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Conserved domains on  [gi|1413331933|emb|SRM22656|]
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periplasmic negative regulator of sigmaE [Shigella flexneri]

Protein Classification

sigma-E factor regulatory protein RseB( domain architecture ID 10013242)

sigma-E factor regulatory protein RseB interacts with the RseA and stimulates RseA binding to sigmaE

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rseB PRK09455
anti-sigma E factor; Provisional
1-318 0e+00

anti-sigma E factor; Provisional


:

Pssm-ID: 236525 [Multi-domain]  Cd Length: 319  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933   1 MKQLWFAMSLVTGSLLFSANASATP-ASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGP 79
Cdd:PRK09455    1 MKQLWFAVSLLTGSLLFSANASAQPlSSGALLQQMNEASQSLNYELSFINITKQGIESLRYRHARLDNKPLAQLLQMDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  80 RREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVW 159
Cdd:PRK09455   81 RREIIQRGNEISYFEPGLEPFTLNGDHIVDSLPSLIYADFKRLSKYYDFISVGRTRIADRLCQVIRIVPKDGTRYSYIVW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 160 MDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTPTWLPQGFSEVSSSRR 239
Cdd:PRK09455  161 IDEESKLPLRVDLLDRDGETLEQFRVISFTVNDDISSLMQGLAKANLPPLLSLPAGEKAKFNWQPGWLPQGFKEVSRSRR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 240 PLPTMDNmPIESRLYSDGLFSFSVNVNRA-TPSSTDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAENIKFGAAQ 318
Cdd:PRK09455  241 TLPTMDN-PIESRLYSDGLFSFSVNVSNAdKDSSSEQLLRQGRRTVYSEVRGNKEITVVGELPPATAKRIAQSIKFGAAQ 319
 
Name Accession Description Interval E-value
rseB PRK09455
anti-sigma E factor; Provisional
1-318 0e+00

anti-sigma E factor; Provisional


Pssm-ID: 236525 [Multi-domain]  Cd Length: 319  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933   1 MKQLWFAMSLVTGSLLFSANASATP-ASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGP 79
Cdd:PRK09455    1 MKQLWFAVSLLTGSLLFSANASAQPlSSGALLQQMNEASQSLNYELSFINITKQGIESLRYRHARLDNKPLAQLLQMDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  80 RREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVW 159
Cdd:PRK09455   81 RREIIQRGNEISYFEPGLEPFTLNGDHIVDSLPSLIYADFKRLSKYYDFISVGRTRIADRLCQVIRIVPKDGTRYSYIVW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 160 MDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTPTWLPQGFSEVSSSRR 239
Cdd:PRK09455  161 IDEESKLPLRVDLLDRDGETLEQFRVISFTVNDDISSLMQGLAKANLPPLLSLPAGEKAKFNWQPGWLPQGFKEVSRSRR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 240 PLPTMDNmPIESRLYSDGLFSFSVNVNRA-TPSSTDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAENIKFGAAQ 318
Cdd:PRK09455  241 TLPTMDN-PIESRLYSDGLFSFSVNVSNAdKDSSSEQLLRQGRRTVYSEVRGNKEITVVGELPPATAKRIAQSIKFGAAQ 319
RseB COG3026
RseB, negative regulator of sigma E activity [Signal transduction mechanisms];
1-316 6.10e-146

RseB, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442262 [Multi-domain]  Cd Length: 322  Bit Score: 413.54  E-value: 6.10e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933   1 MKQLWFAMSLVtgSLLFSANASA---TPASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMD 77
Cdd:COG3026     1 MKRLLLALLLA--LLLASASAAAaaaAADAEALLQRMAQAARQLNYEGTFVYQRGGQIESLRIRHAVDDGGEYERLESLD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  78 GPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYI 157
Cdd:COG3026    79 GPPREVIRRGDEVSCFLPDLKPVSLESRHIVDSFPALLPADLERLSEYYDFRLGGRERVAGRDAQVVRLVPRDGLRYGYR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 158 VWMDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSM--QTLAKANL--PPLLSVPVGEKAKFSWTPTWLPQGFSE 233
Cdd:COG3026   159 LWIDEETGLLLKSDLLDRDGEVLEQFAFTSLELGDPIDDSAlkPSLAGAKLwrPPLLALPPADAAASGWQLGWLPPGFKL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 234 VSSSRRPLPtMDNMPIESRLYSDGLFSFSVNVNRATPSS--TDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAEN 311
Cdd:COG3026   239 VSQSRRPLP-GSGEPVEHLLYSDGLASVSVFIEPADEGSppLEGLSRQGATTAYSRRVGGYEVTVVGEVPAATAKRIADS 317

                  ....*
gi 1413331933 312 IKFGA 316
Cdd:COG3026   318 VRFKA 322
MucB_RseB pfam03888
MucB/RseB N-terminal domain; Members of this family are regulators of the anti-sigma E protein ...
29-210 2.57e-80

MucB/RseB N-terminal domain; Members of this family are regulators of the anti-sigma E protein RseD.


Pssm-ID: 427570  Cd Length: 178  Bit Score: 241.69  E-value: 2.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  29 ALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIV 108
Cdd:pfam03888   4 AWLQRMSQAARQLNYEGTFVYQRGGRIETLRIRHAVDDGGEYERLESLDGPPREVIRRNDEVSCFEPDSKPVTLESRHIV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 109 DSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAF 188
Cdd:pfam03888  84 GSFPALLPADFSRLLEYYDFVLLGRERVAGRPAQVIRILPKDDLRYGYRLWIDEETGLLLKSDLLDRDGEVLEQFAFTSL 163
                         170       180
                  ....*....|....*....|..
gi 1413331933 189 NVNQDISssmqtlaKANLPPLL 210
Cdd:pfam03888 164 EVGDPLD-------KQELPPVL 178
RseB cd16327
RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also ...
29-191 2.11e-67

RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also known as MucB or Mucb/RseB) which exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. The protein is composed of two domains, the larger N-terminal domain resembling an unclosed beta-barrel that is remarkably similar structurally to LolA and LolB, proteins capable of binding the lipid anchor of lipoproteins, suggesting that RseA acts as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319985  Cd Length: 166  Bit Score: 208.19  E-value: 2.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  29 ALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIV 108
Cdd:cd16327     4 QWLERMAQAARQLNYEGTFVYQRGGRLESLRIVHAVDDGGEYERLESLDGPPREVLRRGDEVSCFLPGDEPVSVESRRIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 109 DSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAF 188
Cdd:cd16327    84 GPFPALLPSDLERLADYYDFRLGGRERVAGRPAQVIRLVPKDDLRYGYRLWLDRETGLLLKSDLLDEDGEVLEQFQFTSL 163

                  ...
gi 1413331933 189 NVN 191
Cdd:cd16327   164 EIG 166
 
Name Accession Description Interval E-value
rseB PRK09455
anti-sigma E factor; Provisional
1-318 0e+00

anti-sigma E factor; Provisional


Pssm-ID: 236525 [Multi-domain]  Cd Length: 319  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933   1 MKQLWFAMSLVTGSLLFSANASATP-ASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGP 79
Cdd:PRK09455    1 MKQLWFAVSLLTGSLLFSANASAQPlSSGALLQQMNEASQSLNYELSFINITKQGIESLRYRHARLDNKPLAQLLQMDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  80 RREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVW 159
Cdd:PRK09455   81 RREIIQRGNEISYFEPGLEPFTLNGDHIVDSLPSLIYADFKRLSKYYDFISVGRTRIADRLCQVIRIVPKDGTRYSYIVW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 160 MDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTPTWLPQGFSEVSSSRR 239
Cdd:PRK09455  161 IDEESKLPLRVDLLDRDGETLEQFRVISFTVNDDISSLMQGLAKANLPPLLSLPAGEKAKFNWQPGWLPQGFKEVSRSRR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 240 PLPTMDNmPIESRLYSDGLFSFSVNVNRA-TPSSTDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAENIKFGAAQ 318
Cdd:PRK09455  241 TLPTMDN-PIESRLYSDGLFSFSVNVSNAdKDSSSEQLLRQGRRTVYSEVRGNKEITVVGELPPATAKRIAQSIKFGAAQ 319
RseB COG3026
RseB, negative regulator of sigma E activity [Signal transduction mechanisms];
1-316 6.10e-146

RseB, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442262 [Multi-domain]  Cd Length: 322  Bit Score: 413.54  E-value: 6.10e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933   1 MKQLWFAMSLVtgSLLFSANASA---TPASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMD 77
Cdd:COG3026     1 MKRLLLALLLA--LLLASASAAAaaaAADAEALLQRMAQAARQLNYEGTFVYQRGGQIESLRIRHAVDDGGEYERLESLD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  78 GPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYI 157
Cdd:COG3026    79 GPPREVIRRGDEVSCFLPDLKPVSLESRHIVDSFPALLPADLERLSEYYDFRLGGRERVAGRDAQVVRLVPRDGLRYGYR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 158 VWMDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSM--QTLAKANL--PPLLSVPVGEKAKFSWTPTWLPQGFSE 233
Cdd:COG3026   159 LWIDEETGLLLKSDLLDRDGEVLEQFAFTSLELGDPIDDSAlkPSLAGAKLwrPPLLALPPADAAASGWQLGWLPPGFKL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 234 VSSSRRPLPtMDNMPIESRLYSDGLFSFSVNVNRATPSS--TDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAEN 311
Cdd:COG3026   239 VSQSRRPLP-GSGEPVEHLLYSDGLASVSVFIEPADEGSppLEGLSRQGATTAYSRRVGGYEVTVVGEVPAATAKRIADS 317

                  ....*
gi 1413331933 312 IKFGA 316
Cdd:COG3026   318 VRFKA 322
MucB_RseB pfam03888
MucB/RseB N-terminal domain; Members of this family are regulators of the anti-sigma E protein ...
29-210 2.57e-80

MucB/RseB N-terminal domain; Members of this family are regulators of the anti-sigma E protein RseD.


