|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
11-373 |
1.34e-81 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 254.94 E-value: 1.34e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILS 90
Cdd:TIGR00900 3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 91 IVGTVMStFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALI 170
Cdd:TIGR00900 83 FVALLGG-LNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 171 LLDVLGAILGVGLLILVVIPK---MDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAAS-LYPLMTMGY 246
Cdd:TIGR00900 162 WVDAVGFAISALLIVSVRIPElaaSEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAIVaLFPYVQSKY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 247 FNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATsqgFIYFVLLNAIAGLATPYY 326
Cdd:TIGR00900 242 LGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPN---FPLFLVLWFAIGVGYGPI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1097277236 327 NTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIG 373
Cdd:TIGR00900 319 NVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-394 |
3.39e-60 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 199.76 E-value: 3.39e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILS 90
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 91 IVgTVMSTFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALI 170
Cdd:cd06173 83 LL-ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 171 LLDVLGAILGVGLLILVVIPKMDIQGEAVHLL-ADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNG 249
Cdd:cd06173 162 AINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 250 TVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPAtsqgFIYFVLLNAIAGLATPYYNTL 329
Cdd:cd06173 242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS----LWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1097277236 330 VMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-356 |
3.92e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.36 E-value: 3.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 6 KKNINLFLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIF 85
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 86 ALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVP 165
Cdd:COG2814 89 SLLCALAPS------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 166 MNALILLDVLGAILGVGLLILVVipkmdiQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMG 245
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 246 YFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSItasgLLPATSQGFIYFVLLNAIAGLATPY 325
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL----LLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|.
gi 1097277236 326 YNTLVMAMIQQSFEPSILGRVLGVFNSLMSL 356
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-394 |
3.30e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.26 E-value: 3.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 17 FLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTVm 96
Cdd:cd17325 6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 97 stfplWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLG 176
Cdd:cd17325 85 -----WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 177 AILGVGLLILVVIPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGL 256
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 257 IEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSItasgLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQ 336
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL----LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1097277236 337 SFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-394 |
3.78e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.25 E-value: 3.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 12 FLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSI 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 92 VgtvmstFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMN--AL 169
Cdd:cd06174 81 A------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 170 ILLDVLGAILGVGLLILVV--IPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYF 247
Cdd:cd06174 155 FLIAAALALLAAILLLLVVpdPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 248 NGTVGQAGLIEVIYAVGMLVGGAIIGF-SGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAIAGLatpyY 326
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLlSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG----L 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1097277236 327 NTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-361 |
2.74e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.47 E-value: 2.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 12 FLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILS 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 91 IVGtvmstfPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALI 170
Cdd:pfam07690 81 FAS------SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 171 LLDVLGAILGVGLLILVVIPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGT 250
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 251 VGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLnaIAGLATPYYNTLV 330
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL--LLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|.
gi 1097277236 331 MAMIQQSFEPSILGRVLGVFNSLMSLPGPIG 361
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
52-395 |
1.54e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 74.53 E-value: 1.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 52 MLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGtvmstfPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVP 131
Cdd:cd17474 44 TLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD------SFALLLAGRALQGIGAAGLGPLALTLIGDLFE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 132 EEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIPKMDiqgeAVHLLADTKFGVKK 211
Cdd:cd17474 118 GGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK----AKSSSATKLRDLKK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 212 LYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIG-FSGHFKNRMQLVIISYI 290
Cdd:cd17474 194 ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 291 VLGVSITASGLLPatsqGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLAD 370
Cdd:cd17474 274 LYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
330 340
....*....|....*....|....*
gi 1097277236 371 AIGVEKLFVIAGVGTLLCAIALYLV 395
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-408 |
2.68e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.17 E-value: 2.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 1 MQKYWKKNINLFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKK-----L 74
Cdd:COG2211 4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 75 LIYTDIIVAIFALILSIVGTVMSTFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPE-EELTRINGRLGMVQSANYIVA 153
Cdd:COG2211 84 ILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 154 PGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIP------KMDIQGEAVHLLADtkfgVKKLYEKRGLWHIMLNGAV 227
Cdd:COG2211 164 SVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTffgtkeRPVPEEEKVSLKES----LKALLKNRPFLLLLLAYLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 228 FMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSq 307
Cdd:COG2211 240 FFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 308 gFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSIL-------GRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEK---- 376
Cdd:COG2211 319 -LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaq 397
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1097277236 377 -----------LFVIAGVGTLLCAIALYLVPSARNYDLELQSK 408
Cdd:COG2211 398 spsaltgirllFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
33-390 |
1.18e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.86 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 33 YLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTVmstfplWLVFVSLFIRS 112
Cdd:cd17489 22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV------ALLLVLRLIHG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 113 VAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIPKM 192
Cdd:cd17489 96 IGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 193 DIQGEAVHlladTKFGVKKLYEKRglwhIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAII 272
Cdd:cd17489 176 VAAEEAEA----GTRAFRRLVEKK----VLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 273 GFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAIAGLATPYYNtlvmAMIQQSFEPSILGRVLGVFNS 352
