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Conserved domains on  [gi|1586791997|gb|TCB60879|]
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ROK family transcriptional regulator [Rhizobium leguminosarum bv. viciae]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 12122468)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains a DNA-binding helix-turn-helix (HTH) domain

CATH:  3.30.420.40|1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0005524|GO:0003677
PubMed:  20512568|17979299|7952186|15808743|2644244|8831795|7781919|8800467
SCOP:  3000034|4000330|3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 80-379 4.58e-73

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 230.17  E-value: 4.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  80 NARAGLAVSIDLGSTKIAAAICDLLGNVVAETKVSTD-PRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDP 158
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPaGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 159 ATGHINVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGAR 238
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 239 GAAGEIAYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIA 318
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586791997 319 AIGAALDPELVITGGSIG-ARPELVNAIRGFLPRCTPYP----PRIEISRFGNRAALMGGMGIAVE 379
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSaAGDLLLEPIREALAKYALPParedPRIVPASLGDDAGLLGAAALALE 306
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 20-69 4.97e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.73  E-value: 4.97e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586791997  20 AVIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWLKPV-GQTDGR 69
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREpSPADRR 59
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 80-379 4.58e-73

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 230.17  E-value: 4.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  80 NARAGLAVSIDLGSTKIAAAICDLLGNVVAETKVSTD-PRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDP 158
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPaGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 159 ATGHINVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGAR 238
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 239 GAAGEIAYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIA 318
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586791997 319 AIGAALDPELVITGGSIG-ARPELVNAIRGFLPRCTPYP----PRIEISRFGNRAALMGGMGIAVE 379
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSaAGDLLLEPIREALAKYALPParedPRIVPASLGDDAGLLGAAALALE 306
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 85-372 2.47e-52

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 176.21  E-value: 2.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  85 LAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPR-GGMHLVNQFSDLIMELASAAGTSAdklrlVVLGSPGVLDPATGHI 163
Cdd:cd24068     1 KILGIDIGGTKIKYGLVDADGEILEKDSVPTPASkGGDAILERLLEIIAELKEKYDIEG-----IGISSAGQVDPKTGEV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 -NVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAG 242
Cdd:cd24068    76 iYATDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 243 EIAYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGA 322
Cdd:cd24068   156 ELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEALGEPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVH 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1586791997 323 ALDPELVITGGSI-GARPELVNAIRGFLPRCTPYP----PRIEISRFGNRAALMG 372
Cdd:cd24068   236 IFDPEVIVIGGGIsAQGELFLEELREELRKLLMPPlldaTKIEPAKLGNDAGLLG 290
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 87-377 4.73e-38

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 138.63  E-value: 4.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVST---DPRGGMHlvnqfsDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHI 163
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTpttTTEETLV------DAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSiPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:pfam00480  75 TNTPN-IGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGGDAFDPGGFTLGTFEsAVGSVAMLRRYVGFGGRNAStVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGAA 323
Cdd:pfam00480 154 IGHIQLDPNGPKCGCGNHGCLE-TIASGRALEKRYQQKGEDLE-GKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586791997 324 LDPELVITGGSIGARPELVNAIR--------GFLPRctpYPPRIEISRFGNRAALMGGMGIA 377
Cdd:pfam00480 232 FDPQAIVLGGGVSNADGLLEAIRslvkkylnGYLPV---PPVIIVAASLGDNAGALGAAALA 290
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 87-377 2.02e-32

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 124.24  E-value: 2.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGG---MHLVNQFSDLIMELASaagtSADKLRLVVLGSPGVLDPATGHI 163
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTDTTPEtivDAIASAVDSFIQHIAK----VGHEIVAIGIGAPGPVNRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIpGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:TIGR00744  77 YFAVNL-DWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGGDafdpGGFTLG--------TFESAVGSVAMLRRYVGFGGRNASTVA----------DLFAAFNAGETSAAAA 305
Cdd:TIGR00744 156 IGHIRMVPD----GRLLCNcgkqgcieTYASATGLVRYAKRANAKPERAEVLLAlgdgdgisakHVFVAARQGDPVAVDS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586791997 306 IEETARLVAVAIAAIGAALDPELVITGGSIGARPELV-NAIRGFLPRCTPYPPR----IEISRFGNRAALMGGMGIA 377
Cdd:TIGR00744 232 YREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLlDPIRKSYKRWLFGGARqvadIIAAQLGNDAGLVGAADLA 308
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 90-374 6.68e-16

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 77.72  E-value: 6.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  90 DLGSTKIAAAICDLLGNVVAETKVSTdPRGGMhlvNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHINVApSI 169
Cdd:PRK13310    6 DIGGTKIELGVFNEKLELQWEERVPT-PRDSY---DAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAA-NV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 170 PGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGhgvETSNFAFVA---LGTGVGMGIIANGALLRGARGAAGEIAY 246
Cdd:PRK13310   81 PAASGKPLRADLSARLGRDVRLDNDANCFALSEAWDD---EFTQYPLVMgliLGTGVGGGLVFNGKPISGRSYITGEFGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 247 LPIGGDAFDPGGFTLGTFESAVGSVAMLRRYV---GFG-------GRNASTVaDLFAAFNAGETSAAAAIEETARLVAVA 316
Cdd:PRK13310  158 MRLPVDALTLLGWDAPLRRCGCGQKGCIENYLsgrGFEwlyqhyyGEPLQAP-EIIALYYQGDEQAVAHVERYLDLLAIC 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586791997 317 IAAIGAALDPELVITGGSIGARPELVNAIRGFLPR---CTPYPPRIEISRFGNRaalmGGM 374
Cdd:PRK13310  237 LGNILTIVDPHLVVLGGGLSNFDAIYEQLPKRLPRhllPVARVPRIEKARHGDA----GGV 293
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 20-69 4.97e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.73  E-value: 4.97e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586791997  20 AVIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWLKPV-GQTDGR 69
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREpSPADRR 59
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 20-61 2.49e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.21  E-value: 2.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1586791997  20 AVIRTVFAN-GSISRADIAKLTGLSKQTISDVVRDLEDDGWLK 61
Cdd:COG2512    19 RVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 28-58 1.02e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 39.96  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1586791997  28 NGSISRADIAKLTGLSKQTISDVVRDLEDDG 58
Cdd:cd00092    23 QLPLTRQEIADYLGLTRETVSRTLKELEEEG 53
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
31-66 2.30e-04

