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Conserved domains on  [gi|1437767660|emb|STO79468|]
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Endo-type membrane-bound lytic murein transglycosylase A precursor [Grimontia hollisae]

Protein Classification

LT_MltC_MltE domain-containing protein( domain architecture ID 13013998)

LT_MltC_MltE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 32-194 3.30e-100

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


:

Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 286.76  E-value: 3.30e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  32 DIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKLVKQRPGEPSPEYLFDPARNIDAGTA 111
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 112 YFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFHrSDRKRAMNDLNRLNPSQVYWALTNKHPSSESRRYLQKVTK 191
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFS-SDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLK 159


                  ...
gi 1437767660 192 FQK 194
Cdd:cd16893   160 AKK 162
Mltc_N super family cl13335
Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found ...
 1-29 2.19e-04

Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found associated with pfam01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2.


The actual alignment was detected with superfamily member pfam11873:

Pssm-ID: 432150  Cd Length: 161  Bit Score: 39.93  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*....
gi 1437767660   1 MKTKSLTFQKVFYVEIPMVRDHSSKRRYQ 29
Cdd:pfam11873 133 LKTRKKNGKKVYYVSIPMVANHLDQRAYK 161
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 32-194 3.30e-100

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 286.76  E-value: 3.30e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  32 DIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKLVKQRPGEPSPEYLFDPARNIDAGTA 111
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 112 YFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFHrSDRKRAMNDLNRLNPSQVYWALTNKHPSSESRRYLQKVTK 191
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFS-SDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLK 159


                  ...
gi 1437767660 192 FQK 194
Cdd:cd16893   160 AKK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
1-197 7.27e-93

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 275.01  E-value: 7.27e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660   1 MKTKSLTFQKVFYVEIPMVRDHSSKRRYQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAG 80
Cdd:PRK11671  163 LQSRSNGLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAG 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  81 RDVFKLvKQRPGEPSPEYLFDPARNIDAGTAYFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFHrSDRKRAMND 160
Cdd:PRK11671  243 KDVFRM-KGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFS-NDKIQAANI 320

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1437767660 161 LNRLNPSQVYWALTNKHPSSESRRYLQKVTKFQKEFR 197
Cdd:PRK11671  321 INTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYR 357
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 20-198 2.35e-47

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 155.54  E-value: 2.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  20 RDHSSKRRYQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRdvfkLVKQRPGEPSPEYL 99
Cdd:COG0741    93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR----LGLKLGLGPSPDDL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 100 FDPARNIDAGTAYFYILKTRYLKDVrdplskhYSMISAYNGGTGNVLKTFHRSDrkramndlnrlnpsqvyWALTNKHPS 179
Cdd:COG0741   169 FDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNG-----------------DRDGEIIPY 224

                         170
                  ....*....|....*....
gi 1437767660 180 SESRRYLQKVTKFQKEFRT 198
Cdd:COG0741   225 AETRNYVKKVLANYAIYRA 243
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 34-157 3.26e-37

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 125.11  E-value: 3.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  34 IREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKlvkqrpGEPSPEYLFDPARNIDAGTAYF 113
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR------VNPGVDDLFDPEKNIKAGTKYL 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1437767660 114 YILKTRYLKDvrdplskHYSMISAYNGGTGNVLKTFhRSDRKRA 157
Cdd:pfam01464  75 KELYKQYGGD-------LWLALAAYNAGPGRVRKWI-KNAGAKD 110
Mltc_N pfam11873
Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found ...
 1-29 2.19e-04

Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found associated with pfam01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2.


Pssm-ID: 432150  Cd Length: 161  Bit Score: 39.93  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*....
gi 1437767660   1 MKTKSLTFQKVFYVEIPMVRDHSSKRRYQ 29
Cdd:pfam11873 133 LKTRKKNGKKVYYVSIPMVANHLDQRAYK 161
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 32-194 3.30e-100

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 286.76  E-value: 3.30e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  32 DIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKLVKQRPGEPSPEYLFDPARNIDAGTA 111
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 112 YFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFHrSDRKRAMNDLNRLNPSQVYWALTNKHPSSESRRYLQKVTK 191
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFS-SDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLK 159


                  ...
gi 1437767660 192 FQK 194
Cdd:cd16893   160 AKK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
1-197 7.27e-93

