|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
1-1038 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 1440.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQ-----DGMSI 75
Cdd:PRK05672 3 PPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGpdpdpGGPHL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 76 LVYPTDRAAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGLLGIL------------VPDLPDDVCAIQLRKMAEVFA 143
Cdd:PRK05672 83 LVLARDREGYGRLSRLITRARLRAGKGEYRLDLDDLAEPAGGHWAILtgcrkgfvilalPYGGDAAALAALAALLDAFFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 144 DGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPP 223
Cdd:PRK05672 163 DRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGERHLRSG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 224 EEMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYPEGLPPEVLKIVRHELDL 303
Cdd:PRK05672 243 AEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPGIPPKARAQIEHELAL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 304 IRTMKYAPYFLTVFSIVRFARSQGILCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVDFEHERRE 383
Cdd:PRK05672 323 IAELGYEGYFLTVHDIVRFARSQGILCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDIDVDFEHDRRE 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 384 EVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMWAWSEELVSDRSLRDQGLNPEDRRLALTL 463
Cdd:PRK05672 403 EVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRLRQAGLDPESPIPRRVV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 464 KLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVIEWDKDDVEALKFMKVDILALGMLTCMAKTFALIREH 543
Cdd:PRK05672 483 ELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALGMLSALHRAFDLIAEH 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 544 KDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRREGKE 623
Cdd:PRK05672 563 RGRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPIQGGMVHPYLRRRNGQE 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 624 PVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATFKFTGGVSRFKDKLVSGMIRNGYTAEFAEK 703
Cdd:PRK05672 643 PVTYPHPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAAWRRKGRLERLRERLYDGMLARGYTGEFADR 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 704 TFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRPVCINNSRWDC 783
Cdd:PRK05672 723 IFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQPMGFYSPQQLVQDARRHGVEVLPVDVNASGWDA 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 784 TLERIGNADsHAVRLGMRMVRGLAAADTARVVAARMDQPFESIDDMWRRSGVPAASLVELAEADAFLpSLGLQRRDALWA 863
Cdd:PRK05672 803 TLEPLPDGG-PAVRLGLRLVRGLGEEAAERIVAARARGPFTSVEDLARRAGLDRRQLEALADAGALR-SLGGDRRQALWA 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 864 IKGLRDEPLPLFaaaserearAVAEQQEPEVALRQMTEGHNVVQDYSHIGLTLRDHPVAFLRKALTERRIVTCAQAMNAR 943
Cdd:PRK05672 881 AGAAATERLDLL---------PGAPASEAAPALPGMSEGELVAADYWTTGLSLDSHPLALLRPRLDARGVVSAAELLDVE 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 944 DGRWLMTAGLVLVRQRPGSAKGVIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQREGDVVHLVAQQVFDL 1023
Cdd:PRK05672 952 DGRRVRVAGVVTHRQRPGTASGVTFLTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRVQNAEGVRHLVADRLEDL 1031
|
1050
....*....|....*
gi 1586453981 1024 SGDLSGLADRDAEFR 1038
Cdd:PRK05672 1032 SPLLGGLRTRSRDFH 1046
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-1020 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1342.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 2 RYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQD------GMSI 75
Cdd:COG0587 4 SFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPgsrddaGYHL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 76 LVYPTDRAAYSRLTRLLTLGKGRG-GKANCILNLEDVALYSEGLLGILVPDLPDDVCAI----------QLRKMAEVFAD 144
Cdd:COG0587 84 VLLAKNREGYRNLCRLLSRAYLEGfYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALlagqydeaeaALARLKDIFGD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 145 GAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPPE 224
Cdd:COG0587 164 RFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYLKSPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 225 EMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYPEGLPPEVLKIVRHELDLI 304
Cdd:COG0587 244 EMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEGIPEEYRERLEYELDVI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 305 RTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVDFEHERRE 383
Cdd:COG0587 324 EKMGFPGYFLIVWDFIRWARSNGIpVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSMPDIDIDFCHERRE 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 384 EVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMW---AWSEELVSDRSLRDQGLNPEDRRLA 460
Cdd:COG0587 404 EVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPndpGITLEKALEEEPELRELYDSDPEVR 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 461 LTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVIEWDKDDVEALKFMKVDILALGMLTCMAKTFALI 540
Cdd:COG0587 484 RLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVIRDALDLI 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 541 REHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRRE 620
Cdd:COG0587 564 KENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYRPGPMQGGMVPPYIRRKH 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 621 GKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLVSGMIRNGYTAEF 700
Cdd:COG0587 644 GREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGK-KKKEEMAKQREKFVEGAVANGYDEEF 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 701 AEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRPVCINNSR 780
Cdd:COG0587 723 AEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQYVQEARRHGIEVLPPDVNESD 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 781 WDCTLErignaDSHAVRLGMRMVRGLAAADTARVVAARMDQ-PFESIDDMWRRSG---VPAASLVELAEADAFlPSLGLQ 856
Cdd:COG0587 803 WDFTVE-----PGGAIRLGLGAIKGVGEAAAEAIVAAREENgPFTSLFDFCRRVDlrkLNKRVLEALIKAGAF-DSLGPN 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 857 RRDALWAIKGLRD-----------EPLPLFaaaSEREARAVAEQQEPEvaLRQMTEGHNVVQDYSHIGLTLRDHPVAFLR 925
Cdd:COG0587 877 RRQLLWALEAALDaaqqaqkdkasGQLSLF---GGAGDEEVAEPALPE--LPEWSEKEKLAAEKEALGLYLSGHPLDLYR 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 926 KALTERRIVTCAQAMNARDGRWLMTAGLVLVRQRPGSAKG--VIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAIN 1003
Cdd:COG0587 952 EELRRLGVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGkrMAFVTLEDETGSIEVVVFPEVYERYRRLLLEDRLLLVR 1031
|
1050
....*....|....*..
