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Conserved domains on  [gi|1615743461|gb|TGZ63630|]
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hypothetical protein CRM22_006831 [Opisthorchis felineus]

Protein Classification

peroxiredoxin-like family protein( domain architecture ID 10121943)

peroxiredoxin (PRX)-like family protein containing a CXXC motif, with the second cysteine in the motif corresponding to the peroxidatic cysteine of PRX, however, it does not contain the other two residues of the catalytic triad of PRXs; similar to vertebrate peroxiredoxin-like 2A, 2B (prostamide/prostaglandin F synthase) and 2C

CATH:  3.40.30.10
PubMed:  15518547|12517450|10049365
SCOP:  3000031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 21-121 8.15e-26

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


:

Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 98.20  E-value: 8.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615743461  21 NSFSVESFWRDQTCVIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG-IKDFVDGNFFKGELFLDPDRST 99
Cdd:cd02970    13 ETVTLSALLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPEkLEAFDKGKFLPFPVYADPDRKL 92

                          90       100
                  ....*....|....*....|..
gi 1615743461 100 YRAMDFKRVSSLSGFKSLFTKA 121
Cdd:cd02970    93 YRALGLVRSLPWSNTPRALWKN 114
 
Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 21-121 8.15e-26

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 98.20  E-value: 8.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615743461  21 NSFSVESFWRDQTCVIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG-IKDFVDGNFFKGELFLDPDRST 99
Cdd:cd02970    13 ETVTLSALLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPEkLEAFDKGKFLPFPVYADPDRKL 92

                          90       100
                  ....*....|....*....|..
gi 1615743461 100 YRAMDFKRVSSLSGFKSLFTKA 121
Cdd:cd02970    93 YRALGLVRSLPWSNTPRALWKN 114
AhpC-TSA_2 pfam13911
AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide ...
 54-126 2.55e-11

AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 433575  Cd Length: 114  Bit Score: 58.86  E-value: 2.55e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1615743461  54 LSQMKPAFDKRRIRLVGISF-DENGIKDFVDGNFFKGELFLDPDRSTYRAMDFKRVSSLsGFKSLFTKAGRDLN 126
Cdd:pfam13911   2 LSSLKPELDAAGIRLVAIGCgTPGRIEEFIKLTGFPFPVYVDPSRKLYRALGLKRGLSG-GLLPGFLGKGLRNM 74
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
35-102 1.07e-05

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 43.70  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1615743461  35 VIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG-IKDFVDGNFFKGELFLDPDRSTYRA 102
Cdd:COG1225    24 VVLYFYATWCPGCTAELPELRDLYEEFKDKGVEVLGVSSDSDEaHKKFAEKYGLPFPLLSDPDGEVAKA 92
SelL_rel_redox NF040769
SelL-related redox protein; Members of this family are related to the C-terminal region of ...
 26-118 4.35e-05

SelL-related redox protein; Members of this family are related to the C-terminal region of selenoprotein L (SelL), found in many non-mammalian animals. But while SelL itself has a pair of selenocysteine (U) residues (e.g. XP_029705782.1), typically in the motif ULPU, this family is defined more broadly. Most members of the seed alignment for this HMM are bacterial proteins that have one or zero selenocysteine residues, and are shorter than SelU, although SelU members are also included.


Pssm-ID: 468728  Cd Length: 172  Bit Score: 42.68  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615743461  26 ESFWRDQTCVIAIFRRFGCKFCRlEALN-LSQMKPAFDKRRIRLVGISFDENG-----IKDFVDGNFFkgeLFLDPDRST 99
Cdd:NF040769   19 LEFLPQGPLLLVFLRHLGUIPCR-EHLAqLREHQEEFAARGCRVLVVSFASPEfaekyLERTWLSWPL---VVSDPDRKL 94

                          90
                  ....*....|....*....
gi 1615743461 100 YRAMDFKRvsslSGFKSLF 118
Cdd:NF040769   95 YRAFGLKR----ATFLELW 109
 
Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 21-121 8.15e-26

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 98.20  E-value: 8.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615743461  21 NSFSVESFWRDQTCVIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG-IKDFVDGNFFKGELFLDPDRST 99
Cdd:cd02970    13 ETVTLSALLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPEkLEAFDKGKFLPFPVYADPDRKL 92

                          90       100
                  ....*....|....*....|..
gi 1615743461 100 YRAMDFKRVSSLSGFKSLFTKA 121
Cdd:cd02970    93 YRALGLVRSLPWSNTPRALWKN 114
AhpC-TSA_2 pfam13911
AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide ...
 54-126 2.55e-11

AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 433575  Cd Length: 114  Bit Score: 58.86  E-value: 2.55e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1615743461  54 LSQMKPAFDKRRIRLVGISF-DENGIKDFVDGNFFKGELFLDPDRSTYRAMDFKRVSSLsGFKSLFTKAGRDLN 126
Cdd:pfam13911   2 LSSLKPELDAAGIRLVAIGCgTPGRIEEFIKLTGFPFPVYVDPSRKLYRALGLKRGLSG-GLLPGFLGKGLRNM 74
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
35-102 1.07e-05

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 43.70  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1615743461  35 VIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG-IKDFVDGNFFKGELFLDPDRSTYRA 102
Cdd:COG1225    24 VVLYFYATWCPGCTAELPELRDLYEEFKDKGVEVLGVSSDSDEaHKKFAEKYGLPFPLLSDPDGEVAKA 92
AhpC-TSA pfam00578
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) ...
 30-104 4.16e-05

AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 425763 [Multi-domain]  Cd Length: 124  Bit Score: 41.83  E-value: 4.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1615743461  30 RDQTCVIAIFRRFGCKFCRLEALNLSQMKPAFDKRRIRLVGISFD-ENGIKDFVDGNFFKGELFLDPDRSTYRAMD 104
Cdd:pfam00578  24 RGKWVVLFFYPADWTPVCTTELPALADLYEEFKKLGVEVLGVSVDsPESHKAFAEKYGLPFPLLSDPDGEVARAYG 99
SelL_rel_redox NF040769
SelL-related redox protein; Members of this family are related to the C-terminal region of ...
 26-118 4.35e-05

SelL-related redox protein; Members of this family are related to the C-terminal region of selenoprotein L (SelL), found in many non-mammalian animals. But while SelL itself has a pair of selenocysteine (U) residues (e.g. XP_029705782.1), typically in the motif ULPU, this family is defined more broadly. Most members of the seed alignment for this HMM are bacterial proteins that have one or zero selenocysteine residues, and are shorter than SelU, although SelU members are also included.


Pssm-ID: 468728  Cd Length: 172  Bit Score: 42.68  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615743461  26 ESFWRDQTCVIAIFRRFGCKFCRlEALN-LSQMKPAFDKRRIRLVGISFDENG-----IKDFVDGNFFkgeLFLDPDRST 99
Cdd:NF040769   19 LEFLPQGPLLLVFLRHLGUIPCR-EHLAqLREHQEEFAARGCRVLVVSFASPEfaekyLERTWLSWPL---VVSDPDRKL 94

                          90
                  ....*....|....*....
gi 1615743461 100 YRAMDFKRvsslSGFKSLF 118
Cdd:NF040769   95 YRAFGLKR----ATFLELW 109
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 44-102 6.56e-03

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 35.29  E-value: 6.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1615743461  44 CKFCRLEALNLSQMKPAFDKRRIRLVGISFDENG---IKDFVDGNFFKGELFLDPDRSTYRA 102
Cdd:cd02966    31 CPPCRAEMPELEALAKEYKDDGVEVVGVNVDDDDpaaVKAFLKKYGITFPVLLDPDGELAKA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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