|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
8-597 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 934.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 8 QSLHTKLVVVYVLLIIIGMQIIGLYFTNSLEKELTDNFRKNIKQYATQLEVNIERSYK---DDSVNMQKEVQNLLNEYAN 84
Cdd:NF033092 3 RSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSkedEDDETLEEDIRTILNDFNN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 85 rQEIEEIRFIDKDQIIMATARLSSHNMINQKVNDSSVQKAISLGQSNShNVLKDYGNGkERIWVYNLPVKN-GKDTVGDI 163
Cdd:NF033092 83 -NDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNE-KILIDPEDN-NRVYVLATPIKSsNGEVVGAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 164 YIEANINDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAF 243
Cdd:NF033092 160 YIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 244 NNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQ 323
Cdd:NF033092 240 NNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 324 ENNDSFLLDIN-EEEGIIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALES 402
Cdd:NF033092 320 EEQDSLLLDFStEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 403 GAWKDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINRHEM--SAKDTTFVREIPNET 480
Cdd:NF033092 400 GAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMilKNKNITFKREFPKRD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 481 IFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNalYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGG 560
Cdd:NF033092 480 LWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLET--HNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGG 557
|
570 580 590
....*....|....*....|....*....|....*..
gi 1586175940 561 TGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPC 597
Cdd:NF033092 558 TGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
168-607 |
3.32e-123 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 371.36 E-value: 3.32e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 168 NINDVYNQLNNINQIFIIgTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLS 247
Cdd:NF033093 1 MIDNIKQNIFSFEFAFLL-LLLGFILYFILLALRNRRDNKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLNDLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 248 KRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENND 327
Cdd:NF033093 80 EVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 328 SFLLDINEEEG--IIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALESGAW 405
Cdd:NF033093 160 ELTLDSRDENGefLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 406 KDgALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINR-------HEMSAKDTTFVREIPN 478
Cdd:NF033093 240 SE-PVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRfdqiksqDTETGKKYEIVRDYPI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 479 ETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKM 558
Cdd:NF033093 319 TSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTD--TQLIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQ 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 559 GGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPCE---VIDDgDWDE 607
Cdd:NF033093 397 GGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDkdaVKDD-EWED 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
236-596 |
1.30e-99 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 308.79 E-value: 1.30e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 236 IGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQ 315
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 316 EFSLDEIQENNdsFLLDINEEEGIIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNS 395
Cdd:COG5002 108 LALLILLAALL--LLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 396 YIEALESGAWKDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINRHEMSA--KDTTFV 473
Cdd:COG5002 186 YLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAeeKGIELE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 474 REIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKA 553
Cdd:COG5002 266 LDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED--DQVRISVRDTGIGIPEEDLPRIFERFYRVDKS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1586175940 554 RTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG5002 344 RSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
182-596 |
3.54e-95 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 298.03 E-value: 3.54e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 182 IFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEK 261
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFS-LDEIQENNDSFLLDINEEEGII 340
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAElLREALERGWQEEIELTRDGRRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 341 ARVNFSTIVQEtgfvtGYIAVLHDVTEQQQVERER--REFVANVSHELRTPLTSMNSYIEALE----SGAWKDGALAPQF 414
Cdd:COG5000 170 LLVRASPLRDD-----GYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRrklaDKLEEDREDLERA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 415 LSVTREETERMIRLVNDLLQLSKMdnesDQINKEIVDFNMFINKIIN--RHEMSAKDTTFVREIPNETIFAEIDPDKMTQ 492
Cdd:COG5000 245 LDTIIRQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLREVLAlyEPALKEKDIRLELDLDPDLPEVLADRDQLEQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 493 VFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIV 572
Cdd:COG5000 321 VLINLLKNAIEAIEEGGEIEVSTRRED--GRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIV 392
|
410 420
....*....|....*....|....
gi 1586175940 573 EAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG5000 393 EEHGGTIELESRPGGGTTFTIRLP 416
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
367-596 |
2.17e-75 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 240.19 E-value: 2.17e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 367 EQQQVERERREFVANVSHELRTPLTSMNSYIEALESGAWKDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQIN 446
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 447 KEIVDFNMFINKIINRHEMSA--KDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRM 524
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLAeeKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG--DGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 525 TIRIKDNGIGIPINKVEKIFDRFYRVDkaRTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
275-596 |
9.52e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 223.63 E-value: 9.52e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 275 IIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEGIIARVNFSTIVQETGF 354
Cdd:COG0642 6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 355 VTGYIAVLHDVTEQ----QQVERERREFVANVSHELRTPLTSMNSYIEALESGAwkdGALAPQFLSVTREETERMIRLVN 430
Cdd:COG0642 86 LLLLLLLLLLLLALllllEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL---DEEQREYLETILRSADRLLRLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 431 DLLQLSKMDNESDQINKEIVDFNMFINKIINRHEMSA--KDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGD 508
Cdd:COG0642 163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAeeKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 509 KRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRkmGGTGLGLAISKEIVEAHHGRIWANSVEGQG 588
Cdd:COG0642 243 GTVTVSVRREG--DRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKG 318
|
....*...
gi 1586175940 589 TSIFITLP 596
Cdd:COG0642 319 TTFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
258-589 |
6.59e-67 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 221.31 E-value: 6.59e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 258 ESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYmlsVLNLEQEFSLDE-IQENNDSFLLDI--- 333
Cdd:TIGR02966 2 SALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQR---ITNLIRHPEFVEyLAAGRFSEPLELpsp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 334 -NEEEGIIARVNFSTIVQetgfvtgYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALESGAWKDGALAP 412
Cdd:TIGR02966 79 iNSERVLEIRIAPYGEEQ-------KLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 413 QFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIinRHEMSA----KDTTFVREI-PNETIFAeiDP 487
Cdd:TIGR02966 152 RALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHL--RDEAEAlsqgKNHQITFEIdGGVDVLG--DE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 488 DKMTQVFDNVITNAMKYSRGDKRVE---FHVKQNALYNrmtirIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLG 564
Cdd:TIGR02966 228 DELRSAFSNLVSNAIKYTPEGGTITvrwRRDGGGAEFS-----VTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLG 302
|
330 340
....*....|....*....|....*
gi 1586175940 565 LAISKEIVEAHHGRIWANSVEGQGT 589
Cdd:TIGR02966 303 LAIVKHVLSRHHARLEIESELGKGS 327
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
153-603 |
2.58e-59 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 208.67 E-value: 2.58e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 153 VKNGKdTVGDIYIEANINDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPItdmrnqtvemskGNYTQRVKIYG 232
Cdd:PRK11360 163 ERNGE-VIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANV------------DIIKDGLSTLE 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 233 ND----------EIGELALAFNNLSKRVQEAQANTESekrrldsVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDL 302
Cdd:PRK11360 230 NDlstrlpplpgELGEISQAINNLAQALRETRSLNEL-------ILESIADGVIAIDRQGKITTMNPAAEVITGLQRHEL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 303 IGYYMLSVLNLEQEFS---LDEIQENNDSFLLDI---NEEEGIIARVNFSTIVQETGFVTGYIAVLHDVTE----QQQVE 372
Cdd:PRK11360 303 VGKPYSELFPPNTPFAsplLDTLEHGTEHVDLEIsfpGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTErkrlQRRVA 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 373 RERR-----EFVANVSHELRTPLTSMNSYIEALESGAwkDGALAPQFLSVTREETERMIRLVNDLLQLSKmdneSDQINK 447
Cdd:PRK11360 383 RQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQW 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 448 EIVDFNMFINKIIN--RHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlYNRMT 525
Cdd:PRK11360 457 QPVSLNALVEEVLQlfQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYS-DGQVA 535
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586175940 526 IRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPCEVIDDG 603
Cdd:PRK11360 536 VSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
258-598 |
1.33e-54 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 189.67 E-value: 1.33e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 258 ESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFS--LDEIQENNDSF------ 329
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVterevt 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 330 LLDINEEEgIIARVNFSTIVQETGfVTGYIAVLHDVTEQQQVERERR---------EFVANVSHELRTPLTSMNSYIEAL 400
Cdd:COG3852 83 LRRKDGEE-RPVDVSVSPLRDAEG-EGGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 401 ESGAwKDGALApQFLSVTREETERMIRLVNDLLQLSKmdneSDQINKEIVDFNMFINKIIN--RHEMsAKDTTFVREIPN 478
