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Conserved domains on  [gi|7506113|gb|T28855|]
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hypothetical protein M60.7 - Caenorhabditis elegans

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-290 3.05e-24

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 3.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   90 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLqymkvv 169
Cdd:COG0666 100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL------ 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  170 EQYETPEFRAGDKYPqrenvdePLRLAIKNGHYDCARLLLTNGANANAIYFDG--PEITQVSPLDTNFLELLLEFGADPN 247
Cdd:COG0666 174 EAGADVNARDNDGET-------PLHLAAENGHLEIVKLLLEAGADVNAKDNDGktALDLAAENGNLEIVKLLLEAGADLN 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 7506113  248 VFDRKGLTPIMKACRLRDKGIEAIRILLKSALHFALLSGNHDL 290
Cdd:COG0666 247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 470-511 8.11e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


:

Pssm-ID: 128549  Cd Length: 43  Bit Score: 62.70  E-value: 8.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7506113     470 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 511
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 289-412 1.63e-12

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   289 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 364
Cdd:PHA03100  49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 7506113   365 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 412
Cdd:PHA03100 128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-290 3.05e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 3.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   90 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLqymkvv 169
Cdd:COG0666 100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL------ 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  170 EQYETPEFRAGDKYPqrenvdePLRLAIKNGHYDCARLLLTNGANANAIYFDG--PEITQVSPLDTNFLELLLEFGADPN 247
Cdd:COG0666 174 EAGADVNARDNDGET-------PLHLAAENGHLEIVKLLLEAGADVNAKDNDGktALDLAAENGNLEIVKLLLEAGADLN 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 7506113  248 VFDRKGLTPIMKACRLRDKGIEAIRILLKSALHFALLSGNHDL 290
Cdd:COG0666 247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 126-412 1.60e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.89  E-value: 1.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   126 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY-----MKVVEQYETPEFRAGDK--------YPQRENV--- 189
Cdd:PHA02876 161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgadvnIIALDDLSVLECAVDSKnidtikaiIDNRSNInkn 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   190 DEPLRLAIKNGHYDCARLLLTNGANANAI--YFDGP-EITQVSPLDTNFLELLLEFGADPNVFDRKGLTPI--------- 257
Cdd:PHA02876 241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIddCKNTPlHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLylmakngyd 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   258 ---MKACRLRDKGIEAIRILLKSALHFA-LLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGA 333
Cdd:PHA02876 321 tenIRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDYGA 399

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7506113   334 NPNAVHTYIGSCLHLASCSSllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFveYFRSNDSIDAKVVKLFITHGAKV 412
Cdd:PHA02876 400 DIEALSQKIGTALHFALCGT--NPYMSVKTLIDRGANVNSKNKD-----LSTPL--HYACKKNCKLDVIEMLLDNGADV 469
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-217 1.97e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    114 LHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVveqyetpefragDKYPQRENvdePL 193
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV------------NLKDNGRT---AL 65

                          90       100
                  ....*....|....*....|....
gi 7506113    194 RLAIKNGHYDCARLLLTNGANANA 217
Cdd:pfam12796  66 HYAARSGHLEIVKLLLEKGADINV 89
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 470-511 8.11e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 62.70  E-value: 8.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7506113     470 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 511
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 289-412 1.63e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   289 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 364
Cdd:PHA03100  49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 7506113   365 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 412
Cdd:PHA03100 128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
263-440 2.01e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 2.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  263 LRDKGIEAIRILLKSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYI 342
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  343 GSCLHLASCSsllNQYQIVELLLEHGADMNLQhqfpdGSRLKSPFVEYFRSNdsiDAKVVKLFITHGAKVVMRNPLHdcr 422
Cdd:COG0666 121 ETPLHLAAYN---GNLEIVKLLLEAGADVNAQ-----DNDGNTPLHLAAANG---NLEIVKLLLEAGADVNARDNDG--- 186

                       170
                ....*....|....*...
gi 7506113  423 gqlRNVLKLAALQNQPEV 440
Cdd:COG0666 187 ---ETPLHLAAENGHLEI 201
Ank_2 pfam12796
Ankyrin repeats (3 copies);
279-374 1.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    279 LHFALLSGNHDLVKFMIANGSNVNMDEKyEKPSPIDIAVLKDDPHLLKIVLDaGANPNAVhTYIGSCLHLASCSsllNQY 358
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLE-HADVNLK-DNGRTALHYAARS---GHL 74

                          90
                  ....*....|....*.
gi 7506113    359 QIVELLLEHGADMNLQ 374
Cdd:pfam12796  75 EIVKLLLEKGADINVK 90
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 474-510 1.03e-06