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 275.01  E-value: 7.27e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660   1 MKTKSLTFQKVFYVEIPMVRDHSSKRRYQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAG 80
Cdd:PRK11671  163 LQSRSNGLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAG 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  81 RDVFKLvKQRPGEPSPEYLFDPARNIDAGTAYFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFHrSDRKRAMND 160
Cdd:PRK11671  243 KDVFRM-KGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFS-NDKIQAANI 320

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1437767660 161 LNRLNPSQVYWALTNKHPSSESRRYLQKVTKFQKEFR 197
Cdd:PRK11671  321 INTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYR 357
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 20-198 2.35e-47

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 155.54  E-value: 2.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  20 RDHSSKRRYQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRdvfkLVKQRPGEPSPEYL 99
Cdd:COG0741    93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR----LGLKLGLGPSPDDL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 100 FDPARNIDAGTAYFYILKTRYLKDVrdplskhYSMISAYNGGTGNVLKTFHRSDrkramndlnrlnpsqvyWALTNKHPS 179
Cdd:COG0741   169 FDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNG-----------------DRDGEIIPY 224

                         170
                  ....*....|....*....
gi 1437767660 180 SESRRYLQKVTKFQKEFRT 198
Cdd:COG0741   225 AETRNYVKKVLANYAIYRA 243
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
15-191 1.61e-40

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 136.63  E-value: 1.61e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  15 EIPMvrdhssKRRYQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKLVKQRpGEP 94
Cdd:PRK15470   30 KVPV------QRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWS-GEP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  95 SPEYLFDPARNIDAGTAYFYILKTRYLKDVRDPLSKHYSMISAYNGGTGNVLKTFhRSDRKRAMNDLNRLNPSQVYWALT 174
Cdd:PRK15470  103 TTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTF-SSDRKKAISKINDLDADEFLEHVA 181

                         170
                  ....*....|....*..
gi 1437767660 175 NKHPSSESRRYLQKVTK 191
Cdd:PRK15470  182 RNHPAPQAPRYIYKLEQ 198
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 34-157 3.26e-37

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 125.11  E-value: 3.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  34 IREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDVFKlvkqrpGEPSPEYLFDPARNIDAGTAYF 113
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR------VNPGVDDLFDPEKNIKAGTKYL 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1437767660 114 YILKTRYLKDvrdplskHYSMISAYNGGTGNVLKTFhRSDRKRA 157
Cdd:pfam01464  75 KELYKQYGGD-------LWLALAAYNAGPGRVRKWI-KNAGAKD 110
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 28-194 2.03e-35

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 121.46  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  28 YQYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAgrdvfKLVKQRPGEP--SPEYLFDPARN 105
Cdd:cd16896     2 LKYREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-----EWIAEKLGLEdfSEDDLYDPETN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 106 IDAGTAYFYILKTRYLKDVRdplskhySMISAYNGGTGNV---LKTFHRSDRKRAMNDlnrlnpsqvywaltnkHPSSES 182
Cdd:cd16896    77 IRLGTWYLSYLLKEFDGNLV-------LALAAYNAGPGNVdkwLKDGGWSGDGKTLDQ----------------IPFPET 133

                         170
                  ....*....|..
gi 1437767660 183 RRYLQKVTKFQK 194
Cdd:cd16896   134 RHYVKKVLKNYK 145
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 30-189 7.58e-34

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 117.58  E-value: 7.58e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  30 YADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAgrdvfKLVKQRPGEP--SPEYLFDPARNID 107
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATA-----KDVAKKLGLPyySPRDLFDPEYNIR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 108 AGTAYFYILKTRYLKDVrdPLSkhysmISAYNGGTGNVlktfhrsdrKRAMNDLNRLNPsqVYWALTnkHPSSESRRYLQ 187
Cdd:cd13401    81 LGSAYLAELLDRFDGNP--VLA-----LAAYNAGPGRV---------RRWLKRRGDLDP--DLWIET--IPFSETRNYVK 140


                  ..
gi 1437767660 188 KV 189
Cdd:cd13401   141 RV 142
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 45-189 8.87e-29

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 103.45  E-value: 8.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  45 EDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAgrdvfklvkQRPGEPSPEYLFDPARNIDAGTAYFYILKTRYLKDV 124
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTA---------RDLGRRGVDDLFDPEENIRAGARYLRELLDRFGGDL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1437767660 125 RDplskhysMISAYNGGTGNVLKtfhrsdrkramndlnrlnpsqvyWALTNKHPSSESRRYLQKV 189
Cdd:cd00254    72 EL-------ALAAYNAGPGAVDR-----------------------WGGGEVPPYKETRNYVQRV 106
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 29-192 1.14e-22