Cdd:cd17489 248 GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ----ALAVDLVPPHRRGAANGTFFI 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 1097277236 353 LMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAI 390
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-394 |
1.98e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 71.10 E-value: 1.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILS 90
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 91 IVGTVmstfplWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAvpmNALI 170
Cdd:cd17329 84 FAHSP------WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY---SFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 171 LLDVLGAILGVGLLILVVIPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGT 250
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 251 VGQAGLIEVIYAVGMLVG-GAIIGFSGHFKNRMQLVIisyivlGVSITASGLLPAT-SQGFIYFVLLNAIAGLATPYYNT 328
Cdd:cd17329 235 ESLLGLLLALNALLIVLLqFPVARLVERFRLRKILMI------GILLFAIGFAVLAfANTLAVLILAMIVLTLGEMLVFP 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1097277236 329 LVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
12-396 |
2.82e-13 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 71.88 E-value: 2.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 12 FLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLG---MLPMVLLSPFVGPLIDRWDKKKLLIYTDII-VAIFAL 87
Cdd:PRK08633 14 LLLTQFLNAFNDLGHKILIQNTLIKAYDGSEQVILTAIVNalfLLPFLLLSSPAGFLADKFSKNRVIRIVKLFeVGLTLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 88 IlsIVGTVMSTFplWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAvpMN 167
Cdd:PRK08633 94 I--VLAYYLGWF--WLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFES--VN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 168 ALILLDVLGAILGVGLLILVV----------IPK------MDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLL 231
Cdd:PRK08633 168 GNTPSEILGRIAPAGLVLLAVavlglifayrLPKvpaaapEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYFWFI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 232 --FMPAAsLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIG-FSGHfknrmqlviisYIVLG------VSITASGLL 302
Cdd:PRK08633 248 sqLAQAN-FPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLAGrLSGR-----------HIELGlvplgaLGLALSLFL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 303 PATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLG----VFNSLMSLPGPIGLIFAGPLADAIGVekLF 378
Cdd:PRK08633 316 LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAannfLQNVGMLLFLALTTLFSGLGLSPAGL--FY 393
|
410
....*....|....*...
gi 1097277236 379 VIAGVGTLLCAIALYLVP 396
Cdd:PRK08633 394 LIALVTLIGTLYTLLLLP 411
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
35-395 |
3.18e-13 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 71.54 E-value: 3.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 35 TQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKL---LIYTDIIVAIFAlilsIVGTVMSTFPlwLVFVSLFIR 111
Cdd:PRK06814 45 ALGAYNNALVTLAGAVFILPFFIFSALAGQLADKYDKAKLakiLKFAEIGIAALA----IYGFHLNSVP--LLFAALFLM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 112 SVAQTFQMPTIQSILPTMVPEEELTRINgrlGMVQSANYI------VAPGLgaflfaAVPMNALILLDVLGAILGV-GLL 184
Cdd:PRK06814 119 GIHSALFGPIKYSILPDHLNKDELLGAN---ALVEAGTFIaillgtIIGGL------ATISGNFVILVALLMGIAVlGWL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 185 ILVVIPKMDIQGEAV----HLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVI 260
Cdd:PRK06814 190 ASLFIPKTGNAAPDLkidrNIIRSTITLLKYAKADKRIWLAILGISWFWLVGAVVLSQLPLLAKETLGGDENVATLFLAV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 261 YAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGV----------SITASGLLPATSQGF----------IYFVLLNAIAG 320
Cdd:PRK06814 270 FSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLfgldlafassSVPAEPAQLKSILVFlskrhgwrilIDLFGLAAAGG 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1097277236 321 L-ATPYYntlvmAMIQQSFEPSILGRVLGVFNSLMSLPGPIG-LIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLV 395
Cdd:PRK06814 350 LyIVPLF-----AALQAWANPAHRARVIAANNVLNAAFMVAGtIILALLQALGFSIPWIILFIALANLIVAILILRL 421
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-396 |
1.35e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.36 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQM 119
Cdd:COG2271 43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS------FWQLLLLRFLLGLGEAGFF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 120 PTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLdvlGAILGVGLLILVVipkmdiqgeav 199
Cdd:COG2271 117 PAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI---LGLPGLLLALLRF----------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 200 hlladtkfgvkklyekrglWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSG--H 277
Cdd:COG2271 183 -------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 278 FKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAIAGLATPyyntLVMAMIQQSFEPSILGRVLGVFNSLMSLP 357
Cdd:COG2271 244 GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG----LLWALAAELFPKKARGTASGLVNTFGFLG 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 1097277236 358 GPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVP 396
Cdd:COG2271 320 GALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-397 |
1.01e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.98 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKlliytdiiVAIFALILSIVGTVMSTF--PLWLVFVSLFIRSVAQTF 117
Cdd:COG2223 38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR--------VLLIGLLLLGIGLLLLALavSYWLLLLLGLLLGIGGGG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 118 QMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAV-PMNALILLDVLGAILGVGLLILVVIPKMDIQG 196
Cdd:COG2223 110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 197 EAVHLLADTKFGVKKlyekRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFsg 276
Cdd:COG2223 190 AAKASLRDQLEALRD----PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGW-- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 277 hFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSL 356
Cdd:COG2223 264 -LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1097277236 357 PGPIGLIFAGPLADAIGVEKL-FVIAGVGTLLCAIALYLVPS 397
Cdd:COG2223 343 GGFLGPLLFGALLDATGSYTAaFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
18-396 |
2.17e-10 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 62.46 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 18 LSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDII---VAIFALILSIVGT 94
Cdd:pfam05977 21 ASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLlalVSTLLTLLAGLGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 95 VmstfPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINgrlgMVQSANYIVA----PGLGAFLFAAVPMNALI 170
Cdd:pfam05977 101 L----SPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAV----ALNSVGYNIArsvgPALGGVLLAAFGPAFTF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 171 LLDVLG--AILGVGLLILVVIPKMDIQGEavHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFN 248
Cdd:pfam05977 173 ALNALSyfAVIAALWRWKRAAPASPLPRE--RIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLD 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 249 GTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNA--IAGLATpyY 326
Cdd:pfam05977 251 GDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAawITALTT--L 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 327 NTLVmamiQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVP 396
Cdd:pfam05977 329 NVAV----QLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFR 394
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-396 |
4.70e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 4.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 56 VLLSPFVGPLIDRWDKKKLLiytdiivaIFALILSIVGTVMSTF--PLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEE 133
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLL--------IAGLLLYGIGGVAGLFldSLYALLASRALLGIGVAGIMTLATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 134 ELTRINGRLGMVQSANYIVAPGLGAFLfAAVPMNALILLDVLGaiLGVGLLILVVIPKMDIQGEAVHLLADTKfgvKKLY 213
Cdd:cd17473 121 ERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLA--LPVLILVLLFLPEPARKSKSAASPGAAT---AAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 214 EKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLG 293
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 294 VSItasgLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAI- 372
Cdd:cd17473 275 LGF----LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTg 350
|
330 340
....*....|....*....|....
