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Conserved domains on  [gi|1106369930|emb|SGW52846|]
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Uncharacterised protein [Staphylococcus argenteus]

Protein Classification

alkaline shock response membrane anchor protein AmaP( domain architecture ID 14341279)

alkaline shock response membrane anchor protein AmaP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
anchor_AmaP NF033218
alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP ...
 1-167 3.15e-31

alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.


:

Pssm-ID: 468002  Cd Length: 166  Bit Score: 110.75  E-value: 3.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930   1 MKRLKNFILGLLIVVIVGFLLFMYI---QDGRITEYQDYFLQFEWFQPLLISLAALLILIGLILVF-SIFKPtHRKPGLY 76
Cdd:NF033218    1 MKKFKKFLLSLLGLLLLLLLGFVILlylPPWLLTFFQLYPLINPWLQPYLFWVAAVLLLLALILLLvALFYP-KTRKELV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930  77 KDFDDGHIYVSRKAVEKTAFDTVAKYDQVRQPNVVAKLynKKNKSYIDIKTDFFvpNNVQVQSLTEAIRADVKKNVEHFT 156
Cdd:NF033218   80 LKTDDGKLTISKSAIEGFVREALSKVDGVRNPKVKVKL--KKRKIKVDVKGDLD--PRSNLPELTEEIQEEIKEGLEELL 155

                         170
                  ....*....|.
gi 1106369930 157 EMPVRKLEVNV 167
Cdd:NF033218  156 GIPVKKVKVKV 166
 
Name Accession Description Interval E-value
anchor_AmaP NF033218
alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP ...
 1-167 3.15e-31

alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.


Pssm-ID: 468002  Cd Length: 166  Bit Score: 110.75  E-value: 3.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930   1 MKRLKNFILGLLIVVIVGFLLFMYI---QDGRITEYQDYFLQFEWFQPLLISLAALLILIGLILVF-SIFKPtHRKPGLY 76
Cdd:NF033218    1 MKKFKKFLLSLLGLLLLLLLGFVILlylPPWLLTFFQLYPLINPWLQPYLFWVAAVLLLLALILLLvALFYP-KTRKELV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930  77 KDFDDGHIYVSRKAVEKTAFDTVAKYDQVRQPNVVAKLynKKNKSYIDIKTDFFvpNNVQVQSLTEAIRADVKKNVEHFT 156
Cdd:NF033218   80 LKTDDGKLTISKSAIEGFVREALSKVDGVRNPKVKVKL--KKRKIKVDVKGDLD--PRSNLPELTEEIQEEIKEGLEELL 155

                         170
                  ....*....|.
gi 1106369930 157 EMPVRKLEVNV 167
Cdd:NF033218  156 GIPVKKVKVKV 166
 
Name Accession Description Interval E-value
anchor_AmaP NF033218
alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP ...
 1-167 3.15e-31

alkaline shock response membrane anchor protein AmaP; The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.


Pssm-ID: 468002  Cd Length: 166  Bit Score: 110.75  E-value: 3.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930   1 MKRLKNFILGLLIVVIVGFLLFMYI---QDGRITEYQDYFLQFEWFQPLLISLAALLILIGLILVF-SIFKPtHRKPGLY 76
Cdd:NF033218    1 MKKFKKFLLSLLGLLLLLLLGFVILlylPPWLLTFFQLYPLINPWLQPYLFWVAAVLLLLALILLLvALFYP-KTRKELV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106369930  77 KDFDDGHIYVSRKAVEKTAFDTVAKYDQVRQPNVVAKLynKKNKSYIDIKTDFFvpNNVQVQSLTEAIRADVKKNVEHFT 156
Cdd:NF033218   80 LKTDDGKLTISKSAIEGFVREALSKVDGVRNPKVKVKL--KKRKIKVDVKGDLD--PRSNLPELTEEIQEEIKEGLEELL 155

                         170
                  ....*....|.
gi 1106369930 157 EMPVRKLEVNV 167
Cdd:NF033218  156 GIPVKKVKVKV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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