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 38.58  E-value: 2.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1586791997   31 ISRADIAKLTGLSKQTISDVVRDLEDDGWLKPVGQT 66
Cdd:smart00419   9 LTRQEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 80-379 4.58e-73

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 230.17  E-value: 4.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  80 NARAGLAVSIDLGSTKIAAAICDLLGNVVAETKVSTD-PRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDP 158
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPaGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 159 ATGHINVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGAR 238
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 239 GAAGEIAYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIA 318
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586791997 319 AIGAALDPELVITGGSIG-ARPELVNAIRGFLPRCTPYP----PRIEISRFGNRAALMGGMGIAVE 379
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSaAGDLLLEPIREALAKYALPParedPRIVPASLGDDAGLLGAAALALE 306
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 85-372 2.47e-52

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 176.21  E-value: 2.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  85 LAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPR-GGMHLVNQFSDLIMELASAAGTSAdklrlVVLGSPGVLDPATGHI 163
Cdd:cd24068     1 KILGIDIGGTKIKYGLVDADGEILEKDSVPTPASkGGDAILERLLEIIAELKEKYDIEG-----IGISSAGQVDPKTGEV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 -NVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAG 242
Cdd:cd24068    76 iYATDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 243 EIAYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGA 322
Cdd:cd24068   156 ELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEALGEPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVH 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1586791997 323 ALDPELVITGGSI-GARPELVNAIRGFLPRCTPYP----PRIEISRFGNRAALMG 372
Cdd:cd24068   236 IFDPEVIVIGGGIsAQGELFLEELREELRKLLMPPlldaTKIEPAKLGNDAGLLG 290
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 87-373 1.65e-49

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 166.87  E-value: 1.65e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVSTDP-RGGMHLVNQFSDLIMELASAAGTsADKLRLVVLGSPGVLDPATGHINV 165
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTPAeEGPEAVLDRIAELIEELLAEAGV-RERILGIGIGVPGPVDPETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 166 APSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIA 245
Cdd:cd23763    80 APNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 246 YLPIggdafdpggftlgtFESAVgsvamlrRYVGFGgrnastVADLFAAFNagetsaaaaieetarlvavaiaaigaald 325
Cdd:cd23763   160 HITV--------------LEEAA-------RYLGIG------LANLINLLN----------------------------- 183

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1586791997 326 PELVITGGSIGA-----RPELVNAIRGFLPRCTPYPPRIEISRFGNRAALMGG 373
Cdd:cd23763   184 PELIVLGGGVAEagdllLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLGA 236
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 84-380 9.83e-46

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 159.27  E-value: 9.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  84 GLAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMH-LVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGH 162
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDeVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 163 INVAPSIPGIDaINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAG 242
Cdd:cd24076    81 VLLAPNLGWRD-VPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 243 EIAYLPIggdafDPGGFT-----LGTFESAVGSVAMLRRY-VGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVA 316
Cdd:cd24076   160 EIGHMTV-----DPDGPPcscgnRGCWETYASERALLRAAgRLGAGGEPLSLAELVEAARAGDPAALAALEEVGEYLGIG 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586791997 317 IAAIGAALDPELVITGGSIGA-----RPELVNAIRGflpRCTPYP---PRIEISRFGNRAALMGGMGIAVER 380
Cdd:cd24076   235 LANLVNTFNPELVVLGGALAPlgpwlLPPLRAEVAR---RALPAPardVRIVVSRLGEDAAALGAAALAIDH 303
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 89-372 5.47e-43

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 151.57  E-value: 5.47e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELAsaagtsaDKLRLVVLGSPGVLDPATGHINVAPS 168
Cdd:cd24152     5 FDIGGTFIKYALVDENGNIIKKGKIPTPKDSLEEFLDYIKKIIKRYD-------EEIDGIAISAPGVIDPETGIIYGGGA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 169 IPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYLP 248
Cdd:cd24152    78 LPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 249 IggDAFDPGGFTLGtfeSAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGAALDPEL 328
Cdd:cd24152   158 T--DDDDKDLLFFS---GLASMFGLVKRYNKAKGLEPLDGEEIFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEV 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586791997 329 VITGGSIGARPELVNAIR----GFLPRCTPYPPRIEI--SRFGNRAALMG 372
Cdd:cd24152   233 IVIGGGISEQPLFIEDLKkevnEILANRPGSIPKPEIkaCKFGNDANLLG 282
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 85-373 3.90e-39