gi 1097277236 373 GVEKLFVIAGVGTLLCAIALYLVP 396
Cdd:cd17473 351 GLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-394 |
5.01e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.51 E-value: 5.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGtvmstfPLWLVFVSLFIRS-VAQTFq 118
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR------NLWLLFLARFLDGlTGGNV- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 119 mPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILldVLGAILGVGLLILVVIPKMdiqgea 198
Cdd:cd17330 105 -SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFL--VAAALALLNLVLVLFFLPP------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 199 vhlladtkfgvkklyekrgLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVggAIIGFSGHF 278
Cdd:cd17330 176 -------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGIL--AQLLLIPRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 279 KNRMQLVIISYIVLGVSITASGLLPATSQgFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPG 358
Cdd:cd17330 235 AKRLGERKLLRLGLLLAIIGLLLLPFASS-VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLAR 313
|
330 340 350
....*....|....*....|....*....|....*.
gi 1097277236 359 PIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17330 314 IIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-400 |
8.34e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.70 E-value: 8.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQM 119
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS------YPLLLLALFLLGLGLGLLD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 120 PTIQSILPTMVPEEELTRINgRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIPKMDIQGEAV 199
Cdd:COG0738 115 VAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 200 HLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFK 279
Cdd:COG0738 194 EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 280 NRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLnaiaGLAT-PYYNTLVMAMIQQSFEPSilGRVLGVFNSLMSLPG 358
Cdd:COG0738 274 GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV----GLGLsLMFPTIFSLALDGLGKRT--AAAVSAVLIMGIVGG 347
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1097277236 359 PIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVPSARN 400
Cdd:COG0738 348 AIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-400 |
8.47e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.58 E-value: 8.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 221 IMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSItasg 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 301 LLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVI 380
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|
gi 1097277236 381 AGVGTLLCAIALYLVPSARN 400
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPE 176
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
247-396 |
1.31e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.35 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 247 FNGTVGQAGLIEVIYAVGMLVGGAIIGF-SGHFKNRMqLVIISYIVLGVSitasGLLPATSQGFIYFVLLNAIAGLATPY 325
Cdd:cd17325 26 LGASVAQIGLIVAAYALAQLLFSPPAGRlSDRFGRKR-LLLLGLLLLAVS----TLLFAFATSYWQLLLARFLQGLASAA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097277236 326 YNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVP 396
Cdd:cd17325 101 VWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
215-395 |
1.70e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.67 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 215 KRGLWHIMLNGAVFMLLFMPAASLYPLMtMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGV 294
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 295 SitasGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGV 374
Cdd:COG2814 88 G----SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180
....*....|....*....|.
gi 1097277236 375 EKLFVIAGVGTLLCAIALYLV 395
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
11-373 |
3.16e-07 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 52.31 E-value: 3.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLID----RWDKKK--LLIYTDIIVA 83
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGlSAAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRRRpwLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 84 IFALILSIVGTVMSTFPLWLVFVSLFIRSVAQTFQMPTIqSILPTMVPE-EELTRINGRLGMVQsanyivapGLGAFLFA 162
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYW-SLGPELTRDyDERTSLTSYRSFFS--------VGGGLLAA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 163 AVPMNALILLDVLG---------AILGVGLLILVVIPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFM 233
Cdd:pfam13347 152 ALAFPLVLILGGTGlerkgyrifALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 234 PAASLYPLMTMG------YFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRM---QLVIISYIVLGVSITASGLLPA 304
Cdd:pfam13347 232 SFLLAALAMGVLnglllyYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIgkkNTYILGALITIAGFALALLLGP 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1097277236 305 TSQGFIYFVLlnAIAGLATPYYNTLVMAMIQQSFEPSIL---GRVLGVFNSLMSLP----GPIGLIFAGPLADAIG 373
Cdd:pfam13347 312 NNTLLFLVLY--IIIGFGYGSSFFLPWSMLADVVDYGELrtgKRREGTFFAMWSFIsklaTGVGLGVSGLLLSAFG 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-188 |
3.98e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.81 E-value: 3.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 6 KKNINLFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAI 84
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 85 FALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAV 164
Cdd:cd17325 278 ALLLLPLATS------FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
170 180
....*....|....*....|....
