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Conserved domains on  [gi|1616137393|gb|THB56968|]
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triose-phosphate isomerase [Klebsiella pneumoniae]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-253 5.40e-112

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 322.39  E-value: 5.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   1 MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQThqLPLLTGAQNMHEADQGAWTG 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAG--SPIALGAQNVHWEDSGAYTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  81 EISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSH 160
Cdd:COG0149    77 EISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 161 QQALRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR 240
Cdd:COG0149   157 EQAANVVIAYEPVWAIGT-GKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|...
gi 1616137393 241 AAWDAQGYCDIVQ 253
Cdd:COG0149   236 ASLDAEDFLAIVR 248
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-253 5.40e-112

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 322.39  E-value: 5.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   1 MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQThqLPLLTGAQNMHEADQGAWTG 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAG--SPIALGAQNVHWEDSGAYTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  81 EISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSH 160
Cdd:COG0149    77 EISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 161 QQALRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR 240
Cdd:COG0149   157 EQAANVVIAYEPVWAIGT-GKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|...
gi 1616137393 241 AAWDAQGYCDIVQ 253
Cdd:COG0149   236 ASLDAEDFLAIVR 248
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-253 9.44e-108

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 311.67  E-value: 9.44e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEGchPAIQPFVIPPFTAIQPVSHFLQTHqlPLLTGAQNMHEADQGAWTGEISA 84
Cdd:PRK00042    4 IIAGNWKMNKTLAEAKALVEELKAALPDA--DGVEVAVAPPFTALASVKEALKGS--NIKLGAQNVHPEDSGAFTGEISA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQAL 164
Cdd:PRK00042   80 EMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGeHGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:PRK00042  160 NLVIAYEPVWAIG-TGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLK 237


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:PRK00042  238 AEDFLAIVK 246
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-253 5.18e-100

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 291.75  E-value: 5.18e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQTHQLPLltGAQNMHEADQGAWTGEISA 84
Cdd:cd00311     2 LVAGNWKMNGTLAEALELAKALNAVLKD--ESGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGEISA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLShqQAL 164
Cdd:cd00311    78 EMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVE--DLA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:cd00311   156 PVVIAYEPVWAIGT-GKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:cd00311   234 AESFLDIIK 242
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-253 1.80e-92

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 272.85  E-value: 1.80e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQThqlPLLTGAQNMHEADQGAWTGEISA 84
Cdd:pfam00121   2 IIAGNWKMNGTLAEAAELLAELAEALAD--ESGVEVVVAPPFTYLSAVAELLGS---NIKVGAQNVDPEESGAFTGEISA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQAl 164
Cdd:pfam00121  77 EMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQK- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:pfam00121 156 NLVIAYEPVWAIGT-GKTATPEQAQEVHAFIRAVLAELYK-EVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLK 233


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:pfam00121 234 AEDFLDIIN 242
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 23-241 2.26e-25

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 99.49  E-value: 2.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  23 CETLAArmPEGCHPAIQPfvipPFTAIQPVSHflqthQLPLLTGAQNMHEADQGAWTGEISAAMLAETGATLVELGHSER 102
Cdd:TIGR00419  24 AEEVAS--EAGVAVAVAP----PFVDLPMIKR-----EVEIPVYAQHVDAVLSGAHTGEISAEMLKDIGAKGTLINHSER 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 103 RAAfnESDaaINRKVHSALGHGLRPLICIgdsaeekrwqvsrESVVRQMKIALYGlshqqalRTLIAYEPVWAIGEhGTP 182
Cdd:TIGR00419  93 RMK--LAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAALE-------PDVVAVEPPELIGT-GIP 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1616137393 183 ASPQEAGVIHQALRQAlcerfgHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRA 241
Cdd:TIGR00419 148 VSPAQPEVVHGSVRAV------KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASG 200
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-253 5.40e-112

