|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-375 |
6.75e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 95.71 E-value: 6.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 12 VVAVLGFLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMA 91
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 92 AVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVT--EQGRGMGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGS 169
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPpkERGRALGIFNAGGPLGGALAPP-LLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 170 LILPAVIASVLLLVerlprgvlkspavlggarrglasrpygLILLVYMFAGFAYQGGLTFLPRFI----------GAGFF 239
Cdd:COG2271 170 LGLPGLLLALLRFW---------------------------LLALAYFLVYFALYGFLTWLPTYLvevrglslaqAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 240 AAALGLGAVGQVLSGTLADRRRPDRTLFALstaaAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTR 319
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLA----IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1670351916 320 EAPRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFA 375
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
16-376 |
8.08e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 84.14 E-value: 8.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 16 LGFLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAA 95
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 96 SPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQ-GRGMGWHGMGGSLGIAAGPAYvgATLAFGASWRLVAGSLILPA 174
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRrGLAMSIFSVGGNLGFALGPLI--AAALVALFGGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 175 VIASVLLL----VERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFI---------GAGFFAA 241
Cdd:cd17478 159 GLAVALLLlrlrPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvqrgyslvfAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 242 ALGLGAVGQVLSGTLADRRRPDRTLFAlstaaAGSLAAAGVLLVAGLGPPFLGFTTVAvgFGFLLFSLEALQNTLVTREA 321
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIA-----SLLLAAPFLLLFLLTPGIWSYILLVL--AGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1670351916 322 PRDaRGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAY 376
Cdd:cd17478 312 PGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-342 |
1.70e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 82.71 E-value: 1.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 12 VVAVLGFLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMA 91
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 92 AVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQ--GRGMGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGS 169
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErrGRALGLLGAGLGLGPALGPL-LGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 170 LILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGF----------F 239
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglsasaagllL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 240 AAALGLGAVGQVLSGTLADRRRPDRTLFAlstaaaGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTR 319
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLI------GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|...
gi 1670351916 320 EAPRDARGLAFGFTFLSVFGIGA 342
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
40-376 |
2.45e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 40 EFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPT 119
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 120 GLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAyVGATLAFGASWR---LVAGSLILPAVIASVLLLVERLP---RGVL 191
Cdd:cd17325 105 AMALIADIAPPEERGraMGIFSSAIGLGFLIGPL-LGGLLADALGYRapfLVCAALALLALVLALLLLPEPRPppnKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 192 KSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLP----RFIGAG------FFAAALGLGAVGQVLSGTLADRRR 261
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlyaaELGGLSpaqiglLFGAQGLASALSQPPAGKLSDRIG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 262 PDRTLFAlstaaaGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFtFLSVFGIG 341
Cdd:cd17325 264 RKPLILI------GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FNTAFSLG 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 1670351916 342 -AMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAY 376
Cdd:cd17325 337 mVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-355 |
5.06e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 5.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 18 FLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASP 97
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 98 SLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAYVGAtLAFGASWR---LVAGSLIL 172
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGlaMGIRQTGVPLGGALAAALLPP-LALHYGWRaafVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 173 PAVIASVLLLVERL--PRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFI----------GAGFFA 240
Cdd:cd17475 162 LAAVLFWLFYREPPaaSAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLhdhlglsvvaAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 241 AALGLGAVGQVLSGTLADRRRPDRTLFALSTAAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTRE 320
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350
....*....|....*....|....*....|....*
gi 1670351916 321 APRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRS 355
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAT 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-345 |
1.62e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.91 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 28 LSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLG 107
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 108 ALGLFSSAYHPTGLSVISRTV--TEQGRGMGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGSLILPAVIASVLLLV-- 183
