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Conserved domains on  [gi|1582046518|gb|TAY29171|]
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GntR family transcriptional regulator (plasmid) [Rhizobium leguminosarum]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-232 1.21e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 156.62  E-value: 1.21e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  16 DAIGASSEGASLYQLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRD 95
Cdd:COG1802     5 SPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  96 IYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEEN-NFADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHREVLRA 174
Cdd:COG1802    85 LYEVRAALEGLAARLAAERATPADLARLRALLEELEAAaAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1582046518 175 VSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEGSGRHILEHMRARNA 232
Cdd:COG1802   165 YRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-232 1.21e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 156.62  E-value: 1.21e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  16 DAIGASSEGASLYQLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRD 95
Cdd:COG1802     5 SPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  96 IYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEEN-NFADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHREVLRA 174
Cdd:COG1802    85 LYEVRAALEGLAARLAAERATPADLARLRALLEELEAAaAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1582046518 175 VSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEGSGRHILEHMRARNA 232
Cdd:COG1802   165 YRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
phnR_burk TIGR03338
phosphonate utilization associated transcriptional regulator; This family of proteins are ...
 29-219 4.89e-16

phosphonate utilization associated transcriptional regulator; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Polaromonas, Burkholderia, Ralstonia and Verminephrobacter.


Pssm-ID: 132381 [Multi-domain]  Cd Length: 212  Bit Score: 74.04  E-value: 4.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  29 QLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRDIYEIGVLIEPALT 108
Cdd:TIGR03338  18 DEIERAILSGELPPGAKLNESDIAARLGVSRGPVREAFRALEEAGLVRNEKNRGVFVREISLAEADEIYELRAVLDEIVG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518 109 RWFVNMATVEDIAELER-IQGLIEENNFADTFRHSELDTAFHTVMYQKHYNRHAAELWwkhREVLRAVSrrfnftLARRA 187
Cdd:TIGR03338  98 RRLAARITPTQLKVLKGlLDAMEDAAKAKDADRYARLNLRFHDALVEHAGNNKLTDTY---RRLVKELS------LFRRA 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1582046518 188 AI---------LSEHRELIAHVKAGNASEAAELIARHVEGS 219
Cdd:TIGR03338 169 ALadggamavsAAEHRAIVDAIASGDAERAGALMRAHVAAS 209
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 27-86 9.37e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 66.70  E-value: 9.37e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582046518  27 LYQLIREDIIEGRLAANERLV-VTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVR 86
Cdd:cd07377     6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 95-218 2.90e-12

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 61.61  E-value: 2.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518   95 DIYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEE--NNFADTFRHSELDTAFHTVMYQKHYNRHAAELWwkhREVL 172
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAaaAAGDDLEEFAELDREFHRALAEAAGNPVLLELL---ESLR 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1582046518  173 RAVSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEG 218
Cdd:smart00895  78 ARLRRLRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 95-214 1.82e-10

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 56.61  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  95 DIYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEENN-FADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHREVLR 173
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAAdAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1582046518 174 AVSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIAR 214
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 28-216 1.10e-09

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 56.44  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  28 YQLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRDIYEI-----GVL 102
Cdd:PRK11534   13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDAranmeAML 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518 103 IEPALTR----WFVN-MATVEDIAELERIQGLIEENNFADTfRHSeldtAFHTVMYQKHYNRHAAELwwkhREVLRAVSR 177
Cdd:PRK11534   93 VSLAIARggdeWEADvLAKAHLLSKLEACDASEKMLDEWDL-RHQ----AFHTAIVAGCGSHYLLQM----RERLFDLAA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1582046518 178 RFNFTLARRaAILS---------EHRELIAHVKAGNASEAAELIARHV 216
Cdd:PRK11534  164 RYRFIWLRR-TVLSvemledkhdQHQTLTAAILARDTARASELMRQHL 210
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-232 1.21e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 156.62  E-value: 1.21e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  16 DAIGASSEGASLYQLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRD 95
Cdd:COG1802     5 SPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  96 IYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEEN-NFADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHREVLRA 174
Cdd:COG1802    85 LYEVRAALEGLAARLAAERATPADLARLRALLEELEAAaAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1582046518 175 VSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEGSGRHILEHMRARNA 232
Cdd:COG1802   165 YRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
27-232 3.55e-24