gi 1097277236 165 PMNALILLDVLGAILGVGLLILVV 188
Cdd:cd17325 352 GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
62-394 |
5.36e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.07 E-value: 5.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 62 VGPLIDRWDKKKLLIYTDIIVAIFA-LILSIVGTVmstfplWLVFVSLFIRSVAQTFQMpTIQSILPTMVPEEELTRING 140
Cdd:cd17490 51 LGILSDRIGKRKLFIIIGLLFTVLAsLIMILFPSP------WGLLIARFLSGIAAATWV-SFTVLYASYFPPDEAAKAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 141 RLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIPKMDIQGeAVHLLADtkfgVKKLYEKRGLWH 220
Cdd:cd17490 124 LINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP-VLTELKE----LLSVLKDKKLLF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 221 I-MLNGAVFMLLFMPAASLYPLmTMGYFNGTVGQAGLIEVIYavgMLVGGAIIGFSGHFKNRMQ----LVIISYIVLGVS 295
Cdd:cd17490 199 FsLLAILQQMITFSTTFGFTPL-IAKQLGASSFQLGLLSIIY---LLPNALASLLSGTLFYKKLgernTIIIGFLLLGAY 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 296 ITASGLLPATSQgfiyFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVE 375
Cdd:cd17490 275 CFLIPFAPNLTL----LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQ 350
|
330
....*....|....*....
gi 1097277236 376 KLFVIAGVGTLLCAIALYL 394
Cdd:cd17490 351 TGFFVIGVIALLAAILSLA 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-274 |
6.66e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.58 E-value: 6.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 13 LMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIV 92
Cdd:COG0477 20 ALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 93 GTVmstfplWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILL 172
Cdd:COG0477 100 PSP------ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 173 DVLGAILGVGLLILVVIPKMDIQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVG 252
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250 260
....*....|....*....|..
gi 1097277236 253 QAGLIEVIYAVGMLVGGAIIGF 274
Cdd:COG0477 254 LALLLLAALLLLLLLLLLLALL 275
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-392 |
8.09e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.63 E-value: 8.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 34 LTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLiytdiivAIFALILSIVGTVMSTFP-LWLVFVSLFIRS 112
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAF-------AAGAAITAVSVLLLALTDsPWVWFLLRFVMG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 113 VAQTFQMPTIQSILPTMVPEEELTRINGrlgmVQSANYIVAPGLGAFLFAAVPMNALILLdvlgaILGVGLLILVVIPKM 192
Cdd:cd17477 96 IGLAGLFVVSESWLNALATNENRGRVLG----LYSTVLGLGFALGPLLLALVGTAGALPF-----LIAAVLLLLALVPLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 193 DIQGEAVHLLADTKFGVKKLYekRGLWHIMLNGAVFMLLFMPAASLYPLMTMGyFNGTVGQAGLIEVIYAVGMLVGGAII 272
Cdd:cd17477 167 LTRRAAPEIEEAESISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 273 GFSGHFKNRMQLVIISyivLGVSITASGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNS 352
Cdd:cd17477 244 GWLADRFDRRRVLLGC---ALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1097277236 353 LMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIAL 392
Cdd:cd17477 321 LYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
225-395 |
9.23e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 9.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 225 GAVFMLLFMPAAsLYPLMTmGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSitasGLLPA 304
Cdd:cd17324 9 FAIGTTEYVIQG-LLPDIA-RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG----NLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 305 TSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVG 384
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170
....*....|.
gi 1097277236 385 TLLCAIALYLV 395
Cdd:cd17324 163 ALLAALLLWRL 173
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
22-394 |
1.06e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 50.30 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 22 TSMVVQYAIIWYLTQETGSATIlSFATLLGMLPMVLL--SPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIvgtvmsTF 99
Cdd:cd17331 14 TCYWLQQPVLPYLTKKLGVDSV-VFGYLQTTFSVLQLvgGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAF------AS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 100 PLWLVFVSlFIRSVAQTfQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAIL 179
Cdd:cd17331 87 SVPMLFLS-RLPSVFMH-AMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 180 GVGLLILVVIPKMDIQGEAV---HLLADTKFGVKKLYE---KRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQ 253
Cdd:cd17331 165 SIVLVILLIPSNTKSKREKEakeSASPPSVFNLKEILRllrLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 254 AGLI-EVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLnaiaGLATPYYNTLVMA 332
Cdd:cd17331 245 NGYLmSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPL----VIGGSVLYTVITS 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1097277236 333 MIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17331 321 LLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
63-404 |
2.67e-06 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 49.21 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 63 GPLIDRWDKKKLLIYTDIIVAIFALILSIVGtvMSTFP-LWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEEL------ 135
Cdd:PRK10489 73 GVLADRYDRKKLILLARGTCGLGFIGLALNA--FLPEPsLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLmqagai 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 136 TRINGRLGMVQSanyivaPGLGAFLFAAVPMNALILLDVLGAilGVGLLILVVIPKMDIQG-EAVHLLADTKFGVKKLYE 214
Cdd:PRK10489 151 TMLTVRLGSVIS------PALGGLLIAAGGVAWNYGLAAAGT--FITLLPLLRLPALPPPPqPREHPLRSLLAGFRFLLA 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 215 KRGLWHIMLNGAVFMLLFMPAAsLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGV 294
Cdd:PRK10489 223 SPVVGGIALLGGLLTMASAVRV-LYPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 295 SITASGLLPATSQGFIYFVL---LNAIAGLatpyyntLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADA 371
Cdd:PRK10489 302 AVGLFGLMPMWILAVLCLALfgyLSAISSL-------LQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAM 374
|
330 340 350
....*....|....*....|....*....|....
