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Conserved domains on  [gi|1106692678|emb|SGO80067|]
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phospholipid/glycerol acyltransferase [Mycobacterium tuberculosis]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168420)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006644|GO:0008654
PubMed:  18718904|18931347|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 124-343 4.90e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


:

Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 150.90  E-value: 4.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 124 FKSWFRV-EVSGVENIPRDGAALVVANHaGVLPFDGLMLSVAVHDEHPAhRDLRLLAADMVFDLPVIGEAARKAGHTMAC 202
Cdd:cd07987     1 HRKYFRVyEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 203 TTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTD-----VKLLA 277
Cdd:cd07987    79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106692678 278 RLFGLPYFpiTPLFPlagPVGLVPLPSKWRIAFGEPICTADYASTDAddpmvtfeltDQVRETIQQ 343
Cdd:cd07987   159 RLLPLPRR--LPLYP---VFGEPIVVPRPPIPDPPDEDVEELHQKYI----------AALRELIEK 209
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 124-343 4.90e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 150.90  E-value: 4.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 124 FKSWFRV-EVSGVENIPRDGAALVVANHaGVLPFDGLMLSVAVHDEHPAhRDLRLLAADMVFDLPVIGEAARKAGHTMAC 202
Cdd:cd07987     1 HRKYFRVyEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 203 TTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTD-----VKLLA 277
Cdd:cd07987    79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106692678 278 RLFGLPYFpiTPLFPlagPVGLVPLPSKWRIAFGEPICTADYASTDAddpmvtfeltDQVRETIQQ 343
Cdd:cd07987   159 RLLPLPRR--LPLYP---VFGEPIVVPRPPIPDPPDEDVEELHQKYI----------AALRELIEK 209
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 114-352 6.78e-30

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 113.95  E-value: 6.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 114 AIVRPLLRFFFkswFRVEVSGVENIPRDGAALVVANHAGVLpfDGLMLSVAVhdehpaHRDLRLLAADMVFDLPVIGEAA 193
Cdd:COG0204    18 LWARLLLRLLG---VRVRVEGLENLPADGPVLIVANHQSWL--DILLLLAAL------PRPVRFVAKKELFKIPLLGWLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 194 RKAGH----------TMACTTDAHRLLASGELTAVFPEgykglGKRFEDRyRLQRFGRGGFVsAALRTKAPIVPCSIIGS 263
Cdd:COG0204    87 RALGAipvdrskrraALRALRQAVEALKAGESLVIFPE-----GTRSPDG-RLLPFKTGAAR-LALEAGVPIVPVAIDGT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 264 EEIypmltdvkllarlfglpyfpitplfplaGPVGLVPLPSKWRIAFGEPICTADYASTDADdpmvtfELTDQVRETIQQ 343
Cdd:COG0204   160 ERA----------------------------LPKGFLPRPGKVTVRIGPPIDPSDLEGEDRR------ELAERLRAAIEA 205


                  ....*....
gi 1106692678 344 TLYRLLAGR 352
Cdd:COG0204   206 LLAELRAEA 214
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 129-260 1.95e-24