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 93.97  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  29 QYADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRdvFKlVKQRpgepspeylFDPARNIDA 108
Cdd:COG4623   263 PYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKE--LG-VDDR---------LDPEQSIRA 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 109 GTAYFYILKTRYlKDVRDPLSKHYSMISAYNGGTGNVLKtfhrsDRKRAMNdlNRLNP--------SQVYWALTNKHPSS 180
Cdd:COG4623   331 GAKYLRWLYDRF-PEAIDEPDRWWFALAAYNAGPGHVQD-----ARRLAKK--QGLDPdrwfdvekSQPKYYDTGYARGR 402

                         170
                  ....*....|..
gi 1437767660 181 ESRRYLQKVTKF 192
Cdd:COG4623   403 ETVNYVPNIRAY 414
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 34-147 2.38e-20

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 83.35  E-value: 2.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  34 IREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAgrdvfklvkQRPGEPSpeyLFDPARNIDAGTAYF 113
Cdd:cd13403     1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA---------RELGVND---RLDPEQNIHAGAKYL 68

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1437767660 114 YILKTRYLKDVrDPLSKHYSMISAYNGGTGNVLK 147
Cdd:cd13403    69 RYLRDRFPPDI-DEPDRLKFALAAYNAGPGHVRD 101
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 39-188 2.90e-15

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 69.08  E-value: 2.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  39 KRYGIPEDLIY-AIIktESSFNPYAVSWANAYGLMQVVPRTA---GRDVFKLVKQRpgepspeylFDPARNIDAGtayfy 114
Cdd:cd16894     2 LKEGLPEELKYlALV--ESGFNPDAVSSAGAAGLWQFMPATAreyGLRVDSWVDER---------RDPEKSTRAA----- 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1437767660 115 ilkTRYLKDVRDPLSKHYSMISAYNGGTGNVlktfhrsdrKRAMndlNRLNPSQVYWALTNKHPsSESRRYLQK 188
Cdd:cd16894    66 ---ARYLKDLYKRFGDWLLALAAYNAGEGRV---------RRAI---KRAGTDKWEDYYRLYLP-AETRRYVPK 123
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 41-148 7.74e-13

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 61.94  E-value: 7.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  41 YGIPEDLIYAIIKTESSFNPYAV-SWANAYGLMQVVPRTAgrdvfKLVKQRPGEPSPEYLFDPARNIDAGTAYFYILKTR 119
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTW-----KAYGVDGNGDGKADPFNPEDAIASAANYLCRHGWD 75

                          90       100
                  ....*....|....*....|....*....
gi 1437767660 120 YLKDVRDPLSKhysMISAYNGGTGNVLKT 148
Cdd:cd13399    76 LNAFLGEDNFL---ALAAYNAGPGAYANA 101
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 30-189 1.31e-12

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 65.47  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  30 YADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPRTAGRDV--FKLvkqrPGEPSPEYLFDPARNID 107
Cdd:PRK11619  479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVkmFSI----PGYSSSSQLLDPETNIN 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660 108 AGTAyfyilktrYLKDVRDPLSKHYSMIS-AYNGGTGNVlktfhrsdRKRAMNDLNRLNPSqvywALTNKHPSSESRRYL 186
Cdd:PRK11619  555 IGTS--------YLEYVYQQFGNNRILASaAYNAGPGRV--------RTWLGNSAGRIDAV----AFVESIPFSETRGYV 614


                  ...
gi 1437767660 187 QKV 189
Cdd:PRK11619  615 KNV 617
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 41-142 8.30e-11

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 56.77  E-value: 8.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  41 YGIPEDLIYAIIKTESSFNPYAVSwANA-----YGLMQV----VPRTAgrdvfklvkqRPGEPSPEYLFDPARNIDAGTa 111
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAIN-RNKngsydIGLMQInsiwLPELA----------RYGITREELLNDPCTNIYVGA- 68

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1437767660 112 yfYILKTRylkdvrdpLSKH-YSM--ISAYNGGT 142
Cdd:cd13400    69 --WILARN--------IKRYgNTWkaVGAYNSGT 92
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 29-145 1.97e-09

