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Conserved domains on  [gi|1438685368|emb|SUF84247|]
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permease [Salmonella enterica]

Protein Classification

Bax inhibitor-1 family protein( domain architecture ID 10002096)

Bax inhibitor-1 family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded in an FtsH-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 14-232 2.57e-38

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


:

Pssm-ID: 440434  Cd Length: 231  Bit Score: 133.00  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  14 SRIDRTTFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAgTNQTQLI 93
Cdd:COG0670    15 SDAGLRKVLRNTYGLLALGLL----LTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRA-NSAAALA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  94 GLGIYVLAESLIFAPLLTVA-AYINPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICG- 171
Cdd:COG0670    90 LLFAYTALMGLTLSPILLVYtGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQs 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1438685368 172 FSLGVWFSALMVLLCAGFILYDTSNIIHHYPTDRPA-GAALHLFASIATMFWYILRIFMSRN 232
Cdd:COG0670   170 PALSLAISVAGVLLFSGLTLYDTQRIKHGYETNKQYiMAALSLYLDFINLFLSLLRLLGGRR 231
 
Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 14-232 2.57e-38

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 133.00  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  14 SRIDRTTFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAgTNQTQLI 93
Cdd:COG0670    15 SDAGLRKVLRNTYGLLALGLL----LTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRA-NSAAALA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  94 GLGIYVLAESLIFAPLLTVA-AYINPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICG- 171
Cdd:COG0670    90 LLFAYTALMGLTLSPILLVYtGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQs 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1438685368 172 FSLGVWFSALMVLLCAGFILYDTSNIIHHYPTDRPA-GAALHLFASIATMFWYILRIFMSRN 232
Cdd:COG0670   170 PALSLAISVAGVLLFSGLTLYDTQRIKHGYETNKQYiMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 20-228 9.13e-21

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 86.46  E-value: 9.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  20 TFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAGTNQTQLIGLGIYV 99
Cdd:pfam01027   2 QFLRKVYGLLALGLL----LTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368 100 LAESLIFAPLLTVAAyinPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFS-LGVWF 178
Cdd:pfam01027  78 LLMGLTLGPLLLVYT---GAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSaLSLAI 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1438685368 179 SALMVLLCAGFILYDTSNIIH---HYPTDRPAGAALHLFASIATMFWYILRIF 228
Cdd:pfam01027 155 SYLGVLLFSGFILYDTQRIIKrygEYGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 18-228 2.60e-13

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 66.43  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  18 RTTFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAGTNQtqlIGLGI 97
Cdd:cd10432     2 LRSFMKKVYGLMAAGLL----LTAVGAYVGASTPALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATAL---PLFFA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  98 YVLAESLIFAPLLTVAAyinPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFSLGVW 177
Cdd:cd10432    75 FAALTGLTLSPILLVYT---GASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQF 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1438685368 178 -FSALMVLLCAGFILYDTSNIIHHY-------PTDRPAGAALHLFASIATMFWYILRIF 228
Cdd:cd10432   152 aISAIGVLIFSGLIAYDTQRIKRMYeagggesGYKDAIMGALSLYLDFINLFLFLLRLF 210
 
Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 14-232 2.57e-38

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 133.00  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  14 SRIDRTTFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAgTNQTQLI 93
Cdd:COG0670    15 SDAGLRKVLRNTYGLLALGLL----LTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRA-NSAAALA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  94 GLGIYVLAESLIFAPLLTVA-AYINPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICG- 171
Cdd:COG0670    90 LLFAYTALMGLTLSPILLVYtGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQs 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1438685368 172 FSLGVWFSALMVLLCAGFILYDTSNIIHHYPTDRPA-GAALHLFASIATMFWYILRIFMSRN 232
Cdd:COG0670   170 PALSLAISVAGVLLFSGLTLYDTQRIKHGYETNKQYiMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 20-228 9.13e-21

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 86.46  E-value: 9.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  20 TFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAGTNQTQLIGLGIYV 99
Cdd:pfam01027   2 QFLRKVYGLLALGLL----LTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368 100 LAESLIFAPLLTVAAyinPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFS-LGVWF 178
Cdd:pfam01027  78 LLMGLTLGPLLLVYT---GAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSaLSLAI 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1438685368 179 SALMVLLCAGFILYDTSNIIH---HYPTDRPAGAALHLFASIATMFWYILRIF 228
Cdd:pfam01027 155 SYLGVLLFSGFILYDTQRIIKrygEYGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 18-228 2.60e-13

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 66.43  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  18 RTTFIRRAYLHLAVAIVgfivLSAAWSFIGVGEYALDVLLAGGRYSWLVVLGAFMLVGMLATRLADNAGTNQtqlIGLGI 97
Cdd:cd10432     2 LRSFMKKVYGLMAAGLL----LTAVGAYVGASTPALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATAL---PLFFA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  98 YVLAESLIFAPLLTVAAyinPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFSLGVW 177
Cdd:cd10432    75 FAALTGLTLSPILLVYT---GASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQF 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1438685368 178 -FSALMVLLCAGFILYDTSNIIHHY-------PTDRPAGAALHLFASIATMFWYILRIF 228
Cdd:cd10432   152 aISAIGVLIFSGLIAYDTQRIKRMYeagggesGYKDAIMGALSLYLDFINLFLFLLRLF 210
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 118-230 1.15e-10