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFppEERGRALGLVSAGFGLGAALGPL-LGGLLASLFGWRAAFLILAILSLLAAVLLLLpr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 184 ----ERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFI---------GAGFFAAALGLGAVGQ 250
Cdd:pfam07690 173 pppeSKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQevlglsallAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 251 VLSGTLADRRRPDRTLFALstaAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAF 330
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLA---LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
330
....*....|....*
gi 1670351916 331 GFTFLSVFGIGAMGA 345
Cdd:pfam07690 330 GLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-376 |
7.90e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 7.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 27 ILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASL 106
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 107 GALGLFSSAYHPTGLSVISRTV--TEQGRGMGWHGMGGSLGIAAGPAYVGA-TLAFGASWRLVAGSLILPAVIASVLLLV 183
Cdd:cd06174 92 FLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGIlASSLGFGWRAVFLIAAALALLAAILLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 184 --------ERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFI----------GAGFFAAALGL 245
Cdd:cd06174 172 vvpdppesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLldlgglsvavAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 246 GAVGQVLSGTLADRRRPDRTLFALStaaagSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDA 325
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLIG-----LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1670351916 326 RGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAY 376
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-375 |
2.45e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.52 E-value: 2.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 29 SIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGA 108
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 109 LGLFSSAYHPTGLSVISRTVTEQGRG--MGWHGMGGSLGIAAGpAYVGATLAFGASWR---LVAGSLILPAVIASVLLLV 183
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGlaLGLAAGGGNLGAAVA-AFLAPLLIAAFGWRnafLILGILLLVVAVLAWLFLR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 184 ERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIG---------AGFFAAALGL-GAVGQVLS 253
Cdd:COG2223 182 DPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdqfglsaatAGLLAALFALlGALGRPLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 254 GTLADRRRPDRTLFALstaaaGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFT 333
Cdd:COG2223 262 GWLSDRIGGRRVLLIV-----FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV 336
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1670351916 334 FLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFA 375
Cdd:COG2223 337 GAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-376 |
7.71e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 7.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 43 ADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAA-----SPSLPVLAASLGALGLFSSAYH 117
Cdd:cd06173 31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 118 PTGLSVISRTVTEQ--GRGMGWHGMGGSLGIAAGPAYVGATLA-FGASWRLVAGSLILPAVIASVLLLVERLPRGVLKSP 194
Cdd:cd06173 111 PARQALLPELVPKEqlVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 195 -----AVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFI---------GAGFFAAALGLGA-VGQVLSGTLADR 259
Cdd:cd06173 191 slllrDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAkevlgggaaGYGLLLAAFGVGAlLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 260 RRPDRTLFALSTAAAGSlaaagvLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFTFLSVFG 339
Cdd:cd06173 271 RRRGRLLLIGALLLGLA------LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSG 344
|
330 340 350
....*....|....*....|....*....|....*..
gi 1670351916 340 IGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAY 376
Cdd:cd06173 345 AMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-377 |
1.11e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 40 EFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPT 119
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 120 GLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAyVGATLAfGASWR---LVAGSLILPAVIASVLLLVERLPRGVLKSP 194
Cdd:cd17474 108 ALTLIGDLFEGGERAkaMGLYEAALGLGIAVGPL-LGGLLA-AISWRypfFLLAALIPVAFLAILFLLPEPKEKAKSSSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 195 AVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGF----------FAAALGLGAVGQVLSGTLADRRRPDR 264
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYgispiiigllFAGWSVLLALGSLFVGRLLKKRFGAR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 265 TLFALSTaaagsLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMG 344
Cdd:cd17474 266 RILVIGL-----LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
330 340 350
....*....|....*....|....*....|...
gi 1670351916 345 ATLAGYLLDRSEAPLLFGLLAGSLATSGAFAYA 377
Cdd:cd17474 341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-369 |
2.94e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.41 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 47 TLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISR 126
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 127 TVTE--QGRGMGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGSLILPAVIASVLL--LVERLPRGVLKSPAVLGGARR 202
Cdd:cd17324 115 LVPPekRGRAIGLVFSGLTLGLVLGRP-LGGLLGQLLGWRAAFLAIAVLALLAALLLwrLLPSLPPKKPGSLGLLSSLLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 203 GLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGA----------GFFAAALGLGAVGQVLSGTLADRRRPDRTLFALsta 272
Cdd:cd17324 194 LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDvpgfsssaiiGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL--- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 273 aagSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPrDARGLAFGFTFLSVFGIGAMGATLAGYLL 352
Cdd:cd17324 271 ---LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVL 346
|
330
....*....|....*..