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 142.04  E-value: 3.90e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  85 LAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPR-GGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHI 163
Cdd:cd24062     1 WIVGIDVGGTTIKMAFLTQEGEIVQKWEIPTNKLeGGENIITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIpGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:cd24062    81 EVAVNL-GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGgdafDPGGFT--------LGTFESAVGSVAMLRRYVGFGG----------RNASTVADLFAAFNAGETSAAAA 305
Cdd:cd24062   160 IGHITVN----PEGGAPcncgktgcLETVASATGIVRIAREELEEGKgssalrilalGGELTAKDVFEAAKAGDELALAV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1586791997 306 IEETARLVAVAIAAIGAALDPELVITGGSIGARPE-LVNAIRGFLPRCTpyPPR------IEISRFGNRAALMGG 373
Cdd:cd24062   236 VDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEfLLSPVKEYFDRFT--FPRvrqdteIVLATLGNDAGVIGA 308
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 84-380 8.39e-39

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 140.77  E-value: 8.39e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  84 GLAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHI 163
Cdd:cd24073     1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPsIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:cd24073    81 RWSP-LLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIggdafDPGGF-----TLGTFESAVGSVAMLRRY-VGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAI 317
Cdd:cd24073   160 IGHTTV-----DPDGPpcrcgKRGCLEAYASDPAILRQArEAGLRGEPLTIEDLLAAARAGDPAARAILRRAGRALGLAL 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1586791997 318 AAIGAALDPELVITGGSiGAR------PELVNAIRGFLPRCTPYPPRIEISRFGNRAALMGGMGIAVER 380
Cdd:cd24073   235 ANLVNLLDPELIIISGE-GVRagdllfEPMREALRAHVFPGLASDLELVIHPWGDEAWARGAAALALQE 302
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 87-377 4.73e-38

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 138.63  E-value: 4.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVST---DPRGGMHlvnqfsDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHI 163
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTpttTTEETLV------DAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSiPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:pfam00480  75 TNTPN-IGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGGDAFDPGGFTLGTFEsAVGSVAMLRRYVGFGGRNAStVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGAA 323
Cdd:pfam00480 154 IGHIQLDPNGPKCGCGNHGCLE-TIASGRALEKRYQQKGEDLE-GKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586791997 324 LDPELVITGGSIGARPELVNAIR--------GFLPRctpYPPRIEISRFGNRAALMGGMGIA 377
Cdd:pfam00480 232 FDPQAIVLGGGVSNADGLLEAIRslvkkylnGYLPV---PPVIIVAASLGDNAGALGAAALA 290
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 87-372 2.55e-37

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 136.69  E-value: 2.55e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDllGNVVAETKVSTDPRGGMHLVnqfSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHINVA 166
Cdd:cd24065     3 IGLDLGGTKIAAGVVD--GGRILSRLVVPTPREGGEAV---LDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRFA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 167 PSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAY 246
Cdd:cd24065    78 PNIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 247 LPIGGDAFDPGGFTLGTFEsAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGAALDP 326
Cdd:cd24065   158 TTVLPGGPMCGCGLVGCLE-ALASGRALARDASFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDP 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1586791997 327 ELVITGG--SIGARPELVNAIRGFLPRCTPY-PPRIEISRFGNRAALMG 372
Cdd:cd24065   237 EVFVLGGgvAQVGDYYLLPVQEAARRYTEGWhAPPLRLAHLGTDAGVIG 285
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 86-379 2.94e-37

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 136.95  E-value: 2.94e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMH-LVNQFSDLIMELASAAGTSaDKLRLVVLGSPGVLDPATGHIN 164
Cdd:cd24059     3 VIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEeVLEKLYELIDRLLEKENIK-SKILGIGIGAPGPLDVEKGIIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 165 VAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEI 244
Cdd:cd24059    82 NPPNFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 245 AYLPI--GGDAFDPGGFtlGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAIGA 322
Cdd:cd24059   162 GHTSIdiNGPRCSCGNR--GCLELYASIPAIEKKARSALGSGRSFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNLIN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586791997 323 ALDPELVITGGSIGARPELV------NAIRGFLPRCTpYPPRIEISRFGNRAALMGGMGIAVE 379
Cdd:cd24059   240 LLNPEAIIIGGELIYLGERYlepiekEVNSRLFGRNA-REVRILKSSLGEDAPLLGAAALVLN 301
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 86-373 2.31e-33

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 126.30  E-value: 2.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLlGNVVAETKVSTDPRGGMhlVNQFSDLIMELASAAGTSADKLRLVVLG--SPGVLDPATGHI 163
Cdd:cd24063     2 YVAVDIGGTWIRAGLVDE-DGRILLKIRQPTPKTGD--PGTVSEQVLGLIETLLSKAGKDSIEGIGvsSAGPLDLRKGTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIPGIDaINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:cd24063    79 VNSPNIKGKE-IPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGGDAFDPGG---------FTLGTF------ESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEE 308
Cdd:cd24063   158 VGHLVVDTESGLKCGcggyghweaFASGRGiprfarEWAEGFSSRTSLKLRNPGGEGITAKEVFSAARKGDPLALKIIEK 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586791997 309 TARLVAVAIAAIGAALDPELVITGGSIGARP-ELVNAIRGFLPRCTPY--PPRIEISRFGNRAALMGG 373
Cdd:cd24063   238 LARYNGRGIANVINAYDPELIVIGGSVFNNNkDILDPLIEYLEKNPAIskGPEIVLSELGDDVGLIGA 305
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 86-377 1.36e-32