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 322.39  E-value: 5.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   1 MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQThqLPLLTGAQNMHEADQGAWTG 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAG--SPIALGAQNVHWEDSGAYTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  81 EISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSH 160
Cdd:COG0149    77 EISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 161 QQALRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR 240
Cdd:COG0149   157 EQAANVVIAYEPVWAIGT-GKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|...
gi 1616137393 241 AAWDAQGYCDIVQ 253
Cdd:COG0149   236 ASLDAEDFLAIVR 248
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-253 9.44e-108

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 311.67  E-value: 9.44e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEGchPAIQPFVIPPFTAIQPVSHFLQTHqlPLLTGAQNMHEADQGAWTGEISA 84
Cdd:PRK00042    4 IIAGNWKMNKTLAEAKALVEELKAALPDA--DGVEVAVAPPFTALASVKEALKGS--NIKLGAQNVHPEDSGAFTGEISA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQAL 164
Cdd:PRK00042   80 EMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGeHGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:PRK00042  160 NLVIAYEPVWAIG-TGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLK 237


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:PRK00042  238 AEDFLAIVK 246
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-253 5.18e-100

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 291.75  E-value: 5.18e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQTHQLPLltGAQNMHEADQGAWTGEISA 84
Cdd:cd00311     2 LVAGNWKMNGTLAEALELAKALNAVLKD--ESGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGEISA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLShqQAL 164
Cdd:cd00311    78 EMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVE--DLA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:cd00311   156 PVVIAYEPVWAIGT-GKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:cd00311   234 AESFLDIIK 242
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-253 1.80e-92

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 272.85  E-value: 1.80e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETLAARMPEgcHPAIQPFVIPPFTAIQPVSHFLQThqlPLLTGAQNMHEADQGAWTGEISA 84
Cdd:pfam00121   2 IIAGNWKMNGTLAEAAELLAELAEALAD--ESGVEVVVAPPFTYLSAVAELLGS---NIKVGAQNVDPEESGAFTGEISA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  85 AMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQAl 164
Cdd:pfam00121  77 EMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQK- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 165 RTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWD 244
Cdd:pfam00121 156 NLVIAYEPVWAIGT-GKTATPEQAQEVHAFIRAVLAELYK-EVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLK 233


                  ....*....
gi 1616137393 245 AQGYCDIVQ 253
Cdd:pfam00121 234 AEDFLDIIN 242
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 4-248 6.40e-73

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 226.84  E-value: 6.40e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   4 IWLGTSWKMNKP-------LSQAMAWCETLAARMPegchpaIQPFVIPPFTAIQPVSHFL--QTHQLPLLTGAQNMHEAD 74
Cdd:PRK14905    5 IYFGTNLKMYKGnaetvdyLSELLAFAEKFKSDYD------IELFVIPSYIALKDAVEAAasETGHPKIKIGAQNMNAKD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  75 QGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIA 154
Cdd:PRK14905   79 KGQFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 155 LYGLSHQQALRTLIAYEPVWAIGEHGTPASPQEAGVIHQALRQALCERFGHETgTRIPLLYGGSVTLQNAVELLRQQEIN 234
Cdd:PRK14905  159 LHGVSAEQLPHLFIAYEPVWAIGEGGIPASAEYADEKHAIIKQCLFELFAEES-KKIPVLYGGSVNLENANELIMKPHID 237

                         250
                  ....*....|....
gi 1616137393 235 GLFIGRAAWDAQGY 248
Cdd:PRK14905  238 GLFIGRSAWDAQCF 251
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 1-255 1.12e-72