gi 1097277236 372 IGVEKLFVIAGVGT-LLCAIALYLVPSARNYDLE 404
Cdd:PRK10489 375 MTPVASASASGFGLlIIGVLLLLVLGELRRFRQT 408
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
33-392 |
4.39e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 33 YLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLliytdIIVAIFALILSIVGTVMSTFPLWLVFVSLFIRS 112
Cdd:cd17370 25 FLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKP-----LVILGYGLSALAKPLLALAGSWQLVLLLRILER 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 113 VAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMN--ALILLDVLGAILGVGLLILVVIP 190
Cdd:cd17370 100 LGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 191 KmdiqGEAVHLLADTKFGVKKLYEKRgLWHIMLNGAVFMLlfmpAASLYPLMTMgYFNGTVGQAGLIEVIYAVGMLVGGA 270
Cdd:cd17370 180 Y----PRPPKLRKKSKKTSLKKLPKA-FWLYLLAVALFAL----GNFSFAFLIL-RAQELGLSAALIPLLYALFNLVYAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 271 IIGFSGHFKNRMQLVIISYIVLGVSITASGLLpATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVF 350
Cdd:cd17370 250 AAYPAGRLSDRIGRKKLLILGYLSLALAYLGF-ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1097277236 351 NSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIAL 392
Cdd:cd17370 329 NTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-148 |
1.88e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 5 WKKNINLFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVA 83
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1097277236 84 IFALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSA 148
Cdd:COG2814 285 LGLLLLALAGS------LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
48-393 |
5.00e-05 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 45.30 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 48 TLLGMLPMV----LLSPFVGPLIDRW------DKKKLLIYTDIIVAIFALILSivgTVMSTFPLWLVFVSLFIRSVAQTF 117
Cdd:cd17485 32 TAIGLLKLLylpwVLKFLWAPLVDRYglprlgRRRSWLLPTQLGLALLLLALA---FLPPTTNLLAFLGLLFLLNLFSAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 118 QMPTIQSILPTMVPEEELTRINgrlgMVQSANY----IVAPGLGAFLFAAVP-MNALILLDVLGAILGVGLLILVVIPKM 192
Cdd:cd17485 109 QDIATDGLAVELLTPEERGLGN----AAQVVGYklgsLLGGGGLLWLYDLIGwQSLLLSLAALYLLLLLPVLFLRELELP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 193 DiQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTM--GYfngTVGQAGLIEVIYAVGMLVGGA 270
Cdd:cd17485 185 Q-QPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVdrGF---SLSQIGLLSGVGGSLVSIAGS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 271 IIG--FSGHFKNRMQLVIISYIVLGV----SITASGLLPATS-QGFIYFVLLNAIAGLATpyynTLVMAMIQQSFEPSIL 343
Cdd:cd17485 261 LLGgyLLKRRGRRRLLLLGGLLRLLLlglyTLLALGGSGLNWvLLLASLALLHLVGGMIT----TALFTLMMDCSQQAQA 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1097277236 344 GRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALY 393
Cdd:cd17485 337 GTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
7-146 |
9.74e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 9.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 7 KNINLFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIytdIIVAIF 85
Cdd:cd17503 178 RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGySAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL---AGLLLL 254
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097277236 86 ALILSIVGTVMSTFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQ 146
Cdd:cd17503 255 ALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIR 315
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
178-362 |
9.81e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.54 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 178 ILGVGLLILVVIpkMDIQGEAVHLLADTKFgvkklyeKRGLWHIMLNGAVFM--LLFMPAASLYPLMTMGYFNGTVGQAG 255
Cdd:cd06179 231 VIGGVLLIAFGL--YEWKGTKDGLLPPRLL-------FRGRNFALILIVAFVegMIFYSLNIFWPQQISLLFTTDPLKAG 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 256 LIEVIYAVGMLVGGAIIGFSGHFKN--RMQLViISYIVLGVSITASGLLPATSQGFiyFVLLNAIAGLATPYYNTLVMAM 333
Cdd:cd06179 302 LYQLPFGLGTLFGAILAGLLLTKIKhiKWQLV-AGFVLFTAFLALLALITPDNKAL--AIAFSVLAGIGIGGPLVLAIVI 378
|
170 180
....*....|....*....|....*....