Cdd:COG3852 161 EREL-PDDELR-EYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLEllRAEA-PKNIRIVRDYDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 479 ETIFAEIDPDKMTQVFDNVITNAMKYSRGDK------RVEFHVKQNALYNRM--TIRIKDNGIGIPINKVEKIFDRFYrv 550
Cdd:COG3852 234 SLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGtitirtRVERQVTLGGLRPRLyvRIEVIDNGPGIPEEILDRIFEPFF-- 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1586175940 551 dkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPCE 598
Cdd:COG3852 312 ----TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
185-596 |
4.18e-49 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 178.44 E-value: 4.18e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 185 IGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRL 264
Cdd:COG4251 78 LALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 265 DSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEGIIARVN 344
Cdd:COG4251 158 LLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVL 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 345 FSTIVQETGFVTGYIAVLHDVTEQQQVERERRE--------------FVANVSHELRTPLTSMNSYIEALESG-AWKDGA 409
Cdd:COG4251 238 LLLLILLLLLLILVLELLELRLELEELEEELEErtaelersneeleqFAYVASHDLREPLRKISGFSQLLEEDyGDKLDE 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 410 LAPQFLSVTREETERMIRLVNDLLQLSKMDNEsdQINKEIVDFNMFINKIINRHEMSAKDTTFVREIPN-ETIFAeiDPD 488
Cdd:COG4251 318 EGREYLERIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPlPTVRG--DPT 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 489 KMTQVFDNVITNAMKYSRGDK--RVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDkaRTRKMGGTGLGLA 566
Cdd:COG4251 394 LLRQVFQNLISNAIKYSRPGEppRIEIGAEREG--GEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLA 469
|
410 420 430
....*....|....*....|....*....|
gi 1586175940 567 ISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG4251 470 IVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
233-596 |
4.29e-44 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 163.99 E-value: 4.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 233 NDEIGELALAFNNLSKRVQEAQANTESEKRrLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIG-------- 304
Cdd:COG5809 113 NGDIEGMLAISRDITERKRMEEALRESEEK-FRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGksilelih 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 305 -YYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEgIIARVNFSTIVQEtGFVTGYIAVLHDVTEQQQVERERR------- 376
Cdd:COG5809 192 sDDQENVAAFISQLLKDGGIAQGEVRFWTKDGRW-RLLEASGAPIKKN-GEVDGIVIIFRDITERKKLEELLRkseklsv 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 377 --EFVANVSHELRTPLTSMNSYIEALESGAWKDGAlapQFLSVTREETERMIRLVNDLLQLSKMDNesdqINKEIVDFNM 454
Cdd:COG5809 270 vgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQA----IKYEPKDLNT 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 455 FINKIINRHEMSA--KDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSrgDKRVEFHVKQNAL-YNRMTIRIKDN 531
Cdd:COG5809 343 LIEEVIPLLQPQAllKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM--PEGGNITIETKAEdDDKVVISVTDE 420
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1586175940 532 GIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG5809 421 GCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
358-600 |
1.86e-43 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 160.95 E-value: 1.86e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 358 YIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALESGAWkDGALAPQFLSVTREETERMIRLVNDLLQLSK 437
Cdd:PRK11006 187 LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGALREKALHTMREQTQRMEGLVKQLLTLSK 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 438 MDNESDQINKEIVDFNMFInKIINR--HEMSAKDTTFVREI-PNETIFAeiDPDKMTQVFDNVITNAMKYSRGDKRVE-- 512
Cdd:PRK11006 266 IEAAPTIDLNEKVDVPMML-RVLEReaQTLSQGKHTITFEVdNSLKVFG--NEDQLRSAISNLVYNAVNHTPEGTHITvr 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 513 -FHVKQNALYnrmtiRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSI 591
Cdd:PRK11006 343 wQRVPQGAEF-----SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRF 417
|
....*....
gi 1586175940 592 FITLPCEVI 600
Cdd:PRK11006 418 SFVLPERLI 426
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
262-596 |
1.16e-42 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 157.27 E-value: 1.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEGIIA 341
Cdd:COG4191 13 ALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 342 RVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERR----------------EFVANVSHELRTPLTSMNSYIEALES--G 403
Cdd:COG4191 93 LLLLLLAALDAEENAELEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGNAELLRRrlE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 404 AWKDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNESdqinKEIVDFNMFINKIIN--RHEMSAKDTTFVREIPNETI 481
Cdd:COG4191 173 DEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALEllRPRLKARGIEVELDLPPDLP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 482 FAEIDPDKMTQVFDNVITN---AMKySRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRvdkarTRKM 558
Cdd:COG4191 249 PVLGDPGQLEQVLLNLLINaidAME-EGEGGRITISTRREG--DYVVISVRDNGPGIPPEVLERIFEPFFT-----TKPV 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 1586175940 559 G-GTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG4191 321 GkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
372-604 |
4.06e-41 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 155.18 E-value: 4.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 372 ERERREFVANVSHELRTPLTSMNSYIEALESGAWKdgaLAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVD 451
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK---FTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 452 FNMFINKIIN--RHEMSAKDTTFVREIPNE-TIFAeiDPDKMTQVFDNVITNAMKYSrgDKRVEFHVKQNALYNRMTIRI 528
Cdd:PRK10549 314 LVPLLEVAGGafRERFASRGLTLQLSLPDSaTVFG--DPDRLMQLFNNLLENSLRYT--DSGGSLHISAEQRDKTLRLTF 389
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586175940 529 KDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPCEVIDDGD 604
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQRE 465
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
363-596 |
1.24e-38 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 149.02 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 363 HDVTEQQQVERERREFVANVSHELRTPLTS--MNSYI-----EALESGAwkdgALAPQFLsvtREETERMIRLVNDLLQL 435
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTirMAADVihdsrDDFDPAT----ARSAELL---HTELDRFESLLSDLLEI 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 436 SKMDNESDQINKEIVDFNMFINKIINRHEMSA--KDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGdKRVEF 513
Cdd:NF040691 332 SRFDAGAAELDVEPVDLRPLVRRVVDALRQLAerAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGEG-KPVVV 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 514 HVKQNalYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFI 593
Cdd:NF040691 411 TVAQD--DTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRL 488
|
...
gi 1586175940 594 TLP 596
Cdd:NF040691 489 TLP 491
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
169-596 |
3.30e-38 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 147.57 E-value: 3.30e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 169 INDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMS---KGNY-----TQRVKIYGNDEIGELA 240
Cdd:COG5805 59 INPAMEKLLGYTSEEIIGKTIFDFLEKEYHYRVKTRIERLQKGYDVVMIEQIyckDGELiyvevKLFPIYNQNGQAAILA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 241 LAFNNLSKRVQEAqanTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLE-QEFSL 319
Cdd:COG5805 139 LRDITKKKKIEEI---LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCdKEEFK 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 320 DEIQENND-----SFLLDINEEEG--IIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERR---------EFVANVS 383
Cdd:COG5805 216 ERIESITEvwqefIIEREIITKDGriRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQLAAGIA 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 384 HELRTPLTSMNSYIEALESGAWKDgalaPQFLSVTREETERMIRLVNDLLQLSKMDNESDQ---INKEIVDFNMFINkii 460
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDK----EEYFDIMLSELDRIESIISEFLALAKPQAVNKEkenINELIQDVVTLLE--- 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 461 nrHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNalYNRMTIRIKDNGIGIPINKV 540
Cdd:COG5805 369 --TEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE--DNSVIIRVIDEGIGIPEERL 444
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1586175940 541 EKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG5805 445 KKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
141-596 |
6.38e-37 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 143.43 E-value: 6.38e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 141 NGKERIWVYNLPVKNGKDTvgdiyieaniNDVYNQLNNINQIFIIGtAISLFITVILGFFIARTITRPITDMRNQTVEMS 220
Cdd:NF012163 135 NGQEVGALGASPVERLTRN----------TDINFDSQQKRASWLIV-ALALLLAALAAFLLARGLLAPVKRLVEATHRLA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 221 KGNYTQRVKIYGNDEIGELALAFNNLSKrvqeaqantesekrrldsvithmsdgiiatdrrgrvriindmalkmlgmake 300
Cdd:NF012163 204 AGDYTTRVTPTSNDELGKLAQDFNQLAS---------------------------------------------------- 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 301 dligyymlsvlnleqefsldeiqenndsflldineeegiiarvnfstivqetgfvtgyiaVLHdvteqqQVERERREFVA 380
Cdd:NF012163 232 ------------------------------------------------------------TLE------KNEQMRRDFMA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 381 NVSHELRTPLTSMNSYIEALESGAWKdgaLAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKII 460
Cdd:NF012163 246 DISHELRTPLAVLRAELEAIQDGIRK---FTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 461 N--RHEMSAKDTTFVREIPnETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPIN 538
Cdd:NF012163 323 GafRERFASAGLELEVSLP-DSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRP--KEVTLTVADSAPGVSDE 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1586175940 539 KVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:NF012163 400 QLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
368-596 |
1.89e-35 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 137.39 E-value: 1.89e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 368 QQQVE--RERREF----VANVSHELRTPLTSMNSYIEALESGAWKDG-----ALAPQFLSVTREETERMIRLVNDLLQLS 436
Cdd:PRK09303 138 RQENEtlLEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIDEDtelkpALIEQLQDQARRQLEEIERLITDLLEVG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 437 KMDNESDQINKEIVDFNMFINKIINRHE--MSAKDTTFVREIPNE--TIFAeiDPDKMTQVFDNVITNAMKYSRGdkrvE 512
Cdd:PRK09303 218 RTRWEALRFNPQKLDLGSLCQEVILELEkrWLAKSLEIQTDIPSDlpSVYA--DQERIRQVLLNLLDNAIKYTPE----G 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 513 FHVKQNALYnRMT----IRIKDNGIGIPINKVEKIFDRFYRVDkaRTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQG 588
Cdd:PRK09303 292 GTITLSMLH-RTTqkvqVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
|
....*...
