NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1593647798|gb|TDG95239|]
View 

hypothetical protein C5L28_001413 [Lentilactobacillus parakefiri]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 2.86e-40

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 131.58  E-value: 2.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   1 MYNNILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTnfyygAGAAGMPPSMYDDQHKIAENIIAEVKKYADSQG 80
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPP-----PSAAAGPEELEEELREEAEEALEEAAERLEEAG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1593647798  81 VNYETAIDIGNPKNIIAHvYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:COG0589    76 VEVETVVREGDPAEAILE-AAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 2.86e-40

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 131.58  E-value: 2.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   1 MYNNILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTnfyygAGAAGMPPSMYDDQHKIAENIIAEVKKYADSQG 80
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPP-----PSAAAGPEELEEELREEAEEALEEAAERLEEAG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1593647798  81 VNYETAIDIGNPKNIIAHvYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:COG0589    76 VEVETVVREGDPAEAILE-AAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-142 5.08e-34

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 115.91  E-value: 5.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   4 NILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAagmPPSMYDDQHKIAENIIAEVKKYADSQGVNY 83
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG---LEELADELKEEAEELLEEAKKLAEEAGVEV 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798  84 ETAIDIGNPKN-IIAHVypDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:cd00293    78 ETIVVEGDPAEaILEEA--KELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-142 2.56e-28

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 101.33  E-value: 2.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   5 ILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAAGMPPSMyDDQHKIAENIIAEVKKYADSQGVNYE 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEE-ELELELAEAEALAAAAAAEAGGVKVE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1593647798  85 TAIDIGNPKNIIAhVYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:pfam00582  80 VVVVVGDPAEEIL-EVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVV 136
PRK15005 PRK15005
universal stress protein UspF;
1-142 2.36e-10

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 55.19  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   1 MYNNILVPLD--GSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAA--GMPPSMYDDQHKIAENIIAEVKKYA 76
Cdd:PRK15005    1 MNRTILVPIDisDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPYYASLGLAysAELPAMDDLKAEAKSQLEEIIKKFK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593647798  77 DSQGvNYETAIDIGNPKNIIAHVyPDEHDVDLIVIGKSGVDaINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:PRK15005   81 LPTD-RVHVHVEEGSPKDRILEL-AKKIPADMIIIASHRPD-ITTYLLGSNAAAVVRHAECSVLVV 143
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 2.86e-40

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 131.58  E-value: 2.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   1 MYNNILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTnfyygAGAAGMPPSMYDDQHKIAENIIAEVKKYADSQG 80
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPP-----PSAAAGPEELEEELREEAEEALEEAAERLEEAG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1593647798  81 VNYETAIDIGNPKNIIAHvYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:COG0589    76 VEVETVVREGDPAEAILE-AAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-142 5.08e-34

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 115.91  E-value: 5.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   4 NILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAagmPPSMYDDQHKIAENIIAEVKKYADSQGVNY 83
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG---LEELADELKEEAEELLEEAKKLAEEAGVEV 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798  84 ETAIDIGNPKN-IIAHVypDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:cd00293    78 ETIVVEGDPAEaILEEA--KELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-142 2.56e-28

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 101.33  E-value: 2.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   5 ILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAAGMPPSMyDDQHKIAENIIAEVKKYADSQGVNYE 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEE-ELELELAEAEALAAAAAAEAGGVKVE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1593647798  85 TAIDIGNPKNIIAhVYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:pfam00582  80 VVVVVGDPAEEIL-EVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVV 136
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 4-142 3.46e-18

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 75.35  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   4 NILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVI--NNTNFYYGAGAAGMPPSMYDDQHKIAENIIAEVKKYADSQ-G 80
Cdd:cd23659     2 KVLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIepPSLPAASLGSGSEEWEALEEEAREKAEKLLEKYEKKLKEEkG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1593647798  81 VNYETAIDIGNPKNIIAHvYPDEHDVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:cd23659    82 IKVKVEVVAGDPGEVICK-AAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVV 142
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 2-142 1.11e-13