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 222.95  E-value: 1.12e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   1 MTPIWLGTSWKMNKPLSQAMAWCetlaARMPEGCH--PA---IQPFVIPPFTAIQ-PVSHFLQT-HQLPLLTGAQNMHEA 73
Cdd:PRK15492    1 MKKIYFGTNLKMYKGIADATDFL----AKLSELADdiPAdkdIELFVIPSFTAIQdAIAATLAIpHDHPIIIGAQNMNPN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  74 DQGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKI 153
Cdd:PRK15492   77 DNGQFTGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 154 ALYGLSHQQALRTLIAYEPVWAIGEHGTPASPQEAGVIHQALRQALCERFGhETGTRIPLLYGGSVTLQNAVELLRQQEI 233
Cdd:PRK15492  157 GLHGINPDQLAKLRIAYEPVWAIGEAGIPASADYADEKHAVIKQCLIELFG-DAGDDIPVFYGGSVNAENANELFGQPHI 235

                         250       260
                  ....*....|....*....|..
gi 1616137393 234 NGLFIGRAAWDAQGYCDIVQRV 255
Cdd:PRK15492  236 DGLFIGRSAWDADKFFAIIEGI 257
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 2-256 1.50e-69

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 225.76  E-value: 1.50e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   2 TPIWLGtSWKMNKPLSQAMAWCETLAARMPEGCHPAIqpfVIPPFTAIQPVSHFLQTHQLPLltGAQNMHEADQGAWTGE 81
Cdd:PRK13962  398 KPIIAG-NWKMNKTPAEAKEFVNELKKYVKDAQAEVV---VCPPFTALPSVKEAVDGSNIKL--GAQNVFYEEKGAYTGE 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  82 ISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQ 161
Cdd:PRK13962  472 ISGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNGLSAE 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 162 QALRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRA 241
Cdd:PRK13962  552 QVKKVVIAYEPVWAIGT-GKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGA 630

                         250
                  ....*....|....*
gi 1616137393 242 AWDAQGYCDIVQRVT 256
Cdd:PRK13962  631 SLKAQEFAAIANYFI 645
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 5-257 9.82e-50

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 163.93  E-value: 9.82e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNkpLSQAMAwcETLAARMPEGCHP--AIQPFVIPPFTAIQPVSHFLQTHQLPLltGAQNMHEADQGAWTGEI 82
Cdd:PTZ00333    7 FVGGNWKCN--GTKASI--KELIDSFNKLKFDpnNVDVVVAPPSLHIPLVQEKLKNKNFKI--SSQNVSLTGSGAFTGEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  83 SAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEkRWQVSRESVVR-QMKIALYGLSHQ 161
Cdd:PTZ00333   81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEE-REAGQTSDVLSkQLEAIVKKVSDE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 162 QALRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRA 241
Cdd:PTZ00333  160 AWDNIVIAYEPVWAIGT-GKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGA 238

                         250
                  ....*....|....*.
gi 1616137393 242 AWDAQgYCDIVQRVTQ 257
Cdd:PTZ00333  239 SLKPD-FVDIIKSAEQ 253
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 10-255 4.74e-43

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 146.44  E-value: 4.74e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  10 WKMNKPLSQAMAWCETLAARMPEGCHpAIQPFVIPPFTAIQPVSHFLQTHQLplltGAQNMHEADQGAWTGEISAAMLAE 89
Cdd:PRK14565    9 WKMNGDFSLFSSFLKELSNKLANNEI-TLKLVICPPFTAMSSFVECNPNIKL----GAQNCFYGSSGGYTGEISAKMLKE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  90 TGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIAL--YGlshqqalRTL 167
Cdd:PRK14565   84 CGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCLpkHG-------EFI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 168 IAYEPVWAIGEHGTPASpqeagvihQALRQALCERFGHETGTRIplLYGGSVTLQNAVELLRQQEINGLFIGRAAWDAQG 247
Cdd:PRK14565  157 IAYEPVWAIGGSTIPSN--------DAIAEAFEIIRSYDSKSHI--IYGGSVNQENIRDLKSINQLSGVLVGSASLDVDS 226


                  ....*...
gi 1616137393 248 YCDIVQRV 255
Cdd:PRK14565  227 FCKIIQQV 234
PLN02561 PLN02561
triosephosphate isomerase
 5-256 4.11e-39

