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Conserved domains on  [gi|1412673743|emb|SPZ64159|]
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cytidylate kinase [Shigella boydii]

Protein Classification

(d)CMP kinase( domain architecture ID 10785233)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 3.57e-130

Cytidylate kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 3.57e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGE 85
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  86 DVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEK 165
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLA 225
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 3.57e-130

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 3.57e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGE 85
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  86 DVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEK 165
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLA 225
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 4-220 4.28e-123

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 347.88  E-value: 4.28e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   4 IAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILE 83
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  84 GEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQ 163
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1412673743 164 EKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYA 220
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 8-222 8.67e-115

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 326.57  E-value: 8.67e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   8 ITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTngnlEVILEGEDV 87
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHT----EVFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  88 SGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGF 167
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1412673743 168 SVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQ 222
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
2-223 2.68e-90

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 278.85  E-value: 2.68e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   2 TAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNgnleVI 81
Cdd:PRK11860  439 ADRVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IW 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  82 LEGEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQ 161
Cdd:PRK11860  515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1412673743 162 LQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQK 223
Cdd:PRK11860  595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-205 2.52e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 211.58  E-value: 2.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGaiyrvlalaalhhhvdvasedalvplashldvrfvstngnlevileged 86
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  87 vsgEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKG 166
Cdd:cd02020    32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1412673743 167 FSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDST 205
Cdd:cd02020   109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 3.57e-130

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 3.57e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGE 85
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  86 DVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEK 165
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLA 225
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 4-220 4.28e-123

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 347.88  E-value: 4.28e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   4 IAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILE 83
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  84 GEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQ 163
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1412673743 164 EKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYA 220
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 8-222 8.67e-115

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 326.57  E-value: 8.67e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   8 ITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTngnlEVILEGEDV 87
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHT----EVFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  88 SGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGF 167
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1412673743 168 SVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQ 222
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
2-223 2.68e-90

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 278.85  E-value: 2.68e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   2 TAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNgnleVI 81
Cdd:PRK11860  439 ADRVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IW 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  82 LEGEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQ 161
Cdd:PRK11860  515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1412673743 162 LQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQK 223
Cdd:PRK11860  595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
6-224 2.87e-71

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 225.53  E-value: 2.87e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRF-VSTNGNLEVILEG 84
Cdd:PRK13477  285 PIIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELkPSSGSPQRVWING 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  85 EDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQE 164
Cdd:PRK13477  365 EDVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQRIGEKGGLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQA 444

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1412673743 165 KGFSV-NFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKL 224
Cdd:PRK13477  445 QGFPViDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIIDLYRDRI 505
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-205 2.52e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 211.58  E-value: 2.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGaiyrvlalaalhhhvdvasedalvplashldvrfvstngnlevileged 86
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  87 vsgEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKG 166
Cdd:cd02020    32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1412673743 167 FSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDST 205
Cdd:cd02020   109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 7-218 9.20e-47

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 164.20  E-value: 9.20e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASE--------DALVPLASHLDVRFVSTNGNL 78
Cdd:PRK09518    3 IVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDAElvdeqvvtEAVGEFFTGLHFDISVDPDSP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  79 EVILEGEDVSGEIRTQEVANAASQVATFPRVREALLRRQRA----------FRELPGLIADGRDMGTVVFPDAPVKIFLD 148
Cdd:PRK09518   83 GVFADGEDISEEIRSPEVSSHVSAVAAIPPVRNVLIAAQRAyiareasadsFSGGLGIVAEGRDITTVVAPDAEVRILLT 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 149 ASSEERAHRRMLQLQEKgfsvNFERLLAEIKERDDRDrNRAVAPLVPAADALVLDSTTLSIEQVIEKALQ 218
Cdd:PRK09518  163 AREEVRQARRSGQDRSE----TPGVVLEDVAARDEAD-SKVTSFLSAADGVTTLDNSDLDFDETLDLLIG 227
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 7-223 2.83e-28

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 112.11  E-value: 2.83e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASED-------------ALVPLASHLDVRFVS 73
Cdd:PRK12269   36 IIALDGPAGSGKSSVCRLLASRLGAQCLNTGSFYRAFTLAALRRVSELAVQAcspspdpdaavgcAAVPHATNLDTSYAP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  74 TNGNLEVIL------------------------EGEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIAD 129
Cdd:PRK12269  116 LTAQKKVALfdeaywvsfartvalsyragvmyvGEENVESLLRSDEVESAVSYFAAMPAIRAIMTGKIRSAVCGARVVCE 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 130 GRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKgfsVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSI 209
Cdd:PRK12269  196 GRDLTTVVFVDADLKCYLDASIEARVARRWAQGTSR---LSKQELEQRMRARDAHDRARTVGGLRCAPDALYVDTSCLTI 272

                         250
                  ....*....|....
gi 1412673743 210 EQVIEKALQYARQK 223
Cdd:PRK12269  273 EEVCERIAREAHRR 286
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
7-225 1.97e-11