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 63.48  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   2 YNNILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAAGMPPSMYDDQHKIAENIIAEVKKYAdsqgv 81
Cdd:cd23657     1 YKHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISEYYTGLIDVDIAALQDLESTMLEEALKNLSELA----- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1593647798  82 NY---ETAIDIGNPKNIIAHVYpDEHDVDLIVIGKSGVDAINRLliGSTTAFVVRNATTKVLVV 142
Cdd:cd23657    76 GYpvdHTFIGYGDLKEEILEVA-KKHNVDLIVCGHHGDFGLSLL--GSSARAVLNSAPCDVLIV 136
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 5-142 4.36e-12

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 59.34  E-value: 4.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   5 ILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAagMPPSMYDDQHKIAENIIAEVKKYA-----DSQ 79
Cdd:cd23944     2 IIVGVDGSPASDAAVRWAAREAQLRQIPLTLVHVVPPVVVSWPEGP--RPAEVLDWQQDEARQVIEQARKVAeeasgEGP 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1593647798  80 GVNYETAIDIGNPKNIIAHVYPDehdVDLIVIGKSGVDAINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:cd23944    80 PVKVETEIVPGSPVPTLVEASRD---ATMVVVGSRGIGALAGLLLGSVSTSLVRHAHCPVAVI 139
PRK15005 PRK15005
universal stress protein UspF;
1-142 2.36e-10

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 55.19  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   1 MYNNILVPLD--GSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFYYGAGAA--GMPPSMYDDQHKIAENIIAEVKKYA 76
Cdd:PRK15005    1 MNRTILVPIDisDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPYYASLGLAysAELPAMDDLKAEAKSQLEEIIKKFK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593647798  77 DSQGvNYETAIDIGNPKNIIAHVyPDEHDVDLIVIGKSGVDaINRLLIGSTTAFVVRNATTKVLVV 142
Cdd:PRK15005   81 LPTD-RVHVHVEEGSPKDRILEL-AKKIPADMIIIASHRPD-ITTYLLGSNAAAVVRHAECSVLVV 143
PRK10116 PRK10116
universal stress protein UspC; Provisional
 2-142 1.72e-04

universal stress protein UspC; Provisional


Pssm-ID: 182248  Cd Length: 142  Bit Score: 39.30  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   2 YNNILVPLDGSRNSQQALEEACKLAKQFDSKLQLVTVINNTNFyYGAGAAGMPPSMYDDQHKIAENIIAEVKKYADsqgv 81
Cdd:PRK10116    3 YSNILVAVAVTPESQQLLAKAVSIARPVNGKISLITLASDPEM-YNQFAAPMLEDLRSVMQEETQSFLDKLIQDAD---- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1593647798  82 nYETAidignpKNIIAHVYPDEH--------DVDLIVIGKSGVDAINRLLIGSttAFVVRNATTKVLVV 142
Cdd:PRK10116   78 -YPIE------KTFIAYGELSEHilevcrkhHFDLVICGNHNHSFFSRASCSA--KRVIASSEVDVLLV 137
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 4-143 4.22e-04

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 38.02  E-value: 4.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798   4 NILVPLDGSRNSQQA-------LEEACKLAKQFDSKLQLVTVINNTNFYYGAGAAGMPPSMYDDQHK----------IAE 66
Cdd:cd23660     3 RILVAVDPSNEEEYHedlnlrlIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRgrhleamkalRQK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593647798  67 NIIAEVKKYadsqgvnyetaIDIGNPKNIIAHVYpDEHDVDLIVIG---KSGVDAinrLLIGSTTAFVVRNATTKVLVVN 143
Cdd:cd23660    83 FGIDEEQTH-----------VLEGLPEEVIPDFA-EELDADIVVLGtvaRTGLSG---ALIGNTAEHVLDHLNCDLLALK 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH