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Conserved domains on  [gi|1605840167|gb|TFO41023|]
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transcriptional regulator SlyA [Escherichia coli]

Protein Classification

ArsR family transcriptional regulator( domain architecture ID 10011959)

ArsR family transcriptional regulator such as transcriptional regulator SlyA can specifically activate or repress expression of target genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 1-144 3.82e-103

transcriptional regulator SlyA; Provisional


:

Pssm-ID: 179596  Cd Length: 144  Bit Score: 290.75  E-value: 3.82e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80
Cdd:PRK03573    1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605840167  81 CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLIAKLEHNIIELQAKG 144
Cdd:PRK03573   81 CASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKLEKNIIELQSKG 144
 
Name Accession Description Interval E-value
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 1-144 3.82e-103

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 290.75  E-value: 3.82e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80
Cdd:PRK03573    1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605840167  81 CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLIAKLEHNIIELQAKG 144
Cdd:PRK03573   81 CASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKLEKNIIELQSKG 144
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-136 1.51e-32

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 111.99  E-value: 1.51e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   2 ESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTC 81
Cdd:COG1846     9 EERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPD 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1605840167  82 ASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLIAKLEHN 136
Cdd:COG1846    88 PEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-123 9.07e-28

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 98.44  E-value: 9.07e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   22 HRLKPLELTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLIS 101
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGP-LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90       100
                   ....*....|....*....|..
gi 1605840167  102 EMEAVINKTRAEILHGISAEEL 123
Cdd:smart00347  80 QLLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-88 2.39e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.94  E-value: 2.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167  29 LTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAK 88
Cdd:pfam01047   1 LTLTQFHILRILYEHGP-LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
 
Name Accession Description Interval E-value
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 1-144 3.82e-103

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 290.75  E-value: 3.82e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80
Cdd:PRK03573    1 MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605840167  81 CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLIAKLEHNIIELQAKG 144
Cdd:PRK03573   81 CASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKLEKNIIELQSKG 144
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-136 1.51e-32

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 111.99  E-value: 1.51e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   2 ESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTC 81
Cdd:COG1846     9 EERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPD 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1605840167  82 ASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLIAKLEHN 136
Cdd:COG1846    88 PEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-123 9.07e-28

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 98.44  E-value: 9.07e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167   22 HRLKPLELTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLIS 101
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGP-LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90       100
                   ....*....|....*....|..
gi 1605840167  102 EMEAVINKTRAEILHGISAEEL 123
Cdd:smart00347  80 QLLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-88 2.39e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.94  E-value: 2.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167  29 LTQTHWVTLHNIHQLPPdQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAK 88
Cdd:pfam01047   1 LTLTQFHILRILYEHGP-LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-87 2.98e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.89  E-value: 2.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1605840167  29 LTQTHWVTLHNIHQLPPDqSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRA 87
Cdd:pfam12802   3 LTPAQFRVLLALARNPGL-TVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
29-96 3.07e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 44.97  E-value: 3.07e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1605840167  29 LTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKA 96
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
19-130 9.31e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 42.58  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167  19 LIDHRLKPLELTQTHWVTLHNIhQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEP 98
Cdd:PRK11512   28 LLNEYLSPLDITAAQFKVLCSI-RCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAA 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1605840167  99 LISEMEAVINKT-RAEILHGISAEE---LEQLIKLI 130
Cdd:PRK11512  107 ICEQCHQLVGQDlHQELTKNLTADEvatLEHLLKKV 142
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 48-102 4.28e-04

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 38.67  E-value: 4.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1605840167  48 SQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCAsdrRAKRIKLTEKAEPLISE 102
Cdd:COG1339    24 SSSELAKRLGISQQTASRRLQELEDAGLIERDLVG---DGQWVKITEKGEELLRR 75
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 51-133 1.26e-03

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 37.03  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167  51 QLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLIKLI 130
Cdd:PRK10870   76 ELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQIT 155


                  ...
gi 1605840167 131 AKL 133
Cdd:PRK10870  156 RKL 158
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
48-136 5.68e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 34.79  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605840167  48 SQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQtcasdrRAKRIKLTEKAEPLIsemEAVINKTR---------------- 111
Cdd:COG1321    26 RTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE------PYGGITLTEEGRELA---LRIVRRHRllerflvevlgvdwde 96

                          90       100       110
                  ....*....|....*....|....*....|
gi 1605840167 112 ----AEIL-HGISAEELEQLIKLIAKLEHN 136
Cdd:COG1321    97 aheeAERLeHVLSDETIERLDAFLGFPEED 126
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 41-101 7.45e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 34.89  E-value: 7.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605840167  41 HQLPPdqSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASdrRAKRIKLTEKAE---PLIS 101
Cdd:COG1974    22 RGYPP--SQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS--RAIELLPASPEVvglPLLG 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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