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 96.58  E-value: 1.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 129 RVEVSGVENIPRDGAALVVANHAGVLpfDGLMLSVAVHDEhpaHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTD--- 205
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYL--DVLLLSLALYKR---GRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNrkd 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1106692678 206 -------AHRLLASGELTAVFPEgykglGKRFEDRYRLQrfGRGGFVSAALRTKAPIVPCSI 260
Cdd:pfam01553  76 aagtleyLVELLREGKLVVIFPE-----GTRSREGELLP--FKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 144-263 5.24e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 5.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  144 ALVVANHAGvlPFDGLMLSVAVHDEHpahRDLRLLAADMVFDLPVIGEAARKAGH----------TMACTTDAHRLLASG 213
Cdd:smart00563   1 ALVVANHQS--FLDPLVLSALLPRKL---GRVRFVAKKELFYVPLLGWLLRLLGAifidrsngrkARAALREAVELLKEG 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1106692678  214 ELTAVFPEGykglgKRFEDRyRLQRFgRGGFVSAALRTKAPIVPCSIIGS 263
Cdd:smart00563  76 EWLLIFPEG-----TRSRPG-KLLPF-KKGAARLALEAGVPIVPVAIRGT 118
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 127-268 6.15e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 58.59  E-value: 6.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 127 WFRVEVSGVENIPR-DGAALVVANHAGVLPFDGLMlsvavhdehPAHRDLRLLAADMVFDLPVIGEAARKAGHT------ 199
Cdd:PLN02901   34 FYKIEVEGLENLPSpDEPAVYVSNHQSFLDIYTLF---------HLGRPFKFISKTSIFLIPIIGWAMYMTGHIplkrmd 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1106692678 200 ----MACTTDAHRLLASGELTAVFPEGykglgKRFEDRyRLQRFGRGGFvSAALRTKAPIVPCSIIGSEEIYP 268
Cdd:PLN02901  105 rrsqLECLKRCMELLKKGASVFFFPEG-----TRSKDG-KLAAFKKGAF-SVAAKTGVPVVPITLVGTGKIMP 170
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 124-343 4.90e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 150.90  E-value: 4.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 124 FKSWFRV-EVSGVENIPRDGAALVVANHaGVLPFDGLMLSVAVHDEHPAhRDLRLLAADMVFDLPVIGEAARKAGHTMAC 202
Cdd:cd07987     1 HRKYFRVyEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 203 TTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTD-----VKLLA 277
Cdd:cd07987    79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106692678 278 RLFGLPYFpiTPLFPlagPVGLVPLPSKWRIAFGEPICTADYASTDAddpmvtfeltDQVRETIQQ 343
Cdd:cd07987   159 RLLPLPRR--LPLYP---VFGEPIVVPRPPIPDPPDEDVEELHQKYI----------AALRELIEK 209
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 114-352 6.78e-30

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 113.95  E-value: 6.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 114 AIVRPLLRFFFkswFRVEVSGVENIPRDGAALVVANHAGVLpfDGLMLSVAVhdehpaHRDLRLLAADMVFDLPVIGEAA 193
Cdd:COG0204    18 LWARLLLRLLG---VRVRVEGLENLPADGPVLIVANHQSWL--DILLLLAAL------PRPVRFVAKKELFKIPLLGWLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 194 RKAGH----------TMACTTDAHRLLASGELTAVFPEgykglGKRFEDRyRLQRFGRGGFVsAALRTKAPIVPCSIIGS 263
Cdd:COG0204    87 RALGAipvdrskrraALRALRQAVEALKAGESLVIFPE-----GTRSPDG-RLLPFKTGAAR-LALEAGVPIVPVAIDGT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 264 EEIypmltdvkllarlfglpyfpitplfplaGPVGLVPLPSKWRIAFGEPICTADYASTDADdpmvtfELTDQVRETIQQ 343
Cdd:COG0204   160 ERA----------------------------LPKGFLPRPGKVTVRIGPPIDPSDLEGEDRR------ELAERLRAAIEA 205


                  ....*....
gi 1106692678 344 TLYRLLAGR 352
Cdd:COG0204   206 LLAELRAEA 214
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 121-338 8.70e-25

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 99.27  E-value: 8.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 121 RFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLpfDGLMLSVAVhdehpaHRDLRLLAADMVFDLPVIGEAARKAGH-- 198
Cdd:cd07989     3 LLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYL--DPLVLGAAL------PRPIRFVAKKELFKIPFLGWLLRLLGAip 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 199 --------TMACTTDAHRLLASGELTAVFPEgykglGKRFEDRyRLQRFgRGGFVSAALRTKAPIVPCSIIGSEEIYPml 270
Cdd:cd07989    75 idrgngrsAREALREAIEALKEGESVVIFPE-----GTRSRDG-ELLPF-KSGAFRLAKEAGVPIVPVAISGTWGSLP-- 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1106692678 271 tdvkllarlfglpyfpitplfplagPVGLVPLPSKWRIAFGEPICTADYASTDADDPmvtfELTDQVR 338
Cdd:cd07989   146 -------------------------KGKKLPRPGRVTVRIGEPIPPEGLELAEEDRK----ELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 129-260 1.95e-24