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 45.18  E-value: 1.03e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7506113  474 KNPHSLQHLCRIQIRDTVQT---SEYKTLPIPEYLKAYLL 510
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRrrlELIKKLPLPPRLKDYLL 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 475-510 4.90e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 43.31  E-value: 4.90e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7506113    475 NPHSLQHLCRIQIRDTVQTSEYK---TLPIPEYLKAYLL 510
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGaidKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 251-377 9.51e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 9.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  251 RKGLTPIMKACRLRDkgIEAIRILLKS--------------ALHFALLSGNHDLVKFMIANGSN-VNM---DEKYEKPSP 312
Cdd:cd22192  15 RISESPLLLAAKEND--VQAIKKLLKCpscdlfqrgalgetALHVAALYDNLEAAVVLMEAAPElVNEpmtSDLYQGETA 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506113  313 IDIAVLKDDPHLLKIVLDAGA---NPNAVHTYI---GSCL-----HLASCSSLLNQYQIVELLLEHGADMNLQHQF 377
Cdd:cd22192  93 LHIAVVNQNLNLVRELIARGAdvvSPRATGTFFrpgPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 121-217 2.81e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    121 NYQAAAKLLLNLGAKVQavdnIGCSALHLCAEhGHYRMIKLLLQYMKVVEQYETPEFRAGDKYPQRENVDE-PLRLAIKN 199
Cdd:TIGR00870  64 ENLELTELLLNLSCRGA----VGDTLLHAISL-EYVDAVEAILLHLLAAFRKSGPLELANDQYTSEFTPGItALHLAAHR 138

                          90
                  ....*....|....*...
gi 7506113    200 GHYDCARLLLTNGANANA 217
Cdd:TIGR00870 139 QNYEIVKLLLERGASVPA 156
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 212-377 3.35e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.06  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    212 GANANAIYFDGPEITQVSPL-----DTNFLE---LLLEFGADPNVfdrkGLTPIMKAcRLRDKGI--EAIRILLKSALHf 281
Cdd:TIGR00870  37 LEEPKKLNINCPDRLGRSALfvaaiENENLElteLLLNLSCRGAV----GDTLLHAI-SLEYVDAveAILLHLLAAFRK- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    282 allSGNHDLVKfmiangsNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAV-----------HTYIG---SCLH 347
Cdd:TIGR00870 111 ---SGPLELAN-------DQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgVDSFYhgeSPLN 180

                         170       180       190
                  ....*....|....*....|....*....|
gi 7506113    348 LASCsslLNQYQIVELLLEHGADMNLQHQF 377
Cdd:TIGR00870 181 AAAC---LGSPSIVALLSEDPADILTADSL 207
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 143-170 3.36e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 3.36e-03
                           10        20
                   ....*....|....*....|....*...
gi 7506113     143 GCSALHLCAEHGHYRMIKLLLQYMKVVE 170
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-290 3.05e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 3.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   90 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLqymkvv 169
Cdd:COG0666 100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL------ 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  170 EQYETPEFRAGDKYPqrenvdePLRLAIKNGHYDCARLLLTNGANANAIYFDG--PEITQVSPLDTNFLELLLEFGADPN 247
Cdd:COG0666 174 EAGADVNARDNDGET-------PLHLAAENGHLEIVKLLLEAGADVNAKDNDGktALDLAAENGNLEIVKLLLEAGADLN 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 7506113  248 VFDRKGLTPIMKACRLRDKGIEAIRILLKSALHFALLSGNHDL 290
Cdd:COG0666 247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-325 1.78e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.41  E-value: 1.78e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   32 HEDNSTDVATLRLETVLEISPQSTLSAAALDMMESHDDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGL 111
Cdd:COG0666   9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  112 TPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQymkvveqyetpefRAGDKYPQRENVDE 191
Cdd:COG0666  89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-------------AGADVNAQDNDGNT 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  192 PLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitqVSPL-------DTNFLELLLEFGADPNVFDRKGLTPIMKACRlr 264
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAGADVNARDNDG-----ETPLhlaaengHLEIVKLLLEAGADVNAKDNDGKTALDLAAE-- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7506113  265 dKGIEAIRILLKSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLL 325
Cdd:COG0666 229 -NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-373 4.94e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.26  E-value: 4.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   60 ALDMMESHDDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAV 139
Cdd:COG0666   4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  140 DNIGCSALHLCAEHGHYRMIKLLLQYMKVVEQyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIY 219
Cdd:COG0666  84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNA-------------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  220 FDGpeitqVSPL-------DTNFLELLLEFGADPNVFDRKGLTPimkacrlrdkgieairillksaLHFALLSGNHDLVK 292
Cdd:COG0666 151 NDG-----NTPLhlaaangNLEIVKLLLEAGADVNARDNDGETP----------------------LHLAAENGHLEIVK 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  293 FMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLAscsSLLNQYQIVELLLEHGADMN 372
Cdd:COG0666 204 LLLEAGADVNAKDNDGK-TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA---AAAGAALIVKLLLLALLLLA 279


                .
gi 7506113  373 L 373
Cdd:COG0666 280 A 280
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
207-374 1.34e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.16  E-value: 1.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  207 LLLTNGANANAIYFDGPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLK---------- 276
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD--LEIVKLLLEagadvnardk 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  277 ---SALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSs 353
Cdd:COG0666 119 dgeTPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN- 196