gi 1586175940 589 TSIFITLP 596
Cdd:PRK09303 369 SCFHFTLP 376
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
367-596 |
2.43e-35 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 138.73 E-value: 2.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 367 EQQQVERERREFVANVSHELRTPLTSMNSYIEALESGAwkDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNEsdqiN 446
Cdd:COG5808 233 INTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKY--PELEDQKYFDIIQEEIQRINQIVSEFLVLGKPTAK----K 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 447 KEIVDFNMFINKIIN--RHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALYnrM 524
Cdd:COG5808 307 LELDDLNELIEEILSiiDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEK--A 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 525 TIRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:COG5808 385 VIEVIDNGEGIPEDIIDEIFEPFV------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
378-586 |
2.69e-35 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 138.67 E-value: 2.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 378 FVANVSHELRTPLTSM--------------NSYIEALESGAwkdgalapqflsvtrEETERMIRLVNDLLQLSKMDNESD 443
Cdd:TIGR01386 244 FSADLAHELRTPLTNLlgqtqvalsqprtgEEYREVLESNL---------------EELERLSRMVSDMLFLARADNGQL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 444 QINKEIVDFNMFINKIINRHEMSAKDTTFVREIPNETiFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNR 523
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEG-LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS--DE 385
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 524 MTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEG 586
Cdd:TIGR01386 386 VRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
490-595 |
6.54e-35 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 127.33 E-value: 6.54e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRkmGGTGLGLAISK 569
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEG--DGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 1586175940 570 EIVEAHHGRIWANSVEGQGTSIFITL 595
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
485-596 |
1.33e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.61 E-value: 1.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 485 IDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKaRTRKMGGTGLG 564
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDG--DHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|..
gi 1586175940 565 LAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
359-596 |
1.42e-32 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 130.82 E-value: 1.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 359 IAVLHDVTEQQQVererreFVANVSHELRTPLTSMNsyiealesgawkdgaLAPQFL--------SVTREETE--RMIRL 428
Cdd:PRK09470 233 VTALERMMTSQQR------LLSDISHELRTPLTRLQ---------------LATALLrrrqgeskELERIETEaqRLDSM 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 429 VNDLLQLSKMDNESdQINKEIVDFNMFINKIINRHEMSAKD---TTFVREIPNE-TIFAeiDPDKMTQVFDNVITNAMKY 504
Cdd:PRK09470 292 INDLLVLSRNQQKN-HLERETFKANSLWSEVLEDAKFEAEQmgkSLTVSAPPGPwPING--NPNALASALENIVRNALRY 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 505 SRGDKRVEFHVKQNALynrmTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSV 584
Cdd:PRK09470 369 SHTKIEVAFSVDKDGL----TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDS 444
|
250
....*....|..
gi 1586175940 585 EGQGTSIFITLP 596
Cdd:PRK09470 445 PLGGLRLTIWLP 456
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
486-596 |
6.17e-32 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 119.40 E-value: 6.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNalyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKartRKMGGTGLGL 565
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEG---GELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 1586175940 566 AISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-596 |
3.75e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 113.96 E-value: 3.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 492 QVFDNVITNAMKYSRGDkrVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEI 571
Cdd:cd16949 3 RALENVLRNALRYSPSK--ILLDISQDG--DQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 1586175940 572 VEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
378-596 |
3.39e-28 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 118.34 E-value: 3.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 378 FVANVSHELRTPLTSMNSYIEALESGAWKDGALAPQFLSvTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFIN 457
Cdd:PRK09835 265 FSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYS-NLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVG 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 458 KIINRHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALYNRMTIriKDNGIGIPI 537
Cdd:PRK09835 344 KVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVV--ENPGTPIAP 421
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1586175940 538 NKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSvEGQGTSIFITLP 596
Cdd:PRK09835 422 EHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
372-598 |
3.95e-28 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 120.14 E-value: 3.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 372 ERE--RREFVANVSHELRTPLTSMNSYIEALE-SGAWKDGALAPQfLSVTREETERMIRLVNDLLQLSKMDNESDQINKE 448
Cdd:PRK10490 659 EREqlRNALLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQ-ASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKE 737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 449 IVDFNMFINKIINRHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSrGDKrVEFHVKQNALYNRMTIRI 528
Cdd:PRK10490 738 WLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYA-GAQ-AEIGIDAHVEGERLQLDV 815
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 529 KDNGIGIPINKVEKIFDRFYRVDKARTrkMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPCE 598
Cdd:PRK10490 816 WDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
183-598 |
5.26e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 113.40 E-value: 5.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 183 FIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKR 262
Cdd:COG3290 1 LLLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 263 RL----DSVITHMSDGIIATDRRGRVRIINDMALKMLGMakeDLIGYYMLSVL-NLEQEFSLDEIQENNDSFLLdineee 337
Cdd:COG3290 81 RLveerEAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLaEVLETGERDEEILLNGRVLV------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 338 giiarVNFSTIVQEtGFVTGYIAVLHDVTEQQQVERE---RREFVANV---SHELRTPLTSMNSYIEAlesgawkdgala 411
Cdd:COG3290 152 -----VNRVPIRDD-GRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRNHLHTISGLLQL------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 412 pqflsvtrEETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINRheMSAKDTTFVREIPNETIFAEIDPDKMT 491
Cdd:COG3290 214 --------GEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAAR--ARERGIDLTIDIDSDLPDLPLSDTDLV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 492 QVFDNVITNAM----KYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRvdkarTRKMGGTGLGLAI 567
Cdd:COG3290 284 TILGNLLDNAIeaveKLPEEERRVELSIRDDG--DELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLAL 356
|
410 420 430
....*....|....*....|....*....|.
gi 1586175940 568 SKEIVEAHHGRIWANSVEGQGTSIFITLPCE 598
Cdd:COG3290 357 VKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
368-596 |
9.49e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 113.73 E-value: 9.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 368 QQQVERE--RRE-------FVANVSHELRTPLTSMNSYIEALESGAwKDGALAPQFLSVTREETERMIRLVNDLLQLSKm 438
Cdd:PRK10364 221 RQLLQDEmkRKEklvalghLAAGVAHEIRNPLSSIKGLAKYFAERA-PAGGEAHQLAQVMAKEADRLNRVVSELLELVK- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 439 dneSDQINKEIVDFNMFINKIINRHEMSAKDttfvREI-----PNETI-FAEIDPDKMTQVFDNVITNAMKYSRGDKRVE 512
Cdd:PRK10364 299 ---PTHLALQAVDLNDLINHSLQLVSQDANS----REIqlrftANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVIS 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 513 FHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIF 592
Cdd:PRK10364 372 VTASESG--AGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFT 443
|
....