gi 1586453981 1004 GRIQREGDVVHLVAQQV 1020
Cdd:COG0587 1032 GKVQRRDGVVHLIAERI 1048
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-983 |
4.23e-174 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 537.73 E-value: 4.23e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 6 LQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMS----------- 74
Cdd:TIGR00594 4 LHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfdkkriskgke 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 75 ---ILVYPTDRAAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGL------LGILVPDL----PDDVCAIQLRKMAEV 141
Cdd:TIGR00594 84 ayhLILLAKNNTGYRNLMKLSSLAYLEGFYYKPRIDKELLEEHSEGLialsacLSGEVPYLlllgEERLAEEAALKYQEI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 142 FADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLK 221
Cdd:TIGR00594 164 FGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDEFYLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 222 PPEEMERLFPRYPEALARTMEIVERCR-FSLEELTYQYPEEAILPDKTPQES-LEHYVWECVPNRYPEGLP-----PEVL 294
Cdd:TIGR00594 244 SPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPSYQIPPDFTSQEDyLRHLADEGLRERLAAGPPgykrrAQYK 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 295 KIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDI 373
Cdd:TIGR00594 324 ERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIpVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNPERISMPDI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 374 DVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLP----EDLIKALSSGMwAWSEELVSDRSLRD 449
Cdd:TIGR00594 404 DIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPyaeaDRIAKLIPPRP-GKTLKEALEASPQL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 450 QGLNPEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPI---EPAAMVDRQvieWDKDDVEALKFMKVDILA 526
Cdd:TIGR00594 483 RQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLykdKEGGAISTQ---YDMDDLEAVGLLKMDFLG 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 527 LGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGP 606
Cdd:TIGR00594 560 LKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAVNALYRPGP 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 607 IQGDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDK 686
Cdd:TIGR00594 640 MESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK-KKAEEMAKEREK 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 687 LVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARN 766
Cdd:TIGR00594 719 FVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDIEKVAVYIAEAKK 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 767 HGVEIRPVCINNSRWDCTLERIGnadshaVRLGMRMVRGLAAADTARVVAARMDQ-PFESIDDMWRRsgVPAASL----V 841
Cdd:TIGR00594 799 MGIEVLPPDINESGQDFAVEDKG------IRYGLGAIKGVGESVVKSIIEERNKNgPFKSLFDFINR--VDFKKLnkkvL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 842 E-LAEADAFlPSLGlQRRDALWAI------------KGLRDEPLPLFAAASEREAravaEQQEPEVALRQMTEGHNVVQD 908
Cdd:TIGR00594 871 EaLIKAGAF-DSLG-PNRKTLLASlddaldavsrkkKAEALGQNSLFGALSEGTK----PEYVFFPPDEEWPDKKLLALE 944
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586453981 909 YSHIGLTLRDHPVAFLRKALTERRIVTCAQAMNARDGRWLMTAGL---VLVRQRPGSAKGVIFMTIEDETGPANVVVW 983
Cdd:TIGR00594 945 KETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGlnsVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
3-259 |
1.35e-115 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 357.54 E-value: 1.35e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 3 YAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMSILVYPTDR 82
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKELGLKLIVGSELVLADGTRLVLLARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 83 AAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGLLGILVPD---LPDDVCAIQLRKMAEVFADGAYVSLCLRRRPNDQ 159
Cdd:cd07434 81 AGYGRLCRLITLGRRRAEKGEYRLTLADLLAHAEGLLLILLPPdrlPAAAALLAQLRWLARAFPGRLWLALELHLGGDDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 160 VRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPPEEMERLFPRYPEALAR 239
Cdd:cd07434 161 RRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEAGRRLAANAERHLRSPAELARLFLYPPEALAE 240
|
250 260
....*....|....*....|
gi 1586453981 240 TMEIVERCRFSLEELTYQYP 259
Cdd:cd07434 241 TLEIAARCTFSLDELRYEYP 260
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
271-526 |
2.76e-114 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 354.12 E-value: 2.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 271 ESLEHYVWECVPNRYPEGLPPEVLKIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITS 349
Cdd:pfam07733 1 EYLRKLVEEGLKERYGEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVgPGRGSAAGSLVAYLLGITE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 350 IDPSTNDLLFERFVSQERDEPPDIDVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKA 429
Cdd:pfam07733 81 VDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEIDR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 430 LSSGMWAWSEELVS--DRSLRDQGLNPEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVI 507
Cdd:pfam07733 161 LAKLIPFELGILEKalEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKADDDDRPVT 240
|
250
....*....|....*....
gi 1586453981 508 EWDKDDVEALKFMKVDILA 526
Cdd:pfam07733 241 QFDKDDLEDLGLLKMDFLG 259
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
5-71 |
1.22e-09 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 55.35 E-value: 1.22e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586453981 5 ELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQD 71
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
1-1038 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 1440.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQ-----DGMSI 75
Cdd:PRK05672 3 PPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGpdpdpGGPHL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 76 LVYPTDRAAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGLLGIL------------VPDLPDDVCAIQLRKMAEVFA 143
Cdd:PRK05672 83 LVLARDREGYGRLSRLITRARLRAGKGEYRLDLDDLAEPAGGHWAILtgcrkgfvilalPYGGDAAALAALAALLDAFFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 144 DGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPP 223
Cdd:PRK05672 163 DRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGERHLRSG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 224 EEMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYPEGLPPEVLKIVRHELDL 303
Cdd:PRK05672 243 AEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPGIPPKARAQIEHELAL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 304 IRTMKYAPYFLTVFSIVRFARSQGILCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVDFEHERRE 383
Cdd:PRK05672 323 IAELGYEGYFLTVHDIVRFARSQGILCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDIDVDFEHDRRE 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 384 EVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMWAWSEELVSDRSLRDQGLNPEDRRLALTL 463
Cdd:PRK05672 403 EVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRLRQAGLDPESPIPRRVV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 464 KLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVIEWDKDDVEALKFMKVDILALGMLTCMAKTFALIREH 543
Cdd:PRK05672 483 ELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALGMLSALHRAFDLIAEH 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 544 KDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRREGKE 623
