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Conserved domains on  [gi|1459838484|emb|SYM22660|]
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putative enzyme [Klebsiella pneumoniae]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 11-241 1.15e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.15e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  11 NGFTFKRFFVAHDRCAMKVGTDGILLGAWAPIAGVKHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENAL 90
Cdd:COG4123     4 DGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRNVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  91 ASPWASRIEVWQADIHQWQPS-QTRRYELIISNPPFFAE--GVPCATSQREQARYTTTLDHASLLTCAAEHITEEGFFCV 167
Cdd:COG4123    83 LNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFAL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484 168 VLPVDIGNAFIERARAMGWHLRLRTDVAETELRPPHRVLLAFSPTAGECFS--DRLAIRGPEQQYSEGFTALTEDF 241
Cdd:COG4123   163 IHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 11-241 1.15e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.15e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  11 NGFTFKRFFVAHDRCAMKVGTDGILLGAWAPIAGVKHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENAL 90
Cdd:COG4123     4 DGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRNVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  91 ASPWASRIEVWQADIHQWQPS-QTRRYELIISNPPFFAE--GVPCATSQREQARYTTTLDHASLLTCAAEHITEEGFFCV 167
Cdd:COG4123    83 LNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFAL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484 168 VLPVDIGNAFIERARAMGWHLRLRTDVAETELRPPHRVLLAFSPTAGECFS--DRLAIRGPEQQYSEGFTALTEDF 241
Cdd:COG4123   163 IHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-124 9.06e-14

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 69.04  E-value: 9.06e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENALASpWASRIEVWQADIhqWQPSQTRRYELIISNPP 124
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKER-PDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDW--FEPLPGGRFDLIVSNPP 184
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-125 5.24e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 64.92  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTGdDVHVEAVELDEEAAAQARENALASPwASRIEVWQADIhqWQPSQTRRYELIISNPPF 125
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESP-DAELTMVDINARALESARENLAANG-LENGEVVASDV--YSGVEDGKFDLIISNPPF 108
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-127 1.59e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGDdvHVEAVELDEEAAAQARENALAsPWASRIEVWQADIHQWQPSQTRRYELIISNPPFFA 127
Cdd:cd02440     2 VLDLGCGTGALALALASGPGA--RVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 44-128 9.52e-09

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 54.67  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  44 GVKHVLDIGAGSGLLALMLAQrTGDDVHVEAVELDEEAAAQARENALASPWASRIEVWQADIhqWQPSQTRRYELIISNP 123
Cdd:TIGR00536 114 PILHILDLGTGSGCIALALAY-EFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNL--FEPLAGQKIDIIVSNP 190


                  ....*
gi 1459838484 124 PFFAE 128
Cdd:TIGR00536 191 PYIDE 195
rADc smart00650
Ribosomal RNA adenine dimethylases;
47-125 5.11e-06

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 45.19  E-value: 5.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484   47 HVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQAREnalASPWASRIEVWQADIHQWQPSQTRRYeLIISNPPF 125
Cdd:smart00650  16 TVLEIGPGKGALTEELLERAK---RVTAIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKLQPY-KVVGNLPY 87
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 11-241 1.15e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.15e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  11 NGFTFKRFFVAHDRCAMKVGTDGILLGAWAPIAGVKHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENAL 90
Cdd:COG4123     4 DGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRNVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  91 ASPWASRIEVWQADIHQWQPS-QTRRYELIISNPPFFAE--GVPCATSQREQARYTTTLDHASLLTCAAEHITEEGFFCV 167
Cdd:COG4123    83 LNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFAL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484 168 VLPVDIGNAFIERARAMGWHLRLRTDVAETELRPPHRVLLAFSPTAGECFS--DRLAIRGPEQQYSEGFTALTEDF 241
Cdd:COG4123   163 IHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 38-124 7.10e-15

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 72.10  E-value: 7.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  38 AWAPIAGVKHVLDIGAGSGLLALMLAQRTGdDVHVEAVELDEEAAAQARENALASPWASRIEVWQADIhqWQP-SQTRRY 116
Cdd:COG2890   106 ALLPAGAPPRVLDLGTGSGAIALALAKERP-DARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDL--FEPlPGDGRF 182


                  ....*...
gi 1459838484 117 ELIISNPP 124
Cdd:COG2890   183 DLIVSNPP 190
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-124 9.06e-14

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 69.04  E-value: 9.06e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENALASpWASRIEVWQADIhqWQPSQTRRYELIISNPP 124
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKER-PDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDW--FEPLPGGRFDLIVSNPP 184
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 41-168 3.36e-13

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 65.98  E-value: 3.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  41 PIAGVKHVLDIGAGSGLLALMLAQRTGdDVHVEAVELDEEAAAQARENAlASPWASRIEVWQADIHQWQPSQtrRYELII 120
Cdd:COG2813    46 PEPLGGRVLDLGCGYGVIGLALAKRNP-EARVTLVDVNARAVELARANA-AANGLENVEVLWSDGLSGVPDG--SFDLIL 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1459838484 121 SNPPFfaegvpcatsqREQARYTTTLDHAsLLTCAAEHITEEGFFCVV 168
Cdd:COG2813   122 SNPPF-----------HAGRAVDKEVAHA-LIADAARHLRPGGELWLV 157
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-125 5.24e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 64.92  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTGdDVHVEAVELDEEAAAQARENALASPwASRIEVWQADIhqWQPSQTRRYELIISNPPF 125
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESP-DAELTMVDINARALESARENLAANG-LENGEVVASDV--YSGVEDGKFDLIISNPPF 108
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-122 8.35e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 8.35e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484  47 HVLDIGAGSGLLALMLAQRtGDDVHVEAVELDEEAAAQARENalaspwASRIEVWQADIHQWQPsqTRRYELIISN 122
Cdd:COG4106     4 RVLDLGCGTGRLTALLAER-FPGARVTGVDLSPEMLARARAR------LPNVRFVVADLRDLDP--PEPFDLVVSN 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-127 1.59e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGDdvHVEAVELDEEAAAQARENALAsPWASRIEVWQADIHQWQPSQTRRYELIISNPPFFA 127
Cdd:cd02440     2 VLDLGCGTGALALALASGPGA--RVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-121 2.02e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 63.02  E-value: 2.02e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1459838484  47 HVLDIGAGSGLLALMLAQRTGddVHVEAVELDEEAAAQARENALASPWASRIEVWQADIHQWQPsqTRRYELIIS 121
Cdd:COG2230    54 RVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPA--DGQFDAIVS 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 1.18e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.50  E-value: 1.18e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGDDVHveAVELDEEAAAQARENALASPWasRIEVWQADIHQWqPSQTRRYELIISN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAGL--NVEFVQGDAEDL-PFPDGSFDLVVSS 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 46-122 6.45e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.11  E-value: 6.45e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRtGDDVHveAVELDEEAAAQARENALaspwASRIEVWQADIHQWqPSQTRRYELIISN 122
Cdd:COG2227    26 GRVLDVGCGTGRLALALARR-GADVT--GVDISPEALEIARERAA----ELNVDFVQGDLEDL-PLEDGSFDLVICS 94
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
46-121 1.85e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 58.89  E-value: 1.85e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTGDdvHVEAVELDEEAAAQARENALASPWASRIEVWQADIHQWQPSqtRRYELIIS 121
Cdd:COG4076    37 DVVLDIGTGSGLLSMLAARAGAK--KVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLP--EKADVIIS 108
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-208 2.46e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 57.70  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  38 AWAPIAGVKHVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALaspwasRIEVWQADIHQWqPSQTRRYE 117
Cdd:COG4976    40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGY---RLTGVDLSEEMLAKAREKGV------YDRLLVADLADL-AEPDGRFD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484 118 LIISNppffaeGVPCATSqreqarytttlDHASLLTCAAEHITEEGFFCVVLPVDIGNAFIERARAmgwhlRLRTDVAET 197
Cdd:COG4976   110 LIVAA------DVLTYLG-----------DLAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD-----YVRDLLAAA 167

                         170
                  ....*....|.
gi 1459838484 198 ELRPPHRVLLA 208
Cdd:COG4976   168 GFEVPGLLVVA 178
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
42-125 8.37e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 56.84  E-value: 8.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  42 IAGvKHVLDIGAGSGLLALMLAQRTGDDVHveAVELDEEAAAQARENalASPWASRIEVWQADIHqwQPSQTRRYELIIS 121
Cdd:COG2263    44 IEG-KTVLDLGCGTGMLAIGAALLGAKKVV--GVDIDPEALEIAREN--AERLGVRVDFIRADVT--RIPLGGSVDTVVM 116


                  ....
gi 1459838484 122 NPPF 125
Cdd:COG2263   117 NPPF 120
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
46-122 9.09e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 57.49  E-value: 9.09e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  46 KHVLDIGAGSGLLAlMLAQRTGDDvHVEAVELDEEAAAQARENALASPWASRIEVWQADIhqwqpSQTRRYELIISN 122
Cdd:COG2264   150 KTVLDVGCGSGILA-IAAAKLGAK-RVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDL-----LEDGPYDLVVAN 219
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 38-124 2.34e-09

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 56.72  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  38 AWAPIAGVKHVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALASPWaSRIEVWQADIHQWQPSQ--TRR 115
Cdd:COG2265   227 EWLDLTGGERVLDLYCGVGTFALPLARRAK---KVIGVEIVPEAVEDARENARLNGL-KNVEFVAGDLEEVLPELlwGGR 302


                  ....*....
gi 1459838484 116 YELIISNPP 124
Cdd:COG2265   303 PDVVVLDPP 311
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-122 2.90e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 55.31  E-value: 2.90e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484  47 HVLDIGAGSGLLALMLAQRTGDdvHVEAVELDEEAAAQARENAlASPWASRIEVWQADIHQWQPSQTRRYELIISN 122
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARFGG--RVIGIDLSPEAIALARARA-AKAGLGNVEFLVADLAELDPLPAESFDLVVAF 101
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 44-128 9.52e-09

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 54.67  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  44 GVKHVLDIGAGSGLLALMLAQrTGDDVHVEAVELDEEAAAQARENALASPWASRIEVWQADIhqWQPSQTRRYELIISNP 123
Cdd:TIGR00536 114 PILHILDLGTGSGCIALALAY-EFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNL--FEPLAGQKIDIIVSNP 190


                  ....*
gi 1459838484 124 PFFAE 128
Cdd:TIGR00536 191 PYIDE 195
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-125 1.09e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 53.36  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTGDdvhVEAVELDEEAAAQARENALASPWASR-IEVWQADIhqWQPSQTRRYELIISNPP 124
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNGKK---VVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDL--FEPFRGDKFDVILFNPP 99


                  .
gi 1459838484 125 F 125
Cdd:PRK14968  100 Y 100
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 42-120 1.96e-08

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 52.96  E-value: 1.96e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484  42 IAGvKHVLDIGAGSGLLALMLAQRTGDDvhVEAVELDEEAAAQARENALASpwASRIEVWQADIHQWQPSQtrRYELII 120
Cdd:COG3897    69 VAG-KRVLELGCGLGLVGIAAAKAGAAD--VTATDYDPEALAALRLNAALN--GVAITTRLGDWRDPPAAG--GFDLIL 140
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 42-108 2.34e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 52.11  E-value: 2.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  42 IAGVKHVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARENALASPWASRIEVWQADIHQW 108
Cdd:COG4122    14 LLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEV 80
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 38-122 2.96e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 51.15  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  38 AWAPIAGVKHVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALASPWasRIEVWQADIHQWqPSQTRRYE 117
Cdd:COG2226    16 AALGLRPGARVLDLGCGTGRLALALAERGA---RVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDL-PFPDGSFD 89


                  ....*
gi 1459838484 118 LIISN 122
Cdd:COG2226    90 LVISS 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-122 4.96e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 50.88  E-value: 4.96e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARENAlASPWASRIEVWQADIHQWQPSQTR-RYELIISN 122
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENA-QKLGFDNVEFEQGDIEELPELLEDdKFDVVISN 81
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
41-125 4.53e-07

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 49.94  E-value: 4.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  41 PIAGvkHVLDIGAGSGLLALMLAQR------TGDDVHVEAVEldeeaAAQA--RENAL-----ASPWASRIEvwqadihq 107
Cdd:PRK09489  195 HTKG--KVLDVGCGAGVLSAVLARHspkirlTLSDVSAAALE-----SSRAtlAANGLegevfASNVFSDIK-------- 259

                          90
                  ....*....|....*...
gi 1459838484 108 wqpsqtRRYELIISNPPF 125
Cdd:PRK09489  260 ------GRFDMIISNPPF 271
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 48-104 2.24e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 46.62  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENaLASPWASRIEVWQAD 104
Cdd:COG2518    70 VLEIGTGSGYQAAVLARLAG---RVYSVERDPELAERARER-LAALGYDNVTVRVGD 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 38-88 3.01e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 47.08  E-value: 3.01e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1459838484  38 AWAPIAGVKHVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQAREN 88
Cdd:COG2519    85 ARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKN 135
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 16-104 3.70e-06

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 46.34  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  16 KRFFVAHDRCAMKVGTD-GILLGAWAPIAGVKHVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARENALASPW 94
Cdd:pfam01596  14 REETAKLPLAPMQVSPDeGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPEAYEIAKKFIQKAGV 93

                          90
                  ....*....|
gi 1459838484  95 ASRIEVWQAD 104
Cdd:pfam01596  94 AHKISFILGP 103
PRK14967 PRK14967
putative methyltransferase; Provisional
 48-133 5.00e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 46.20  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  48 VLDIGAGSGLLALMlAQRTGDDvHVEAVELDEEAAAQARENALASpwASRIEVWQADIHQWQPsqTRRYELIISNPPFfa 127
Cdd:PRK14967   40 VLDLCTGSGALAVA-AAAAGAG-SVTAVDISRRAVRSARLNALLA--GVDVDVRRGDWARAVE--FRPFDVVVSNPPY-- 111


                  ....*.
gi 1459838484 128 egVPCA 133
Cdd:PRK14967  112 --VPAP 115
rADc smart00650
Ribosomal RNA adenine dimethylases;
47-125 5.11e-06

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 45.19  E-value: 5.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484   47 HVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQAREnalASPWASRIEVWQADIHQWQPSQTRRYeLIISNPPF 125
Cdd:smart00650  16 TVLEIGPGKGALTEELLERAK---RVTAIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKLQPY-KVVGNLPY 87
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 46-124 5.11e-05

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 43.70  E-value: 5.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAqRTGDDVHVEAVELDEEAAAQARE---------NALASPwasRIEVWQADIHQWQPSQTRRY 116
Cdd:COG4262   288 RRVLVLGGGDGLAAREVL-KYPDVESVTLVDLDPEVTDLAKTnpflrelngGALNDP---RVTVVNADAFQFLRETDEKY 363


                  ....*...
gi 1459838484 117 ELIISNPP 124
Cdd:COG4262   364 DVIIVDLP 371
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 40-105 1.01e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 42.42  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1459838484  40 APIAGVKHVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALASPwasRIEVWQADI 105
Cdd:COG0030    33 AGITPGDTVLEIGPGLGALTRALLERAA---RVTAVEIDRRLAAILRETFAAYP---NLTVIEGDA 92
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
46-122 1.65e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 41.68  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLL---ALML-AQrtgddvHVEAVELDEEAAAQARENALASPWASRIEVWQADihqwqpsqtRRYELIIS 121
Cdd:PRK00517  121 KTVLDVGCGSGILaiaAAKLgAK------KVLAVDIDPQAVEAARENAELNGVELNVYLPQGD---------LKADVIVA 185


                  .
gi 1459838484 122 N 122
Cdd:PRK00517  186 N 186
PRK06202 PRK06202
hypothetical protein; Provisional
 48-89 1.80e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 41.52  E-value: 1.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1459838484  48 VLDIGAGSGLLALML---AQRTGDDVHVEAVELDEEAAAQARENA 89
Cdd:PRK06202   64 LLDIGCGGGDLAIDLarwARRDGLRLEVTAIDPDPRAVAFARANP 108
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 46-122 3.89e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 40.73  E-value: 3.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRtGDDVHVEAVELDEEAAAQARENAlaspwASRIEVWQADIHQwQPSQTRRYELIISN 122
Cdd:TIGR02072  36 ASVLDIGCGTGYLTRALLKR-FPQAEFIALDISAGMLAQAKTKL-----SENVQFICGDAEK-LPLEDSSFDLIVSN 105
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 71-127 3.98e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 40.94  E-value: 3.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  71 HVEAVELDEEAAAQARENALASPWASRIEVWQADIHQW---QPSQTRRYELIISNPPFFA 127
Cdd:COG1092   241 SVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWlreLAREGERFDLIILDPPAFA 300
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 48-127 4.36e-04

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 41.00  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  48 VLDIGAGSGLLALML------AQRTGDDVHVEAVELdeeaaaqARENALASPWASRIEVwqadIH-QW-QPSQTRRYELI 119
Cdd:PRK01544  142 ILELGTGSGCIAISLlcelpnANVIATDISLDAIEV-------AKSNAIKYEVTDRIQI----IHsNWfENIEKQKFDFI 210


                  ....*...
gi 1459838484 120 ISNPPFFA 127
Cdd:PRK01544  211 VSNPPYIS 218
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
47-125 4.52e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 40.70  E-value: 4.52e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484  47 HVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARenALASPWASRIEVWQADIHQWQpsQTRRYELIISNPPF 125
Cdd:COG0827   118 RILDPAVGTGNLLTTVLNQLKKKVNAYGVEVDDLLIRLAA--VLANLQGHPVELFHQDALQPL--LIDPVDVVISDLPV 192
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
39-185 5.84e-04

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 39.53  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  39 WAPIAGVKHVLDIGAGSGLLALMLAQRTGDDVHveAVELDEEAAAQAREN--ALASPWASRIevwQADIHQW--QPSQTR 114
Cdd:pfam03602  36 LAPYIEGARVLDLFAGSGALGLEALSRGAKRVT--LVEKDKRAVQILKENlqLLGLPGAVLV---MDALLALlrLAGKGP 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1459838484 115 RYELIISNPPFFAEGVPCATSQREQARYtttLDHASLLTCaaEHITEEGffcvvLPVDIGNAFIERARAMG 185
Cdd:pfam03602 111 VFDIVFLDPPYAKGLIEEVLDLLAEKGW---LKPNALIYV--ETEKRGE-----LPEQPGNLELVREKKYG 171
arsM PRK11873
arsenite methyltransferase;
48-89 7.67e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.93  E-value: 7.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARENA 89
Cdd:PRK11873   81 VLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKARANA 122
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
46-138 8.70e-04

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 39.04  E-value: 8.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAqRTGDDVHVEAVELDEEAAAQARE------NALASPwasRIEVWQADIHQWQPSQTRRYELI 119
Cdd:COG0421    39 KRVLIIGGGDGGLARELL-KHPPVERVDVVEIDPEVVELAREyfpllaPAFDDP---RLRVVIGDGRAFLREAEESYDVI 114