gi 1670351916 353 DRSEAPLLFGLLAGSLA 369
Cdd:cd17324 347 DHGGWAGVGWVGAALLL 363
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-381 |
1.46e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.03 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 27 ILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASL 106
Cdd:COG2807 34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 107 GALGLFSSAYHPTGLSVISRTVTEQ-GRGMGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGSLILPAVIASVLLLVER 185
Cdd:COG2807 114 ALIGAGIAVGNVLLPGLIKRWFPDRvGLMTGLYTAAMGLGAALAAG-LTVPLAAALGWRGALAVWALLALLALLLWLPLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 186 LPRGVLKSPAVLGGARRGLASRPYGLILLVYMFA-GFAYQGGLTFLPRFI---------GAGFFAAALGLGAVGQVLSGT 255
Cdd:COG2807 193 RRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLqSLLYYAVVAWLPPILrdaglsaatAGLLLSLFQLAGIPGSLLVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 256 LADRRRPDRTLFALSTAAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLealqnTLVTREAPRDARGLAFGFTFL 335
Cdd:COG2807 273 LADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT-----LIGLRARTPAEAAALSGMAQS 347
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1670351916 336 SVFGIGAMGATLAGYLLDRSEAP-LLFGLLAGSLATSGAFAYAAGQA 381
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATGSWtAALLLLAALAVLMLVAGLLAGRP 394
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-378 |
1.61e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 1.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 12 VVAVLGFLHGTVHAnilSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMA 91
Cdd:COG0738 12 AIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 92 AVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQGRG-MGWHGMGGSLGIAAGPAYVGATLAFG--ASWRLVAG 168
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASrLNLLHAFFSLGALLGPLLGGLLILLGlsLSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 169 SLILPAVIASVLLLVERLPRGVL---KSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRF----------IG 235
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIEEeeeEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYlkdvlglseaTA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 236 AGFFAAALGLGAVGQVLSGTLADRRRPDRTLFALStaaaGSLAAAGVLLVAGLGPPFLGFTTVAVGFGF-LLFSleaLQN 314
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA----LLAAVGLLLALLAPGPWLALIGLALVGLGLsLMFP---TIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1670351916 315 TLVTREAPRDARGLAFGFTFLSVFGiGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAYAA 378
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVG-GAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
47-355 |
3.11e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.00 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 47 TLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISR 126
Cdd:cd06180 35 QAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLH 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 127 TVTEQGRGM--GWHGMGGSLGIAAGPAYVGATLAFGASWRLVAGSLILPAVIASVLLLVeRLPRGVLKSPAVLGGARRGL 204
Cdd:cd06180 115 HATAAGRGHliGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFL-LLRRGPSAPTEASAAESAPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 205 ASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGFFAAAL--------GLGAV-GQVLSGTLADRRRPDRTLFALstaaag 275
Cdd:cd06180 194 LNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLagllwslfGLAAVpSCFLWGALSDRWGTRRALAAN------ 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 276 SLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFTflSVFGIGAM-GATLAGYLLDR 354
Cdd:cd06180 268 LLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMT--ASFGVGQIlGPLLAGWLADA 345
|
.