gi 1586175940 593 ITLP 596
Cdd:PRK10364 444 LWLP 447
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-596 |
9.79e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 104.47 E-value: 9.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGL 565
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTP--QEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1586175940 566 AISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
492-597 |
5.03e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 102.57 E-value: 5.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 492 QVFDNVITNAMKY-SRGDkrVEFHVK---QNALYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAI 567
Cdd:cd16922 3 QILLNLLGNAIKFtEEGE--VTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 1586175940 568 SKEIVEAHHGRIWANSVEGQGTSIFITLPC 597
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-596 |
1.67e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 98.17 E-value: 1.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGD--KRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKarTRKMGGTGLGLAI 567
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVG--EEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAI 76
|
90 100
....*....|....*....|....*....
gi 1586175940 568 SKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16921 77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
364-607 |
3.30e-24 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 107.72 E-value: 3.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 364 DVTEQQQVE-------RERREFVANVSHELRTPLTSmnsyIEALeSGAWKDGALAPQ---FLSVTREETERMIRLVNDLL 433
Cdd:PRK11091 265 DITERKRYQdalekasRDKTTFISTISHELRTPLNG----IVGL-SRILLDTELTAEqrkYLKTIHVSAITLGNIFNDII 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 434 QLSKMDNESDQINKEIVDFNMFINKIINRHEMSA--KDTTFVREI----PnetIFAEIDPDKMTQVFDNVITNAMKYSRG 507
Cdd:PRK11091 340 DMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAeqKGLRFDLEPllplP---HKVITDGTRLRQILWNLISNAVKFTQQ 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 508 DK---RVEFHVKQnalynRMTIRIKDNGIGIPINKVEKIFDRFYRV-DKARTRKMGGTGLGLAISKEIVEAHHGRIWANS 583
Cdd:PRK11091 417 GGvtvRVRYEEGD-----MLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTS 491
|
250 260
....*....|....*....|....
gi 1586175940 584 VEGQGTSIFITLPCEVIDDGDWDE 607
Cdd:PRK11091 492 EEGKGSCFTLTIHAPAVAEEVEDA 515
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
380-596 |
8.80e-24 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 103.15 E-value: 8.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 380 ANVSHELRTPLTSMNSYIEALESGAWK-DGALAPQFLSvtreETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINK 458
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEpDPALFKSLLN----QVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 459 IINRHE--MSAKDTTFVREIPNETIFAeiDPDKMTQVFDNVITNAMKYSR-GDKRVEFHVKQNALynrmTIRIKDNGIGI 535
Cdd:NF012226 219 VLKMFEdrLEQAQLTIVLNLTATPVFC--DRRRIEQVLIALIDNAIRYANaGKLKISSSVIQDDW----ILQIEDEGPGI 292
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 536 PINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRI-WANSvegQGTSIF-ITLP 596
Cdd:NF012226 293 AEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIeYSNS---QGNSVFtIKLP 352
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
363-599 |
9.48e-24 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 106.40 E-value: 9.48e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 363 HDVTEQQ--QVERERREFVANVSHELRTPLTSMNSYIEALesgawKDGALAP---QFLSVTREETERMIRLVNDLLQLSK 437
Cdd:TIGR02956 450 HAKARAEaeEANRAKSAFLATMSHEIRTPLNGILGTLELL-----GDTGLTSqqqQYLQVINRSGESLLDILNDILDYSK 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 438 MDNESDQINKEIVDFNMFINKIInrHEMSA----KDTTFVREIP-NETIFAEIDPDKMTQVFDNVITNAMKY-SRGDKRV 511
Cdd:TIGR02956 525 IEAGHLSISPRPFDLNALLDDVH--HLMVSraqlKGIQLRLNIPeQLPNWWQGDGPRIRQVLINLVGNAIKFtDRGSVVL 602
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 512 EFHVkqnALYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSI 591
Cdd:TIGR02956 603 RVSL---NDDSSLLFEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCF 677
|
....*...
gi 1586175940 592 FITLPCEV 599
Cdd:TIGR02956 678 WFTLPLTR 685
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
375-596 |
7.63e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.60 E-value: 7.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 375 RREFVANVSHELRTPLTSMNSYIEALesgawkDGALAPQFLSVTREETErMIRLVNDLLQLSKMDNESDQINKEIVDFNM 454
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMS------DNLSAAESQALNRDIGQ-LEALIEELLTYARLDRPQNELHLSEPDLPA 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 455 FINKIINRHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGdkRVEFHVKQNAlyNRMTIRIKDNGIG 534
Cdd:PRK10604 285 WLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHS--RVRVSLLLDG--NQACLIVEDDGPG 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 535 IPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:PRK10604 361 IPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
369-596 |
2.13e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 100.37 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 369 QQVERERREFVANVSHELRTPLTSmnsyiealesgawkdgalapqflsvtreetermIRLVndllqlSKMDNESDQ---- 444
Cdd:PRK09467 223 KQLEDDRTLLMAGVSHDLRTPLTR---------------------------------IRLA------TEMMSEEDGylae 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 445 -INKEIVDFNMFINKIIN--RH--EMSAkDTTFVREIPNETIFAE-------------------IDPDKMTQVFDNVITN 500
Cdd:PRK09467 264 sINKDIEECNAIIEQFIDylRTgqEMPM-EMADLNALLGEVIAAEsgyereietalqpgpievpMNPIAIKRALANLVVN 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 501 AMKYSRGDKRVEFHVKQNALYnrmtIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKmgGTGLGLAISKEIVEAHHGRI- 579
Cdd:PRK09467 343 AARYGNGWIKVSSGTEGKRAW----FQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVe 416
|
250
....*....|....*..
gi 1586175940 580 WANSVEGqGTSIFITLP 596
Cdd:PRK09467 417 LGNSEEG-GLSARAWLP 432
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
333-596 |
1.08e-21 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 99.43 E-value: 1.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 333 INEEEGIIARVNFSTIVQETGFVTGYIAVLhdVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALESGawKDGALAP 412
Cdd:TIGR03785 445 IDSQGRISGAIPASRSRDEIGDLSRSFAQM--VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLELQ--ALEQEKQ 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 413 QFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINRHEMSAKDTTFVREIPNETIFAEIDPDKMTQ 492
Cdd:TIGR03785 521 KYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQ 600
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 493 VFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIV 572
Cdd:TIGR03785 601 MLDKLVDNAREFSPEDGLIEVGLSQNK--SHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIA 678
|
250 260
....*....|....*....|....*
gi 1586175940 573 EAHHGRIWA-NSVEGQGTSIFITLP 596
Cdd:TIGR03785 679 DFHQGRIQAeNRQQNDGVVFRISLP 703
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
486-596 |
2.80e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 86.39 E-value: 2.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGL 565
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRL-NRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1586175940 566 AISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
358-600 |
1.52e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 93.26 E-value: 1.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 358 YIAVLHDVTEQQ------QVERER--------REFVANVSHELRTPLTSMNSYIEALeSGAWKDGALAPQFLSVTREETE 423
Cdd:PRK09959 681 YICGWQDITETRdlihalEVERNKainatvakSQFLATMSHEIRTPISSIMGFLELL-SGSGLSKEQRVEAISLAYATGQ 759
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 424 RMIRLVNDLLQLSKMDNESDQINKEIVDFNMFINKIINRHEMSAKDTTFVREIPN---ETIFAEIDPDKMTQVFDNVITN 500
Cdd:PRK09959 760 SLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSN 839
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 501 AMKYS-RGDKRVE---FHVKQNALYNRMTIriKDNGIGIPINKVEKIFDRFYRVDKARTRKmgGTGLGLAISKEIVEAHH 576
Cdd:PRK09959 840 ALKFTtEGAVKITtslGHIDDNHAVIKMTI--MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQ 915
|
250 260
....*....|....*....|....
gi 1586175940 577 GRIWANSVEGQGTSIFITLPCEVI 600
Cdd:PRK09959 916 GDLSLESHPGIGTTFTITIPVEIS 939
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-595 |
2.22e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 83.99 E-value: 2.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEfhVKQNAlYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKartRKMGGTGLGL 565
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVE--IKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGL 83
|
90 100 110
....*....|....*....|....*....|
gi 1586175940 566 AISKEIVEAHHGRIWANSVEGQGTSIFITL 595
Cdd:cd16940 84 SIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
369-596 |
4.21e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 90.29 E-value: 4.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 369 QQVERerreFVANVSHELRTPLTSMNSYIEALESGAwkDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKE 448
Cdd:PRK11100 254 AYVEQ----YVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 449 IVDFNMFINKIINRHEM--SAKDTTFVREIPNETIFAeiDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTI 526
Cdd:PRK11100 328 PVALAALLEELVEAREAqaAAKGITLRLRPDDARVLG--DPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDG--EQVAL 403
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 527 RIKDNGIGIPINKVEKIFDRFY---RVDKARTrkmgGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:PRK11100 404 SVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
487-596 |
5.42e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 82.47 E-value: 5.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 487 PDKMTQVFDNVITNAMKYSRGDKRVEfhVKQNALYNRMTIRIKDNGIGIPINKVEKIFDRFYRvdkarTRKMG-GTGLGL 565
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRIT--IRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 1586175940 566 AISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16943 74 SLSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-596 |
6.26e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 82.25 E-value: 6.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 494 FDNVITNAMKYSRGDKRVEfhVKQNALYNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVE 573
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTIT--VRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMS 82
|
90 100
....*....|....*....|...
