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Conserved domains on  [gi|1052755272|emb|SCI53065|]
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putative iron-only hydrogenase system regulator [uncultured Roseburia sp.]

Protein Classification

iron-only hydrogenase system regulator( domain architecture ID 10024258)

iron-only hydrogenase system regulator similar to Thermotoga Maritima protein Tm1266 that may act as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hyd_TM1266 TIGR03959
putative iron-only hydrogenase system regulator; Members of this protein family occur as part ...
 6-81 4.55e-36

putative iron-only hydrogenase system regulator; Members of this protein family occur as part of a system for producing iron-only hydrogenases, dependent on radical SAM proteins HydE and HydG and GTPase HydF. One member of this family, TM_1266 from Thermotoga maritima, has a known crystal structure. The small size, about 80 residues, and a distant relationship to the nickel regulator NikR of the CopG transcriptional regulator family suggest a role as a transcription factor. [Regulatory functions, DNA interactions]


:

Pssm-ID: 274882  Cd Length: 76  Bit Score: 116.44  E-value: 4.55e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052755272  6 RVAVIGIVIEKDESVGALNEILHEYAAYIIGRMGIPYRERGINIVSIAIDAPQDTISALTGKIGKLPGISVKTAYS 81
Cdd:TIGR03959  1 RIAVVGIIVEDRESVAKVNEILHEYGDYIIGRMGIPYREKGVSIISIIVDATTDEIGALTGKLGMIKGVSVKTAYS 76
 
Name Accession Description Interval E-value
hyd_TM1266 TIGR03959
putative iron-only hydrogenase system regulator; Members of this protein family occur as part ...
 6-81 4.55e-36

putative iron-only hydrogenase system regulator; Members of this protein family occur as part of a system for producing iron-only hydrogenases, dependent on radical SAM proteins HydE and HydG and GTPase HydF. One member of this family, TM_1266 from Thermotoga maritima, has a known crystal structure. The small size, about 80 residues, and a distant relationship to the nickel regulator NikR of the CopG transcriptional regulator family suggest a role as a transcription factor. [Regulatory functions, DNA interactions]


Pssm-ID: 274882  Cd Length: 76  Bit Score: 116.44  E-value: 4.55e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052755272  6 RVAVIGIVIEKDESVGALNEILHEYAAYIIGRMGIPYRERGINIVSIAIDAPQDTISALTGKIGKLPGISVKTAYS 81
Cdd:TIGR03959  1 RIAVVGIIVEDRESVAKVNEILHEYGDYIIGRMGIPYREKGVSIISIIVDATTDEIGALTGKLGMIKGVSVKTAYS 76
 
Name Accession Description Interval E-value
hyd_TM1266 TIGR03959
putative iron-only hydrogenase system regulator; Members of this protein family occur as part ...
 6-81 4.55e-36

putative iron-only hydrogenase system regulator; Members of this protein family occur as part of a system for producing iron-only hydrogenases, dependent on radical SAM proteins HydE and HydG and GTPase HydF. One member of this family, TM_1266 from Thermotoga maritima, has a known crystal structure. The small size, about 80 residues, and a distant relationship to the nickel regulator NikR of the CopG transcriptional regulator family suggest a role as a transcription factor. [Regulatory functions, DNA interactions]


Pssm-ID: 274882  Cd Length: 76  Bit Score: 116.44  E-value: 4.55e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052755272  6 RVAVIGIVIEKDESVGALNEILHEYAAYIIGRMGIPYRERGINIVSIAIDAPQDTISALTGKIGKLPGISVKTAYS 81
Cdd:TIGR03959  1 RIAVVGIIVEDRESVAKVNEILHEYGDYIIGRMGIPYREKGVSIISIIVDATTDEIGALTGKLGMIKGVSVKTAYS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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