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 96.16  E-value: 3.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  27 LYQLIREDIIEGRLAANERL-VVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRP---------------IDQ 90
Cdd:COG2186    12 VAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREpspwalldplalllaLDD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  91 DFVRDIYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEENnFADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHRE 170
Cdd:COG2186    92 ASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAA-ADDGEAFAEADLAFHRAIAEASGNPLLALLLESLRE 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1582046518 171 VLRAVSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEGSGRHILEHMRARNA 232
Cdd:COG2186   171 LLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
phnR_burk TIGR03338
phosphonate utilization associated transcriptional regulator; This family of proteins are ...
 29-219 4.89e-16

phosphonate utilization associated transcriptional regulator; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Polaromonas, Burkholderia, Ralstonia and Verminephrobacter.


Pssm-ID: 132381 [Multi-domain]  Cd Length: 212  Bit Score: 74.04  E-value: 4.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  29 QLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRDIYEIGVLIEPALT 108
Cdd:TIGR03338  18 DEIERAILSGELPPGAKLNESDIAARLGVSRGPVREAFRALEEAGLVRNEKNRGVFVREISLAEADEIYELRAVLDEIVG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518 109 RWFVNMATVEDIAELER-IQGLIEENNFADTFRHSELDTAFHTVMYQKHYNRHAAELWwkhREVLRAVSrrfnftLARRA 187
Cdd:TIGR03338  98 RRLAARITPTQLKVLKGlLDAMEDAAKAKDADRYARLNLRFHDALVEHAGNNKLTDTY---RRLVKELS------LFRRA 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1582046518 188 AI---------LSEHRELIAHVKAGNASEAAELIARHVEGS 219
Cdd:TIGR03338 169 ALadggamavsAAEHRAIVDAIASGDAERAGALMRAHVAAS 209
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 27-86 9.37e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 66.70  E-value: 9.37e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582046518  27 LYQLIREDIIEGRLAANERLV-VTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVR 86
Cdd:cd07377     6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 95-218 2.90e-12

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 61.61  E-value: 2.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518   95 DIYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEE--NNFADTFRHSELDTAFHTVMYQKHYNRHAAELWwkhREVL 172
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAaaAAGDDLEEFAELDREFHRALAEAAGNPVLLELL---ESLR 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1582046518  173 RAVSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIARHVEG 218
Cdd:smart00895  78 ARLRRLRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 95-214 1.82e-10

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 56.61  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  95 DIYEIGVLIEPALTRWFVNMATVEDIAELERIQGLIEENN-FADTFRHSELDTAFHTVMYQKHYNRHAAELWWKHREVLR 173
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAAdAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1582046518 174 AVSRRFNFTLARRAAILSEHRELIAHVKAGNASEAAELIAR 214
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 27-85 2.86e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 54.54  E-value: 2.86e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  27 LYQLIREDIIEGRLAANERL-VVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARV 85
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 28-216 1.10e-09