gi 1586175940 574 AHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16952 83 RHDARLLIASELGKGSRFTCLFP 105
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
377-597 |
1.21e-18 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 88.39 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 377 EFVANVSHELRTPLTSMNSYIEALESGAWKDGALApQFLSVTREETERMIRLVNDLLQLSKMDNEsdqiNKEIVDFNMFI 456
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRK-QYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 457 NKIIN-RHEMSAKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGI 535
Cdd:COG5806 278 EHVIDvLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDK--NKVIISIKDTGVGM 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 536 PINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPC 597
Cdd:COG5806 356 TKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-596 |
2.28e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 80.55 E-value: 2.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRgdKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISK 569
Cdd:cd16939 1 MARALDNLLRNALRYAH--RTVRIALLVSG--GRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*..
gi 1586175940 570 EIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16939 77 RVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-596 |
4.29e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.80 E-value: 4.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGDKRVEFHVKQNalynRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTrkMGGTGLGLAISK 569
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGN----RTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 1586175940 570 EIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-596 |
7.86e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 78.97 E-value: 7.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKArtRKMGGTGLGLAISK 569
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTD--DVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAK 76
|
90 100
....*....|....*....|....*..
gi 1586175940 570 EIVEAHHGRIWAnSVEGQGTSIFITLP 596
Cdd:cd16923 77 AIIELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-600 |
9.76e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 87.39 E-value: 9.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 369 QQVERERR---EFVANVSHELRTPLTSMNSYIEALESGAWKDGALapQFLSVTREETERMIRLVNDLLQLSKMdnESDQI 445
Cdd:PRK15347 389 QRAEQANKrksEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRI--ESGQM 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 446 --NKE------IVDFNMF------INKIINRHemsakdtTFV-REIPNEtifAEIDPDKMTQVFDNVITNAMKYSRgDKR 510
Cdd:PRK15347 465 tlSLEetallpLLDQAMLtiqgpaQSKSLTLR-------TFVgAHVPLY---LHLDSLRLRQILVNLLGNAVKFTE-TGG 533
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 511 VEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKartrKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTS 590
Cdd:PRK15347 534 IRLRVKRHE--QQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSC 607
|
250
....*....|
gi 1586175940 591 IFITLPCEVI 600
Cdd:PRK15347 608 FSLVLPLNEY 617
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
524-596 |
1.61e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.21 E-value: 1.61e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 524 MTIRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16920 38 VTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
374-441 |
3.98e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 3.98e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586175940 374 ERREFVANVSHELRTPLTSMNSYIEALESgaWKDGALAPQFLSVTREETERMIRLVNDLLQLSKMDNE 441
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
372-437 |
8.96e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 74.56 E-value: 8.96e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586175940 372 ERERREFVANVSHELRTPLTSMNSYIEALESGAWKDGALApQFLSVTREETERMIRLVNDLLQLSK 437
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
374-441 |
2.11e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 73.75 E-value: 2.11e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586175940 374 ERREFVANVSHELRTPLTSMNSYIEALESGAWKDGALapQFLSVTREETERMIRLVNDLLQLSKMDNE 441
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
167-586 |
4.50e-16 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 81.66 E-value: 4.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 167 ANINDVYNQLNNINQIFIIGTAI-SLFITVILG-FFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELAlafn 244
Cdd:COG4192 311 VALNQETAQLVQQSGILLLAIALlSLLLAVLINyFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA---- 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 245 nlsKRVQEAQANTESEKRRLDSVITHmsdgiiatdrrgRVRIINDmalkmLGMAKEDLIgyymlsvlnleQEFSLdeiqe 324
Cdd:COG4192 387 ---RLLRVFRDQAIEKTQELETEIEE------------RKRIEKN-----LRQTQDELI-----------QAAKM----- 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 325 nndsflldineeegiiarvnfsTIVQETgfvtgyiavlhdvteqqqvererrefVANVSHELRTPLTSMNSYIEALESGA 404
Cdd:COG4192 431 ----------------------AVVGQT--------------------------MTSLAHELNQPLNAMSMYLFSAKKAL 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 405 WKDG-ALAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQInkeiVDFNMFINKIINRHEMSAKDTTFVREIPNETiFA 483
Cdd:COG4192 463 EQENyAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDL-MV 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 484 EIDPDKMTQVFDNVITNAMKYSRGDKRVefHVKQNALYNRMTIRIKDNGIGIPInkVEKIFDRFYrvdkarTRKMGGTGL 563
Cdd:COG4192 538 QGDQVLLEQVLVNLLVNALDAVATQPQI--SVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT------TTKEVGLGL 607
|
410 420
....*....|....*....|....
gi 1586175940 564 GLAISKEIVEAHHGRIW-ANSVEG 586
Cdd:COG4192 608 GLSICRSIMQQFGGDLYlASTLER 631
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
369-599 |
5.14e-16 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 81.82 E-value: 5.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 369 QQVERERREFVANVSHELRTPL------------TSMNS----YIEALESGAwkdgalaPQFLSVtreetermirlVNDL 432
Cdd:PRK11107 287 QEAARIKSEFLANMSHELRTPLngvigftrqtlkTPLTPtqrdYLQTIERSA-------NNLLAI-----------INDI 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 433 LQLSKMdnESDQINKEIVDFNM--FINKIINRHEMSAKD-----TTFVR-EIPNETIFaeiDPDKMTQVFDNVITNAMKY 504
Cdd:PRK11107 349 LDFSKL--EAGKLVLENIPFSLreTLDEVVTLLAHSAHEkglelTLNIDpDVPDNVIG---DPLRLQQIITNLVGNAIKF 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 505 S-RG--DKRVEfHVKQNAlyNRMTIR--IKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHHGRI 579
Cdd:PRK11107 424 TeSGniDILVE-LRALSN--TKVQLEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDI 500
|
250 260
....*....|....*....|
gi 1586175940 580 WANSVEGQGTSIFITLPCEV 599
Cdd:PRK11107 501 SFHSQPNRGSTFWFHLPLDL 520
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-591 |
5.52e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 74.15 E-value: 5.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGDK-RVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYrVDKARTRKMG-GTGLGLAI 567
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTG--KMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSI 77
|
90 100
....*....|....*....|....
gi 1586175940 568 SKEIVEAHHGRIWANSVEGQGTSI 591
Cdd:cd16953 78 SRQIIEAHGGISVAENHNQPGQVI 101
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-596 |
1.72e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 72.70 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 493 VFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMgGTGLGLAISKEIV 572
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNE--QGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 1586175940 573 EAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
372-579 |
2.34e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 78.91 E-value: 2.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 372 ERER----REFVANVSHELRTPLTSMNSYIEALESGawkdgalapQFLSVTR------EETERMIRLVNDLLQLSKMDNE 441
Cdd:PRK10815 259 ERERytkyRTTLTDLTHSLKTPLAVLQSTLRSLRSG---------KQMSVEQaepimlEQISRISQQIGYYLHRASMRSE 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 442 SDQINKEI------VD-FNMFINKIINRhemsaKDTTFVREIPNETIFAEIDPDKMtQVFDNVITNAMKYSrgdkrVEFh 514
Cdd:PRK10815 330 HNLLSRELhsvaplLDnLTSALNKVYQR-----KGVNITLDISPEITFVGEKNDFM-EVMGNVLDNACKYC-----LEF- 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586175940 515 VKQNALY--NRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTrkmgGTGLGLAISKEIVEAHHGRI 579
Cdd:PRK10815 398 VEISARQtdEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
359-596 |
9.36e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 77.71 E-value: 9.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 359 IAVLHDVTEQQQVERERRE--------------FVANVSHELRTPLTSMNSYIEALESGAWKDGalAPQFLSVTREETER 424
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDLLQTKELPKG--VDRLVTAMNNSSSL 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 425 MIRLVNDLLQLSKMdnESDQINKEIVDFN--MFINKII-NRHEMSAKDTTfvreipneTIFAEIDPD----------KMT 491
Cdd:PRK10841 495 LLKIISDILDFSKI--ESEQLKIEPREFSprEVINHITaNYLPLVVKKRL--------GLYCFIEPDvpvalngdpmRLQ 564
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 492 QVFDNVITNAMKYSRGDKRVeFHVKQNALYnrMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMGGTGLGLAISKEI 571
Cdd:PRK10841 565 QVISNLLSNAIKFTDTGCIV-LHVRVDGDY--LSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKL 641
|
250 260
....*....|....*....|....*.