gi 1670351916 355 S 355
Cdd:cd06180 346 T 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-375 |
3.70e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.87 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 43 ADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLS 122
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 123 VISRTVTEQGRG--MGWHGMGGSLGIAAGPAYVGATLAFGASWRLVAGSLILpavIASVLLLVERLPRGVLKSPAVLGGA 200
Cdd:cd17477 108 WLNALATNENRGrvLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLL---LALVPLLLTRRAAPEIEEAESISLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 201 RRGLASRPYGLILLVYmfaGFAYQGGLTFLPRF--------IGAGFFAAALGLG-AVGQVLSGTLADRRrpDRTLFALST 271
Cdd:cd17477 185 RLLRIAPLALLGAFVA---GFLEGAFYSLLPLYglrlglsvAQAALLLAAFVLGgLLLQWPLGWLADRF--DRRRVLLGC 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 272 AAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEAlqnTLVTREAPRDARGLAFGfTFLSVFGIGAM-GATLAGY 350
Cdd:cd17477 260 ALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLAL---ALAGDRLPGDELVAANA-ALLLLYGLGSViGPLLAGA 335
|
330 340
....*....|....*....|....*
gi 1670351916 351 LLDRSEAPLLFGLLAGSLATSGAFA 375
Cdd:cd17477 336 LMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-355 |
8.18e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 8.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 12 VVAVLGFLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMA 91
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 92 AVAASPSLPVLAASLGALGLFSSA--YHPTGLSVISRTVTEQ-GRGMGWHGMGGSLGIAAGPaYVGATLAFGASWR---L 165
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGtlAAVAFATVAAWWFERRrGLALGILTAGGGLGSLVFL-PLGAALIEAFGWRtalL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 166 VAGSLILPAVIASVLLLVERLPRGVLKSPAVLGGA------RRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGFF 239
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPAspgstlKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 240 AAALGLGA---------VGQVLSGTLADRRRPDRTLFALSTAAAGSlaaagVLLVAGLGPPFLGFTTVAVGFGFLLFSLE 310
Cdd:cd17355 243 SPAAAAVAlaliglfniVGRLLSGWLGDRYSPRRLLAASYALRALG-----LALLLLLPFPPLALLLFAALFGLGWGATV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1670351916 311 ALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRS 355
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
129-374 |
1.26e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 129 TEQGRGMGWHGMGGSLGIAAGPAYVGATLAF-GASWRLVAGSLILPAVIASVLLL-VERLPRGVLKSPAVLGGARRGLAS 206
Cdd:cd17370 120 SGRGKAFGLHRALDTLGAVLGPLLAALLLYLlGGNYRTIFLLAAIPALLALLILLfVVKEYPRPPKLRKKSKKTSLKKLP 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 207 RPYGLILLVYMFAGF--------AYQGGLTFLPRFIGAGFFAAALGLGAVGQVLSGTLADRRrpDRTLFALSTAAAGSLA 278
Cdd:cd17370 200 KAFWLYLLAVALFALgnfsfaflILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI--GRKKLLILGYLSLALA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 279 AAGVLLVAGLGPPFLGFTTVAVGFGFllfsLEALQNTLVTREAPRDARGLAFGFtFLSVFGIGAM-GATLAGYLLDRSEA 357
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGA----QESIERAAVADLVPAELRGTAYGL-FNTVVGIGWLlASLIAGYLWDLISP 352
|
250
....*....|....*..
gi 1670351916 358 PLLFGLLAGSLATSGAF 374
Cdd:cd17370 353 SAAFLFSAVLALIALLL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
32-289 |
3.35e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 3.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 32 VFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGL 111
Cdd:COG0477 35 VALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 112 FSSAYHPTGLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAyVGATLAFGASWRLVAGSLILPAVIASVLLLVERLPRG 189
Cdd:COG0477 115 GAGGLMPGALALIAELFPARERGraLGLWGAAIGLGLALGPL-LGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 190 VLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGFFAAALGLGAVGQVLSGTLADRRRPDRTLFAL 269
Cdd:COG0477 194 LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
|
250 260
....*....|....*....|
gi 1670351916 270 STAAAGSLAAAGVLLVAGLG 289
Cdd:COG0477 274 LLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
61-365 |
3.73e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 61 LGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQGRGMGWH-- 138
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSll 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 139 GMGGSLGIAAGPAYVGATLAFGASWR--LVAGSLILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLASRPYGLILLVY 216
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLLYSFRLLflAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLAS 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 217 MFAGFAYQGGLTFLPRFIG----------AGFFAAALGLGAVGQVLSGTLADRRRPDRTLFALStaaagslaaagVLLVA 286
Cdd:cd17329 210 FLISLIYFQLESTLPVYVVeilglgesllGLLLALNALLIVLLQFPVARLVERFRLRKILMIGI-----------LLFAI 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 287 GLGPPFLGFTTVAVGFGFLLFSL-----EALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLF 361
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLgemlvFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
....