                       170       180
                ....*....|....*....|.
gi 7506113  354 llNQYQIVELLLEHGADMNLQ 374
Cdd:COG0666 197 --GHLEIVKLLLEAGADVNAK 215
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 126-412 1.60e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.89  E-value: 1.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   126 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY-----MKVVEQYETPEFRAGDK--------YPQRENV--- 189
Cdd:PHA02876 161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgadvnIIALDDLSVLECAVDSKnidtikaiIDNRSNInkn 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   190 DEPLRLAIKNGHYDCARLLLTNGANANAI--YFDGP-EITQVSPLDTNFLELLLEFGADPNVFDRKGLTPI--------- 257
Cdd:PHA02876 241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIddCKNTPlHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLylmakngyd 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   258 ---MKACRLRDKGIEAIRILLKSALHFA-LLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGA 333
Cdd:PHA02876 321 tenIRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDYGA 399

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7506113   334 NPNAVHTYIGSCLHLASCSSllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFveYFRSNDSIDAKVVKLFITHGAKV 412
Cdd:PHA02876 400 DIEALSQKIGTALHFALCGT--NPYMSVKTLIDRGANVNSKNKD-----LSTPL--HYACKKNCKLDVIEMLLDNGADV 469
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 86-342 1.08e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.94  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    86 NYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAA-----AKLLLNLGAKVQAVDNIGCSALHLCAEH--GHYRM 158
Cdd:PHA03100  44 EARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   159 IKLLLQYMKVVEqyetpefragDKYPQRENvdePLRLAIKNGHYD--CARLLLTNGANANAIyfdgpeitqvspldtNFL 236
Cdd:PHA03100 124 VEYLLDNGANVN----------IKNSDGEN---LLHLYLESNKIDlkILKLLIDKGVDINAK---------------NRV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   237 ELLLEFGADPNVFDRKGLTPIMKACRlrdkgieairillksalhfallSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIA 316
Cdd:PHA03100 176 NYLLSYGVPINIKDVYGFTPLHYAVY----------------------NNNPEFVKYLLDLGANPNLVNKYGD-TPLHIA 232

                        250       260
                 ....*....|....*....|....*.
gi 7506113   317 VLKDDPHLLKIVLDAGANPNAVHTYI 342
Cdd:PHA03100 233 ILNNNKEIFKLLLNNGPSIKTIIETL 258
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-217 1.97e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    114 LHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVveqyetpefragDKYPQRENvdePL 193
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV------------NLKDNGRT---AL 65

                          90       100
                  ....*....|....*....|....
gi 7506113    194 RLAIKNGHYDCARLLLTNGANANA 217
Cdd:pfam12796  66 HYAARSGHLEIVKLLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 111-374 1.60e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 75.69  E-value: 1.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   111 LTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHL-CAEHGHYRMIKLLLQYMKVVEQYEtpeFRAgdkypqrenv 189
Cdd:PHA02878  38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIiCKEPNKLGMKEMIRSINKCSVFYT---LVA---------- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   190 depLRLAIKNGHYDCARLLLTNGANANA----IYFDgpEITQVSPLDTNFLELLLEFGADPNVFDRKGLtpimkacrlrd 265
Cdd:PHA02878 105 ---IKDAFNNRNVEIFKIILTNRYKNIQtidlVYID--KKSKDDIIEAEITKLLLSYGADINMKDRHKG----------- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   266 kgieairillKSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSC 345
Cdd:PHA02878 169 ----------NTALHYATENKDQRLTELLLSYGANVNIPDKTNN-SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                        250       260
                 ....*....|....*....|....*....
gi 7506113   346 LHLAScSSLLNqYQIVELLLEHGADMNLQ 374
Cdd:PHA02878 238 LHISV-GYCKD-YDILKLLLEHGVDVNAK 264
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 162-373 2.30e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   162 LLQYMkvVEQYETPEFRAGDKYpqrenvdEPLRLAIKNGHYDCARLLLTNGANANAIYfdgPEITqvSPL-------DTN 234
Cdd:PHA02875  17 IARRL--LDIGINPNFEIYDGI-------SPIKLAMKFRDSEAIKLLMKHGAIPDVKY---PDIE--SELhdaveegDVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   235 FLELLLEFGADPN-VFDRKGLTPIMKACRLrdKGIEAIRILLK-------------SALHFALLSGNHDLVKFMIANGSN 300
Cdd:PHA02875  83 AVEELLDLGKFADdVFYKDGMTPLHLATIL--KKLDIMKLLIArgadpdipntdkfSPLHLAVMMGDIKGIELLIDHKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7506113   301 VNMDEKYeKPSPIDIAVLKDDPHLLKIVLDAGANPNavhtYIGS--CLHLASCSSLLNQYQIVELLLEHGADMNL 373
Cdd:PHA02875 161 LDIEDCC-GCTPLIIAMAKGDIAICKMLLDSGANID----YFGKngCVAALCYAIENNKIDIVRLFIKRGADCNI 230
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 470-511 8.11e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 62.70  E-value: 8.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7506113     470 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 511
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 289-412 1.63e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   289 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 364
Cdd:PHA03100  49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 7506113   365 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 412
Cdd:PHA03100 128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
PHA03095 PHA03095
ankyrin-like protein; Provisional
 79-377 5.16e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 5.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    79 ALADKITNYAP--IEEIRYILLRGAQVDGQVTAGLTPLHYacYINYQAAA-----KLLLNLGAKVQAVDNIGCSALHLCA 151
Cdd:PHA03095  14 ALYDYLLNASNvtVEEVRRLLAAGADVNFRGEYGKTPLHL--YLHYSSEKvkdivRLLLEAGADVNAPERCGFTPLHLYL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   152 EHGH-YRMIKLLLqymkvveqyetpefRAGdkypqrENVDEplrlaiKNGhydcarllltNGANANAIYFDGPEItqvsp 230
Cdd:PHA03095  92 YNATtLDVIKLLI--------------KAG------ADVNA------KDK----------VGRTPLHVYLSGFNI----- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   231 lDTNFLELLLEFGADPNVFDRKGLTPImkACRLRDKGIEAirillksalhfallsgnhDLVKFMIANGSNV-NMDEKYEK 309
Cdd:PHA03095 131 -NPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNANV------------------ELLRLLIDAGADVyAVDDRFRS 189