gi 1586175940 572 VEAHHGRIWANSVEGQGtSIF-ITLP 596
Cdd:PRK10841 642 INMMDGDISVDSEPGMG-SQFtIRIP 666
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-595 |
1.17e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 70.62 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 475 EIPNETIFAEIDPDKMTQVFDNVITNAMKYSrGDKR---VEFHVKQNALYnrmtIRIKDNGIGIPINKVEKIFDRFYRVD 551
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYG-SDGKflgMTLREDEKHVY----IDIWDKGKGISETEKDHVFERLYTLE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1586175940 552 KARTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITL 595
Cdd:cd16947 81 DSRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
368-586 |
1.69e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 75.84 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 368 QQQVERERReFVANVSHELRTPLTSMNSYIE----ALESGAWKDGALAPQFLSVtreetERMIRLVNDLLQLSKMDNESD 443
Cdd:PRK10337 231 HAMMVRERR-FTSDAAHELRSPLAALKVQTEvaqlSDDDPQARKKALLQLHAGI-----DRATRLVDQLLTLSRLDSLDN 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 444 QINKEIVDFNMFINKIINRHEMSAK--DTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALy 521
Cdd:PRK10337 305 LQDVAEIPLEDLLQSAVMDIYHTAQqaGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNF- 383
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586175940 522 nrmtiRIKDNGIGIPINKVEKIFDRFYRvdkARTRKMGGTGLGLAISKEIVEAHHGRI-WANSVEG 586
Cdd:PRK10337 384 -----TVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVsFGNAPEG 441
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
355-596 |
1.79e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 77.03 E-value: 1.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 355 VTGYIAVLHDVTE----QQQVERERR-----EFVANVSHELRTPLTSMNSYIEALESgAWKDGALAPQFLSVTREETERM 425
Cdd:PRK13837 421 LAHAIERRRLETErdalERRLEHARRleavgTLASGIAHNFNNILGAILGYAEMALN-KLARHSRAARYIDEIISAGARA 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 426 IRLVNDLLQLSKMDNEsdqiNKEIVDFNMFINKIINRHEMS-AKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKY 504
Cdd:PRK13837 500 RLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRVSlPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQA 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 505 SRGDKRVEFHVKQNAL--YNRMT-----------IRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTGLGLAISKEI 571
Cdd:PRK13837 576 MDGAGRVDISLSRAKLraPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGI 649
|
250 260
....*....|....*....|....*
gi 1586175940 572 VEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:PRK13837 650 VSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
270-596 |
2.40e-14 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 76.11 E-value: 2.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 270 HMSDGIIATDRRGRVRIINDMALKMLGMAK---EDLIG---YYMLSVLNLEQ-----EFSLDEIQENNDSFLLdINEeeg 338
Cdd:PRK11086 229 SIKEGVIAVDDRGEVTLINDEAKRLFNYKKgleDDPLGtdvESWMPVSRLKEvlrtgTPRRDEEININGRLLL-TNT--- 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 339 IIARVNfstivqetGFVTGYIAVLHDVTE-QQQVERerrefvanvshelrtpLTSMNSYIEALesgawkdgalapqflsv 417
Cdd:PRK11086 305 VPVRVN--------GEIIGAIATFRDKTEvRQLAQR----------------LDGMVNYADAL----------------- 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 418 tREET-ERMIRL--VNDLLQLSKMDNESDQINK-------EIvdfNMFINKI------------INR-----HEMSAKDT 470
Cdd:PRK11086 344 -RAQShEFMNKLhvILGLLHLKSYDQLEDYILKtannyqeEI---GSLLGKIkspviagfllgkISRarelgITLIISED 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 471 TFVREIPNETIFAEidpdkMTQVFDNVITNAM----KYSRGDKRVEFHVKQNALYnrmtIRIKDNGIGIPINKVEKIFDR 546
Cdd:PRK11086 420 SQLPDSGDEDQVHE-----LITILGNLIENALeavgGEEGGEISVSLHYRNGWLH----CEVSDDGPGIAPDEIDAIFDK 490
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1586175940 547 FYrvdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:PRK11086 491 GY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
367-596 |
3.93e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 75.71 E-value: 3.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 367 EQQQVERERREFVANVSHELRTPLTSMNSYIEALesgawKDGALAPQ---FLSVTREETERMIRLVNDLLQLSKMD--NE 441
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLL-----ADNPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 442 SDQINKEIVDFNMFINKIIN------RHEMSAKDTTFVREIPNetiFAEIDPDKMTQVFDNVITNAMKYS-RGDKRVEFH 514
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQlmsgrvKGRPIRLATDIADDLPT---ALMGDPRRIRQVITNLLSNALRFTdEGSIVLRSR 587
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 515 VKQNALYnrmtIRIKDNGIGIPINKVEKIFDRFYRVdkarTRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFIT 594
Cdd:PRK11466 588 TDGEQWL----VEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLR 659
|
..
gi 1586175940 595 LP 596
Cdd:PRK11466 660 LP 661
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
264-596 |
6.38e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.49 E-value: 6.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 264 LDSVIThmsdGIIATDRRGRVRIINDMAL--------KMLGMAKEDLIGYYMLSVLNLEQefSLDEIQENNDSFLLDINE 335
Cdd:PRK11073 13 LNSLIN----SILLLDDDLAIHYANPAAQqllaqssrKLFGTPLPELLSYFSLNIELMRE--SLQAGQGFTDNEVTLVID 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 336 EEGIIARVNFSTIVQetgfvtGYIAV-LHDVTEQQQVERER---------REFVANVSHELRTPLTSMNSYIEALESgAW 405
Cdd:PRK11073 87 GRSHILSLTAQRLPE------GMILLeMAPMDNQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-AL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 406 KDGALApQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIVDfnmfinKIINRHEMSAKDT-TFVRE----IPNet 480
Cdd:PRK11073 160 PDPALT-EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAE------RVVQLVSLELPDNvRLIRDydpsLPE-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 481 ifAEIDPDKMTQVFDNVITNAMKY-----------SRGDKRVEFHVKQNALYNRmtIRIKDNGIGIPinkvEKIFDR-FY 548
Cdd:PRK11073 231 --LAHDPDQIEQVLLNIVRNALQAlgpeggtitlrTRTAFQLTLHGERYRLAAR--IDIEDNGPGIP----PHLQDTlFY 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1586175940 549 RVDKARTrkmGGTGLGLAISKEIVEAHHGRIWANSVEGQgTSIFITLP 596
Cdd:PRK11073 303 PMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
254-377 |
8.21e-13 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 70.57 E-value: 8.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 254 QANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYymlSVLNLEQEFSLDEIQENNDSFLLDI 333
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGK---NVTELIPNSPLLEVLKTGKPVTGVI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1586175940 334 NEEEGIIARVNFSTI-VQETGFVTGYIAVLHDVTEQQQVERERRE 377
Cdd:COG3829 80 QKTGGKGKTVIVTAIpIFEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
372-596 |
9.10e-13 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 70.00 E-value: 9.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 372 ERERrEFVANVSHELRTPLTSMNSYIEALEsgawKDGALAPQFLsVTReeTERMIRLVNDLLQLSKMDNESDQINKEIVD 451
Cdd:PRK10755 135 DQER-LFTADVAHELRTPLAGIRLHLELLE----KQHHIDVAPL-IAR--LDQMMHTVEQLLQLARAGQSFSSGHYQTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 452 FnmfINKII--NRHEMS----AKDTTFVREIPNETIFAEIDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALYNRMT 525
Cdd:PRK10755 207 L---LEDVIlpSQDELSemleQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLA 283
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 526 IRikDNGIGIPINKVEKIFDRFYRVDkartRKMGGTGLGLAISKEIVEAHHGR-IWANSVEGQGTSIFITLP 596
Cdd:PRK10755 284 VE--DEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQfFLQNRQERSGTRAWVWLP 349
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-586 |
1.26e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 64.41 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNALYnrMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKmGGTGLGL 565
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEY--LYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|..