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 54.53  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  29 QYADIIREASKRYGIPEDLIYAIIKTESSFNpyAVSW-------ANAYGLMQVVPRTagrdvfklvkqrpgePSPEYLFD 101
Cdd:cd01021    36 KYKDCIKQVGKKLCIDPALIAAIISRESRAG--AALDkngwgdhGNGFGLMQVDKRY---------------HPPKGAWD 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1437767660 102 PARNIDAGTAyfyILKTrYLKDVRD--P-LSKHYSM---ISAYNGGTGNV 145
Cdd:cd01021    99 SEEHIEQATG---ILID-FIKTVQRkhPsWSPEQQLkggIAAYNAGVGNV 144
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 42-152 2.03e-07

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 48.31  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  42 GIPEDLIYAIIKTESSFNPYAVSW------------------ANAY---------GLMQV----VPRtagrdvFKLvkqr 90
Cdd:cd16892     8 GVHPETLAAIVQVESGGNPYAIGVnggklsrqpktkaeaiatARQLiaaghnfdvGLGQInsrnLAR------LGL---- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1437767660  91 pgepSPEYLFDPARNIDAGTAyfyILK---TRYLKDVRDPLSKHYSMISAYNggTGNVLKTFHRS 152
Cdd:cd16892    78 ----TVEDVFDPCTNLKAGAT---ILTecyARAKKTGGDGQAALRAALSCYN--TGNFTRGFSNG 133
PHA00368 PHA00368
internal virion protein D
 30-123 1.17e-06

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 48.24  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660   30 YADIIREASKRYGIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVprTAGRDVFKLVKQRPGEpspeylFDPARNIDAG 109
Cdd:PHA00368    11 YDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQFT--KATAKALGLIVDDDDR------LDPELAIDAG 82

                           90
                   ....*....|....
gi 1437767660  110 TAYFYILKTRYLKD 123
Cdd:PHA00368    83 ARYLADLVGKYDGD 96
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 28-173 2.18e-06

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 47.04  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437767660  28 YQYAdIIREASKRyGIPEDLIYAIIkTESSFNPYAVSWANAYGLMQVVPRTaGRDvFKLVKQRpgepspeyLFDPARNID 107
Cdd:PRK10783  104 YMYW-IVGQIKKR-NMPMELVLLPI-VESAFDPHATSGANAAGIWQIIPST-GRN-YGLKQTR--------WYDARRDVV 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1437767660 108 AGTayfyilkTRYLkDVRDPLSKHYS-----MISAYNGGTGNVLKTFHRSDRKRAMNDlnrlnpsqvYWAL 173
Cdd:PRK10783  171 AST-------TAAL-DMMQRLNKMFDgdwllTVAAYNSGEGRVMKAIKANKAKGKPTD---------FWSL 224
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 48-112 3.46e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.78  E-value: 3.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1437767660  48 IYAIIKTESSFNP--YAVSWANAYGLMQVVPRTAGRDVFKLVKQRpgepspeylFDPARNIDAGTAY 112
Cdd:cd00442     2 LAAIIGQESGGNKpaNAGSGSGAAGLFQFMPGTWKAYGKNSSSDL---------NDPEASIEAAAKY 59
Mltc_N pfam11873
Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found ...
 1-29 2.19e-04

Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found associated with pfam01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2.


Pssm-ID: 432150  Cd Length: 161  Bit Score: 39.93  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*....
gi 1437767660   1 MKTKSLTFQKVFYVEIPMVRDHSSKRRYQ 29
Cdd:pfam11873 133 LKTRKKNGKKVYYVSIPMVANHLDQRAYK 161
PRK15328 PRK15328
type III secretion system invasion protein IagB;
30-74 6.86e-03

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 35.61  E-value: 6.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1437767660  30 YADIIREASKRYGIPEDLIYAIIKTESSFNPYAV----SWANAYGLMQV 74
Cdd:PRK15328   18 WADCWLQAEKMFNIESELLYAIAQQESAMKPGAIghnrDGSTDLGLMQI 66
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 46-78 7.92e-03

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 34.86  E-value: 7.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1437767660  46 DLIYAIIKTESSFNPYAVS-----WAN---AYGLMQVVPRT 78
Cdd:cd13402     2 NALLRQIQTESGGNPNAINnwdsnAKAghpSKGLMQVIPPT 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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