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7506113   310 PSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLA----SCSSLLnqyqiVELLLEHGADMNLQHQF 377
Cdd:PHA03095 190 LLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMatgsSCKRSL-----VLPLLIAGISINARNRY 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
232-302 1.99e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    232 DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLK-----------SALHFALLSGNHDLVKFMIANGSN 300
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNGH--LEIVKLLLEhadvnlkdngrTALHYAARSGHLEIVKLLLEKGAD 86


                  ..
gi 7506113    301 VN 302
Cdd:pfam12796  87 IN 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
263-440 2.01e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 2.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  263 LRDKGIEAIRILLKSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYI 342
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  343 GSCLHLASCSsllNQYQIVELLLEHGADMNLQhqfpdGSRLKSPFVEYFRSNdsiDAKVVKLFITHGAKVVMRNPLHdcr 422
Cdd:COG0666 121 ETPLHLAAYN---GNLEIVKLLLEAGADVNAQ-----DNDGNTPLHLAAANG---NLEIVKLLLEAGADVNARDNDG--- 186

                       170
                ....*....|....*...
gi 7506113  423 gqlRNVLKLAALQNQPEV 440
Cdd:COG0666 187 ---ETPLHLAAENGHLEI 201
Ank_2 pfam12796
Ankyrin repeats (3 copies);
93-165 7.21e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 7.21e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7506113     93 IRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAkvQAVDNIGCSALHLCAEHGHYRMIKLLLQY 165
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVKLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
110-163 2.01e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 2.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7506113    110 GLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLL 163
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 91-260 5.59e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 5.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    91 EEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQ---YMK 167
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEkgaYAN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   168 VveqyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitqVSPLDTNFL------ELLLE 241
Cdd:PHA02874 185 V----------------KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNG-----FTPLHNAIIhnrsaiELLIN 243

                        170
                 ....*....|....*....
gi 7506113   242 fGADPNVFDRKGLTPIMKA 260
Cdd:PHA02874 244 -NASINDQDIDGSTPLHHA 261
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 188-371 6.38e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 6.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   188 NVDEPLRLAIKNGHYDCARLLLTNGANANaiyfdgpeITQVSPLDTNFLELLLEFGADPNVFDRKgltpimkacrlrdkg 267
Cdd:PHA02874  67 KIPHPLLTAIKIGAHDIIKLLIDNGVDTS--------ILPIPCIEKDMIKTILDCGIDVNIKDAE--------------- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   268 ieairilLKSALHFALLSGNHDLVKFMIANGSNVNMdEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLH 347
Cdd:PHA02874 124 -------LKTFLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                        170       180
                 ....*....|....*....|....
gi 7506113   348 LascSSLLNQYQIVELLLEHGADM 371
Cdd:PHA02874 196 N---AAEYGDYACIKLLIDHGNHI 216
Ank_2 pfam12796
Ankyrin repeats (3 copies);
279-374 1.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    279 LHFALLSGNHDLVKFMIANGSNVNMDEKyEKPSPIDIAVLKDDPHLLKIVLDaGANPNAVhTYIGSCLHLASCSsllNQY 358
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLE-HADVNLK-DNGRTALHYAARS---GHL 74

                          90
                  ....*....|....*.
gi 7506113    359 QIVELLLEHGADMNLQ 374
Cdd:pfam12796  75 EIVKLLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 82-275 1.84e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    82 DKITNYAPIEE--IRYILLRGAQVDGQV-TAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRM 158
Cdd:PHA02878 137 DKKSKDDIIEAeiTKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPI 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   159 IKLLLQYMKVVEqyetpefrAGDKYPqrenvDEPLRLAIKN-GHYDCARLLLTNGANANA-IYFDGPEITQVSPLDTNFL 236
Cdd:PHA02878 217 VHILLENGASTD--------ARDKCG-----NTPLHISVGYcKDYDILKLLLEHGVDVNAkSYILGLTALHSSIKSERKL 283