gi 1097277236 334 IQQSFEPSILGRVLGVFNSLMSLPGPIGL 362
Cdd:cd06179 379 VQLSVPPEDIGTASGLLGSARALGGAVGT 407
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
40-394 |
1.38e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.77 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDR----WDKKKLLIYTDIIVAIFALIL----SIVGTVMSTFPLWLVFVSLFIR 111
Cdd:cd17313 32 SHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRPFILVGAPLAALGLILipnaADIGLALGDGPRTWALVLFVLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 112 SV-----AQTFQMPTIqSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFL-----FAAVPMNALILLDVLGAILGV 181
Cdd:cd17313 112 IVlldfaMNVCQGPVR-ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwFGFALGGNLKVPFYIGAIILL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 182 GLLILVVI-----------PKMDIQGEAVHLLADTKFGVKKLyeKRGLWHIMLNGAVFMLLFMPAASLYPL-MTMGYFNG 249
Cdd:cd17313 191 VCVLVTLFfvkepplspeaGEHSENPSLGEVLKSLLKLLKIM--PRSLLRLLLVIFFWWIAFFPFELFFTDyMGEEVYHG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 250 T----------VGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAia 319
Cdd:cd17313 269 TsaasshygagVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGI-- 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1097277236 320 GLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17313 347 GWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-393 |
1.57e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTvmstfpLWLVFVSLFIRSVAQTFQM 119
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN------YWLLLLLVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 120 PtIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVVIPKMDIQgeav 199
Cdd:cd17478 103 P-EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 200 hllADTKFGVKKLYEKRGLWH--IMLNGAVFM--LLFMPAASLYPLMTMGYFNGTVgQAGLIEVIYAVGMLVGGAIIGFS 275
Cdd:cd17478 178 ---KKAAAKSSARSTLKGVWRalLLLLIIVFLrsWVLSSLTTFLPFYLVQRGYSLV-FAGLLLSLFLFAGAIGTLIGGPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 276 GHFKNRMQLVIISYIVlgvSITASGLLPATSqGFIYFVLLnAIAGLATPYYNTLVMAMIQQSFePSILGRVLGVFNSLMS 355
Cdd:cd17478 254 SDRFGRRRVIIASLLL---AAPFLLLFLLTP-GIWSYILL-VLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSF 327
|
330 340 350
....*....|....*....|....*....|....*...
gi 1097277236 356 LPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALY 393
Cdd:cd17478 328 GLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
227-399 |
2.17e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 227 VFMLLFMPAASLYPLMT--MGYFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGvsitASGLLPA 304
Cdd:cd06174 4 GFFLTGLARGLISPLLPalLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFA----LGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 305 TSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEK--LFVIAG 382
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraVFLIAA 159
|
170
....*....|....*..
gi 1097277236 383 VGTLLCAIALYLVPSAR 399
Cdd:cd06174 160 ALALLAAILLLLVVPDP 176
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-395 |
2.93e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQyAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLiytdiivaIFALIL 89
Cdd:cd17324 3 ALALAAFAIGTTEYVIQ-GLLPDIARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--------LVLLLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 90 SIVGTVMSTF--PLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMN 167
Cdd:cd17324 74 FILGNLLAALapSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 168 ALILLDVLGAILGVGLLILVViPKMDiQGEAVHLLAdtKFGVKKLYEKRGLWHIMLNGA-VFMLLFMPAASLYPLMTMGY 246
Cdd:cd17324 154 AAFLAIAVLALLAALLLWRLL-PSLP-PKKPGSLGL--LSSLLLLLRNPRLRLAYLITFlLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 247 FNGTVGQAGLIeVIYAVGMLVGGAIIGFSGHFKNRMQLViisyIVLGVSITASGLLPATSQGFIYFVLLNAIAGLATPYY 326
Cdd:cd17324 230 GFSSSAIIGLL-LLFGVAGVVGSPLAGRLADRGGRRALL----IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1097277236 327 NTLVMAMIQQSfEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEklfVIAGVGTLLCAIALYLV 395
Cdd:cd17324 305 HSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA---GVGWVGAALLLLALLLA 369
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
44-188 |
3.53e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 3.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 44 LSFAtLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTVmstfplWLVFVSLFIRSVAqTFQMPTIQ 123
Cdd:cd17388 246 LSLA-VFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQG------WMVFPILILLALG-GIAGPALQ 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1097277236 124 SILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILGVGLLILVV 188
Cdd:cd17388 318 GLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAY 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
34-395 |
3.68e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 34 LTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLiytdiIVAIFALILSIVGTVMSTFPLWLVFVSLFIRS 112
Cdd:cd17355 29 IIAEFGwSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVM-----LLGLLLLAAGLVLLALATSLWQLYLLWGLLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 113 VAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVP-MNALILLDVLGAILGVGLLILVVIPK 191
Cdd:cd17355 104 GGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 192 MDIQGEAVHLLADTKFG--VKKLYEKRGLWhiMLNGAVFMLLF---MPAASLYPLMTMGYFngTVGQAGLIEVIYAVGML 266
Cdd:cd17355 184 ADLALRAYDDASPASPGstLKEALRSASFW--LLALAFFLCGFavvGLIVHLVPYLADRGI--SPAAAAVALALIGLFNI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 267 VGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPATSQGFIYFVLLNAIAGLATpyyNTLVMAMIQQSFEPSILGRV 346
Cdd:cd17355 260 VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGAT---VPLTAALAARYFGARSYGTL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1097277236 347 LGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLV 395
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
247-401 |