Cdd:PRK05672 563 RGRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPIQGGMVHPYLRRRNGQE 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 624 PVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATFKFTGGVSRFKDKLVSGMIRNGYTAEFAEK 703
Cdd:PRK05672 643 PVTYPHPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAAWRRKGRLERLRERLYDGMLARGYTGEFADR 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 704 TFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRPVCINNSRWDC 783
Cdd:PRK05672 723 IFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQPMGFYSPQQLVQDARRHGVEVLPVDVNASGWDA 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 784 TLERIGNADsHAVRLGMRMVRGLAAADTARVVAARMDQPFESIDDMWRRSGVPAASLVELAEADAFLpSLGLQRRDALWA 863
Cdd:PRK05672 803 TLEPLPDGG-PAVRLGLRLVRGLGEEAAERIVAARARGPFTSVEDLARRAGLDRRQLEALADAGALR-SLGGDRRQALWA 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 864 IKGLRDEPLPLFaaaserearAVAEQQEPEVALRQMTEGHNVVQDYSHIGLTLRDHPVAFLRKALTERRIVTCAQAMNAR 943
Cdd:PRK05672 881 AGAAATERLDLL---------PGAPASEAAPALPGMSEGELVAADYWTTGLSLDSHPLALLRPRLDARGVVSAAELLDVE 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 944 DGRWLMTAGLVLVRQRPGSAKGVIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQREGDVVHLVAQQVFDL 1023
Cdd:PRK05672 952 DGRRVRVAGVVTHRQRPGTASGVTFLTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRVQNAEGVRHLVADRLEDL 1031
|
1050
....*....|....*
gi 1586453981 1024 SGDLSGLADRDAEFR 1038
Cdd:PRK05672 1032 SPLLGGLRTRSRDFH 1046
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-1020 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1342.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 2 RYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQD------GMSI 75
Cdd:COG0587 4 SFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPgsrddaGYHL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 76 LVYPTDRAAYSRLTRLLTLGKGRG-GKANCILNLEDVALYSEGLLGILVPDLPDDVCAI----------QLRKMAEVFAD 144
Cdd:COG0587 84 VLLAKNREGYRNLCRLLSRAYLEGfYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALlagqydeaeaALARLKDIFGD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 145 GAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPPE 224
Cdd:COG0587 164 RFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYLKSPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 225 EMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYPEGLPPEVLKIVRHELDLI 304
Cdd:COG0587 244 EMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEGIPEEYRERLEYELDVI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 305 RTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVDFEHERRE 383
Cdd:COG0587 324 EKMGFPGYFLIVWDFIRWARSNGIpVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSMPDIDIDFCHERRE 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 384 EVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMW---AWSEELVSDRSLRDQGLNPEDRRLA 460
Cdd:COG0587 404 EVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPndpGITLEKALEEEPELRELYDSDPEVR 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 461 LTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVIEWDKDDVEALKFMKVDILALGMLTCMAKTFALI 540
Cdd:COG0587 484 RLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVIRDALDLI 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 541 REHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRRE 620
Cdd:COG0587 564 KENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYRPGPMQGGMVPPYIRRKH 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 621 GKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLVSGMIRNGYTAEF 700
Cdd:COG0587 644 GREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGK-KKKEEMAKQREKFVEGAVANGYDEEF 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 701 AEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRPVCINNSR 780
Cdd:COG0587 723 AEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQYVQEARRHGIEVLPPDVNESD 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 781 WDCTLErignaDSHAVRLGMRMVRGLAAADTARVVAARMDQ-PFESIDDMWRRSG---VPAASLVELAEADAFlPSLGLQ 856
Cdd:COG0587 803 WDFTVE-----PGGAIRLGLGAIKGVGEAAAEAIVAAREENgPFTSLFDFCRRVDlrkLNKRVLEALIKAGAF-DSLGPN 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 857 RRDALWAIKGLRD-----------EPLPLFaaaSEREARAVAEQQEPEvaLRQMTEGHNVVQDYSHIGLTLRDHPVAFLR 925
Cdd:COG0587 877 RRQLLWALEAALDaaqqaqkdkasGQLSLF---GGAGDEEVAEPALPE--LPEWSEKEKLAAEKEALGLYLSGHPLDLYR 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 926 KALTERRIVTCAQAMNARDGRWLMTAGLVLVRQRPGSAKG--VIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAIN 1003
Cdd:COG0587 952 EELRRLGVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGkrMAFVTLEDETGSIEVVVFPEVYERYRRLLLEDRLLLVR 1031
|
1050
....*....|....*..
gi 1586453981 1004 GRIQREGDVVHLVAQQV 1020
Cdd:COG0587 1032 GKVQRRDGVVHLIAERI 1048
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-983 |
4.23e-174 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 537.73 E-value: 4.23e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 6 LQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMS----------- 74
Cdd:TIGR00594 4 LHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfdkkriskgke 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 75 ---ILVYPTDRAAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGL------LGILVPDL----PDDVCAIQLRKMAEV 141
Cdd:TIGR00594 84 ayhLILLAKNNTGYRNLMKLSSLAYLEGFYYKPRIDKELLEEHSEGLialsacLSGEVPYLlllgEERLAEEAALKYQEI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 142 FADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLK 221
Cdd:TIGR00594 164 FGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDEFYLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 222 PPEEMERLFPRYPEALARTMEIVERCR-FSLEELTYQYPEEAILPDKTPQES-LEHYVWECVPNRYPEGLP-----PEVL 294
Cdd:TIGR00594 244 SPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPSYQIPPDFTSQEDyLRHLADEGLRERLAAGPPgykrrAQYK 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 295 KIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDI 373
Cdd:TIGR00594 324 ERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIpVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNPERISMPDI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 374 DVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLP----EDLIKALSSGMwAWSEELVSDRSLRD 449
Cdd:TIGR00594 404 DIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPyaeaDRIAKLIPPRP-GKTLKEALEASPQL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 450 QGLNPEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPI---EPAAMVDRQvieWDKDDVEALKFMKVDILA 526
Cdd:TIGR00594 483 RQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLykdKEGGAISTQ---YDMDDLEAVGLLKMDFLG 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 527 LGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGP 606
Cdd:TIGR00594 560 LKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAVNALYRPGP 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 607 IQGDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDK 686
Cdd:TIGR00594 640 MESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK-KKAEEMAKEREK 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 687 LVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARN 766
Cdd:TIGR00594 719 FVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDIEKVAVYIAEAKK 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 767 HGVEIRPVCINNSRWDCTLERIGnadshaVRLGMRMVRGLAAADTARVVAARMDQ-PFESIDDMWRRsgVPAASL----V 841
Cdd:TIGR00594 799 MGIEVLPPDINESGQDFAVEDKG------IRYGLGAIKGVGESVVKSIIEERNKNgPFKSLFDFINR--VDFKKLnkkvL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 842 E-LAEADAFlPSLGlQRRDALWAI------------KGLRDEPLPLFAAASEREAravaEQQEPEVALRQMTEGHNVVQD 908
