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Conserved domains on  [gi|1670514787|gb|TMA97677|]
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MAG: hypothetical protein E6J77_00040 [Deltaproteobacteria bacterium]

Protein Classification

RidA family protein( domain architecture ID 817)

RidA (reactive intermediate/imine deaminase A) family protein

PubMed:  25975565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_family super family cl10015
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 5-128 5.91e-48

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


The actual alignment was detected with superfamily member TIGR00004:

Pssm-ID: 447879  Cd Length: 124  Bit Score: 150.14  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEGAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1670514787  85 LGEFAAMNAVYGRYFSPPYPARATVGVAALPAGARVEIEAVAVR 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 5-128 5.91e-48

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 150.14  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEGAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1670514787  85 LGEFAAMNAVYGRYFSPPYPARATVGVAALPAGARVEIEAVAVR 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 5-129 5.81e-40

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 129.91  E-value: 5.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEgAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRlVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:COG0251     3 RELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1670514787  85 LGEFAAMNAVYGRYFSPPYPARATVGVAALPAGARVEIEAVAVRR 129
Cdd:COG0251    81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-127 2.06e-36

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 120.48  E-value: 2.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  13 APRVLGPYAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMN 92
Cdd:pfam01042   2 APAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVN 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1670514787  93 AVYGRYFS-PPYPARATVGVAALPAGARVEIEAVAV 127
Cdd:pfam01042  82 EVYAEYFDaDKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 20-126 7.73e-35

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 116.12  E-value: 7.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPAsGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMNAVYGRYF 99
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPD-GELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 1670514787 100 S-PPYPARATVGVAALPAGARVEIEAVA 126
Cdd:cd00448    80 GeGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
5-128 1.18e-24

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 91.28  E-value: 1.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEGAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRlVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:PRK11401    2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1670514787  85 LGEFAAMNAVYGRYF---SPPYPARATVGVAALPAGARVEIEAVAVR 128
Cdd:PRK11401   81 LNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAVR 127
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 5-128 5.91e-48

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 150.14  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEGAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1670514787  85 LGEFAAMNAVYGRYFSPPYPARATVGVAALPAGARVEIEAVAVR 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 5-129 5.81e-40

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 129.91  E-value: 5.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEgAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRlVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:COG0251     3 RELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1670514787  85 LGEFAAMNAVYGRYFSPPYPARATVGVAALPAGARVEIEAVAVRR 129
Cdd:COG0251    81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-127 2.06e-36

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 120.48  E-value: 2.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  13 APRVLGPYAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMN 92
Cdd:pfam01042   2 APAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVN 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1670514787  93 AVYGRYFS-PPYPARATVGVAALPAGARVEIEAVAV 127
Cdd:pfam01042  82 EVYAEYFDaDKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 20-126 7.73e-35

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 116.12  E-value: 7.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPAsGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMNAVYGRYF 99
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPD-GELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 1670514787 100 S-PPYPARATVGVAALPAGARVEIEAVA 126
Cdd:cd00448    80 GeGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
5-128 1.18e-24

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 91.28  E-value: 1.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   5 RTAITAEGAPRVLGPYAQAVAVGDLVFCAGQVGLDPASGRlVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVD 84
Cdd:PRK11401    2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1670514787  85 LGEFAAMNAVYGRYF---SPPYPARATVGVAALPAGARVEIEAVAVR 128
Cdd:PRK11401   81 LNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAVR 127
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 20-128 2.60e-18

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 74.22  E-value: 2.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPASGrlVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDL-GEFAAMNAVYGRY 98
Cdd:cd02198     3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDEY 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1670514787  99 FSPPYPARATVGVAALPA-GARVEIEAVAVR 128
Cdd:cd02198    81 FKEPYPAWTAVGVAWLARpGLLVEIKVVAVR 111
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 20-127 1.50e-17

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 72.18  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPAsgrlvpGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMNAVYGRYF 99
Cdd:cd06150     3 MSQAVVHNGTVYLAGQVADDTS------ADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                          90       100
                  ....*....|....*....|....*....
gi 1670514787 100 SPPY-PARATVGVAALPAGARVEIEAVAV 127
Cdd:cd06150    77 PPGHaPARACVEAKLADPGYLVEIVVTAA 105
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 20-126 5.91e-16

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 68.35  E-value: 5.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPAsGRLVPGGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLVDLGEFAAMNAVYGRYF 99
Cdd:cd06154    13 YSRAVRVGNWVFVSGTTGYDYD-GMVMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVF 91

                          90       100
                  ....*....|....*....|....*...
gi 1670514787 100 SPPYPARATVGVAALPA-GARVEIEAVA 126
Cdd:cd06154    92 GDIRPAATMVVVSLLVDpEMLVEIEVTA 119
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 20-127 5.40e-12

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 58.09  E-value: 5.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPASGRlVPGGVEAETARVLENLAAVLAAAALGL-GDIVKTTVYLVDLGE---FAAMNAVY 95
Cdd:cd06152     3 YSQAVRIGDRIEISGQGGWDPDTGK-IPEDLEEEIDQAFDNVELALKAAGGKGwEQVYKVNSYHVDIKNeeaFGLMVENF 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1670514787  96 GRYFSPPYPARATVGVAALP-AGARVEIEAVAV 127
Cdd:cd06152    82 KKWMPNHQPIWTCVGVTALGlPGMRVEIEVDAI 114
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 74-126 7.32e-12

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 57.27  E-value: 7.32e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1670514787  74 DIVKTTVYLVDLGEFAAMNAVYGRYFSPPYP-ARATVGvAALPAGARVEIEAVA 126
Cdd:cd06155    48 DILYVTLYLRDMSDFAEVNSVYGTFFDKPNPpSRVCVE-CGLPEGCDVQLSCVA 100
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 20-60 9.11e-09

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 49.64  E-value: 9.11e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1670514787  20 YAQAVAVGDLVFCAGQVGLDPASGRLVPGGVEAETARVLEN 60
Cdd:cd06156     1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQH 41
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 21-126 1.21e-06

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 44.23  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787  21 AQAVAVG---DLVFCAGQVG--LDPASGRLVP---GGVEAETARVLENLAAVLAAAALGLGDIVKTTVYLV----DLGE- 87
Cdd:cd06151     2 AQAVEVPagaATIYLSGTVPavVNASAPKGSParyGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLVadpaLDGKm 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1670514787  88 -FAAMNAVYGRYFS----PPYPARATVGVAALP-AGARVEIEAVA 126
Cdd:cd06151    82 dFAGFMKAYRQFFGtaeqPNKPARSTLQVAGLVnPGWLVEIEVVA 126
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 8-126 2.82e-03

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 35.51  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670514787   8 ITAEGAPRVLGPYAQAVAVGDLVFCAGQV----GLDPASGRlVPGGVEAETAR-----VLENLAAVLAAAA---LGLGDI 75
Cdd:cd02199     4 LELPPAPAPVGNYVPAVRTGNLLYVSGQLprvdGKLVYTGK-VGADLSVEEGQeaarlCALNALAALKAALgdlDRVKRV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1670514787  76 VKTTVYLVDLGEFAA-----------MNAVYGRyfsPPYPARATVGVAALPAGARVEIEAVA 126
Cdd:cd02199    83 VRLTGFVNSAPDFTEqpkvangasdlLVEVFGE---AGRHARSAVGVASLPLNAAVEVEAIV 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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