8.55e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 8.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 247 FNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLLPatsqGFIYFVLLNAIAGLATPYY 326
Cdd:COG0477 44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1097277236 327 NTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVPSARNY 401
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-394 |
8.89e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 8.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 40 SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIVGTVmstfplWLVFVSLFIRSVAQTFqm 119
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV------ALLLAGTALIGAGIAV-- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 120 ptIQSILPTMVPEeeltRINGRLGMVQSAnYIVAPGLGAFLFAAVpmnALILLDVLG-----AILGV-GLLILVVIPKMD 193
Cdd:COG2807 123 --GNVLLPGLIKR----WFPDRVGLMTGL-YTAAMGLGAALAAGL---TVPLAAALGwrgalAVWALlALLALLLWLPLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 194 IQGEAVHLLADTKFGVKKLYEKRGLWHIMLNGAVFMLLFMPAASLYP--LMTMGYfngTVGQAGLIEVIYAVGMLVGGAI 271
Cdd:COG2807 193 RRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPpiLRDAGL---SAATAGLLLSLFQLAGIPGSLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 272 IGF-SGHFKNRMQLVIISYIVLGVSITasGLLPATSQGFIYFVLLNAIAGLATPyynTLVMAMIQQSF-EPSILGRVLGV 349
Cdd:COG2807 270 VPLlADRLGDRRPLLLLLGLLGLAGLL--GLLLAPGSLPWLWAVLLGLGQGGLF---PLALTLIGLRArTPAEAAALSGM 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1097277236 350 FNSLMSLPGPIGLIFAGPLADAIG--VEKLFVIAGVGTLLCAIALYL 394
Cdd:COG2807 345 AQSVGYLLAALGPLLVGALHDATGswTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
59-397 |
1.41e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.29 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 59 SPFVGPLIDRWDKKKLLIYTDIIVAIFALILSIvgtvmsTFPLWLVFVSLFIRSVAQTFQMpTIQSILPTMVPEEELTRI 138
Cdd:cd17390 48 SPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF------STSLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 139 NGRLGMVQSANYIVAPGLGAFLfaAVPMNALILLDVLGAILGVGLLILV--VIPKM-DIqgeavhlladtkFGVKKLYek 215
Cdd:cd17390 121 LGRFNAASSLGFILGPVVGGHL--AETDGGFYYVALLCSAIFILNAGLVwfLLSKLwDL------------LLVRFLM-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 216 rglwhimlngAVFMLLFMPAASLY-------PLMTMGYfngtvgqagLIEVIYAVGMLVGGAIIGFSGHFKNRMQ-LVII 287
Cdd:cd17390 185 ----------GFSVLLFRSNFSLYleerfdlSPKTIGY---------LISYSGVLGALSGFLVGRILKLYKNNEYlLLLH 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 288 SYIVLGVSITASGLLPATSqgfiYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGp 367
Cdd:cd17390 246 SFILLALSLLGLALAPSIW----LLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSG- 320
|
330 340 350
....*....|....*....|....*....|
gi 1097277236 368 LADAIGVEKLFVIAGVGTLLCAIALYLVPS 397
Cdd:cd17390 321 LLQEFSVSGPGLLGAVLALAAILLMLARQR 350
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-189 |
1.51e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 12 FLMGQFLSGITSMVVQyaiiwyltQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAIFALILSI 91
Cdd:cd17329 214 LIYFQLESTLPVYVVE--------ILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 92 VGTvmstfpLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVpmNALIL 171
Cdd:cd17329 286 ANT------LAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL--GPGLP 357
|
170
....*....|....*...
gi 1097277236 172 LDVLGAILGVGLLILVVI 189
Cdd:cd17329 358 WLILAALGLIAAALLLGL 375
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
246-395 |
1.95e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 246 YFNGTVGQAGLIEVIYAVGMLVGGAIIGFSGHFKNRMQLVIISYIVLGVSITASGLlpatSQGFIYFVLLNAIAGLATPY 325
Cdd:cd17328 28 DFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF----APNFWQLLLFRALVGIGEAS 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097277236 326 YNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPLADAIGVEKL-FVIAGVGTLLCAIALYLV 395
Cdd:cd17328 104 YSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWaFRVTGVLGVLLAILLLLF 174
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
52-361 |
2.08e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 52 MLPMVLLSPFVGPLIDRWDKKKLLIytdiIVAIFALILSIVGTVMSTFPLWLVFvsLFIRSVAQTFQMPTIQSILPTMVP 131
Cdd:cd17503 41 LLALAIMIPLSGWLADRFGTRRLFL----TALALFTLGSLLCGLAPNLASLIIF--RILQGFGGGVLIPLAQTILLRIYP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 132 EEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLdvlgaILGVGLLILVVIPKMDiqgeaVHLLADTKFGVkk 211
Cdd:cd17503 115 PEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI-----NLPIGILALLLAPLLD-----LRLFKDRNFTL-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 212 lyekrglwHIMLNGAVFMLLFMPAAsLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIG-FSGHFKNRMqLVIISYI 290
Cdd:cd17503 183 --------GLLLSFLLGLGLFGAMF-LLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGrLLDKFGPRL-LLLAGLL 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097277236 291 VLGVSiTASGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIG 361
Cdd:cd17503 253 LLALG-TLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
52-394 |
2.27e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 52 MLPMVLLSPFVGPLIDRWDKKKLLIytdiiVAIFALILSIVGTVMSTFPLWLVFVSlFIRSVAQTFQMPTIQSILPTMVP 131
Cdd:cd17320 44 LLGFALGQLLYGPLSDRFGRRPVLL-----AGLLLFILASLLCALASSIEQLLIAR-FLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 132 EEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVLGAILgVGLLILVVIPKMDIQGEAVHLLADTKFGVKK 211
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL-LLLLVLLFLPETLPEEKRKPLLSSLLRAYKR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 212 LYEKRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIG-FSGHFKNRMQLVIISYI 290
Cdd:cd17320 197 VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGrLVRRFGPRRLLRLGLLL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 291 VLGVSITASGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFePSILGRVLGVFNSLMSLPGPIGLIFAGPLAD 370
Cdd:cd17320 277 LLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGALVGLLPN 355
|
330 340
....*....|....*....|....