gi 1670351916 362 GLLA 365
Cdd:cd17329 359 LILA 362
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-259 |
1.16e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.31 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 30 IPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGAL 109
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 110 GLFSSAYHPTGLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAYVGATLAFGASWR---LVAGSLILPAVIAsVLLLVE 184
Cdd:cd17328 98 GIGEASYSPIAPTIIADLFPKEKRTraLGVFYFAIPLGSGLGYVVGGLVAQATGGWRwafRVTGVLGVLLAIL-LLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 185 RLPRGVLKSPAVLGGARRGLAS--------RPYGLILLVYMFAGFAYQGGLTFLPRFI--------------GAGFFAAA 242
Cdd:cd17328 177 EPPRGAAEGGVMAKSTATSFLAdlkalaknPSFILSTLGFTAVSFVTGALAFWAPTFFlrafgvgdlssadvGLIFGAIT 256
|
250
....*....|....*..
gi 1670351916 243 LGLGAVGQVLSGTLADR 259
Cdd:cd17328 257 CIAGVLGVLLGGILADR 273
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
48-177 |
1.27e-06 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 50.05 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 48 LGLLAASAYIPYGLGSVPFGFLADGRAPDRLL-------LVCAFGIAGSMAAVAASPSLpvLAASLGALGLFSSAYHPTG 120
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLpfllilsAICMLGFGASLGSGSVSLGL--MIALWALSGFFQSTGGPCS 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1670351916 121 LSVISRTV--TEQGRGMGW----HGMGGSLgiAAGPAYVGATLAFGASwrlVAGSLILPAVIA 177
Cdd:PRK09556 144 YSTITRWTprRKRGRFLGFwnisHNLGGAG--AGGVALWGANYFFDGH---VIGMFIFPSIIA 201
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-354 |
1.39e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.07 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 48 LGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRT 127
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 128 V--TEQGRGMGWHGMGGSLGIAAGPAYVGATLAFGASWRLVagsLILPAVIASV-----LLLVERLPRGVLKSPAVL--- 197
Cdd:TIGR00881 112 FsrSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV---FIVPGIIAIIvslicFLLLRDSPQSCGLPPAEEmpn 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 198 ------------------GGARRGLASRPYGLILLVYMFAGFAYQGGLTFLPRF---------IGAGFFAAALGLGA-VG 249
Cdd:TIGR00881 189 eepdgdaekkeeeltkkqIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYltqekgfskEKASWAFTLYELGGlVG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 250 QVLSGTLADRR-RPDRTLFALSTAAAGSLAAAGVLLVAGLGPPFLgfTTVAVGFGFLLFSLEALQNTLVTREAPRDARGL 328
Cdd:TIGR00881 269 TLLAGWLSDKLfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMD--LICLFALGFLVYGPQMLIGVIASELAPKKAAGT 346
|
330 340
....*....|....*....|....*.
gi 1670351916 329 AFGFTFLSVFGIGAMGATLAGYLLDR 354
Cdd:TIGR00881 347 AAGFVGFFAYLGGILAGLPLGYLADG 372
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-376 |
1.54e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.49 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 40 EFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPT 119
Cdd:cd17319 32 DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 120 GLSVISR--TVTEQGRGMGWHGMGGSLGIAAGPAYVGAtLAFGASWRLVAGSLILPAVIASVLLLverlprgvlkspavl 197
Cdd:cd17319 112 AIKALAEwfPARERGRATGLFNSGAPLGAAIGPPLSGW-LLLLFGWRWAFIIEGLLGLLLAVLWW--------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 198 ggarrgLASRPYGLILLVYMFAGFAYQGGLTFLPRFI---------GAGFFAAA-LGLGAVGQVLSGTLADRRRPDRTlf 267
Cdd:cd17319 176 ------FYLRQVWGLALGYFGINYALYGLLTWLPTYLkqargfslkQVGLLAAIpFLAGAIGMILGGRLSDRLLRGAR-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 268 ALSTAAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQnTLVTREAPRDARGLAFGFTFLSVFGIGAMGATL 347
Cdd:cd17319 248 RLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW-SLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
330 340
....*....|....*....|....*....
