hypothetical protein EX895_004030 [Sporisorium graminicola]
Protein Classification
CUE domain-containing protein( domain architecture ID 10199116)
CUE domain-containing protein similar to Candida albicans coupling of ubiquitin conjugation to ER degradation protein 1 (CUE1), a component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CUE_Cue1p_like | cd14424 | CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ... |
49-85 | 4.64e-18 | ||
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p. : Pssm-ID: 270607 Cd Length: 37 Bit Score: 74.47 E-value: 4.64e-18
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| Name | Accession | Description | Interval | E-value | ||
| CUE_Cue1p_like | cd14424 | CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ... |
49-85 | 4.64e-18 | ||
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p. Pssm-ID: 270607 Cd Length: 37 Bit Score: 74.47 E-value: 4.64e-18
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
51-87 | 1.06e-08 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 49.40 E-value: 1.06e-08
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
49-87 | 1.62e-07 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 46.33 E-value: 1.62e-07
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| Name | Accession | Description | Interval | E-value | ||
| CUE_Cue1p_like | cd14424 | CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ... |
49-85 | 4.64e-18 | ||
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p. Pssm-ID: 270607 Cd Length: 37 Bit Score: 74.47 E-value: 4.64e-18
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| CUE_AUP1_AMFR_like | cd14376 | CUE domain found in ancient ubiquitous protein 1 (AUP1), autocrine motility factor receptor ... |
49-85 | 9.03e-11 | ||
CUE domain found in ancient ubiquitous protein 1 (AUP1), autocrine motility factor receptor (AMFR) and similar proteins; AUP1 is a component of the HRD1-SEL1L endoplasmic reticulum (ER) quality control complex and is essential for US11-mediated dislocation of class I MHC heavy chains. AMFR is an internalizing cell surface glycoprotein that is localized in both plasma membrane caveolae and the ER, and involves in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. Cue1p is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). This family also includes plant E3 ubiquitin protein ligases RIN2, RIN3, and similar proteins. Comparing with other CUE domain-containing proteins, some family members from higher eukaryotes do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. Pssm-ID: 270559 Cd Length: 37 Bit Score: 55.18 E-value: 9.03e-11
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
51-87 | 1.06e-08 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 49.40 E-value: 1.06e-08
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
49-87 | 1.62e-07 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 46.33 E-value: 1.62e-07
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| CUE_AMFR | cd14421 | CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins; AMFR is an ... |
49-86 | 9.10e-07 | ||
CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins; AMFR is an internalizing cell surface glycoprotein that is localized in both plasma membrane caveolae and the endoplasmic reticulum (ER), and involves in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. It is also called ER-protein gp78 that has been identified as a RING finger-dependent ubiquitin protein ligase (E3) implicated in degradation from the ER. AMFR contains an N-terminal RING-finger domain and a C-terminal CUE domain. Pssm-ID: 270604 Cd Length: 41 Bit Score: 44.18 E-value: 9.10e-07
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| CUE_AUP1 | cd14420 | CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a ... |
48-88 | 2.46e-04 | ||
CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a component of the HRD1-SEL1L endoplasmic reticulum (ER) quality control complex and is essential for US11-mediated dislocation of class I MHC heavy chains. It also binds to the membrane-proximal KVGFFKR motif of the cytoplasmic tail of the integrin alphaCTs that plays a crucial role in the inside-out signaling of alpha(IIb)beta(3). AUP1 is found in both the ER and in lipid droplets. It contains two conserved cytoplasmic domains, an acyltransferase domain, a CUE domain and an E2 ubiquitin conjugase G2 (Ube2g2)-binding domain (G2BR). The acyltransferase domain transfers fatty acids onto phospholipids and CUE domain participates in ubiquitin binding or in recruitment of ubiquitin-conjugating enzymes to the site of dislocation. Pssm-ID: 270603 Cd Length: 45 Bit Score: 37.59 E-value: 2.46e-04
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| CUE_RIN3_plant | cd14422 | CUE domain found in plant E3 ubiquitin protein ligases RIN2, RIN3 and similar proteins; RIN2 ... |
51-85 | 2.88e-04 | ||
CUE domain found in plant E3 ubiquitin protein ligases RIN2, RIN3 and similar proteins; RIN2 and RIN3 are two closely related RPM1-interacting proteins conserved in higher eukaryotes. They are orthologs of the mammalian autocrine motility factor receptor (AMFR), a cytokine receptor localized in both plasma membrane caveolae and the endoplasmic reticulum (ER). RIN2 and RIN3 have been identified as membrane-bound RING-finger type ubiquitin ligases with six apparent transmembrane domains, a RING-finger domain and a CUE domain. They act as positive regulators of RPM1- and RPS2-dependent hypersensitive response (HR). Pssm-ID: 270605 Cd Length: 38 Bit Score: 37.27 E-value: 2.88e-04
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