Pssm-ID: 427570  Cd Length: 178  Bit Score: 241.69  E-value: 2.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  29 ALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIV 108
Cdd:pfam03888   4 AWLQRMSQAARQLNYEGTFVYQRGGRIETLRIRHAVDDGGEYERLESLDGPPREVIRRNDEVSCFEPDSKPVTLESRHIV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 109 DSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAF 188
Cdd:pfam03888  84 GSFPALLPADFSRLLEYYDFVLLGRERVAGRPAQVIRILPKDDLRYGYRLWIDEETGLLLKSDLLDRDGEVLEQFAFTSL 163
                         170       180
                  ....*....|....*....|..
gi 1413331933 189 NVNQDISssmqtlaKANLPPLL 210
Cdd:pfam03888 164 EVGDPLD-------KQELPPVL 178
RseB cd16327
RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also ...
29-191 2.11e-67

RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also known as MucB or Mucb/RseB) which exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. The protein is composed of two domains, the larger N-terminal domain resembling an unclosed beta-barrel that is remarkably similar structurally to LolA and LolB, proteins capable of binding the lipid anchor of lipoproteins, suggesting that RseA acts as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319985  Cd Length: 166  Bit Score: 208.19  E-value: 2.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  29 ALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIV 108
Cdd:cd16327     4 QWLERMAQAARQLNYEGTFVYQRGGRLESLRIVHAVDDGGEYERLESLDGPPREVLRRGDEVSCFLPGDEPVSVESRRIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 109 DSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAF 188
Cdd:cd16327    84 GPFPALLPSDLERLADYYDFRLGGRERVAGRPAQVIRLVPKDDLRYGYRLWLDRETGLLLKSDLLDEDGEVLEQFQFTSL 163

                  ...
gi 1413331933 189 NVN 191
Cdd:cd16327   164 EIG 166
MucB_RseB_C pfam17188
MucB/RseB C-terminal domain; Members of this family are regulators of the anti-sigma E protein ...
216-313 5.65e-39

MucB/RseB C-terminal domain; Members of this family are regulators of the anti-sigma E protein RseD.


Pssm-ID: 435775 [Multi-domain]  Cd Length: 98  Bit Score: 132.70  E-value: 5.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 216 EKAKFSWTPTWLPQGFSEVSSSRRPLPtMDNMPIESRLYSDGLFSFSVNVNRATPSS-TDQMLRTGRRTVSTSVRDNAEI 294
Cdd:pfam17188   1 TAAASGWQLGWLPAGFKLVSQDRRPLP-GSGEPVEHLLYSDGLASVSVFIEPADGASlPEGLLRQGATTAYSRRVGDYEV 79
                          90
                  ....*....|....*....
gi 1413331933 295 TIVGELPPQTAKRIAENIK 313
Cdd:pfam17188  80 TVVGEVPLATAKRIAESIE 98
LolA_fold-like cd16324
family containing periplasmic molecular chaperone LolA, the outer membrane lipoprotein ...
42-190 3.15e-26

family containing periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB; This family contains the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the N-terminal domain of periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319982  Cd Length: 162  Bit Score: 101.78  E-value: 3.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933  42 NYELSFISINK-----QGVESLRYRHARLDNRPLAQLLQMDGP-RREVVQRGNEISYFEPGLE-PFTLNGDYIV----DS 110
Cdd:cd16324     1 QWSARFSFRVTgpsggAQEADGRLKAIPPRDLARILFTQPDALaDNEVVSDGKEVWNYLPLTNqVTTQPLAKATipglGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 111 LPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDG--TRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAF 188
Cdd:cd16324    81 LFSTIAGDTSLLSDQYDVKLDGTEVIPGGEARKLVGTPKDNdaGFATVTVWIDKASWRPLRMQLLDGDGGQLADLNFSNF 160

                  ..
gi 1413331933 189 NV 190
Cdd:cd16324   161 KT 162
LolA_like cd16329
proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein ...
113-194 4.80e-06

proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB; This family contains uncharacterized proteins similar to the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319986  Cd Length: 225  Bit Score: 46.92  E-value: 4.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1413331933 113 SLIYTDF-------KRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSY---IVWMDTESKLPMRVDLLDRDGETLEQ 182
Cdd:cd16329    98 SFMGSDFsyedlsrSRLLEDYTYKLLGEEEVDGRDCYVLELTPKDGADSGYskrVLWVDKDTFLPLKAEYYDRSGKLLKT 177
                          90
                  ....*....|..
gi 1413331933 183 FRVIAFNVNQDI 194
Cdd:cd16329   178 LTFSDIKKIGGY 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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