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Conserved domains on  [gi|1679579521|emb|SNQ41560|]
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IS2 repressor TnpA [Klebsiella quasipneumoniae]

Protein Classification

MarR family transcriptional regulator; ArsR family transcriptional regulator( domain architecture ID 10013221)

MarR family transcriptional regulator such as the multiple antibiotic resistance transcriptional regulator MarR, the repressor of the marRAB operon involved in the activation of both antibiotic resistance and oxidative stress genes| ArsR family transcriptional regulator containing an N-terminal ArsR family helix-turn-helix (HTH) DNA-binding domain and a C-terminal SAM-dependent methyltransferase domain, may function as a metalloregulatory transcriptional repressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 588-708 2.46e-74

IS2 repressor TnpA; Reviewed


:

Pssm-ID: 181833  Cd Length: 121  Bit Score: 235.47  E-value: 2.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 588 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 667
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1679579521 668 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 708
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
 
Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 588-708 2.46e-74

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 235.47  E-value: 2.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 588 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 667
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1679579521 668 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 708
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
594-690 1.86e-22

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 91.91  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 594 PEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElaaamkQIKELQRL 673
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1679579521 674 LGKKTMENELLKEAVEY 690
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
transpos_IS3 NF033516
IS3 family transposase;
603-695 9.32e-21

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 94.55  E-value: 9.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 603 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVaAGEQVVPaseLAAAMKQIKELQRLLGKKTMENE 682
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD-AGRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90
                  ....*....|...
gi 1679579521 683 LLKEAVEYGRAKK 695
Cdd:NF033516   77 ILKKARKLLRPAV 89
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 595-674 1.90e-17

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 77.39  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 595 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELAAAMKQIKELQRLL 674
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
 
Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 588-708 2.46e-74

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 235.47  E-value: 2.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 588 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 667
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1679579521 668 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 708
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
594-690 1.86e-22

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 91.91  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 594 PEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElaaamkQIKELQRL 673
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1679579521 674 LGKKTMENELLKEAVEY 690
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
transpos_IS3 NF033516
IS3 family transposase;
603-695 9.32e-21

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 94.55  E-value: 9.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 603 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVaAGEQVVPaseLAAAMKQIKELQRLLGKKTMENE 682
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD-AGRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90
                  ....*....|...
gi 1679579521 683 LLKEAVEYGRAKK 695
Cdd:NF033516   77 ILKKARKLLRPAV 89
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 595-674 1.90e-17

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 77.39  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679579521 595 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELAAAMKQIKELQRLL 674
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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