Cdd:TIGR00594 871 EaLIKAGAF-DSLG-PNRKTLLASlddaldavsrkkKAEALGQNSLFGALSEGTK----PEYVFFPPDEEWPDKKLLALE 944
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586453981 909 YSHIGLTLRDHPVAFLRKALTERRIVTCAQAMNARDGRWLMTAGL---VLVRQRPGSAKGVIFMTIEDETGPANVVVW 983
Cdd:TIGR00594 945 KETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGlnsVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
6-1024 |
1.45e-168 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 526.59 E-value: 1.45e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 6 LQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMSILVYPTDRAA- 84
Cdd:PRK05673 5 LHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKKDDVSGGGAYTh 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 85 ----------YSRLTRLLTLG--KGRGGKANCIlNLEDVALYSEGLL-------GI----LVPDLPDDVCAIqLRKMAEV 141
Cdd:PRK05673 85 ltllaknetgYRNLFKLSSRAylEGQYGYKPRI-DREWLAEHSEGLIalsgcpsGEvgtaLLAGQYDEAEEA-AAEYQEI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 142 FADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVgfERERH--ADRF 219
Cdd:PRK05673 163 FGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDP--DRFRFysPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 220 LKPPEEMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYPEGLPPEVLKIVR- 298
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEAKEGLEERLAFLFPDEERPEYVe 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 299 ---HELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDID 374
Cdd:PRK05673 321 rleYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVgPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVSMPDFD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 375 VDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLP----EDLIKA--------LSSgmwAWSEE-- 440
Cdd:PRK05673 401 IDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPygfvDRITKLippdpgitLAK---AYEEEpe 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 441 LvsdRSLRDQglNPEDRRLaltLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIepaaMVDRQ----VIEWDKDDVEA 516
Cdd:PRK05673 478 L---RELYES--DPEVKRL---IDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPL----YRDPDsgmpVTQFDMKDVEA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 517 LKFMKVDILALGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLV 596
Cdd:PRK05673 546 AGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDII 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 597 IQVAIVRPGPIQGDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSM----- 671
Cdd:PRK05673 626 ALVALYRPGPMESGMIPNFIDRKHGREEIEYPHPELEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMgkkkp 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 672 -------ATFkftggvsrfkdklVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCA 744
Cdd:PRK05673 706 eemakqrEIF-------------VEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMA 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 745 ALLNSQpM-------GFYAPaqivgcARNHGVEIRPVCINNSRWDCTlerignADSHAVRLGMRMVRGLAAADTARVVAA 817
Cdd:PRK05673 773 ALLTSD-MdntdkvaVYLDE------CRRMGIKVLPPDVNESLYDFT------VVDGDIRYGLGAIKGVGEGAVEAIVEA 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 818 RMDQ-PFESIDDMWRRsgVPAASL----VE-LAEADAFlPSLGLQRR-------DAL-WAIKGLRDEPL---PLFAAASE 880
Cdd:PRK05673 840 REEGgPFKDLFDFCAR--VDLKKVnkrvLEsLIKAGAF-DSLGPNRAallasleDAVdAADQHKKAEASgqfDLFGGLGE 916
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 881 REARAVAEQQE-PEVALRQMTEGhnvvqDYSHIGLTLRDHPVAFLRKALTERRIVTCAQAMNARDGRWLMTAGLVLVRQR 959
Cdd:PRK05673 917 EPEDVEVSVPDvEEWDKKEKLAG-----ERETLGLYLSGHPLDGYEDELRRLRDTRLADLEPTEGGSVVTVAGLVVSVRR 991
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586453981 960 PGSAKG--VIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQREGDVVHLVAQQVFDLS 1024
Cdd:PRK05673 992 RVTKRGnkMAIVTLEDLSGRIEVMLFSEALEKYRDLLEEDRIVVVKGQVSFDDGGLRLTAREVMDLE 1058
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
1-1029 |
1.29e-154 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 490.17 E-value: 1.29e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGC--------RLDLQDG 72
Cdd:PRK06826 3 MSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCevyvaprsRFDKEPD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 73 -------MSILVypTDRAAYSRLTRLLTLG-------KGRggkanciLNLEDVALYSEGLL---GILVPDLPDDVCAIQL 135
Cdd:PRK06826 83 idnetyhLVLLA--KNETGYKNLMKIVSKAftegfyyKPR-------VDHELLKEHSEGLIalsACLAGEVPRYILKGNY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 136 RKMAE-------VFA-DGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDT 207
Cdd:PRK06826 154 EKAKEaalfykdIFGkENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 208 VGfeRERHA-DRF-LKPPEEMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRY 285
Cdd:PRK06826 234 EN--RMRFPsDEFyLKSPEEMYELFSYVPEALENTVKIAERCNVEFEFGKSKLPKFPLPEGYDPYEYLRELCYEGLKKRY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 286 PEgLPPEVLKIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVS 364
Cdd:PRK06826 312 PN-PSEELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVgPGRGSAAGSLVAYTLGITKIDPIKYNLLFERFLN 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 365 QERDEPPDIDVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPE---DLI-------------K 428
Cdd:PRK06826 391 PERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYaevDRIakmiptelgitidK 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 429 ALSSgmwawSEELvsdRSLRDQglNPEDRRLaltLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAmvDRQVIE 508
Cdd:PRK06826 471 ALEL-----NPEL---KEAYEN--DERVREL---IDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQKND--GSIVTQ 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 509 WDKDDVEALKFMKVDILALGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLK 588
Cdd:PRK06826 536 FTMTTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNRGIEIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELK 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 589 PRTFYDLVIQVAIVRPGPIqgDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLR 668
Cdd:PRK06826 616 PDSLEDIIAGISLYRPGPM--DSIPRYIKNKNNPEKIEYLHPKLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVR 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 669 KSMATFK----------FTGGVsrfKDKLVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHH 738
Cdd:PRK06826 694 RAMSKKKhdvmeeerknFIYGI---VDEGGPGCIRNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYY 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 739 PDVFCAALLNS-----QPMGFYapaqiVGCARNHGVEIRPVCINNSRWDCTLEriGNadshAVRLGMRMVRGLAAADTAR 813
Cdd:PRK06826 771 PVEFMAALLNSvmgnsDKVAFY-----IEECRRLGIEVLPPDINESYSKFTVE--GD----KIRFGLAAVKNVGENAIDS 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 814 VVAARMDQ-PFESIDDMWRR---SGVPAASLVELAEADAFlPSLGLQRRDAL--------WAIKGLRDE---PLPLFAAA 878
Cdd:PRK06826 840 IVEEREKKgKFKSLVDFCERvdtSQINKRAVESLIKAGAF-DSLGVYRSQLLavyekildSISKQRKKNiegQISLFDLI 918
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 879 SErearavAEQQEPEVALRQmteghnvVQDYSH----------IGLTLRDHPVAFLRKALTERRIVTCAQAMNA------ 942
Cdd:PRK06826 919 GE------EEESSLEIKYPD-------IKEFDKkellamekemLGLYISGHPLEEYEETLKKQTSATISDIISDeeedge 985
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 943 ---RDGRWLMTAGLVLVRQRPGSAKGVI--FMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQ-REGDVVHLV 1016
Cdd:PRK06826 986 sklKDGDKVIIGGIITEVKRKTTRNNEMmaFLTLEDLYGTVEVIVFPKVYEKYRSLLNEDNIVLIKGRVSlREDEEPKLI 1065
|
1130
....*....|...