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 7506113   237 ELLLEFGADPNVFDRKGLTPIMKACRLRdKGIEAIRILL 275
Cdd:PHA02878 284 KLLLEYGADINSLNSYKLTPLSSAVKQY-LCINIGRILI 321
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 234-374 2.02e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.54  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   234 NFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLK-------------SALHFALLSGNHDLVKFMIANGSN 300
Cdd:PHA02875  16 DIARRLLDIGINPNFEIYDGISPIKLAMKFRD--SEAIKLLMKhgaipdvkypdieSELHDAVEEGDVKAVEELLDLGKF 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7506113   301 VNmDEKYEKP-SPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLLNqyqIVELLLEHGADMNLQ 374
Cdd:PHA02875  94 AD-DVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK---GIELLIDHKACLDIE 164
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 193-431 2.63e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   193 LRLAIKNGHYDCARLLLTNGANANAIYFD---GPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIe 269
Cdd:PHA02874   5 LRMCIYSGDIEAIEKIIKNKGNCINISVDettTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDI- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   270 aIRILLKSALHFALLSG---NHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCL 346
Cdd:PHA02874  84 -IKLLIDNGVDTSILPIpciEKDMIKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   347 HLASCSsllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPF---VEYFrsndsiDAKVVKLFITHGAKVVMR-----NPL 418
Cdd:PHA02874 162 HIAIKH---NFFDIIKLLLEKGAYANVKDNN-----GESPLhnaAEYG------DYACIKLLIDHGNHIMNKckngfTPL 227

                        250
                 ....*....|...
gi 7506113   419 HDCRGQLRNVLKL 431
Cdd:PHA02874 228 HNAIIHNRSAIEL 240
PHA03095 PHA03095
ankyrin-like protein; Provisional
 91-338 1.41e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    91 EEIRYILLRGAQVDGQVTAGLTPLH-YACYINYQAAAKLLLNLGAKVQAVDNIGCSALH--LCAEHGHYRMIKLLLQYMK 167
Cdd:PHA03095  64 DIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   168 VVEQYETPEFRAGDKYPQRENVD-EPLRLAIKNGHYDCARllltnganaNAIYFDGPEITQVSPLDTN-FLELLLEFGAD 245
Cdd:PHA03095 144 DVNALDLYGMTPLAVLLKSRNANvELLRLLIDAGADVYAV---------DDRFRSLLHHHLQSFKPRArIVRELIRAGCD 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   246 PNVFDRKGLTPIMKA-----CR------LRDKG--IEAIRILLKSALHFALLSGNHDLVKFMIANGSNVNM---DEKyek 309
Cdd:PHA03095 215 PAATDMLGNTPLHSMatgssCKrslvlpLLIAGisINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAvssDGN--- 291

                        250       260
                 ....*....|....*....|....*....
gi 7506113   310 pSPIDIAVLKDDPHLLKIVLDAGANPNAV 338
Cdd:PHA03095 292 -TPLSLMVRNNNGRAVRAALAKNPSAETV 319
PHA03095 PHA03095
ankyrin-like protein; Provisional
 273-419 2.83e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   273 ILLKSALHFALLSGNH---DLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDD-PHLLKIVLDAGANPNAVHTYIGSCLHl 348
Cdd:PHA03095  45 EYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGF-TPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLH- 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506113   349 ASCSSLLNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFVEYFRSNDsIDAKVVKLFITHGAKV-----VMRNPLH 419
Cdd:PHA03095 123 VYLSGFNINPKVIRLLLRKGADVNALDLY-----GMTPLAVLLKSRN-ANVELLRLLIDAGADVyavddRFRSLLH 192
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 474-510 1.03e-06

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 45.18  E-value: 1.03e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7506113  474 KNPHSLQHLCRIQIRDTVQT---SEYKTLPIPEYLKAYLL 510
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRrrlELIKKLPLPPRLKDYLL 40
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 475-510 1.40e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 44.77  E-value: 1.40e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 7506113  475 NPHSLQHLCRIQIRDTVQTSEY---KTLPIPEYLKAYLL 510
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLdliDKLPLPPRLKDYLL 39
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 478-509 3.64e-06