                          90
                  ....*....|....*....
gi 1459838484 120 ISNpPFFAEGVPCATSQRE 138
Cdd:COG0421   115 IVD-LTDPVGPAEGLFTRE 132
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
48-125 9.36e-04

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 39.66  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALASPwasRIEVWQADIHQWQP-----SQTRRYeLIISN 122
Cdd:pfam00398  34 VLEIGPGKGALTVILAKRAK---QVVAIEIDPRLAKLLQKKLSLDE---NLTVIHQDFLKFEFpslvtHIHQEF-LVVGN 106


                  ...
gi 1459838484 123 PPF 125
Cdd:pfam00398 107 LPY 109
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
40-104 9.45e-04

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.50  E-value: 9.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1459838484  40 APIAGVKHVLDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENAlasPWASRIEVWQAD 104
Cdd:PRK14896   25 AEDTDGDPVLEIGPGKGALTDELAKRAK---KVYAIELDPRLAEFLRDDE---IAAGNVEIIEGD 83
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 47-89 9.67e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 39.76  E-value: 9.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1459838484  47 HVLDIGAGSGLLAL--MLAQRTGddvHVEAVELDEEAAAQARENA 89
Cdd:COG2242   250 VLWDIGAGSGSVSIeaARLAPGG---RVYAIERDPERAALIRANA 291
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 48-122 1.10e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.56  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1459838484  48 VLDIGAGSGLLALMlAQRTGDDvHVEAVELDEEAAAQARENALASPWASRIEVwqadiHQWQPSQTRRYELIISN 122
Cdd:pfam06325 165 VLDVGCGSGILAIA-ALKLGAK-KVVGVDIDPVAVRAAKENAELNGVEARLEV-----YLPGDLPKEKADVVVAN 232
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 46-125 1.36e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 38.52  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  46 KHVLDIGAGSGLLALMLAQRtGDDvHVEAVELDEEAAAQARENALASPWASRIEVWQADIHQWQPSQT-RRYELIISNPP 124
Cdd:COG0742    43 ARVLDLFAGSGALGLEALSR-GAA-SVVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFLKRLAgEPFDLVFLDPP 120


                  .
gi 1459838484 125 F 125
Cdd:COG0742   121 Y 121
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-107 2.05e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.49  E-value: 2.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1459838484  49 LDIGAGSGLLALMLAQRTGddvHVEAVELDEEAAAQARENALASPWASRievwQADIHQ 107
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA---RVTGVDISPEMLELAREKAPREGLTFV----VGDAED 52
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 47-89 2.28e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 36.92  E-value: 2.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1459838484  47 HVLDIGAGSGLLALMLAQRTGdDVHVEAVELDEEAAAQARENA 89
Cdd:TIGR02469  22 VLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNL 63
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
47-88 5.03e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 36.96  E-value: 5.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1459838484  47 HVLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQAREN 88
Cdd:pfam01135  76 RVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRN 117
PRK08317 PRK08317
hypothetical protein; Provisional
 48-104 7.14e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 36.84  E-value: 7.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1459838484  48 VLDIGAGSGLLALMLAQRTGDDVHVEAVELDEEAAAQARENALASpwASRIEVWQAD 104
Cdd:PRK08317   23 VLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGL--GPNVEFVRGD 77
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 13-129 8.79e-03

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 36.98  E-value: 8.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1459838484  13 FTFKRFFVAHDRCAMKVGTDGILLGAWAPIAGVKHVLDIGAGSGLLALMLAQRTgDDVHVEAVELDEEAAAQARENAlaS 92
Cdd:PRK14966  220 FYGRRFAVNPNVLIPRPETEHLVEAVLARLPENGRVWDLGTGSGAVAVTVALER-PDAFVRASDISPPALETARKNA--A 296

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1459838484  93 PWASRIEVWQADIHQWQPSQTRRYELIISNPPFFAEG 129
Cdd:PRK14966  297 DLGARVEFAHGSWFDTDMPSEGKWDIIVSNPPYIENG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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