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 56.44  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  28 YQLIREDIIEGRLAANERLVVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRPIDQDFVRDIYEI-----GVL 102
Cdd:PRK11534   13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDAranmeAML 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518 103 IEPALTR----WFVN-MATVEDIAELERIQGLIEENNFADTfRHSeldtAFHTVMYQKHYNRHAAELwwkhREVLRAVSR 177
Cdd:PRK11534   93 VSLAIARggdeWEADvLAKAHLLSKLEACDASEKMLDEWDL-RHQ----AFHTAIVAGCGSHYLLQM----RERLFDLAA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1582046518 178 RFNFTLARRaAILS---------EHRELIAHVKAGNASEAAELIARHV 216
Cdd:PRK11534  164 RYRFIWLRR-TVLSvemledkhdQHQTLTAAILARDTARASELMRQHL 210
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
27-85 6.56e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 50.65  E-value: 6.56e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518   27 LYQLIREDIIEGRLAANERL-VVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARV 85
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 27-87 6.44e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 52.52  E-value: 6.44e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1582046518  27 LYQLIREDIIEGRLAANERL-VVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRP 87
Cdd:COG1167    17 LADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
27-87 1.61e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 50.63  E-value: 1.61e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1582046518  27 LYQLIREDIIEGRLAANERL-VVTDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARVRP 87
Cdd:COG2188    10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 27-219 1.11e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 45.01  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  27 LYQLIR-EDIIEGRLAANERlvvtDLARRHGTSTNPVREALQLLRGEGFVTLVPNRGARV-RP-----IDQ--------- 90
Cdd:PRK03837   22 LEQMIRsGEFGPGDQLPSER----ELMAFFGVGRPAVREALQALKRKGLVQISHGERARVsRPsadtiIGQlsgmakdfl 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  91 ----DFVRDIYEIGVLIEPALTRWFVNMATVEDIAELERIqglIEEN----NFADTFRhsELDTAFHTVMYQKHYNR--- 159
Cdd:PRK03837   98 sqspDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKA---LERNsqslGDNAAFI--RSDMEFHRVIAEIPGNPifm 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1582046518 160 --HAAELWW---KHREVLRAVSRRfNFTLArraailsEHRELIAHVKAGNASEAAELIARHVEGS 219
Cdd:PRK03837  173 aiHEALLDWlieARPEVVILHGHE-NVTLQ-------EHIAIVDAIRAHDPDEADRALQSHLNRV 229
PRK10225 PRK10225
Uxu operon transcriptional regulator;
30-225 3.76e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 43.47  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  30 LIREDIIEGRLAANERLVVT-DLARRHGTSTNPVREALQLLRGEGFVTLvpNRGA-----------RVRPIDQDFVRD-- 95
Cdd:PRK10225   17 MIRDLIIKTPYNPGERLPPErEIAEMLDVTRTVVREALIMLEIKGLVEV--RRGAgiyvldssgshNTDSPDANVCNDag 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  96 ---IYEIGVLIEPALTRWFVNMATVEDIAELeRIQGLIEENNFADTFRHSEL--DTAFHTVMYQKHYNRHAAELW---WK 167
Cdd:PRK10225   95 pfeLLQARQLLESNIAEFAALQATREDIVKM-RQALQLEERELASSAPGSSEsgDMQFHLAIAEATHNSMLVELFrqsWQ 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582046518 168 HRE---VLRAVSRRFNFTLARRAAiLSEHRELIAHVKAGNASEAAELIARHVEGSGRHILE 225
Cdd:PRK10225  174 WREnnpMWIQLHSHLDDSLYRKEW-LGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLE 233
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 27-235 2.08e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 38.21  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  27 LYQLIREDIIEG--RLAAnERlvvtDLARRHGTSTNPVREALQLLRGEGfvTLVPNRG---------------ARVRPI- 88
Cdd:PRK10421   11 VRALIEEKNLEAgmKLPA-ER----QLAMQLGVSRNSLREALAKLVSEG--VLLSRRGggtfirwrhetwseqNIVQPLk 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582046518  89 -----DQDFVRDIYEIGVLIEpALTRWFVNM-ATVEDiaeLERIQGLIEENNFADTFRHSELDTAFHTVMYQKHYNRHAA 162
Cdd:PRK10421   84 tlmadDPDYSFDILEARHAIE-ASTAWHAAMrATPGD---KEKIQLCFEATLSEDPDLASQADVRFHLAIAEASHNVVLL 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1582046518 163 ELWWKHREVLR---AVSRRFNFTLARRAAILSE-HRELIAHVKAGNASEAAELIARHVEgsgrHILEHMRARNAARA 235
Cdd:PRK10421  160 QTMRGFFDVLQssvKQSRQRMYLVPPVFSQLTEqHQAVMDAILAGDAEGARKAMMAHLS----FVHTTIKRFDEDQA 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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