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 124.39  E-value: 1.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLLGNVVAETKVSTdPRGGMHLVNQFSDLIMELASAAGTSAdklrlVVLGSPGVLDPATGHINV 165
Cdd:cd24061     1 TIGVDIGGTKIAAGVVDEEGEILATERVPT-PPTADGIVDAIVEAVEELREGHDVSA-----VGVAAAGFVDADRATVLF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 166 APSIPgIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIA 245
Cdd:cd24061    75 APNIA-WRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 246 YLPIGGDAFDPGGFTLGTFEsAVGSVAMLRRYV-------GFGGRNASTVA--------DLFAAFNAGETSAAAAIEETA 310
Cdd:cd24061   154 HIRVVPDGLLCGCGSRGCWE-QYASGRALVRYAkeaanatPEGAAVLLADGsvdgitgkHISEAARAGDPVALDALRELA 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586791997 311 RLVAVAIAAIGAALDPELVITGGSIGARPELV-----NAIRGFLPRCTPYP-PRIEISRFGNRAALMGGMGIA 377
Cdd:cd24061   233 RWLGAGLASLAALLDPELFVIGGGVSDAGDLLldpirEAFERWLPGRGWRPiPRLRTAQLGNDAGLIGAADLA 305
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 87-377 2.02e-32

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 124.24  E-value: 2.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGG---MHLVNQFSDLIMELASaagtSADKLRLVVLGSPGVLDPATGHI 163
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTDTTPEtivDAIASAVDSFIQHIAK----VGHEIVAIGIGAPGPVNRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIpGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:TIGR00744  77 YFAVNL-DWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIGGDafdpGGFTLG--------TFESAVGSVAMLRRYVGFGGRNASTVA----------DLFAAFNAGETSAAAA 305
Cdd:TIGR00744 156 IGHIRMVPD----GRLLCNcgkqgcieTYASATGLVRYAKRANAKPERAEVLLAlgdgdgisakHVFVAARQGDPVAVDS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586791997 306 IEETARLVAVAIAAIGAALDPELVITGGSIGARPELV-NAIRGFLPRCTPYPPR----IEISRFGNRAALMGGMGIA 377
Cdd:TIGR00744 232 YREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLlDPIRKSYKRWLFGGARqvadIIAAQLGNDAGLVGAADLA 308
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 88-372 2.07e-30

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 118.10  E-value: 2.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  88 SIDLGSTKIAAAICDLLGNVVAETKVSTdPRGGMhlvNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHInVAP 167
Cdd:cd24057     4 GFDIGGTKIEFAVFDEALQLVWTKRVPT-PTDDY---AAFLAAIAELVAEADARFGVKGPVGIGIPGVIDPEDGTL-ITA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYL 247
Cdd:cd24057    79 NIPAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGEWGHG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 248 PIGGDAFDPG----------GFTlGTFESAVGSVAMLRRYVGFGGRNASTVaDLFAAFNAGETSAAAAIEETARLVAVAI 317
Cdd:cd24057   159 PLPADALLLGydlpvlrcgcGQT-GCLETYLSGRGLERLYAHLYGEELDAP-EIIAAWAAGDPQAVAHVDRWLDLLAGCL 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1586791997 318 AAIGAALDPELVITGGSIGARPELVNAIRGFLPRCT---PYPPRIEISRFGNRAALMG 372
Cdd:cd24057   237 ANILTALDPDVVVLGGGLSNFPALIAELPAALPAHLlsgARTPRIVPARHGDAGGVRG 294
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 84-380 5.69e-26

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 106.09  E-value: 5.69e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  84 GLAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDpaTGHI 163
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVD--ENEI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIPGIDaINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHgvETSNFAFVALGTGVGMGIIANGALLRGARGAAGE 243
Cdd:cd24077    79 IFTPYYDLED-IDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 244 IAYLPIggdafDPGGFT-----LGTFESAVGSVAMLRRYVGFGGRNASTVADLFAAFNAGETSAAAAIEETARLVAVAIA 318
Cdd:cd24077   156 IGHMII-----VPNGKPcpcgnKGCLEQYASEKALLKELSEKKGLETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGIN 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586791997 319 AIGAALDPELVITGGSIGAR-PELVNAIRGFLPRCTPYPPRIEISRFGNRAALMGGMGIAVER 380
Cdd:cd24077   231 NIINTFNPEIIIINSSLINEiPELLEKIKEQLSSSFNKYVEILISTLGKNATLLGGAAVAIKN 293
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 89-373 4.87e-23

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 97.62  E-value: 4.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKVSTDPR-GGMHLVNQFSDLIMELASAAGtsaDKLRLVVLGSPGVLDPATGHINVAP 167
Cdd:cd24070     6 IDIGGTNIRIGLVDEDGKLLDFEKVPSKDLlRAGDPVEVLADLIREYIEEAG---LKPAAIVIGVPGTVDKDRRTVISTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGErWRGHGVETSNFAF-VALGTGVGMGIIANGALLRGARGAAGEIAY 246
Cdd:cd24070    83 NIPGLDGVNLADILENKLGIPVILERDVNLLLLYD-MRAGNLDDEGVVLgFYIGTGIGNAILINGKPLRGKNGVAGELGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 247 LPIGGDAFDPGGFTLGTFESAVGSVAMLRRYvgfgGRNASTVADLFAAFNAGEtsaAAAIEETARLVAVAIAAIGAALDP 326
Cdd:cd24070   162 IPVYGNGKPCGCGNTGCLETYASGRALEEIA----EEHYPDTPILDIFVDHGD---EPELDEFVEDLALAIATEINILDP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1586791997 327 ELVITGGSIGA-----RPELVNAIRGFLPRctPYPPR-IEI--SRFGNRAALMGG 373
Cdd:cd24070   235 DAVILGGGVIDmkgfpRETLEEYIRKHLRK--PYPADnLKIiyAELGPEAGVIGA 287
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 86-335 1.38e-20