gi 1586453981 1017 AQQVFDLSGDLSG 1029
Cdd:PRK06826 1066 CEEIEPLVINSEK 1078
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
1-1023 |
1.94e-132 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 429.99 E-value: 1.94e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMSILVYP- 79
Cdd:PRK06920 1 MKFVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASIFSEEEEKSYPl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 80 ----TDRAAYSRLTRLLT--LGKGRGGkanciLNLEDVALYSEGLLGI----------LVPDLPDDVCAIQLRKMAEVFA 143
Cdd:PRK06920 81 vllaENEIGYQNLLKISSsiMTKSKEG-----IPKKWLAHYAKGLIAIspgkdgeieqLLLEDKESQAEEVARAYQNMFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 144 DGaYVSLCLRRRPNDQV---RLHALSNMAvkhRVKTVVTNDVLFHepgRRQLQDVVTC---IRHNTIIDTVGFERERHAD 217
Cdd:PRK06920 156 NF-YMSLQHHAIQDELLlqeKLPEFSNRV---NIPVVATNDVRYI---NQSDALVHECllsVESGTKMTDPDRPRLKTDQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 218 RFLKPPEEMERLFPRYPEALARTMEIVERCRFSLEELTYQYPEEAILPDKTPQESLEHYVWECVPNRYpeGLPPEV-LKI 296
Cdd:PRK06920 229 YYLKSSDEMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGLQKRY--GTPKEVhINR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 297 VRHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDV 375
Cdd:PRK06920 307 LNHELNVISRMGFSDYFLIVWDFMKYAHENHILTgPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDIDI 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 376 DFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSS------GM-----WAWSEELvsD 444
Cdd:PRK06920 387 DFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKlipsklGItlkdaYEESQSL--R 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 445 RSLRdqglnpEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMvDRQVIEWDKDDVEALKFMKVDI 524
Cdd:PRK06920 465 EFIQ------GNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAIQEGHN-DVYVTQYPADALEELGLLKMDF 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 525 LALGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRP 604
Cdd:PRK06920 538 LGLRNLTLLENIIKFIEQKTGKEIDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYRP 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 605 GPIQGdmVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFK 684
Cdd:PRK06920 618 GPMEQ--IPTFIESKHGKRKIEYLHPDLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVSK-KNRDILDQER 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 685 DKLVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCA 764
Cdd:PRK06920 695 KHFVQGCLQNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKIVQYIRET 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 765 RNHGVEIRPVCINNSRWDCTLErignadSHAVRLGMRMVRGLAAADTARVVAARMDQPFESIDDMWRRsgVPAASLVElA 844
Cdd:PRK06920 775 KRKGFHVLPPSLQRSGYNFQIE------GNAIRYSLLSIRNIGMATVTALYEEREKKMFEDLFEFCLR--MPSKFVTE-R 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 845 EADAFLPSLGL----QRRDALWA-IKGLRDEPLPLFAAASEREARAVAEQQE-PEVALRQmteghnvvQDYSHIGLTLRD 918
Cdd:PRK06920 846 NLEAFVWSGCFddfgVSRTNLWKsLKGALEYANLARDLGDAVPKSKYVQGEElSFIEQLN--------KEKEVLGFYLSS 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 919 HPVAFLRKALTERRIVTCAQAMNARDGRWLMTAGLVLVRQ-RPGSAKGVIFMTIEDETGPANVVVWPKLFEQRRRVVLGA 997
Cdd:PRK06920 918 YPTAQYVKLAKELEIPSLAQAMRHKKKVQRAIVYITSVKViRTKKGQKMAFITFCDQNDEMEAVVFPETYIHFSDKLQEG 997
|
1050 1060
....*....|....*....|....*.
gi 1586453981 998 SMIAINGRIQREGDVVHLVAQQVFDL 1023
Cdd:PRK06920 998 AIVLVDGTIELRNHKLQWIVNGLYPL 1023
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
1-1016 |
1.95e-123 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 406.80 E-value: 1.95e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRL-----DLQDGMS- 74
Cdd:PRK07374 1 MAFVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMyvingSIDDPQPk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 75 ------ILVYPTDRAAYSRLTRLLTLG-----KGRGGKANCILNLEDVALYSEGLL---GILVPDLPDDVCAIQL---RK 137
Cdd:PRK07374 81 kekryhLVVLAKNATGYKNLVKLTTIShlngmRGRGIFSRPCIDKELLKQYSEGLIvstACLGGEIPQAILRGRPdvaRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 138 MA----EVFADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVgfERE 213
Cdd:PRK07374 161 VAawykEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDE--KRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 214 RHA-DRFLKPPEEMERLFPRY------PEALARTMEIVERcrfsLEEL----TYQYPEEAILPDKTPQESLEHYVWECVP 282
Cdd:PRK07374 239 RYTgTEYIKSEEEMLRLFRDHldpeviQEAIANTVEVAEK----VEEYdilgTYRMPRFPIPEGHTAVSYLTEVTEQGLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 283 NR----YPEGLPPEVLKIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDL 357
Cdd:PRK07374 315 KRlklnSLDEIDENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIpVGPGRGSAAGSLVAYALGITNIDPVKNGL 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 358 LFERFVSQERDEPPDIDVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLP----EDLIKAL--S 431
Cdd:PRK07374 395 LFERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPygeaDRLAKLIpvV 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 432 SGMWAWSEELVSDRSLrdqglNPE-------DRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAmvDR 504
Cdd:PRK07374 475 RGKPAKLKAMIGKESP-----SPEfrekyekDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNN--DG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 505 QVI-EWDKDDVEALKFMKVDILALGMLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAM 583
Cdd:PRK07374 548 QVItQYFMEDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTGERIDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQV 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 584 LPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGE 663
Cdd:PRK07374 628 VRDLKPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFAHPLLEPILTETYGIMVYQEQIMKIAQDLAGYSLGQ 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 664 ADQLRKSMATFKftggVS---RFKDKLVSGMIRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPD 740
Cdd:PRK07374 708 ADLLRRAMGKKK----VSemqKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLKAHYPV 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 741 VFCAALLNSQpmgfyAPAQ------IVGCaRNHGVEIRPVCINNSRWDCTLerigNADShaVRLGMRMVRGLAAADTARV 814
Cdd:PRK07374 784 AYMAALLTVN-----AGSSdkvqryISNC-NSMGIEVMPPDINRSGIDFTP----KGNR--ILFGLSAVKNLGDGAIRNI 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 815 VAAR-MDQPFESIDDMWRRsgVPAA--------SLVELAEADAFLPSLGlqrRDAL---------WAIKGLRDEPL---P 873
Cdd:PRK07374 852 IAARdSDGPFKSLADLCDR--LPSNvlnrrsleSLIHCGALDAFSPNAN---RAQLiadldlvldWASSRARDRASgqgN 926
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 874 LFAAASEREARAVAEQQE-PEVAlrqmteghnVVQDYS----------HIGLTLRDHPVaflrKALTE-RRIVT------ 935
Cdd:PRK07374 927 LFDLLAGSEEEASNDLSSaPKAA---------PVPDYPpteklklekeLLGFYLSDHPL----KQLTEpAKLLApislss 993
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 936 -CAQAMNARDGRWLMTAGLVLVRQRPGSAKGVIfmTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQREGDVVH 1014
Cdd:PRK07374 994 lEEQPDKAKVSAIAMIPEMKQVTTRKGDRMAIL--QLEDLTGSCEAVVFPKSYERLSDHLMTDTRLLVWAKVDRRDDRVQ 1071
|
..