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 96.58  E-value: 1.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 129 RVEVSGVENIPRDGAALVVANHAGVLpfDGLMLSVAVHDEhpaHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTD--- 205
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYL--DVLLLSLALYKR---GRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNrkd 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1106692678 206 -------AHRLLASGELTAVFPEgykglGKRFEDRYRLQrfGRGGFVSAALRTKAPIVPCSI 260
Cdd:pfam01553  76 aagtleyLVELLREGKLVVIFPE-----GTRSREGELLP--FKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 144-263 5.24e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 5.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  144 ALVVANHAGvlPFDGLMLSVAVHDEHpahRDLRLLAADMVFDLPVIGEAARKAGH----------TMACTTDAHRLLASG 213
Cdd:smart00563   1 ALVVANHQS--FLDPLVLSALLPRKL---GRVRFVAKKELFYVPLLGWLLRLLGAifidrsngrkARAALREAVELLKEG 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1106692678  214 ELTAVFPEGykglgKRFEDRyRLQRFgRGGFVSAALRTKAPIVPCSIIGS 263
Cdd:smart00563  76 EWLLIFPEG-----TRSRPG-KLLPF-KKGAARLALEAGVPIVPVAIRGT 118
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 114-260 7.07e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 63.82  E-value: 7.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 114 AIVRPLLRFFFKswfRVEVSGVENIPRDGAALVVANHAGVLpFDGLMLSVAVhdehpaHRDLRLLAADMVFDLPVIGEAA 193
Cdd:cd07992     3 LLSRVILRIYFR---RITVVGRENVPKDGPVIFLGNHPNAL-IDPLLLAATL------RRPVRFLAKADLFKNPLIGWLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 194 RKAG---------------------HTMACTTDAhrlLASGELTAVFPEGYKGlgkrfeDRYRLQRFgRGGFVSAAL--- 249
Cdd:cd07992    73 ESFGaipvyrpkdlarggigkisnaAVFDAVGEA---LKAGGAIGIFPEGGSH------DRPRLLPL-KAGAARMALeal 142

                         170
                  ....*....|....
gi 1106692678 250 ---RTKAPIVPCSI 260
Cdd:cd07992   143 eagQKDVKIVPVGL 156
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 129-257 2.38e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 62.65  E-value: 2.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 129 RVEVSGVENIPRDGAALVVANHagvlPF---DGLMLSVAVHDEHP-----AHRDLRLLAADMVFDLPVIGEAARKAGHTM 200
Cdd:cd07986     9 EVDVSGLENIPKDGPVVIVANH----PFgilDGLILADLLGSVRPdvrilANQLLSKIPELRDLFIPVDPLEGRAALAKN 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1106692678 201 ACTTD-AHRLLASGELTAVFPEG----YKGLGKRFEDRyRLQRFgrggFVSAALRTKAPIVP 257
Cdd:cd07986    85 RESLReALRHLKNGGALIIFPAGrvstASPPFGRVSDR-PWNPF----VARLARKAKAPVVP 141
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 127-268 6.15e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 58.59  E-value: 6.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 127 WFRVEVSGVENIPR-DGAALVVANHAGVLPFDGLMlsvavhdehPAHRDLRLLAADMVFDLPVIGEAARKAGHT------ 199
Cdd:PLN02901   34 FYKIEVEGLENLPSpDEPAVYVSNHQSFLDIYTLF---------HLGRPFKFISKTSIFLIPIIGWAMYMTGHIplkrmd 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1106692678 200 ----MACTTDAHRLLASGELTAVFPEGykglgKRFEDRyRLQRFGRGGFvSAALRTKAPIVPCSIIGSEEIYP 268
Cdd:PLN02901  105 rrsqLECLKRCMELLKKGASVFFFPEG-----TRSKDG-KLAAFKKGAF-SVAAKTGVPVVPITLVGTGKIMP 170
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 109-257 8.42e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 57.24  E-value: 8.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  109 PHFnsaIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHagVLPFDGLMLSVAVHD-----------EHPAhrdLRL 177
Cdd:PRK08633   411 PDS---LLRFLLLLLMHTRYRLRVEGRENIPAKGGALLLGNH--VSWIDWALLQAASPRpirfvmersiyEKWY---LKW 482