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 91.02  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLLGNVVAETKVSTD-PRGGMHLVNQFSDLIMELASAAGTSAdklrlVVLGSPGVLDPATGHIN 164
Cdd:cd24064     1 VIGIDLGGTDTKIGIVDENGDILKKKTIDTKvENGKEDVINRIAETVNELIEEMELLG-----IGIGSPGSIDRENGIVR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 165 VAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEI 244
Cdd:cd24064    76 FSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAEL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 245 AYLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTVA---------DLFAAFNAGETSAAAAIEETARLVAV 315
Cdd:cd24064   156 GHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPDSLAgesekinakHVFDAARKNDPLATMVFRRVVDALAI 235

                         250       260
                  ....*....|....*....|
gi 1586791997 316 AIAAIGAALDPELVITGGSI 335
Cdd:cd24064   236 AIGGFVHIFNPEIIIIGGGI 255
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 86-247 3.28e-20

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 90.17  E-value: 3.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLLGNVVAETKVSTDprggmHLVNQFSDLIMELASAAGTSADKLRLVVLG----SPGVLDPATG 161
Cdd:cd24060     2 ALAVDLGGTNLRVAIVSMKGEIVKKYTQPNP-----KTYEERIDLILQMCVEAASEAVKLNCRILGvgisTGGRVNPREG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 162 HI-NVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGA 240
Cdd:cd24060    77 IVlHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFC 156


                  ....*..
gi 1586791997 241 AGEIAYL 247
Cdd:cd24060   157 AAELGHI 163
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 88-372 5.85e-20

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 88.88  E-value: 5.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  88 SIDLGSTKIAAAICDllGNVVAETKVSTDPRggMHLVNQFSDLIMELASAAGTSADKLRLVVLG--SPGVLDPAtghinV 165
Cdd:cd24069     2 AIDIGGTKIAAALIG--NGQIIDRRQIPTPR--SGTPEALADALASLLADYQGQFDRVAVASTGiiRDGVLTAL-----N 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 166 APSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIA 245
Cdd:cd24069    73 PKNLGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 246 YLPIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNASTvADLFAAFNAGETSAAAAIEETARLVAVAIAAIGAALD 325
Cdd:cd24069   153 HTLADPPGPVCGCGRRGCVEAIASGTAIAAAASEILGEPVDA-KDVFERARSGDEEAARLIDRAARALADLIADLKATLD 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586791997 326 PELVITGGSIGARPELVNAIRGFL---PRCtpYPPRIEISRFGNRAALMG 372
Cdd:cd24069   232 LDCVVIGGSVGLAEGFLERVEQYLadePAI--FRVSLEPARLGQDAGLLG 279
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 84-249 8.36e-20

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 88.88  E-value: 8.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  84 GLAVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMH-----LVNQFSDLIMELASAAgtsadKLRLVVLGSPGVLDP 158
Cdd:cd24071     1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETDPEkvielIAENIKKLIKNKHVEK-----KLLGIGIAVSGLVDS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 159 ATGhINVAPSIPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGAR 238
Cdd:cd24071    76 KKG-IVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNF 154

                         170
                  ....*....|.
gi 1586791997 239 GAAGEIAYLPI 249
Cdd:cd24071   155 GGAGEIGHMTI 165
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 89-375 9.31e-20

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 89.01  E-value: 9.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAE-TKVSTDPRGGMHLVNQFSDLIMELASAagtSADKLRLVVLGSPGVLDPATGHINVAP 167
Cdd:cd24072     6 IVVSPNSLRAQVGNACGELLGEfEYRVITLETPEALIDEIIDCIDRLLKL---WKDRVKGIALAIQGLVDSHKGVSLWSP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIPGIDaINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYL 247
Cdd:cd24072    83 GAPWRN-IEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGHT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 248 PIGGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGGRNAS-------TVADLFAAFNAGETSAAAAIEETARLVAVAIAAI 320
Cdd:cd24072   162 KVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVsadpeklTMEQLIEALEEGEPIATQIFDRAANAIGRSLANI 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586791997 321 GAALDPELVITGGSIGA-----RPELVNAIRGFLPR--CTPyPPRIEISRFGNRAALMGGMG 375
Cdd:cd24072   242 LNLLNPEQVLLYGRGCRagdllLPAIRRAIAENPFSqhATQ-IGFGQLSTEQGCAQQALGLV 302
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 86-335 9.48e-17

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 80.10  E-value: 9.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  86 AVSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHINV 165
Cdd:cd24075     3 ILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVVHY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 166 APSIPgIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIA 245
Cdd:cd24075    83 MPHIQ-VKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 246 YLPIggdafDPGGF-----TLGTFESAVGSVAMLRR--------YVGFGGRNASTVADLFAAFNAGETSAAAAIEETARL 312
Cdd:cd24075   162 HIQI-----EPLGErchcgNFGCLETVASNAAIEQRvkkllkqgYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRY 236