gi 1670351916 348 AGYLLDRSEAPLLFGLLAGSLATSGAFAY 376
Cdd:cd17319 327 IGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
67-379 |
7.52e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 7.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 67 GFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQ--GRGMGWHGMGGSL 144
Cdd:cd17489 52 GRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSrrGEGIGYYGLATTL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 145 GIAAGPAYVGATLAFGASWRLVAGSLILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFAYQ 224
Cdd:cd17489 132 AMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 225 GGLTFLPRFI------GAGFFAAALGLGAVG-QVLSGTLADRRRPDRTLfalstaAAGSLAAAGVLLVAGLGPPFLGFTT 297
Cdd:cd17489 212 AISTFLPLYAaergisNAGLFFTVYAIALLLsRPFSGKLSDRKGPKTVI------IPGLLLLALGLLLLSFAGSPWMLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 298 VAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLATSGAFAYA 377
Cdd:cd17489 286 AAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
..
gi 1670351916 378 AG 379
Cdd:cd17489 366 LL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-183 |
9.42e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 9.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 31 PVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALG 110
Cdd:cd17325 220 PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1670351916 111 LFSSAYHPTGLSVISRTVTEQGRG--MGWHGMGGSLGIAAGPAYVGATL-AFGASWRLVAGSLILPAVIASVLLLV 183
Cdd:cd17325 300 LGLGLVFPATLALLADIVPPEGRGtaMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
57-379 |
7.56e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 7.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 57 IPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVTE--QGRG 134
Cdd:cd17321 42 LAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGerRGRA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 135 MGWHGMGGSLGIAAGPAYVGATLAFgASWRLVagsLILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLasrpygLILL 214
Cdd:cd17321 122 LGLWGAVVGIGAALGPLLGGLLLEL-FGWRWI---FLINVPIGLVALLLARTFSGAVLAAFLLGAALGGL------LFLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 215 VYMFAGF----AYQGGLTFLPRFIGAGFFAaalglgavgqVLSGTLADRRRPdRTLFALSTAAAGSLAAAGVLLVAGLGP 290
Cdd:cd17321 192 PLYLQGVlgysPLQAGLALLPLALAMLVAA----------PLAGRLADRFGP-RLVLVAGLLLTAVGLLLLALLGADSSV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 291 PFLGFTTVAVGFGFLLFSleALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMGATLAGYLLDRSEAPLLFGLLAGSLAT 370
Cdd:cd17321 261 WLLLPGLVLLGLGLGLFA--TPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLS 338
|
....*....