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 43.57  E-value: 3.64e-06
                        10        20        30
                ....*....|....*....|....*....|..
gi 7506113  478 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 509
Cdd:cd03733   5 SLQHLCRMALRRVMTTQQVLALPIPKKMKEFL 36
PHA03095 PHA03095
ankyrin-like protein; Provisional
 289-419 3.78e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   289 DLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIV---LDAGANPNAVHTYIGSCLHLASCSSllNQYQIVELLL 365
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGK-TPLHLYLHYSSEKVKDIVrllLEAGADVNAPERCGFTPLHLYLYNA--TTLDVIKLLI 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 7506113   366 EHGADMNLQHQFPDgsrlkSPFVEYFrSNDSIDAKVVKLFITHGA-----KVVMRNPLH 419
Cdd:PHA03095 105 KAGADVNAKDKVGR-----TPLHVYL-SGFNINPKVIRLLLRKGAdvnalDLYGMTPLA 157
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 475-510 4.90e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 43.31  E-value: 4.90e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7506113    475 NPHSLQHLCRIQIRDTVQTSEYK---TLPIPEYLKAYLL 510
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGaidKLPLPPLLKDYLL 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 62-221 6.16e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.10  E-value: 6.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    62 DMMESHDDFESQSQLQRALAdkITNYAPIEEiryiLLRgAQVDGQVT--AGLTPLHYACYINYQAAAKLLLNLGAKVQAV 139
Cdd:PLN03192 515 DNGGEHDDPNMASNLLTVAS--TGNAALLEE----LLK-AKLDPDIGdsKGRTPLHIAASKGYEDCVLVLLKHACNVHIR 587

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   140 DNIGCSALHLCAEHGHYRMIKLLLQYMKVVEQYETPEF-----RAGDKYPQRE------NVDE-------PLRLAIKNGH 201
Cdd:PLN03192 588 DANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDLlctaaKRNDLTAMKEllkqglNVDSedhqgatALQVAMAEDH 667

                        170       180
                 ....*....|....*....|
gi 7506113   202 YDCARLLLTNGANANAIYFD 221
Cdd:PLN03192 668 VDMVRLLIMNGADVDKANTD 687
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 478-509 7.71e-06

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 42.88  E-value: 7.71e-06
                        10        20        30
                ....*....|....*....|....*....|..
gi 7506113  478 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 509
Cdd:cd03746   5 SLQHLCRMAIRRVMPTQQVKELPIPSKLLEFL 36
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 90-257 8.28e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.04  E-value: 8.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    90 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVV 169
Cdd:PHA02874 137 LESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHI 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   170 EQyetpefragdkypQRENVDEPLRLAIKngHYDCARLLLTNGANANAIYFDGPEITQVS---PLDTNFLELLLEFGADP 246
Cdd:PHA02874 217 MN-------------KCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinpPCDIDIIDILLYHKADI 281

                        170
                 ....*....|.
gi 7506113   247 NVFDRKGLTPI 257
Cdd:PHA02874 282 SIKDNKGENPI 292
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 251-377 9.51e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 9.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113  251 RKGLTPIMKACRLRDkgIEAIRILLKS--------------ALHFALLSGNHDLVKFMIANGSN-VNM---DEKYEKPSP 312
Cdd:cd22192  15 RISESPLLLAAKEND--VQAIKKLLKCpscdlfqrgalgetALHVAALYDNLEAAVVLMEAAPElVNEpmtSDLYQGETA 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506113  313 IDIAVLKDDPHLLKIVLDAGA---NPNAVHTYI---GSCL-----HLASCSSLLNQYQIVELLLEHGADMNLQHQF 377
Cdd:cd22192  93 LHIAVVNQNLNLVRELIARGAdvvSPRATGTFFrpgPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 80-165 1.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.74  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    80 LADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMI 159
Cdd:PHA03100 162 LIDKGVDINAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIF 241


                 ....*.
gi 7506113   160 KLLLQY 165
Cdd:PHA03100 242 KLLLNN 247
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 91-245 1.37e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    91 EEIRYILLRGAQVDGQVTAGLTPLHYACYIN-YQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVV 169
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   170 EQ-------------YETPEF--------RAGDKYPQRENVDEPLRLAIKNG-HYDCARLLLTNGANANAIYFDGPEITQ 227
Cdd:PHA02876 402 EAlsqkigtalhfalCGTNPYmsvktlidRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLL 481

                        170
                 ....*....|....*...
gi 7506113   228 VSPLDTNFLELLLEFGAD 245
Cdd:PHA02876 482 IALEYHGIVNILLHYGAE 499
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 478-510 2.17e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 2.17e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 7506113  478 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLL 510
Cdd:cd03717   5 SLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLK 37
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 478-510 2.75e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.24  E-value: 2.75e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 7506113     478 SLQHLCRIQIRDtvQTSEYKTLPIPEYLKAYLL 510
Cdd:smart00969   2 SLQHLCRLAIRR--SLGGIDKLPLPPRLKDYLL 32
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 192-373 4.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 4.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   192 PLRLAIKNGHYDCARLLLTNGANANAIYFD-------GPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLR 264
Cdd:PHA03100  38 PLYLAKEARNIDVVKILLDNGADINSSTKNnstplhyLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKK 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   265 DKGIEAIRILL-------------KSALHFALLSGNHDL--VKFMIANGSNVNMDEKyekpspidiavlkddphlLKIVL 329
Cdd:PHA03100 118 SNSYSIVEYLLdnganvniknsdgENLLHLYLESNKIDLkiLKLLIDKGVDINAKNR------------------VNYLL 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 7506113   330 DAGANPNAVHTYIGSCLHLASCSSLLNqyqIVELLLEHGADMNL 373
Cdd:PHA03100 180 SYGVPINIKDVYGFTPLHYAVYNNNPE---FVKYLLDLGANPNL 220
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 205-257 5.84e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 5.84e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 7506113   205 ARLLLTNGANANAIYFDGPEITQVSPLD--TNFLELLLEFGADPNVFDRKGLTPI 257
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANghVQVVRVLLEFGADPTLLDKDGKTPL 152
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 475-510 9.82e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.12  E-value: 9.82e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 7506113  475 NPHSLQHLCRIQIRDTVQTSEYKT---LPIPEYLKAYLL 510
Cdd:cd03723   2 TPRSLQHLCRCAIRKLLGSRCHKLvpqLSLPTSLKNYLL 40
Ank_2 pfam12796
Ankyrin repeats (3 copies);
90-140 1.57e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 1.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 7506113     90 IEEIRYiLLRGAQVDGQvTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVD 140
Cdd:pfam12796  43 LEIVKL-LLEHADVNLK-DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 475-510 2.50e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.04  E-value: 2.50e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7506113  475 NPHSLQHLCRIQIRDTV------QTSEYKTLPIPEYLKAYLL 510
Cdd:cd03731   2 NPRPLKHLCRLKIRKLMglqklqQPSSMKKLPLPPALKRYIL 43
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-165 2.53e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7506113    93 IRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY 165
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 121-217 2.81e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    121 NYQAAAKLLLNLGAKVQavdnIGCSALHLCAEhGHYRMIKLLLQYMKVVEQYETPEFRAGDKYPQRENVDE-PLRLAIKN 199
Cdd:TIGR00870  64 ENLELTELLLNLSCRGA----VGDTLLHAISL-EYVDAVEAILLHLLAAFRKSGPLELANDQYTSEFTPGItALHLAAHR 138

                          90
                  ....*....|....*...
gi 7506113    200 GHYDCARLLLTNGANANA 217
Cdd:TIGR00870 139 QNYEIVKLLLERGASVPA 156
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 474-509 3.78e-04

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 38.15  E-value: 3.78e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 7506113  474 KNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 509
Cdd:cd03741   1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYL 36
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 475-510 3.94e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.67  E-value: 3.94e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7506113  475 NPHSLQHLCRIQIRDTVQTSEYKT------LPIPEYLKAYLL 510
Cdd:cd03730   2 NPRSLKHLCRLKIRACMGRLRLRCpvfmsfLPLPNRLKAYIL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
145-209 6.03e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 6.03e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7506113    145 SALHLCAEHGHYRMIKLLLQYMKvveqyetpefragDKYPQRENVDEPLRLAIKNGHYDCARLLL 209
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA-------------DINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 289-412 8.70e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 8.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   289 DLVKFMIANGSNVN-MDEKYEKPSPIDIAVLKDDPHLLKIVL---DAGANPNAVHTYIGSCLHLASCSSLLNQYQIVELL 364
Cdd:PHA02798  52 DIVKLFINLGANVNgLDNEYSTPLCTILSNIKDYKHMLDIVKiliENGADINKKNSDGETPLYCLLSNGYINNLEILLFM 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 7506113   365 LEHGADMNLQhqfpDGSRLKSPFVeYFRSNDSIDAKVVKLFITHGAKV 412
Cdd:PHA02798 132 IENGADTTLL----DKDGFTMLQV-YLQSNHHIDIEIIKLLLEKGVDI 174
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 110-248 9.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.52  E-value: 9.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   110 GLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKvveqyeTPEFRAGDKYpqrenv 189
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA------CLDIEDCCGC------ 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7506113   190 dEPLRLAIKNGHYDCARLLLTNGANANaiYFD-GPEITQVSPLDTN----FLELLLEFGADPNV 248
Cdd:PHA02875 170 -TPLIIAMAKGDIAICKMLLDSGANID--YFGkNGCVAALCYAIENnkidIVRLFIKRGADCNI 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 80-219 1.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.13  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    80 LADKITNyapIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMI 159
Cdd:PHA02875 108 LATILKK---LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAIC 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   160 KLLLqymkvveqyetpEFRAGDKYPQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIY 219
Cdd:PHA02875 185 KMLL------------DSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 236-412 1.41e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   236 LELLLEFGADPNVFDRKGLTPIMKACRLRDK-GI-EAIRILLKSALHFALLS----------------------GNHD-- 289
Cdd:PHA02878  53 VKSLLTRGHNVNQPDHRDLTPLHIICKEPNKlGMkEMIRSINKCSVFYTLVAikdafnnrnveifkiiltnrykNIQTid 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   290 ----------------LVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSS 353
Cdd:PHA02878 133 lvyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHY 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 7506113   354 llnQYQIVELLLEHGADMNLQHQFPDgsrlkSPFveYFRSNDSIDAKVVKLFITHGAKV 412
Cdd:PHA02878 213 ---NKPIVHILLENGASTDARDKCGN-----TPL--HISVGYCKDYDILKLLLEHGVDV 261
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 279-350 1.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 1.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7506113   279 LHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLAS 350
Cdd:PHA02884  74 LIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAL 145
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 110-141 2.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 2.54e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 7506113    110 GLTPLHYACYI-NYQAAAKLLLNLGAKVQAVDN 141
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 344-374 2.97e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 2.97e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7506113    344 SCLHLASCSSllNQYQIVELLLEHGADMNLQ 374
Cdd:pfam00023   4 TPLHLAAGRR--GNLEIVKLLLSKGADVNAR 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 126-231 3.30e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   126 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLqymkvveqyetpEFRAGDKYPQRENvDEPLRLAIKNGHYDCA 205
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL------------EFGADPTLLDKDG-KTPLELAEENGFREVV 164