gi 1586175940 566 AISKEIVEAHHGRIW-ANSVEG 586
Cdd:cd16975 78 YIAKNLVEKHGGSLIiENSQKG 99
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
206-249 |
2.60e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 61.31 E-value: 2.60e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1586175940 206 TRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKR 249
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAER 44
|
|
| HAMP |
pfam00672 |
HAMP domain; |
200-252 |
2.72e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 61.49 E-value: 2.72e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 200 FIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQE 252
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
468-583 |
3.08e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.19 E-value: 3.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 468 KDTTFVREIPNETIFAeIDPDKMTQVFDNVITNAMKYSrgDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRF 547
Cdd:cd16954 17 KGVSISLDISPELRFP-GERNDLMELLGNLLDNACKWC--LEFVEVTARQTD--GGLHLIVDDDGPGVPESQRSKIFQRG 91
|
90 100 110
....*....|....*....|....*....|....*.
gi 1586175940 548 YRVDKARTrkmgGTGLGLAISKEIVEAHHGRIWANS 583
Cdd:cd16954 92 QRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSD 123
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-275 |
8.60e-12 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 67.74 E-value: 8.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 1 MKWLKQLQSLHTKLVVVYVLLIIIGMQIIGLYFTNSLEKELTDNFRKNIKQYATQLEVNIERSYKDDSVNMQKEVQNLLN 80
Cdd:COG0840 2 LILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 81 EYANRQEIEEIRFIDKDQIIMATARLSSHNMINQKVNDSSVQKAISLGQSNSHNVLKDYGNGKERIWVYNLPVKNGKDTV 160
Cdd:COG0840 82 LALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 161 GDIYIEANINDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELA 240
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLA 241
|
250 260 270
....*....|....*....|....*....|....*
gi 1586175940 241 LAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGI 275
Cdd:COG0840 242 DAFNRMIENLRELVGQVRESAEQVASASEELAASA 276
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
203-255 |
8.82e-12 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 60.34 E-value: 8.82e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 203 RTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQA 255
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
181-387 |
8.89e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 67.60 E-value: 8.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 181 QIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESE 260
Cdd:COG3850 118 KLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 261 --KRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEG 338
Cdd:COG3850 198 eeLEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASA 277
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1586175940 339 IIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELR 387
Cdd:COG3850 278 LLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANA 326
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-382 |
2.70e-11 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 66.68 E-value: 2.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 1 MKWLKQLQSLHTKLVVVYVLLIIIGMQIIGLYFTNSLEKELTDNFRKNIKQYATQLEVNIERSYKDDSVNMQKEVQNLLN 80
Cdd:COG2770 32 SLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 81 EYANRQEIEEIRFIDKDQIIMATARLSSHNMINQKVNDSSVQKAISLGQSNSHNVLKDYGNGKERIWVYNLPVKNGKDTV 160
Cdd:COG2770 112 LLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 161 GDIYIEANINDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELA 240
Cdd:COG2770 192 LLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 241 LAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLD 320
Cdd:COG2770 272 RAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLL 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586175940 321 EIQENNDSFLLDINEEEGIIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANV 382
Cdd:COG2770 352 LALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELV 413
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
367-598 |
4.25e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 63.48 E-value: 4.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 367 EQQQVERERREFVA----NVSHELrtplTSMNSYIEALESGAWKDGALAPQFLSVTREETERMIRLVNDLL-QLSKMDNE 441
Cdd:COG4585 46 AEEAREEERRRIARelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVrGLRPPALD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 442 SDQINKEIVDFnmfINKIINRHEMsakDTTFVREIPNEtifaEIDPDKMTQVFDNV---ITNAMKYSRGDK-RVEFHVKQ 517
Cdd:COG4585 122 DLGLAAALEEL---AERLLRAAGI---RVELDVDGDPD----RLPPEVELALYRIVqeaLTNALKHAGATRvTVTLEVDD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 518 NALynrmTIRIKDNGIGIPINKVekifdrfyrvdkartrkmGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLPC 597
Cdd:COG4585 192 GEL----TLTVRDDGVGFDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
.
gi 1586175940 598 E 598
Cdd:COG4585 250 A 250
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-588 |
6.43e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 6.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 492 QVFDNVITNAMKYSRGDKRVEFHVKQNALYNRMTIRIKDNGIGIPINKVEKIFDRFYRvdkarTRKMG-GTGLGLAISKE 570
Cdd:cd16976 3 QVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYG 77
|
90
....*....|....*...
gi 1586175940 571 IVEAHHGRIWANSVEGQG 588
Cdd:cd16976 78 IVEEHGGRLSVANEEGAG 95
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-596 |
8.29e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 59.09 E-value: 8.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVK---QNALYNRMTIRIKDNGIGIPINKVEKIFDRFYrvdkarTRKMGGTG 562
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRirvEADQDGRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 1586175940 563 LGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
252-377 |
9.16e-11 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 62.73 E-value: 9.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 252 EAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGyymlsvLNLEQEFSLDEIQENNDSFLL 331
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLG------KTLRDLLPPEDDDEFLELLRA 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 332 DINEEEG--------------IIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERRE 377
Cdd:COG2202 75 ALAGGGVwrgelrnrrkdgslFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-596 |
1.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.95 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGD-------KRVEFHVKQNALYNRMTIR--IKDNGIGIPINKVEKIFDRFYrvdkarTRKMGG 560
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrTRTQRQVTLGHPRHRLALRvsVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 1586175940 561 TGLGLAISKEIVEAHHGRIWANSVEGQgTSIFITLP 596
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
22-264 |
8.85e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.19 E-value: 8.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 22 IIIGMQIIGLYFTNSLEKELTDNFRKNIKQYATQLEVNIERSYKDDSVNMQKEVQNLLNEYANRQEIEEIRFIDKDQIIM 101
Cdd:COG2972 5 LSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 102 ATARLSSHNMINQKVNDSSVQKAISLGQSNSHNVLKDYGNGKERIWVYNLPVKNgkdtvgdIYIEANINDVYNQLNNINQ 181
Cdd:COG2972 85 LLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWT-------LVSLIPKSELFRGLFSLRR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 182 IFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTqRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEK 261
Cdd:COG2972 158 LILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELE 236
|
...
gi 1586175940 262 RRL 264
Cdd:COG2972 237 LEK 239
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-596 |
2.82e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 54.10 E-value: 2.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 498 ITNAMKYSRGDK-RVEFHVKQNALynrmTIRIKDNGIGipinkvekifdrFYRVDKArtrkmGGTGLGLAISKEIVEAHH 576
Cdd:cd16917 9 LTNALKHAGASRvRVTLSYTADEL----TLTVVDDGVG------------FDGPAPP-----GGGGFGLLGMRERAELLG 67
|
90 100
....*....|....*....|
gi 1586175940 577 GRIWANSVEGQGTSIFITLP 596
Cdd:cd16917 68 GTLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-579 |
3.52e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 54.39 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 486 DPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYRVDKARTRKMgGTGLGL 565
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADT--EGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGL 77
|
90
....*....|....