gi 1586453981 1015 LV 1016
Cdd:PRK07374 1072 LI 1073
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
3-259 |
1.35e-115 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 357.54 E-value: 1.35e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 3 YAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGMSILVYPTDR 82
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKELGLKLIVGSELVLADGTRLVLLARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 83 AAYSRLTRLLTLGKGRGGKANCILNLEDVALYSEGLLGILVPD---LPDDVCAIQLRKMAEVFADGAYVSLCLRRRPNDQ 159
Cdd:cd07434 81 AGYGRLCRLITLGRRRAEKGEYRLTLADLLAHAEGLLLILLPPdrlPAAAALLAQLRWLARAFPGRLWLALELHLGGDDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 160 VRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPPEEMERLFPRYPEALAR 239
Cdd:cd07434 161 RRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEAGRRLAANAERHLRSPAELARLFLYPPEALAE 240
|
250 260
....*....|....*....|
gi 1586453981 240 TMEIVERCRFSLEELTYQYP 259
Cdd:cd07434 241 TLEIAARCTFSLDELRYEYP 260
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
271-526 |
2.76e-114 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 354.12 E-value: 2.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 271 ESLEHYVWECVPNRYPEGLPPEVLKIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITS 349
Cdd:pfam07733 1 EYLRKLVEEGLKERYGEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVgPGRGSAAGSLVAYLLGITE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 350 IDPSTNDLLFERFVSQERDEPPDIDVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKA 429
Cdd:pfam07733 81 VDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEIDR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 430 LSSGMWAWSEELVS--DRSLRDQGLNPEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQVI 507
Cdd:pfam07733 161 LAKLIPFELGILEKalEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKADDDDRPVT 240
|
250
....*....|....*....
gi 1586453981 508 EWDKDDVEALKFMKVDILA 526
Cdd:pfam07733 241 QFDKDDLEDLGLLKMDFLG 259
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
3-828 |
4.67e-105 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 353.57 E-value: 4.67e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 3 YAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQ-DGMSILVY--P 79
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNIFvEEQEVTLRliA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 80 TDRAAYSRLTRLLTLgkgrggKANCILNLEDVALYSEGLlGILVP--DLPDDVcaiqlrkmaeVFADGAYVSLclrrrpn 157
Cdd:PRK07279 82 KNTQGYKNLLKISTA------KMSGKKQFSDLSQYLEGI-AVIVPyfDWSETL----------ELPFDYYIGV------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 158 DQVRLHALSNMAVK--HRVKTVVTNDvlfhepgRRQLQdVVTCIRHNTIIDTVGFereRHADRFLKPPEEMERLFP-RYP 234
Cdd:PRK07279 138 DQETPGSDFKRPILplRTVRYFESAD-------RETLQ-MLHAIRDNLSLREVPL---VSSDQELISCQSLETLFQeRFP 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 235 EALARtmeivercrfsLEELT----YQYPEEAILP----DKTPQESL---------EHYVWECVpnrYPEGLppevlkiv 297
Cdd:PRK07279 207 QALDN-----------LEKLVsgisYDFDTDLKLPrfnrDRPAVEELrelaelglkEKGLWSSP---YQERL-------- 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 298 RHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVD 376
Cdd:PRK07279 265 DKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMgMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKERYSMPDIDID 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 377 FEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSgMWAWSEELVS--DRSLR-DQGLN 453
Cdd:PRK07279 345 LPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVPEYELSNLTK-KISFRDSLASvyEKNISfRQIIN 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 454 pedRRLAL--TLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAmvDRQVIEWDKDDVEALKFMKVDILALGMLT 531
Cdd:PRK07279 424 ---SKLEYqkAFEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPLKYGD--DMMITQYDAHAVEANGLLKMDFLGLRNLT 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 532 CMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPiqGDM 611
Cdd:PRK07279 499 FVQKMQEKVAKDYGIHIDIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFEDIVATTSLNRPGA--SDY 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 612 VHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLVSGM 691
Cdd:PRK07279 577 TDNFVKRRHGQEKVDLIDPVIAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSK-KNASEMQKMEEDFLQGA 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 692 IRNGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNsqpmgfYAPAQIVGCARNHGVEI 771
Cdd:PRK07279 656 LELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMLN------YSSSDYITDALEFGFEV 729
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 1586453981 772 RPVCINNSRWDctlERIGNadsHAVRLGMRMVRGLaAADTARVVAArmDQPFESIDD 828
Cdd:PRK07279 730 AKLSINTIPYH---DKIEN---KKIYLGLKNIKGL-PRDLAYWIIE--NRPFSSIED 777
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
1-849 |
5.32e-93 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 318.94 E-value: 5.32e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDlQDGMSILVYPT 80
Cdd:PRK07135 1 MKLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLE-VENFRFILLAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 81 DRAAYsRLTRLLTLGKGRGGKanciLNLEDvaLYSEGLLGIlvpDLPDDVCAIQLRKMAEVfaDGAYVSlclrrrpndqv 160
Cdd:PRK07135 80 NYSGY-KLLNELSSKKSKNKE----IELND--LDSDNIIII---DHPKNGFYAKNKEQLEL--KNYYIN----------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 161 rlhalSNMAVKHRVKTVVTNDVLFHEpgrrqlqDVVTCIRHNTIIDtvGFERERHADRFlkppeEMERLFPRYPEA-LAR 239
Cdd:PRK07135 137 -----SNDPKIENAVYVQERKLLFAE-------DNEYLKILNKIGN--NKEENSNFKFF-----DFEKWFEDIDEKiLKR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 240 TMEIVERCRFsleeltyQYPEEAI-LPD------KTPQESLEHYVWECVPNRYPEgLP--PEVLKIVRHELDLIRTMKYA 310
Cdd:PRK07135 198 TNYLVENINI-------EFPKKEFnLPDfdnnlgLESDLFLKKILKESVINKKAE-LKyyPNVKERINYEYSVIKKLKFS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 311 PYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDIDVDFEHERREEVIQWI 389
Cdd:PRK07135 270 NYFLIIWDFIKWARKNKISIgPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRITMPDIDIDIQDDRRDEVIDYI 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 390 YKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMWAW---SEELVSDRSLRDQGLNPEDRRLALTLKLA 466