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 136.49  E-value: 4.11e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393   5 WLGTSWKMNKPLSQAMAWCETL-AARMPegCHPAIQPFVIPPFTAIQPVSHFLQTHqlpLLTGAQNMHEADQGAWTGEIS 83
Cdd:PLN02561    6 FVGGNWKCNGTVEEVKKIVTTLnEAEVP--SEDVVEVVVSPPFVFLPLVKSLLRPD---FQVAAQNCWVKKGGAFTGEIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  84 AAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQa 163
Cdd:PLN02561   81 AEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVSDWA- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 164 lRTLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAW 243
Cdd:PLN02561  160 -NVVLAYEPVWAIGT-GKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASL 237

                         250
                  ....*....|...
gi 1616137393 244 DAQgYCDIVQRVT 256
Cdd:PLN02561  238 KPE-FIDIIKSAT 249
PLN02429 PLN02429
triosephosphate isomerase
 42-258 1.31e-33

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 124.13  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  42 VIPPFTAIQPVSHFLqTHQLPLltGAQNMHEADQGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSAL 121
Cdd:PLN02429  101 VSPPFVYIDQVKSSL-TDRIDI--SGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYAL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 122 GHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQALrtLIAYEPVWAIGEhGTPASPQEAGVIHQALRQALCE 201
Cdd:PLN02429  178 SEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWDNI--VVAYEPVWAIGT-GKVASPQQAQEVHVAVRGWLKK 254

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1616137393 202 RFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRAAWDAQGYCDIVQRVTQE 258
Cdd:PLN02429  255 NVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATIVNSVTSK 311
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 23-241 2.26e-25

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 99.49  E-value: 2.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  23 CETLAArmPEGCHPAIQPfvipPFTAIQPVSHflqthQLPLLTGAQNMHEADQGAWTGEISAAMLAETGATLVELGHSER 102
Cdd:TIGR00419  24 AEEVAS--EAGVAVAVAP----PFVDLPMIKR-----EVEIPVYAQHVDAVLSGAHTGEISAEMLKDIGAKGTLINHSER 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 103 RAAfnESDaaINRKVHSALGHGLRPLICIgdsaeekrwqvsrESVVRQMKIALYGlshqqalRTLIAYEPVWAIGEhGTP 182
Cdd:TIGR00419  93 RMK--LAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAALE-------PDVVAVEPPELIGT-GIP 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1616137393 183 ASPQEAGVIHQALRQAlcerfgHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRA 241
Cdd:TIGR00419 148 VSPAQPEVVHGSVRAV------KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASG 200
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 42-130 2.71e-08

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 52.95  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  42 VIPPFTAIQPVShflQTHQLPLLtgAQNMHEADQGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRkvhsAL 121
Cdd:PRK04302   41 VAPQALDIRRVA---EEVDIPVY--AQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTLADIEAVVER----AK 111


                  ....*....
gi 1616137393 122 GHGLRPLIC 130
Cdd:PRK04302  112 KLGLESVVC 120
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 48-240 8.44e-03

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 36.41  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393  48 AIQPVSHFLQTHQLPLLTGAQNMHEADQGAWtgEISAAMLAETGATLVELGHSERRAAfnESDAAINRKVHSALGHGLrP 127
Cdd:cd04722    43 TDDKEVLKEVAAETDLPLGVQLAINDAAAAV--DIAAAAARAAGADGVEIHGAVGYLA--REDLELIRELREAVPDVK-V 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616137393 128 LICIGDSAEEKRwqvsresvvrqMKIALYGLshqqalrTLIAYEPVWaigehGTPASPQEAGVIHQALRQALCerfghet 207
Cdd:cd04722   118 VVKLSPTGELAA-----------AAAEEAGV-------DEVGLGNGG-----GGGGGRDAVPIADLLLILAKR------- 167

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1616137393 208 GTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR 240
Cdd:cd04722   168 GSKVPVIAGGGINDPEDAAEALALGADGVIVGS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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