gi 1586175940 566 AISKEIVEAHHGRI 579
Cdd:cd16945 78 AFVQEVAQLHGGRI 91
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-596 |
5.30e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.83 E-value: 5.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 496 NVITNAMKYS----RGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYrvdkaRTRKMGGTGLGLAISKEI 571
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEG--DDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 1586175940 572 VEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
259-375 |
1.96e-08 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 53.06 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 259 SEKRrLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEG 338
Cdd:TIGR00229 1 SEER-YRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEER 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1586175940 339 IIARVNFSTI--------VQETGFVTGYIAVLHDVTEQQQVERER 375
Cdd:TIGR00229 80 RVRRKDGSEIwvevsvspIRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
522-596 |
3.43e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 52.00 E-value: 3.43e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586175940 522 NRMTIRIKDNGIGIPINKVEKIFDRFYRvdkarTRKMG-GTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
248-375 |
9.78e-08 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 53.49 E-value: 9.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 248 KRVQEAQAntESEkRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGyymLSVLNLEQEFSLDEIQENND 327
Cdd:COG2202 126 KRAEEALR--ESE-ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLG---KSLLDLLHPEDRERLLELLR 199
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1586175940 328 SFL----------LDINEEEGIIARVNFSTI-VQETGFVTGYIAVLHDVTEQQQVERER 375
Cdd:COG2202 200 RLLeggresyeleLRLKDGDGRWVWVEASAVpLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
262-365 |
8.46e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 47.80 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDE-----IQENNDSFLLDINEE 336
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAEllrqaLLQGEESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1586175940 337 ----EGIIARVNFSTIVQETGFVTGYIAVLHDV 365
Cdd:pfam00989 81 vpdgRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
257-333 |
2.78e-06 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 50.19 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 257 TESEKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGyymLSVLNLEQEFSLD-------------EIQ 323
Cdd:COG3283 75 SEREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIG---QPLSELLKGFNFSrwlesneprpqseRVV 151
|
90
....*....|
gi 1586175940 324 ENNDSFLLDI 333
Cdd:COG3283 152 INGQDYLADI 161
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
271-365 |
3.11e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 46.09 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 271 MSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDS--------FLLDINEEEGIIAR 342
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSggepvtleVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 1586175940 343 VNFSTIVQETGFVTGYIAVLHDV 365
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
262-324 |
6.47e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 43.93 E-value: 6.47e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGyymLSVLNLEQEFSLDEIQE 324
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIG---KSLLELIHPEDRERVQE 60
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
262-593 |
1.30e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 48.29 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAK--EDLIGYYMLSVLNlEQEFSLDEIQENNDSFLLDINeeeGI 339
Cdd:PRK15053 222 RQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSpgRQWLGKPIAEVVR-PADFFTEQIDEKRQDVVANFN---GL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 340 IARVNFSTIVQETGFVTGYIAVlhdvteqqqveRERREFvanvsHELRTPLTSMNSYIEALESgawkdgalapqflsvTR 419
Cdd:PRK15053 298 SVIANREAIRSGDDLLGAIISF-----------RSKDEI-----STLNAQLTQIKQYVESLRT---------------LR 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 420 EETERMIRLVNDLLQLSKMD-------NESdQINKEIVD-----FN------MFINKIINRHEMSAK----DTTFVREIP 477
Cdd:PRK15053 347 HEHLNWMSTLNGLLQMKEYDrvlemvqGES-QAQQQLIDslreaFAdrqvagLLFGKVQRARELGLKmvivPGSQLSQLP 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 478 ---NETIFAEIdpdkMTQVFDNVITNAMKYSRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKIFDRFYrvdKAR 554
Cdd:PRK15053 426 pglDSTEFAAI----VGNLLDNAFEASLRSDEGNKIVELFLSDEG--DDVVIEVADQGCGVPESLRDKIFEQGV---STR 496
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1586175940 555 TRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGT--SIFI 593
Cdd:PRK15053 497 ADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTlfSIFI 537
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
282-367 |
2.88e-05 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 42.83 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 282 GRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEE------EGIIARVNFSTIVQETGFV 355
Cdd:pfam13426 2 GRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVVlyrkdgEPFPVLVSLAPIRDDGGEL 81
|
90
....*....|..
gi 1586175940 356 TGYIAVLHDVTE 367
Cdd:pfam13426 82 VGIIAILRDITE 93
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
179-258 |
5.75e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 46.20 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 179 INQIFIIGTAISLFITVilgFFIARTITRPItdmrNQTVEM----SKGNYTQRVKIYGNDEIGELALAFNNLS------- 247
Cdd:PRK10600 126 VHRVFAVFMALLLVFTI---IWLRRRLLQPW----RQLLSManavSHRDFTQRANISGRDEMAMLGTALNNMSaelaesy 198
|
90
....*....|....*
gi 1586175940 248 ----KRVQEAQANTE 258
Cdd:PRK10600 199 avleQRVQEKTAGLE 213
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
188-596 |
1.21e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.90 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 188 AISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEkRRLDSV 267
Cdd:COG3920 95 AAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEEL-AALRLA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 268 ITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQENNDSFLLDINEEEGIIARVNFST 347
Cdd:COG3920 174 AAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 348 IVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTP--------------LTSMNSYIeALESGAWKDGAlAPQ 413
Cdd:COG3920 254 LLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKelllrelhhrvknnLQVVSSLL-RLQARRADDPE-ARE 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 414 FLsvtrEETERMIR---LVNDLLqlskmdneSDQINKEIVDFNMFINKIIN--RHEMSAKDTTFVREIPNetifAEIDPD 488
Cdd:COG3920 332 AL----EESQNRIQalaLVHELL--------YQSEDWEGVDLRDYLRELLEplRDSYGGRGIRIELDGPD----VELPAD 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 489 KMTQ---VFDNVITNAMKY---SRGDKRVEFHVKQNAlyNRMTIRIKDNGIGIPINkvekifdrfyrVDKARTRkmggtG 562
Cdd:COG3920 396 AAVPlglILNELVTNALKHaflSGEGGRIRVSWRRED--GRLRLTVSDNGVGLPED-----------VDPPARK-----G 457
|
410 420 430
....*....|....*....|....*....|....
gi 1586175940 563 LGLAISKEIVEAHHGRIwaNSVEGQGTSIFITLP 596
Cdd:COG3920 458 LGLRLIRALVRQLGGTL--ELDRPEGTRVRITFP 489
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
382-596 |
1.23e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 45.05 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 382 VSHELRTPLTSMNSYIEALESGAWKDGALAPQFL-SV--TREETERMIRLVNDLLQLSKmdneSDQINKEIVDFNMFI-- 456
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMArSVenIRAAAERAATLTQQLLAFAR----KQRLEGRVLNLNGLVsg 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 457 -NKIINRhemsakdtTFVREIPNETIFAE------IDPDKMTQVFDNVITN---AMKySRGDKRV-----EFHVKQNALY 521
Cdd:PRK13557 246 mGELAER--------TLGDAVTIETDLAPdlwncrIDPTQAEVALLNVLINardAMP-EGGRVTIrtrnvEIEDEDLAMY 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 522 NRM------TIRIKDNGIGIPINKVEKIFDRFYrvdkaRTRKMG-GTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFIT 594
Cdd:PRK13557 317 HGLppgryvSIAVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLY 391
|
..
gi 1586175940 595 LP 596
Cdd:PRK13557 392 FP 393
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
260-374 |
5.49e-04 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 43.12 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 260 EKRRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIqENNDSFL-----LDIN 334
Cdd:PRK09776 534 EKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHITFGDNGPLM-ENIYSCLtsrsaAYLE 612
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1586175940 335 EEEGIIARVNFSTIVQET--------GFVTGYIAVLHDVTEQQQVERE 374
Cdd:PRK09776 613 QDVVLHCRSGGSYDVHYSitplstldGENIGSVLVIQDVTESRKMLRQ 660
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
490-596 |
1.39e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.02 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 490 MTQVFDNVITNAMKYSRGDKRVEFHVKQNALYNR--MTIRIKDNGIGIPINKVEKIFDRFY-------------RVDKAR 554
Cdd:cd16929 48 LFELLKNAMRATVESHGDDSDDLPPIKVTVAKGDedLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGTQ 127
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1586175940 555 TRKMGGTGLGLAISKEIVEAHHGRIWANSVEGQGTSIFITLP 596
Cdd:cd16929 128 PSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
262-324 |
1.88e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.14 E-value: 1.88e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586175940 262 RRLDSVITHMSDGIIATDRRGRVRIINDMALKMLGMAKEDLIGYYMLSVLNLEQEFSLDEIQE 324
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
498-566 |
5.22e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 37.20 E-value: 5.22e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1586175940 498 ITNAMKYSRGDK-----RVEFHVKQNALynrmTIRIKDNGIGIPINKVEkifdrfyrvDKARTRKMGGTGLGLA 566
Cdd:COG2172 43 VTNAVRHAYGGDpdgpvEVELELDPDGL----EIEVRDEGPGFDPEDLP---------DPYSTLAEGGRGLFLI 103
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
498-596 |
6.64e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 39.19 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586175940 498 ITNAMKYSRGDkRVEFHVKQNAlyNRMTIRIKDNGIGIPINKVEKifdrfyrvdkartrkmggtGLGLAISKEIVEAHHG 577
Cdd:PRK11644 419 LNNIVKHADAS-AVTLQGWQQD--ERLMLVIEDDGSGLPPGSGQQ-------------------GFGLRGMRERVTALGG 476
|
90
....*....|....*....
gi 1586175940 578 RIWANSVegQGTSIFITLP 596
Cdd:PRK11644 477 TLTISCT--HGTRLSVSLP 493
|
|
| |