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  178 LAaDMVFDLPVIGEAARKAGHTMActtdahRLLASGELTAVFPEG---YKGlgkrfedryRLQRFgRGGFVSAALRTKAP 254
Cdd:PRK08633   483 FF-KLFGVIPISSGGSKESLEFIR------KALDDGEVVCIFPEGaitRNG---------QLNEF-KRGFELIVKGTDVP 545


                   ...
gi 1106692678  255 IVP 257
Cdd:PRK08633   546 IIP 548
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 119-260 1.41e-07

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 50.88  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 119 LLRFFFKSWFRVEVSGVENIPRDGAALVVANHAgvLPFDGLMLSVAVHDEHPahRDLR-LLAADMVFDLPVIG------- 190
Cdd:cd06551     3 YLLLNFFGFVRLEVKGPPPPPGGGPVLFVSNHS--SWWDGLILFLLLERGLR--RDVYgLMDEELLERYPFFTrlgafsv 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106692678 191 -----EAARKAGHTMacttdAHRLLASGELTAVFPEGykglgkRFED-RYRLQRFgRGGFVSAALRTKAPIVPCSI 260
Cdd:cd06551    79 drdspRSAAKSLKYV-----ARLLSKPGSVVWIFPEG------TRTRrDKRPLQF-KPGVAHLAEKAGVPIVPVAL 142
COG3176 COG3176
Putative hemolysin [General function prediction only];
120-280 1.39e-05

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 46.19  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 120 LRFFFKSW-FRVEVS--GVENIPRDGAALVVANHA-GVLpfDGLMLSVAVHDEHP-----AHRDLR----LLAADMVFDL 186
Cdd:COG3176    46 LRYVFEELgARLEVPegDLDRIDADGHLLVVANHPlGIL--DGLALLKLVGTVRPdyrilANDLALripgGFYSELEFPV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678 187 PVIGEAARKAghtmacttdAHRLLASGELTAVFPEgykglgkrfedrYRLQRFGR-------GGFVSAALRTKAPIVPCS 259
Cdd:COG3176   124 DPFNLETLKA---------ARRHLLEGGRSCVFPA------------GRVSGARRvidllwsGLAAKLARKAGAPVVPVY 182

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1106692678 260 I----------IGSeeIYPMLTDVKLLARLF 280
Cdd:COG3176   183 FdgrnsglfylFGS--IHPTLRTAALPRELL 211
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
113-264 2.15e-05

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 46.50  E-value: 2.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  113 SAIVRPLLRFFFKSWFRVEVSGVENIPRDG-AALVVANHAGVLpfDGLMLSVavhdehpahrdlrLLAADMVFD------ 185
Cdd:PRK06814   424 TNLLRDIFSILFRAFYRVEVKGLENLQKAGkKAVIAANHVSFL--DGPLLAA-------------YLPEEPTFAidtdia 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106692678  186 --------LPVIGEAARKAGHTMAcTTDAHRLLASGELTAVFPEG----YKGLGKRFEdryrlqrfgrgGFVSAALRTKA 253
Cdd:PRK06814   489 kawwvkpfLKLAKALPVDPTNPMA-TRTLIKEVQKGEKLVIFPEGritvTGSLMKIYD-----------GPGMIADKAGA 556

                          170
                   ....*....|.
gi 1106692678  254 PIVPCSIIGSE 264
Cdd:PRK06814   557 MVVPVRIDGLQ 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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