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Conserved domains on  [gi|1090691441|emb|SEF53129|]
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Acetyltransferase (GNAT) domain-containing protein [Lachnospira multipara]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10607277)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  27367672|26818562|15581578|10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-120 4.72e-11

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


:

Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  43 TVFSAYDGDKLVGMVCAM-DDGIMNAYVHYLLVNPEYHNQMIGRTLINKIKD--KYQDYLRIAVIAYDNEMHFYQNCGFE 119
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLpLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAaaKEGGIKLLELETTNRAAAFYEKLGFE 83


                  .
gi 1090691441 120 K 120
Cdd:pfam13508  84 E 84
 
Name Accession Description Interval E-value
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-120 4.72e-11

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  43 TVFSAYDGDKLVGMVCAM-DDGIMNAYVHYLLVNPEYHNQMIGRTLINKIKD--KYQDYLRIAVIAYDNEMHFYQNCGFE 119
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLpLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAaaKEGGIKLLELETTNRAAAFYEKLGFE 83


                  .
gi 1090691441 120 K 120
Cdd:pfam13508  84 E 84
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-119 6.13e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.55  E-value: 6.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  40 NFNTVFSAYDGDKLVGMVCAMDDGIMN----AYVHYLLVNPEYHNQMIGRTLINKIKDKYQD--YLRIAVIAYDNEMHFY 113
Cdd:COG3153    37 AAGLSLVAEDDGEIVGHVALSPVDIDGegpaLLLGPLAVDPEYRGQGIGRALMRAALEAARErgARAVVLLGDPSLLPFY 116


                  ....*.
gi 1090691441 114 QNCGFE 119
Cdd:COG3153   117 ERFGFR 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 44-93 4.12e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.49  E-value: 4.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1090691441  44 VFSAYDGDKLVGMVCAMDDGIMN--AYVHYLLVNPEYHNQMIGRTLINKIKD 93
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Name Accession Description Interval E-value
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-120 4.72e-11

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  43 TVFSAYDGDKLVGMVCAM-DDGIMNAYVHYLLVNPEYHNQMIGRTLINKIKD--KYQDYLRIAVIAYDNEMHFYQNCGFE 119
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLpLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAaaKEGGIKLLELETTNRAAAFYEKLGFE 83


                  .
gi 1090691441 120 K 120
Cdd:pfam13508  84 E 84
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 15-118 5.21e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.60  E-value: 5.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  15 ELEELFLSVNWSSGHYPEKLCVAMKNFNTVFSAYDGDKLVGMVCA--MDDGIMNAYVHYLLVNPEYHNQMIGRTLINKIK 92
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLsiIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1090691441  93 DKYQD---YLRIAVIAYDNE--MHFYQNCGF 118
Cdd:pfam00583  86 EWARErgcERIFLEVAADNLaaIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-119 6.13e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.55  E-value: 6.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  40 NFNTVFSAYDGDKLVGMVCAMDDGIMN----AYVHYLLVNPEYHNQMIGRTLINKIKDKYQD--YLRIAVIAYDNEMHFY 113
Cdd:COG3153    37 AAGLSLVAEDDGEIVGHVALSPVDIDGegpaLLLGPLAVDPEYRGQGIGRALMRAALEAARErgARAVVLLGDPSLLPFY 116


                  ....*.
gi 1090691441 114 QNCGFE 119
Cdd:COG3153   117 ERFGFR 122
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 43-119 3.11e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 48.83  E-value: 3.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1090691441  43 TVFSAYDGDKLVGMVCAMDDGIMNAYVHYLLVNPEYHNQMIGRTLINKIKD--KYQDYLRIAVIAYDNEMHFYQNCGFE 119
Cdd:COG1246    29 EFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAeaRELGLKRLFLLTTSAAIHFYEKLGFE 107
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 42-123 2.47e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 46.50  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  42 NTVFSAYDGDKLVGMVCAMDDGimnaYVHYLLVNPEYHNQMIGRTLINKIKDKY-QDYL---RIAVIAYDNEMHFYQNCG 117
Cdd:pfam13673  31 YFFFVAFEGGQIVGVIALRDRG----HISLLFVDPDYQGQGIGKALLEAVEDYAeKDGIklsELTVNASPYAVPFYEKLG 106


                  ....*.
gi 1090691441 118 FEKSND 123
Cdd:pfam13673 107 FRATGP 112
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 43-132 1.56e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 44.27  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  43 TVFSAYDGDKLVGMVCA--MDDGImnAYVHYLLVNPEYHNQMIGRTLINKI----KDKYQDYLRIAVIAYDNE-MHFYQN 115
Cdd:COG0454    35 EFIAVDDKGEPIGFAGLrrLDDKV--LELKRLYVLPEYRGKGIGKALLEALlewaRERGCTALELDTLDGNPAaIRFYER 112

                          90       100
                  ....*....|....*....|.
gi 1090691441 116 CGFEKS----NDASPMFITSL 132
Cdd:COG0454   113 LGFKEIeryvAYVGGEFEKEL 133
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 44-93 4.12e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.49  E-value: 4.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1090691441  44 VFSAYDGDKLVGMVCAMDDGIMN--AYVHYLLVNPEYHNQMIGRTLINKIKD 93
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEE 52
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 55-120 1.82e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 40.79  E-value: 1.82e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1090691441  55 GMVCAMDDGIMN-AYVHYLLVNPEYHNQMIGRTLINKIKDKYQD----YLRIAVIAyDNE--MHFYQNCGFEK 120
Cdd:COG0456     1 GFALLGLVDGGDeAEIEDLAVDPEYRGRGIGRALLEAALERARErgarRLRLEVRE-DNEaaIALYEKLGFEE 72
COG3375 COG3375
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
15-87 3.33e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 442602 [Multi-domain]  Cd Length: 271  Bit Score: 36.08  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090691441  15 ELEELFLSVnWSSG---HYPEKLCVAM-KNFNTVFSAYDGDKLVGMVC---AMDDGIMNAYVHYLLVNPEYHNQMIGRTL 87
Cdd:COG3375    18 AVQRLQRSV-WGSPpnePVPVHLLRALaHAGGYVLGAFDGGELVGFSFgfpGFRPGGLYLHSHMAGVLPEYRGRGVGYAL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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