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 59.14  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368 118 PSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFS-LGVWFSALMVLLCAGFILYDTSN 196
Cdd:cd10433    90 GQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPaLSLAISAAFVLFSSGFILYDTSR 169

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1438685368 197 IIHHYPTDRpAGAALHLFASIATMFWYILRIFMS 230
Cdd:cd10433   170 IIHGGETNY-IMATVSLYVSIYNLFVSLLNLLGA 202
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 90-232 8.62e-10

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 56.84  E-value: 8.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  90 TQLIGLGIYVLAESLIFAplLTVAAYiNPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMA--GFIAFGAIIAS 167
Cdd:cd10429    92 VNLILLSLFTLCEAYTVG--LVVSFY-DGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILlwALILLALIFQF 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438685368 168 VICGFSLGVWFSALMVLLCAGFILYDTSNIIHHYPTDRPAGAALHLFASIATMFWYILRIFMSRN 232
Cdd:cd10429   169 FPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 92-228 1.37e-07

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 50.23  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  92 LIGLGIYVLAESLIfapLLTVAAYINPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFgaiIASVICG 171
Cdd:cd10428    78 LILLGIFTLAMSYM---LGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLL---IFGIVAI 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1438685368 172 FSLGVWF----SALMVLLCAGFILYDTSNII--HHYPTDrPAG---AALHLFASIATMFWYILRIF 228
Cdd:cd10428   152 FFYVKWLhivyASLGALLFSLYLAVDTQLLMggRKYELS-PEEyifAALNIYVDIVNIFLYILQLI 216
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 18-228 2.00e-05

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 43.94  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  18 RTTFIRRAYLHLAVAIVGFIVLSAAWSFIGVGEYALDVLLaggryswlvvlGAFMLVGMLATRLADNAGTNQTQLIGLGI 97
Cdd:cd06181     2 TKDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPALM-----------GLLTSMLALMATAAMIRAKMPVNLILLFG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  98 YVLAESLIFAPLLTvaaYINPSSIGAAAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMA-GFIAFGAIIASVICGFSLGV 176
Cdd:cd06181    71 FTGLMGYVVGPLLF---FYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGlGFLLLSFLLNTFFYSPWLHL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1438685368 177 WFSALMVLLCAGFILYDTSNIIH---HYPTDrPAGAALHLFASIATMFWYILRIF 228
Cdd:cd06181   148 VAAAVGLVLFCGFLLYDTQLIIHkaeVGPED-YINACISLYLDIINIFIRLLTIL 201
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 22-200 1.24e-04

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 41.98  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  22 IRRAYLHLAVAIvGFIVLSAAWSFIgvgEYALDVLLAGGrySWLVVLGAFMLV---GMLATRLADNAGTNQTQLIGLGIY 98
Cdd:cd10431    44 IHSTYMYFGGSL-GLTALAAVALSR---SPALMRLMAAG--PWLAIGATLAAMigsGMLVRSYTYPENPGAKHLAWLGHS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  99 VLaESLIFAPLltvaAYINPSSIGAAAITTLLLVGGLTFTAFSIKKDfsflrSFLTMAG--FIAFGAIIASVICGF---- 172
Cdd:cd10431   118 GV-QGAVLAPL----CFLGGPLLIRAALYTAGIVGGLSTVAACAPSE-----KFLYMGGplAIGLGVVFASSLGSMflpp 187

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1438685368 173 --SLGVWFSALMV----LLCAGFILYDTSNIIHH 200
Cdd:cd10431   188 ttALGAGLYSVSLygglVLFGGFLLYDTQKIIKR 221
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 24-231 1.18e-03

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 38.74  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368  24 RAYLHLAVAIVgfivLSAawsfigVGEYALDVLLAGGRYSWLVVLGAFmlVGMLATrlADNAGTNQTQLIGLGIYVLAES 103
Cdd:cd10430    14 KVYLTLAVALL----AAA------VGAYVHMVINIGGLLTGLLSLGLS--LWLAFT--PSTGKNEPKRLGLLLGFAFLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438685368 104 LIFAPLLTVAAYINPSsigaaAITTLLLVGGLTFTAFSIKKDFSFLRSFLTMAGFIAFGAIIASVICGFSLgVWFSALM- 182
Cdd:cd10430    80 ASLGPLLDLVIAINPS-----IIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANI-FGGSKFLf 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1438685368 183 -------VLLCAGFILYDTSNIIHHyptdRPAG------AALHLFASIATMFWYILRIFMSR 231
Cdd:cd10430   154 qaelylgLLVFCGFVLFDTQMIIEK----AENGdrdyiwHALDLFVDFVALFRRLLIILAKK 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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