPTSP 570
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
1424-1484 |
5.66e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.29 E-value: 5.66e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1682042785 1424 EKSMQNLQTKIDEKQKQLSAARKQLKAAKAEHKASHD---------DKSKKAVEVKR-KAVQRIEEQLMKL 1484
Cdd:COG1579 109 EDEILELMERIEELEEELAELEAELAELEAELEEKKAeldeelaelEAELEELEAEReELAAKIPPELLAL 179
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1358-1498 |
7.82e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 40.91 E-value: 7.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1358 KHLQELMDGLTA--KVFRTYNASITLQQQLKELSCSDDSVPAKILSYNRANRAVAILcnhqrappktfEKSMQNLQTKID 1435
Cdd:COG4717 112 EELREELEKLEKllQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEEL-----------EAELAELQEELE 180
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1682042785 1436 EKQKQLS-AARKQLKAAKAEHKASHDDKS--KKAVEVKRKAVQRIEEQLMKLQVQATDREENKQIA 1498
Cdd:COG4717 181 ELLEQLSlATEEELQDLAEELEELQQRLAelEEELEEAQEELEELEEELEQLENELEAAALEERLK 246
|
|
| SP4_N |
cd22536 |
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ... |
172-378 |
7.87e-03 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.
Pssm-ID: 411773 [Multi-domain] Cd Length: 623 Bit Score: 40.67 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 172 SACLNQPPVSSHSNN----PSPIATAASIN---CPTPSTNTNVSTVPNPVTSGQIIPALTLSNSSSTQNQPSSAPKQSPS 244
Cdd:cd22536 259 SGQLVQPSDGGVSNGnqlvSTPITTASVSTmpeSPSSSTTCTTTASTSLTSSDTLVSSAETGQYASTAASSERTEEEPQT 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 245 PKPITSAQHPHQWSPT--------MVAVPNKNIRPQDIRQQTPVARTPQFITTTpvfINPIFQVPGGSVAPNTTVVPhsv 316
Cdd:cd22536 339 SAAESEAQSSSQLQSNglqnvqdqSNSLQQVQIVGQPILQQIQIQQPQQQIIQA---IQPQSFQLQSGQTIQTIQQQ--- 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1682042785 317 tmmgPIQvsttNIQLSAASSSTQLSVANMT---SAQSTRNTVgQVQITSMTSTAPVGTQQPAQQI 378
Cdd:cd22536 413 ----PLQ----NVQLQAVQSPTQVLIRAPTltpSGQISWQTV-QVQNIQSLSNLQVQNAGLPQQL 468
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
467-637 |
9.17e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 40.62 E-value: 9.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 467 QSPADRPPQSTAgAVPPQVFHPPTSAALQTEAPAPRTTAAQSNVTLPAVSFSIPIQVAVPTQIVSQVSVPAPSSVSSSVK 546
Cdd:PRK07994 362 AAPLPEPEVPPQ-SAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 547 ALPTQTTVATAVSVSSAPLLStvVPGQNSVKSNVPGTGPLQDVPPITSPPVANLSGVPPSQSIPAPLEPSLPSTAAPtea 626
Cdd:PRK07994 441 SEPAAASRARPVNSALERLAS--VRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAAK--- 515
|
170
....*....|.
gi 1682042785 627 sqIAPESVQQE 637
Cdd:PRK07994 516 --LAAEAIERD 524
|
|
| OmpH |
smart00935 |
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ... |
1424-1497 |
9.82e-03 |
|
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.
Pssm-ID: 214922 [Multi-domain] Cd Length: 140 Bit Score: 37.95 E-value: 9.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1682042785 1424 EKSMQNLQTKIDEKQKQLSAARKQLKAAKAEHKASHDDKSKKAVEVKRKAVQRIEEQLMKLQ------VQATDREENKQI 1497
Cdd:smart00935 17 KAAQKQLEKEFKKRQAELEKLEKELQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQqklqqdLQKRQQEELQKI 96
|
|
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