gi 1097277236 371 AIGVEKLFVIAGVGTLLCAIALYL 394
Cdd:cd17320 356 GTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
33-396 |
3.33e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 33 YLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIytdiivaIFALILSIVGTVMSTFP---LWLVFVSLF 109
Cdd:cd17335 23 YLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALL-------LLSLLAAVLFFLSLFFVaqiFWLLLLLVI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 110 IRSVAQTFQMPTIQSILPTMVPEEEL----TRINGRLGMvqsanyivapGLGAFLFAAVPMNALILLDVLGA-ILGVGLL 184
Cdd:cd17335 96 LGAFFSAPVVPLVDSITLQYLGEERErygkQRLWGSIGF----------GIAALLVGILIDRSSTYKNYTIAfYVFAVLM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 185 ILVVIPKMDIQGEAVHLLADTKFGvkklyekrGLWHIMLNGAVFMLLFMPAA-SLYPLMTMGYFNGTVGQAGLIEVIYAV 263
Cdd:cd17335 166 LLALLLALKFPFRPKHPEPNENTG--------GLLALLRNPRVLAFLLVAFLmGFGHGLIYSFLFWHLQDLGGSKTLIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 264 GMLVGG----AIIGFSGHFKNRMQLVIISYIVLGVSItASGLLPATSQGFIYFVLLNAIAGLATPYYNTLVMAMIQQSFE 339
Cdd:cd17335 238 LWTVGVvseiPFFFFSSRLIQRFGHVGLLYLGLLAYV-VRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1097277236 340 PSILGRVLGVFNSLMS-LPGPIGLIFAGPLADAIGVEKLFVIAGVGTLLCAIALYLVP 396
Cdd:cd17335 317 PGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-141 |
3.55e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.37 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 28 YAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIytdiivAIFALiLSIVGTVMSTF----PLWL 103
Cdd:COG2270 38 FTSVAALGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFL------AFFTL-LGVLATAALFFvapgGLWL 110
|
90 100 110
....*....|....*....|....*....|....*...
gi 1097277236 104 VFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGR 141
Cdd:COG2270 111 GLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGRVSGL 148
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
7-186 |
3.69e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.12 E-value: 3.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 7 KNINLFLMGQFLSGITSMVVQYAIIWYLTQETG-----SATILSFATLLGMLPMVLLspfVGPLIDRWDKKKLLIYTDII 81
Cdd:cd17331 207 PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGltpeeNGYLMSYAGVLGMVVQGLL---VGPLTKRFGERSLLKLSVAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 82 VAIFALILSIVGTVmstfplWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLF 161
Cdd:cd17331 284 LAIGYLLLAFVTTV------WQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
|
170 180
....*....|....*....|....*
gi 1097277236 162 AAVPMNALILLDVLGAILGVGLLIL 186
Cdd:cd17331 358 QAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
5-154 |
3.83e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 5 WKKNINLFLMGQFLSGITSMVVQYAIIWYLTQETGSATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKLLIYTDIIVAI 84
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 85 FALILSIVGtvmSTFPLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAP 154
Cdd:pfam07690 278 AALGLLLLS---LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
52-368 |
5.41e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 5.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 52 MLPMVLLSPFVGPLIDRWDKKKLLIytdIIVAIFALilSIVGTVMSTFPLWLVfVSLFIRSVAQTFQMPTIQSILPTMVP 131
Cdd:cd17321 41 LLAFAALLLLAGRLGDRFGRKRVFL---IGLALFGL--ASLLCALAPSLAFLI-AARALQGIGAAAIMPASLALIAATFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 132 EEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMNALILLDVlgaILGVGLLILVvipkmdiqgeavhlladtkfgvkk 211
Cdd:cd17321 115 GERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV---PIGLVALLLA------------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 212 lyekRGLWHIMLNGAVFMLLFMPAASLYPLMTMGYFNGTVGQAGLIEVIYAVGMLVGGAIIG-FSGHFKNRmQLVIISYI 290
Cdd:cd17321 168 ----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGrLADRFGPR-LVLVAGLL 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1097277236 291 VLGVSITASGLLPATSQGFIYFVLLnAIAGLATPYYNTLVMAMIQQSFEPSILGRVLGVFNSLMSLPGPIGLIFAGPL 368
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-190 |
7.86e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 11 LFLMGQFLSGITSMVVQYAIIWYLTQETG-SATILSFATLLGMLPMVLLSPFVGPLIDRWDKKKlliytdIIVAIFALIL 89
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR------KLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097277236 90 SIVGTVMSTF--PLWLVFVSLFIRSVAQTFQMPTIQSILPTMVPEEELTRINGRLGMVQSANYIVAPGLGAFLFAAVPMN 167
Cdd:COG2271 258 AALALLLLALlpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|...
gi 1097277236 168 ALILLDVLGAILGVGLLILVVIP 190
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRE 360
|
|
| |