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 60.61  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDsGAIyrvLALAALHHHVDVAsedalvpLASHLDVRFVStngnlevILEGED 86
Cdd:COG1102     2 VITISREPGSGGTTIAKRLAEKLGLPLYD-GEI---LREAAKERGLSEE-------EFEKLDEKAPS-------LLYRDT 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  87 VSGEirtqevanaasqvatfpRVREALLRRQRAFRELPGLIADGRdMGTVVFPDAP--VKIFLDASSEERAHRRMlqlqe 164
Cdd:COG1102    64 AEED-----------------EIDRALDKVIRELARKGNCVIVGR-LADWILRDRPnvLKVFLTAPLEVRVKRIA----- 120

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743 165 KGFSVNFERLLAEIKERDDRDRNR-----AVAPlvpaADA----LVLDSTTLSIEQVIEKALQYARQKLA 225
Cdd:COG1102   121 EREGISEEEAEKEIKKRDKSRAKYykyyyGIDW----GDPsnydLVINTSRLGIEEAVDLILAAIEAREK 186
PRK04182 PRK04182
cytidylate kinase; Provisional
 7-188 1.47e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 46.72  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLA------LAALHhhvDVASEDalvplashldvrfvstngnlev 80
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAkergmsLEEFN---KYAEED---------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  81 ilegedvsgeirtqevanaasqvatfPRVREALLRRQRAF-RELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRrm 159
Cdd:PRK04182   57 --------------------------PEIDKEIDRRQLEIaEKEDNVVLEGRLAGWMAKDYADLKIWLKAPLEVRAER-- 108

                         170       180
                  ....*....|....*....|....*....
gi 1412673743 160 LQLQEKGfsvNFERLLAEIKERDDRDRNR 188
Cdd:PRK04182  109 IAEREGI---SVEEALEETIEREESEAKR 134
PRK06547 PRK06547
hypothetical protein; Provisional
 5-119 1.56e-04

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 40.88  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   5 APVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVL-ALAALHHHVdvaSEDALVPLAS-------HLDVR--FVST 74
Cdd:PRK06547   15 MITVLIDGRSGSGKTTLAGALAARTGFQLVHLDDLYPGWhGLAAASEHV---AEAVLDEGRPgrwrwdwANNRPgdWVSV 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1412673743  75 NGNLEVILEGedvSGEIrTQEVANAASQVATFPRVR----EAlLRRQRA 119
Cdd:PRK06547   92 EPGRRLIIEG---VGSL-TAANVALASLLGEVLTVWldgpEA-LRKERA 135
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 7-40 7.25e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 36.93  E-value: 7.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEAL---QWHLLDSGAIY 40
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLggrSVVVLDEIVIL 37
AAA_17 pfam13207
AAA domain;
12-160 1.52e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 37.60  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  12 GPSGAGKGTLCKAMAEALQWHLLDSGAIYRvlalaalhhhvDVASEDALVPLASHLDvrfvstngnlEVILEGEDVSGEI 91
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLR-----------EEAKERGLVEDRDEMR----------KLPLEPQKELQKL 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1412673743  92 RTQEVANAASQ----VATFPRVREallrRQRAFRELPgliadgRDMGTVVFPDApvKIFLDASSEERAHRRML 160
Cdd:pfam13207  61 AAERIAEEAGEggviVDGHPRIKT----PAGYLPGLP------VEVLRELKPDA--IILLEADPEEILERRLK 121
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 7-34 2.96e-03

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 37.59  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*...
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLL 34
Cdd:cd01673     1 VIVVEGNIGAGKSTLAKELAEHLGYEVV 28
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 7-186 3.50e-03

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 37.22  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLashldvRFVSTngnleviLEGED 86
Cdd:pfam13189   1 VITISRQYGSGGTTIAKKLAEKLGYPFYDREILDEIAKELGISEEEFELFDEKSRLS------SFLYS-------LAGGR 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743  87 VSGEIRTQEvanaasqvatfpRVREALLRRQRAFRELPGLIADGRDmGTVVFPDAP--VKIFLDASSEERAhRRMLQLQE 164
Cdd:pfam13189  68 VRGDALSDD------------RLFDAQSKVIRELAAEDNCVIVGRG-ADYILKDIPnvLRVFLTAPLEDRV-KRVMEREG 133

                         170       180
                  ....*....|....*....|..
gi 1412673743 165 KGfsvnfERLLAEIKERDDRDR 186
Cdd:pfam13189 134 LS-----EEEARELIKETDKRR 150
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 7-29 5.97e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 36.74  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|...
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEAL 29
Cdd:COG0572     9 IIGIAGPSGSGKTTFARRLAEQL 31
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 7-87 8.45e-03

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 36.13  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1412673743   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAI----YRVLALAAlhhHVDVASEDAlvplASHLDVRFVstNGNLEVIL 82
Cdd:cd02028     1 VVGIAGPSGSGKTTFAKKLSNQLRVNGIGPVVIslddYYVPRKTP---RDEDGNYDF----ESILDLDLL--NKNLHDLL 71


                  ....*
gi 1412673743  83 EGEDV 87
Cdd:cd02028    72 NGKEV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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