Cdd:PRK07135 350 FEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIPNNqslEEAYDKNKSFFRELISKGDPIYKKLYKIA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 467 QQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAMVDRQViEWDKDDVEALKFMKVDILALGMLTCMAKTFALIREHK-- 544
Cdd:PRK07135 430 KKLEGLPRQSGTHAAGIIISNKPITNYVPTFESKDNYNQV-QYSMEFLEDFGLLKIDLLGLKNLTIIKNIEEKINKELlf 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 545 DEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQgdMVHPYLRRREGKEP 624
Cdd:PRK07135 509 DHLINFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKVGIDSFEDIVAIISLYRPGPIQ--YIPIYAKNKKNPKN 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 625 VVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLVSGMIRNGYTAEFAEKT 704
Cdd:PRK07135 587 IEKIHPEYDEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAISK-KDETKLDKIKDKFIEGGIKNGYSKKVLEKI 665
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 705 FSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRPVCINNSRWDCT 784
Cdd:PRK07135 666 YSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALISNSNGSQENIKKYVKEAKNNGIKVYSPDINFSTENAV 745
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1586453981 785 LERiGNadshaVRLGMRMVRGLAAADTARVVAARMDQ-PFESIDDMWRR---SGVPAASLVELAEADAF 849
Cdd:PRK07135 746 FDN-GK-----IFLPLIMIKGLGSVAIKKIIDERNKNgKYKNFFDFILRlkfIGISKSIIEKLIKANTL 808
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
295-824 |
7.21e-90 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 310.24 E-value: 7.21e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 295 KIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGILC-QGRGSAANSAVCYILGITSIDPSTNDLLFERFVSQERDEPPDI 373
Cdd:PRK05898 256 KRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIgPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDI 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 374 DVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLPEDLIKALSSGMWAWSEELVSDRSLRDQGLN 453
Cdd:PRK05898 336 DTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRILGIDLKVIDKICKNIKPDYEEDLDLAIKKNTILK 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 454 PEDRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEpAAMVDRQVIEWDKDDVEALKFMKVDILALGMLTCM 533
Cdd:PRK05898 416 EMYVLHKELFDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQ-LGINDRPLSQYSMEYLERFGLIKMDLLGLKNLTII 494
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 534 AKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGdmVH 613
Cdd:PRK05898 495 DNVLKLIKENQNKKIDLFNINLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQQN--IK 572
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 614 PYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLVSGMIR 693
Cdd:PRK05898 573 TFVERRFKREEFSYWNEATKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAISK-KDEKILIQLKKDFIEGALK 651
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 694 NGYTAEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYVKCHHPDVFCAALLNSQPMGFYAPAQIVGCARNHGVEIRP 773
Cdd:PRK05898 652 NNYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLNEAKEFNISIKK 731
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1586453981 774 VCINNSRWDCTLerigNADSHAVRLGMRMVRGLAAADTARVVAARMDQPFE 824
Cdd:PRK05898 732 PDINYSSNSFVL----DTQKQIIRFGFNTIKGFGDELLKKIKSALQNKTFS 778
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
1-714 |
1.06e-83 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 290.88 E-value: 1.06e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 1 MRYAELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRL-----DLQDGMSI 75
Cdd:PRK09532 1 MSFVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMyvingDIEKQKRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 76 -----LVYPTDRAAYSRLTRLLTLG-----KGRGGKANCILNLEDVALYSEGLL---GILVPDLPDDVCAIQL---RKMA 139
Cdd:PRK09532 81 rkyhqVVLAKNTQGYKNLVKLTTIShlqgvQGKGIFARPCINKELLEQYHEGLIvtsACLGGEIPQAILSGRPdaaRKVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 140 ----EVFADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIdtVGFERERH 215
Cdd:PRK09532 161 kwykKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLI--TEDKRLRY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 216 A-DRFLKPPEEMERLFPRY------PEALARTMEIVERCRfsleelTY------QYPEEAILPDKTPQESLEHYVWECVP 282
Cdd:PRK09532 239 SgTEYLKSAEEMRLLFRDHlpddviAEAIANTLEVADKIE------PYnilgepRIPNYPVPSGHTPDTYVEEVAWQGLL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 283 NRYP----EGLPPEVLKIVRHELDLIRTMKYAPYFLTVFSIVRFARSQGI-LCQGRGSAANSAVCYILGITSIDPSTNDL 357
Cdd:PRK09532 313 ERLNcksrSEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIpVGPGRGSAAGSLVAYCLKITNIDPVHHGL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 358 LFERFVSQERDEPPDIDVDFEHERREEVIQWIYKTYGKDKAALCSTVTRYRAKGAIRDVGKALGLP---EDLIKAL---S 431
Cdd:PRK09532 393 LFERFLNPERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPygeADKMAKLipvS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 432 SGMWAWSEELVSdrslrDQGLNPE-------DRRLALTLKLAQQLMGAPRHLGQHPGGFVLTHDRLDDLVPIEPAAmvDR 504
Cdd:PRK09532 473 RGKPTKLKVMIS-----DETPEPEfkekydnDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNN--DG 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 505 QVI-EWDKDDVEALKFMKVDILALGMLTCMAKTFALIREHKDEHLDLAKIPQED-------------------PPTYAMI 564
Cdd:PRK09532 546 AVItQYFMEDLESLGLLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDErkalkilakgeakklpkdvQKTHKLL 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 565 RNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPL 644
Cdd:PRK09532 626 ERGDLEGIFQLESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDYEHQLLEPILNETYGVLV 705
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 645 FQESAMKVAMVCAGFTGGEADQLRKSMATFKFTgGVSRFKDKLVSGMIRNGYTAEFAEKTFSQLEGFGSY 714
Cdd:PRK09532 706 YQEQIMKMAQDLAGYSLGEADLLRRAMGKKKIS-EMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
529-695 |
3.42e-74 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 242.44 E-value: 3.42e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 529 MLTCMAKTFALIREHKDEHLDLAKIPQEDPPTYAMIRNADTLGTFQIESRAQMAMLPRLKPRTFYDLVIQVAIVRPGPIQ 608
Cdd:pfam17657 1 TLTIIRDALDLIKENRGIGIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRPGPMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 609 GDMVHPYLRRREGKEPVVYPTPELEAVLGKTLGVPLFQESAMKVAMVCAGFTGGEADQLRKSMATfKFTGGVSRFKDKLV 688
Cdd:pfam17657 81 GGNVDDYIKRKHGKEKIEYPHPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGK-KKPEEMEKLREKFI 159
|
....*..