gi 1670351916 371 SGAFAYAAG 379
Cdd:cd17321 339 AAAAAFAAG 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-353 |
1.06e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 79 LLVCAFGIAGSMAAVAASPSLPVLAASLGALG---LFSSAYH----PTG--LSVISRTVTEQGRGMGWHGMGGSLGIAAG 149
Cdd:COG2211 84 ILIGAIPLALSFVLLFTAPDLSPTGKLIYALVtylLLGLAYTlvniPYSalGAELTPDYEERTRLSSWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 150 PA-------YVGATLAFGASWRLVAGSLILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLASRPYGLILLVYMFAGFA 222
Cdd:COG2211 164 SVlppplvaAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 223 YQGGLTFLPRFI----------GAGFFAAALGLGAVGQVLSGTLADRRRPDRTLFALSTAAAGSLAAAGVLLVAGLGPPF 292
Cdd:COG2211 244 LALVAALLLYYFkyvlglsaalVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1670351916 293 LGFTTVAVGFGFLLFSLEALQNTLVTREAPR---DARGLAFG-FTFLSVFGiGAMGATLAGYLLD 353
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrRREGLYFGiFTFAIKLG-QALAGALAGLLLA 387
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
48-183 |
4.16e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 48 LGLLAASAYIPYGLGSVPFGFLADGRAPDRL----LLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSV 123
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFlaigLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRT 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1670351916 124 ISR--TVTEQGRGMGW----HGMGGslGIAAGPAYVGATLAFGASWRlvaGSLILPAVIASVLLLV 183
Cdd:cd17345 120 MVHwfSKKERGTWTSIwnisHNVGG--GLVGPLAGLGLAIFGDGWWR---GAFIFPAIIAIIVAVI 180
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
60-190 |
4.27e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 60 GLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPT--GLSVISRTVTEQGRGMGW 137
Cdd:PRK11551 269 ALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVlyALAPLFYPTQVRGTGVGA 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1670351916 138 HGMGGSLGIAAGPAYVGATLAFGASWRLVAGSLILPAVIASV--LLLVERLPRGV 190
Cdd:PRK11551 349 AVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASIPVILVAALaaLLLVSRPSRAD 403
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
67-307 |
1.04e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 67 GFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVISRTVT--EQGRGMGWHGMGGSL 144
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPpeKRGAAMGLVGLVILL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 145 GIAAGPAyVGATLAFGASWRLVAGSLILPAVIASVLLLVERLprgvlkspavlggarRGLASRPYGLILLVYMFAGFAYQ 224
Cdd:cd17503 132 APAIGPT-LGGWLTDNLSWRWIFYINLPIGILALLLAPLLDL---------------RLFKDRNFTLGLLLSFLLGLGLF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 225 GGLTFLPRFIG---------AGFFAAALGLGAVG-QVLSGTLADRRRPdRTLFALSTAAAGSLAAAGVLLVAGLGPPFLG 294
Cdd:cd17503 196 GAMFLLPLYLQnvlgysafeSGLVLAPGGLASAIlSPLVGRLLDKFGP-RLLLLAGLLLLALGTLLLAFLTPDTSLWLII 274
|
250
....*....|...
gi 1670351916 295 FTTVAVGFGFLLF 307
Cdd:cd17503 275 LPLFIRGLGMGLV 287
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-352 |
2.53e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.56 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 18 FLHGTVHANILSIPVFLLAWQPEFRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASP 97
Cdd:cd17312 10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 98 SLPVLAASLGALGLFSSAYHPTGLSVISRTVTEQGRGMGWHGMGGSLGIAAGPAYVGAT-LAFGASWR---LVAGSLILP 173
Cdd:cd17312 90 SLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAAsLASYYGWRaafLVPGIVGLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 174 AVIASVLLLVERlPRGVLkspavlggarrglasrpygLILLVYMFAGFAYQGGLTFLPRF---------IGAGFFAAALG 244
Cdd:cd17312 170 VAIILFFFLRDS-PPYVW-------------------VLSLAYAFVYIVRYACLDWGPLYlyevkgyslIDAGWFSSLYE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 245 L-GAVGQVLSGTLADRRRPDRTLFALSTAAAGSLAAAGVLLVAGlGPPFLGFTTVAVgFGFLLFSLEALQNTLVTREAPR 323