                         250       260
                  ....*....|....*....|...
gi 1586791997 313 VAVAIAAIGAALDPELVITGGSI 335
Cdd:cd24075   237 LGKVIAILINLLNPQKIIIAGEI 259
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 88-390 2.35e-16

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 79.28  E-value: 2.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  88 SIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHINvap 167
Cdd:cd24074     6 SIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIVH--- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIPGIDAIN--LRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIA 245
Cdd:cd24074    83 RLPFYDIKNlpLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 246 YLPI--GGDAFDPGGFtlGTFESAVGSVAMLRRYVGFGGR--------NASTVADLFAAFNAGETSAAAAIEETARLVAV 315
Cdd:cd24074   163 HTQIdpYGKRCYCGNH--GCLETVASIPAILEQANQLLEQspdsmlhgQPISIESLCQAALAGDPLAQDIIIQVGRHLGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 316 AIAAIGAALDPELVITGGSIGAR-----PELVNAIRGFLPRCTPYPPRIEISRFGNRAAlMGGMGIAVERMHDDLFGVKL 390
Cdd:cd24074   241 ILAILVNLFNPEKILIGSPLNNAaeilfPALSQSIRQQSLPAYSQHLQIESTKFYNDGT-MPGAALIKDALYDGSLLLKL 319
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 90-374 6.68e-16

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 77.72  E-value: 6.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  90 DLGSTKIAAAICDLLGNVVAETKVSTdPRGGMhlvNQFSDLIMELASAAGTSADKLRLVVLGSPGVLDPATGHINVApSI 169
Cdd:PRK13310    6 DIGGTKIELGVFNEKLELQWEERVPT-PRDSY---DAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAA-NV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 170 PGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGhgvETSNFAFVA---LGTGVGMGIIANGALLRGARGAAGEIAY 246
Cdd:PRK13310   81 PAASGKPLRADLSARLGRDVRLDNDANCFALSEAWDD---EFTQYPLVMgliLGTGVGGGLVFNGKPISGRSYITGEFGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 247 LPIGGDAFDPGGFTLGTFESAVGSVAMLRRYV---GFG-------GRNASTVaDLFAAFNAGETSAAAAIEETARLVAVA 316
Cdd:PRK13310  158 MRLPVDALTLLGWDAPLRRCGCGQKGCIENYLsgrGFEwlyqhyyGEPLQAP-EIIALYYQGDEQAVAHVERYLDLLAIC 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586791997 317 IAAIGAALDPELVITGGSIGARPELVNAIRGFLPR---CTPYPPRIEISRFGNRaalmGGM 374
Cdd:PRK13310  237 LGNILTIVDPHLVVLGGGLSNFDAIYEQLPKRLPRhllPVARVPRIEKARHGDA----GGV 293
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 87-374 2.91e-15

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 75.27  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVST-DPRGGMHLVNQFSDlimelasaagTSADKLRLVVLGSPGVLD-----PAT 160
Cdd:cd24067     2 GGIEAGGTKFVCAVGTGDGNIIERTEFPTtTPEETLQAVIDFFR----------EQEEPIDAIGIASFGPIDlnptsPTY 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 161 GHINVAPSiPGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGA-RG 239
Cdd:cd24067    72 GYITTTPK-PGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLlHP 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 240 AAGEIaYLPIGGDAFDPGG---FTLGTFESAVGSVAMLRRYvgfgGRNASTVADLFAAFN-AGETSAAAAIEETarlvav 315
Cdd:cd24067   151 EMGHI-RVPRHPDDDGFPGvcpFHGDCLEGLASGPAIAARW----GIPAEELPDDHPAWDlEAYYLAQACANLT------ 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 316 aiaaigAALDPELVITGGSIGARPELVNAIRG-FLPRCTPYPPR----------IEISRFGNRAALMGGM 374
Cdd:cd24067   220 ------LTLSPERIVLGGGVMQRPGLFPRIREkFRKLLNGYLEVprllpdideyIVPPALGNDAGILGAL 283
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 89-351 3.66e-15

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 75.32  E-value: 3.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKVSTdPRGGM-HLVNQFSDLIMELASAAGTSADklrlVVLGSPGVLDPATGHINVAP 167
Cdd:cd24066     4 IDLGGTKIEGIALDRAGRELLRRRVPT-PRGDYeATLDAIADLVEEAEEELGAPAT----VGIGTPGSISPRTGLVKNAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIpGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYL 247
Cdd:cd24066    79 ST-WLNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 248 PI--GGDAFDPG-----GFTlGTFESAVGSVAMLRRYVGFGGRnASTVADLFAAFNAGETSAAAAIEETARLVAVAIAAI 320
Cdd:cd24066   158 PLpwPDEDELPGppcycGKR-GCVETFLSGPALERDYARLTGK-TLSAEEIVALARAGDAAAVATLDRFLDRLGRALANV 235

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1586791997 321 GAALDPELVITGGSIGARPELVNAIRGFLPR 351
Cdd:cd24066   236 INILDPDVIVLGGGLSNIDELYTEGPAALAR 266
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 89-372 2.87e-13