                         90       100       110
                 ....*....|....*....|....*....|....
gi 7506113   206 RLLLTN-------GANANAIYFDG-PEITQVSPL 231
Cdd:PTZ00322 165 QLLSRHsqchfelGANAKPDSFTGkPPSLEDSPI 198
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 212-377 3.35e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.06  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    212 GANANAIYFDGPEITQVSPL-----DTNFLE---LLLEFGADPNVfdrkGLTPIMKAcRLRDKGI--EAIRILLKSALHf 281
Cdd:TIGR00870  37 LEEPKKLNINCPDRLGRSALfvaaiENENLElteLLLNLSCRGAV----GDTLLHAI-SLEYVDAveAILLHLLAAFRK- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113    282 allSGNHDLVKfmiangsNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAV-----------HTYIG---SCLH 347
Cdd:TIGR00870 111 ---SGPLELAN-------DQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgVDSFYhgeSPLN 180

                         170       180       190
                  ....*....|....*....|....*....|
gi 7506113    348 LASCsslLNQYQIVELLLEHGADMNLQHQF 377
Cdd:TIGR00870 181 AAAC---LGSPSIVALLSEDPADILTADSL 207
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 143-170 3.36e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 3.36e-03
                           10        20
                   ....*....|....*....|....*...
gi 7506113     143 GCSALHLCAEHGHYRMIKLLLQYMKVVE 170
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 478-509 3.49e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 35.26  E-value: 3.49e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 7506113  478 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 509
Cdd:cd03745   5 SLRHLCRKALRHFLTTYQVLALPIPKKMKEFL 36
Ank_4 pfam13637
Ankyrin repeats (many copies);
87-130 3.52e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 7506113     87 YAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLL 130
Cdd:pfam13637  11 SGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 476-510 5.26e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.11  E-value: 5.26e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 7506113  476 PHSLQHLCRIQIRDTVQ----TSEYKTLPIPEYLKAYLL 510
Cdd:cd03725   3 PPPLKHLCRVFIRLCLRpwpvDVKVKALPLPDRLKWYLL 41
PHA02798 PHA02798
ankyrin-like protein; Provisional
 231-409 5.46e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.43  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   231 LDTNFLELLLEFGADPNVFDRKGLTPImkaCRLRDKGIEairilLKSALhfallsgnhDLVKFMIANGSNVNMDEKyEKP 310
Cdd:PHA02798  49 PSTDIVKLFINLGANVNGLDNEYSTPL---CTILSNIKD-----YKHML---------DIVKILIENGADINKKNS-DGE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   311 SPIDIAVLKDDPHLLKIVL---DAGANPNAVHTYIGSCLHLASCSSLLNQYQIVELLLEHGADMNLQHQFPDGSRLKSpf 387
Cdd:PHA02798 111 TPLYCLLSNGYINNLEILLfmiENGADTTLLDKDGFTMLQVYLQSNHHIDIEIIKLLLEKGVDINTHNNKEKYDTLHC-- 188

                        170       180
                 ....*....|....*....|...
gi 7506113   388 veYFRSN-DSIDAKVVKLFITHG 409
Cdd:PHA02798 189 --YFKYNiDRIDADILKLFVDNG 209
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 287-397 8.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 37.88  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506113   287 NHDLVKFMIANGSNVNMDEKYEKPSPID--IAVLKD-DPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLLNqYQIVEL 363
Cdd:PHA02859  65 NVEILKFLIENGADVNFKTRDNNLSALHhyLSFNKNvEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNVR-INVIKL 143

                         90       100       110
                 ....*....|....*....|....*....|....
gi 7506113   364 LLEHGADMnLQHQFPDGSRLKSPFVeyFRSNDSI 397
Cdd:PHA02859 144 LIDSGVSF-LNKDFDNNNILYSYIL--FHSDKKI 174
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 478-510 8.44e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 34.32  E-value: 8.44e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 7506113  478 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLL 510
Cdd:cd03740   5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYLL 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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