Cdd:cd17312 230 VgGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFP-HNKLLSIVLLFL-IGFFVGGPINLIGGAAAQDIGR 307
|
330 340 350
....*....|....*....|....*....|
gi 1670351916 324 -DARGLAFGFtflsVFGIGAMGATLAGYLL 352
Cdd:cd17312 308 kEAAGTATGF----VGLFGYLGASLAGLPL 333
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-182 |
3.29e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.14 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 41 FRADNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTG 120
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1670351916 121 LSVISRTVTEQ--GRGMGWHGMGGSLGIAAGPAYVG-ATLAFGASWRLVAGSLILPAVIASVLLL 182
Cdd:cd06173 319 NTLLQLRVPDElrGRVFSVYNALNSGAMPLGALLAGlLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-365 |
3.90e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.12 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 64 VPFGFLAD--GRAPdrLLLVC-AFGIAGS-MAAVAASPSLPVLAASLGALGLFSSAyhptGLSVISRTVTEQGRGMGWHG 139
Cdd:cd17472 50 IPFGLLSDriGRKP--VILFGlLLFIAGSlLAAYATSIYGLILGRALQGSGAISSV----VMALLADLTREENRTKAMAL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 140 MGGSLGIAAGPAYVGATL---AFGASWRLVAGSLILPAVIASVLLLVERLPRGVLKSPAVLGGARRGLASRPY------G 210
Cdd:cd17472 124 IGASIGIAFAISMVLGPLlaaHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLlrldfsI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 211 LILLVYMFAGFaYQGGLTFLPRFIGAGF----FAAALGLGAVGQVLSGTLADRRRPDRTLFALSTAAAGSLAAAGVLLVA 286
Cdd:cd17472 204 FILHFVLMAFF-YILPLLLTQLGGGKGQlwkvYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAAT 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 287 GLGPPFLGFTTVAVGFgfllFSLEALQNTLVTREAPRDARGLAFG----FTFLSVFgigaMGATLAGYLLDRSEAPLLFG 362
Cdd:cd17472 283 SLWLLIIGLIIFFIGF----NLLEALLPSLVSKIAPKEYRGTAMGiyntSQFLGSF----LGGALGGLLWGLLGYSSVFL 354
|
...
gi 1670351916 363 LLA 365
Cdd:cd17472 355 TIL 357
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
48-268 |
5.73e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.51 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 48 LGLLAASAYIPYGLGSVPFGFLADGRAPDR--LLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSVIS 125
Cdd:pfam06779 30 AGLLAAANYAGYLAGALLASFAWRHGASRLrpALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAVMIFGSSLIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 126 RTVTEQGRG--MGWHGMGGSLGIAAGPAYVGATLAFG---ASWRLVAGSLILPAVIASVLLLVERLPRGvlkSPAVLGGA 200
Cdd:pfam06779 110 GHATAARRAfvGALLFAGVGIGIALSGLLVPLGLQLGlggSSLWYGAGVLSAVLTLAVFPLLPRRAPRH---ASAPAPAA 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1670351916 201 RRGLASRPYGLILLVYMFAGFAYQGGLTFLPRFIGAGFFAAAL--------GLGAVGQVLSGTLADRRRPDRTLFA 268
Cdd:pfam06779 187 KPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAaalfwslfGLAAALGVLVWLRAAKRWGTRPALT 262
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
44-375 |
6.70e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 6.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 44 DNLTLGLLAASAYIPYGLGSVPFGFLADGRAPDRLLLVCAFGIAGSMAAVAASPSLPVLAASLGALGLFSSAYHPTGLSV 123
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 124 ISRTVTEQGRG--MGWHGMGGSLGIAAGPA---YVGATLAFGASWRLVAGSLILPAVIASVLllverlprgvlkspavlg 198
Cdd:cd17316 114 VAEFAPSKRRGfaLGLLQSGWALGALLAALvasLLIPLLSGDWGWRILFLIGALPALLALLL------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 199 gaRRGLAsrpygLILLVYMFAGFAYQGGLTFLPRFIGAG----------FFAAALGLGAVGQVLSGTLADRRRPDRTLFA 268
Cdd:cd17316 176 --RRRTL-----LLILLWFFISFGYYGLTTFLPTYLQTVlglspatsslYLLLISLGALVGALIAGLLSDRIGRKKTLVI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1670351916 269 lstaAAGSLAAAGVLLVAGLGPPFLGFTTVAVGFGFLLFSLEALQNTLVTREAPRDARGLAFGFTFLSVFGIGAMGATLA 348
Cdd:cd17316 249 ----GLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI 324
|
330 340
....*....|....*....|....*..
gi 1670351916 349 GYLLDRSEAPLLFGLLAGSLATSGAFA 375
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVALIV 351
|
|
| |