gi 1586453981 689 SGMIRNG 695
Cdd:pfam17657 160 EGAKENG 166
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
6-260 |
2.44e-30 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 121.43 E-value: 2.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 6 LQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGM------SILVYP 79
Cdd:cd07433 5 LRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDdadepfRLTLLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 80 TDRAAYSRLTRLLTLG--KGRGGKANCIlNLEDVALYSEGLLGI-----------LVPDLPDDvCAIQLRKMAEVFADGA 146
Cdd:cd07433 85 QNEQGYKNLTELISRAylEGQRNGGPHI-KLEWLAEYSEGLIALsggrdgdigqlLLEGNPDL-AEALLQFLKKIFPDRF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 147 YVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDTVGFERERHADRFLKPPEEM 226
Cdd:cd07433 163 YLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAEEM 242
|
250 260 270
....*....|....*....|....*....|....
gi 1586453981 227 ERLFPRYPEALARTMEIVERCRFSLEELTYQYPE 260
Cdd:cd07433 243 AELFADLPEAIENTVEIAKRCNVRIELGKPFLPD 276
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
4-251 |
3.78e-23 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 97.66 E-value: 3.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 4 AELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDGM---SILVYPT 80
Cdd:cd07431 1 AHLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVEGDGepyPLLLLAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 81 DRAAYSRLTRLLTLGKGRGGKANCI-LNLEDVALYSEGLLGILVPDLPDDvcaiqlrkmaevfadgayvslclrrrpndq 159
Cdd:cd07431 81 NNEGYQNLLRLSTAAMLGEEKDGVPyLDLEELAEAASGLLVVLLGPLLLL------------------------------ 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 160 vrlhalsnMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCirhntiidtvgfererhadrflkppeemerlfpryPEALAR 239
Cdd:cd07431 131 --------LAAEQGLPLVATNDVHYLNPEDAFAADVLTA-----------------------------------FLAVAN 167
|
250
....*....|..
gi 1586453981 240 TMEIVERCRFSL 251
Cdd:cd07431 168 TVRIAKECAVEL 179
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
768-860 |
8.37e-22 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 90.61 E-value: 8.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 768 GVEIRPVCINNSRWDCTLErignadSHAVRLGMRMVRGLAAADTARVVAARMDQPFESIDDMWRR--SGVPAASLVELAE 845
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVE------GGGIRLGLGAIKGLGEAAAERIVEERENGPFKSLEDFARRvdLKLNKRVLEALIK 74
|
90
....*....|....*
gi 1586453981 846 ADAFlPSLGLQRRDA 860
Cdd:pfam14579 75 AGAF-DSLGGNRRQL 88
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
6-259 |
2.22e-21 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 95.58 E-value: 2.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 6 LQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGC--------RLDLQDGMS--- 74
Cdd:cd12113 5 LHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCevyvapgsRFDKKDKKGdkr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 75 ---ILVYPTDRAAYSRLTRLLTLG-------KGRggkanciLNLEDVALYSEGL------LGILVPDL-----PDDVCAI 133
Cdd:cd12113 85 yyhLVLLAKNEEGYRNLMKLVSLAylegfyyKPR-------IDKELLAKYSEGLialsacLAGEIPQLllngdEEEAREA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 134 qLRKMAEVF-ADGAYVSLCLRRRPNDQVRLHALSNMAVKHRVKTVVTNDVLFHEPGRRQLQDVVTCIRHNTIIDtvgfER 212
Cdd:cd12113 158 -ALEYRDIFgKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLD----DP 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1586453981 213 ER---HADRF-LKPPEEMERLFPRYPEALARTMEIVERCRFSLEELTYQYP 259
Cdd:cd12113 233 NRmrfDTDEFyLKSPEEMRELFPDVPEALENTLEIAERCNVELDFGKLHLP 283
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
951-1024 |
4.95e-18 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 79.86 E-value: 4.95e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586453981 951 AGLVLVRQRPGSAKG--VIFMTIEDETGPANVVVWPKLFEQRRRVVLGASMIAINGRIQREGDVVHLVAQQVFDLS 1024
Cdd:cd04485 3 AGLVTSVRRRRTKKGkrMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERRDGGLRLIAERIEDLE 78
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
5-150 |
1.82e-10 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 61.02 E-value: 1.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 5 ELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQDG------------ 72
Cdd:pfam02811 1 HLHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVAPGsreetekllaky 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 73 --MSILVypTDRAAYSRLTRLLTLGKGRGGKANciLNLEDVALYSEGLLgILVPDL-------------PDDVCAIqLRK 137
Cdd:pfam02811 81 fdLVLLA--VHEVGYKNLIKLSSRAYLEGFKPR--IDKELLEEYFEGLI-ALSGCVlghldlillapgdYEEAEEL-AEE 154
|
170
....*....|....
gi 1586453981 138 MAEVFA-DGAYVSL 150
Cdd:pfam02811 155 YLEIFGeDGFYLEI 168
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
5-71 |
1.22e-09 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 55.35 E-value: 1.22e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586453981 5 ELQVTTHFSFLRGASSADELFATARELGIEALGVVDRNSLAGIVRALEASRATGVRLVVGCRLDLQD 71
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
956-1023 |
3.50e-08 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 51.47 E-value: 3.50e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586453981 956 VRQRPGSAKGVIFMTIEDETGPANVVVWPK-LFEQRRRVVLGASmIAINGRIQ-REGDVVHLVAQQVFDL 1023
Cdd:pfam01336 7 VTSIRRSGGKLLFLTLRDGTGSIQVVVFKEeAEKLAKKLKEGDV-VRVTGKVKkRKGGELELVVEEIELL 75
|
|
| |