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 69.56  E-value: 2.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKVSTdPRGGMhlVNQFSDLIMELASAAGTSADKlrlVVLGSPGVLDPAtghinvaps 168
Cdd:PRK05082    6 IDIGGTKIAAALVGEDGQIRQRRQIPT-PASQT--PEALRQALSALVSPLQAQADR---VAVASTGIINDG--------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 169 ipGIDAIN-----------LRQVFSDRMGIPVIVENDVNLAAQGErWRGHGVETSNFAFVALGTGVGMGIIANGALLRGA 237
Cdd:PRK05082   71 --ILTALNphnlggllhfpLVQTLEQLTDLPTIALNDAQAAAWAE-YQALPDDIRNMVFITVSTGVGGGIVLNGKLLTGP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 238 RGAAGEiaylpIGGDAFDPGGFTLGTFESA-VGSVAMLRRYVG-----FGGRNASTVadlFAAFNAGETSAAAAIEETAR 311
Cdd:PRK05082  148 GGLAGH-----IGHTLADPHGPVCGCGRRGcVEAIASGRAIAAaaqgwLAGCDAKTI---FERAGQGDEQAQALINRSAQ 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1586791997 312 LVAVAIAAIGAALDPELVITGGSIGARP---ELVNAIRGFLPrcTPYPPRIEISRFGNRAALMG 372
Cdd:PRK05082  220 AIARLIADLKATLDCQCVVLGGSVGLAEgylELVQAYLAQEP--AIYHVPLLAAHYRHDAGLLG 281
PRK09698 PRK09698
D-allose kinase; Provisional
 87-250 4.63e-11

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 63.08  E-value: 4.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLImelasaAGTSADKLRL---VVLGSPGVLDPATGHI 163
Cdd:PRK09698    7 LGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMI------DEYLRRFNARchgIVMGFPALVSKDRRTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 164 NVAPSIP--GIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVaLGTGVGMGIIANGALLRGARGAA 241
Cdd:PRK09698   81 ISTPNLPltALDLYDLADKLENTLNCPVFFSRDVNLQLLWDVKENNLTQQLVLGAY-LGTGMGFAVWMNGAPWTGAHGVA 159


                  ....*....
gi 1586791997 242 GEIAYLPIG 250
Cdd:PRK09698  160 GELGHIPLG 168
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 90-307 1.25e-09

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 58.50  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  90 DLGSTKIAAAICDLLGNVVAETKVSTDPRGGMHLVNQFSDLIMELASAAGTSADklrlVVLGSPGVLDPATGHINVApSI 169
Cdd:PRK13311    6 DMGGTKIELGVFDENLQRIWHKRVPTPREDYPQLLQILRDLTEEADTYCGVQGS----VGIGIPGLPNADDGTVFTA-NV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 170 PGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYLPI 249
Cdd:PRK13311   81 PSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEFGHFRL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586791997 250 GGDAFDPGGFTLGTFESAVGSVAMLRRYVGFGG---------RNASTVADLFAAFNAGETSAAAAIE 307
Cdd:PRK13311  161 PVDALDILGADIPRVPCGCGHRGCIENYISGRGfewmyshfyQHTLPATDIIAHYAAGEPKAVAHVE 227
PRK09557 PRK09557
fructokinase; Reviewed
 89-333 1.00e-07

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 53.11  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKVSTdPRGGMHL-VNQFSDLIMELASAAGTSADklrlVVLGSPGVLDPATGHINVAP 167
Cdd:PRK09557    5 IDLGGTKIEVIALDDAGEELFRKRLPT-PRDDYQQtIEAIATLVDMAEQATGQRGT----VGVGIPGSISPYTGLVKNAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 168 SIpGIDAINLRQVFSDRMGIPVIVENDVNLAAQGERWRGHGVETSNFAFVALGTGVGMGIIANGALLRGARGAAGEIAYL 247
Cdd:PRK09557   80 ST-WLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEWGHN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 248 PI---GGDAFDPGGFT---------LGTFESAVGSVamlRRYVGFGGrNASTVADLFAAFNAGETSAAAAIEETARLVAV 315
Cdd:PRK09557  159 PLpwmDEDELRYRNEVpcycgkqgcIETFISGTGFA---TDYRRLSG-KALKGSEIIRLVEEGDPVAELAFRRYEDRLAK 234

                         250
                  ....*....|....*...
gi 1586791997 316 AIAAIGAALDPELVITGG 333
Cdd:PRK09557  235 SLAHVINILDPDVIVLGG 252
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 20-69 4.97e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.73  E-value: 4.97e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586791997  20 AVIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWLKPV-GQTDGR 69
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREpSPADRR 59
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 20-61 2.49e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.21  E-value: 2.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1586791997  20 AVIRTVFAN-GSISRADIAKLTGLSKQTISDVVRDLEDDGWLK 61
Cdd:COG2512    19 RVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 89-351 3.92e-05

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 44.87  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLLGNVVAETKV-STDPR--GGMHLVNQFSDLIMELASAAGTSADkLRLVVLGSPGVLDPAtghinv 165
Cdd:COG2971     6 VDGGGTKTRAVLVDADGEVLGRGRAgGANPQsvGLEEALASLREALEEALAAAGDPAD-IEAVGFGLAGAGTPE------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 166 apsipgiDAINLRQVFSDRMG-IPVIVENDVNLAAQGERWRGHGVetsnfaFVALGTG-VGMGIIANGALLR-------- 235
Cdd:COG2971    79 -------DAEALEAALRELFPfARVVVVNDALAALAGALGGEDGI------VVIAGTGsIAAGRDGDGRTARvggwgyll 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 236 GARGAAGEI------AYLpiggDAFDPGGFT---LGTFESAVG--SVAMLRRYVGFGGRNASTVADL----FAAFNAGET 300
Cdd:COG2971   146 GDEGSGAWLgrealrAAL----RALDGRGPPtalTEAVLAEFGldDPEELIAWVYRGPAPPADLASLaplvFEAAEAGDP 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586791997 301 SAAAAIEETARLVAVAIAAIGAALDPELVITGGSIGARPELVNAIRGFLPR 351
Cdd:COG2971   222 VARAILEEAADELAELARALLERGALPVVLAGGVAAAQPLLREALRARLAA 272
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
20-60 4.75e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 40.49  E-value: 4.75e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1586791997  20 AVIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWL 60
Cdd:pfam13412   5 KILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
ASKHA_NBD_eukNAGK-like cd24007
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ...
 87-360 6.35e-05

nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466857 [Multi-domain]  Cd Length: 295  Bit Score: 44.22  E-value: 6.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  87 VSIDLGSTKIAAAICDLLGNVVAETKVSTdprGGMHLV------NQFSDLIMELASAAGTSADkLRLVVLGSPGVLDPAt 160
Cdd:cd24007     2 LGVDGGGTKTRAVLADEDGKILGRGKGGP---SNPASVgieeakENLKEAVREALSQAGSLGE-IDAICLGLAGIDSEE- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 161 ghinvapsipgiDAINLRQVFSDR-MGIPVIVENDVNLAAQGERWRGHGVetsnfaFVALGTG-VGMGIIANGALLR--- 235
Cdd:cd24007    77 ------------DRERLRSALKELfLSGRIIIVNDAEIALAAALGGGPGI------VVIAGTGsVAYGRNGDGEEARvgg 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 236 -----GARGAAGEIAYLPIGG--DAFDpGGFTLGTFESAV------GSVAMLRRYVGFGGRNASTVADL----FAAFNAG 298
Cdd:cd24007   139 wghllGDEGSGYWIGRRALRAalRALD-GRGPKTPLLDAIlkflglDSIEELITAIYRSSDRKKEIASLaplvFEAAEEG 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 299 ETSAAA----AIEETARLVAVAIAAIGAALDPELVITGGSIGA----RPELVNAIRGFLPRCTPYPPRIE 360
Cdd:cd24007   218 DPVAQAilkeAAEELAKLVVALAKLLLLGEKLPLALSGGVFKNnyylAEFLEELLKKKKPNAKVVEPKGS 287
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 28-58 1.02e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 39.96  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1586791997  28 NGSISRADIAKLTGLSKQTISDVVRDLEDDG 58
Cdd:cd00092    23 QLPLTRQEIADYLGLTRETVSRTLKELEEEG 53
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
31-66 2.30e-04

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 38.58  E-value: 2.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1586791997   31 ISRADIAKLTGLSKQTISDVVRDLEDDGWLKPVGQT 66
Cdd:smart00419   9 LTRQEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
21-69 2.57e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 40.72  E-value: 2.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586791997  21 VIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWL-KPVGQTDGR 69
Cdd:COG1846    43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVeREPDPEDRR 92
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
21-69 6.65e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 6.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1586791997   21 VIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWL-KPVGQTDGR 69
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVrREPSPEDRR 64
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
14-83 9.78e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.48  E-value: 9.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  14 RKISTNAVIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWLkpvgqtDGRPGRNAITYEINARA 83
Cdd:COG3398    95 RRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV------ERERDGRNVRYYLNPPE 158
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 89-252 1.08e-03

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 40.25  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997  89 IDLGSTKIAAAICDLL-GNVVAE-TKVSTDPRGGMHLVnqfSDLIMELASAAGtsaDKLRLVVlGSPGVLdpatgHINVA 166
Cdd:cd24058     4 IDIGGSGIKGAIVDTDtGELLSErIRIPTPQPATPEAV---ADVVAELVAHFP---WFGPVGV-GFPGVV-----RRGVV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586791997 167 PSIPGIDA----INLRQVFSDRMGIPVIVENDVNLAAQGE-----RWRGHGVETsnfaFVALGTGVGMGIIANGALLRGA 237
Cdd:cd24058    72 RTAANLDKswigFDAAKLLSKRLGRPVRVLNDADAAGLAEmkggaGKGEKGVVL----VLTLGTGIGSALFVDGHLVPNT 147

                         170
                  ....*....|....*
gi 1586791997 238 rgaagEIAYLPIGGD 252
Cdd:cd24058   148 -----ELGHLEIRGK 157
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 21-60 1.37e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1586791997  21 VIRTVFANGSISRADIAKLTGLSKQTISDVVRDLEDDGWL 60
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI 47
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 27-91 1.45e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 1.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1586791997  27 ANGSISRADIAKLTGLSKQTISDVVRDLEDDGWLKpvgqtdGRPGRNAITYEINARAGLAVSIDL 91
Cdd:cd00090    17 LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVE------SRREGRRVYYSLTDAERLLALLES 75
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
27-69 5.05e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.34  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1586791997  27 ANGSISRADIAKLTGLSKQTISDVVRDLEDDGWlkpVGQTDGR 69
Cdd:COG4742    26 AEGPKTRSELAESLDVSRSTILRQLKELEERGL---IERDDGE 65
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 31-61 9.72e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 34.35  E-value: 9.72e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1586791997  31 ISRADIAKLTGLSKQTISDVVRDLEDDGWLK 61
Cdd:pfam13545  23 LTQEDLADLLGTTRETVSRVLSELRREGLIE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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