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Conserved domains on  [gi|1567928536|gb|RYD66765|]
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MAG: phosphatase PAP2 family protein [Sphingomonadales bacterium]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130261)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Bacillus subtilis phosphatidylglycerophosphatase B that catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016020|GO:0016791|GO:1901137|GO:0006629
PubMed:  9122162
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-227 1.33e-38

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


:

Pssm-ID: 239486  Cd Length: 182  Bit Score: 132.35  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  40 AASTGSGFEFDRAIMLAMRVPGHPdtptgpaWLPSAVRDVTALGSSIVLTAVVVVTATFLGLRRRMRSVALVLLATISGS 119
Cdd:cd03392     3 VVQAGWLTAFDQSVLSLLRSLRTP-------LLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 120 LAVTLIKALVGRSRPDLIDrLMVEASHSFPSGHAANSAIVYLTLATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLG 199
Cdd:cd03392    76 ALNTLLKLLVQRPRPPLHL-LVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLG 154

                         170       180
                  ....*....|....*....|....*...
gi 1567928536 200 VHWPSDVLAGWVFGSGWAIAWWRLELKL 227
Cdd:cd03392   155 VHYPSDVLAGWLLGLAWLALLILLYRRL 182
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-227 1.33e-38

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 132.35  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  40 AASTGSGFEFDRAIMLAMRVPGHPdtptgpaWLPSAVRDVTALGSSIVLTAVVVVTATFLGLRRRMRSVALVLLATISGS 119
Cdd:cd03392     3 VVQAGWLTAFDQSVLSLLRSLRTP-------LLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 120 LAVTLIKALVGRSRPDLIDrLMVEASHSFPSGHAANSAIVYLTLATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLG 199
Cdd:cd03392    76 ALNTLLKLLVQRPRPPLHL-LVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLG 154

                         170       180
                  ....*....|....*....|....*...
gi 1567928536 200 VHWPSDVLAGWVFGSGWAIAWWRLELKL 227
Cdd:cd03392   155 VHYPSDVLAGWLLGLAWLALLILLYRRL 182
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 40-223 2.10e-22

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 90.48  E-value: 2.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  40 AASTGSGFEFDRAIMLAMRVPGHPDTPTGPAWLPSAVRDVTALGSSIVLTAVVVVTATFLGLRRRMRSVALVLLATISGS 119
Cdd:COG0671     3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 120 LAVT----LIKALVGRSRP----DLIDRLMVEASHSFPSGHAANSAIVYLTLATLLLpilqeremRRFVIVVALLLTGVI 191
Cdd:COG0671    83 LLLLllllLLKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLP--------RRWLAALLLALALLV 154

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1567928536 192 GISRVYLGVHWPSDVLAGWVFGSGWAIAWWRL 223
Cdd:COG0671   155 GLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
acidPPc smart00014
Acid phosphatase homologues;
112-221 1.49e-21

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 86.25  E-value: 1.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  112 LLATISGSLAVTLIKALVGRSRPDLID----------RLMVEASHSFPSGHAANSAIVYLTLATLLlpilQEREMRRFVI 181
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSigdacctpnfLLTLEAGYSFPSGHTAFAFAFALFLLLYL----PARAGRKLLI 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1567928536  182 VVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:smart00014  77 FLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 111-226 3.75e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 80.16  E-value: 3.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 111 VLLATISGSLAVTLIKALVGRSRPDLIDRL---------MVEASHSFPSGHAANSAIVYLTLATLLLPILQERemRRFVI 181
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEgglvpapstLPGLGYSFPSGHSATAFALALLLALLLRRLRKIV--RVLLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1567928536 182 VVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWWRLELK 226
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 143-209 2.39e-05

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 44.25  E-value: 2.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1567928536 143 EASHSFPSGHAANSAIVYLTLATLLLPilqereMRRFVIVVALLL--TGVIGiSRVYLGVHWPSDVLAG 209
Cdd:PRK10699  154 ETGFAFPSGHTMFAASWALLAVGLLWP------RRRYKTVALLMLwaTGVMG-SRLLLGMHWPRDLVVA 215
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-227 1.33e-38

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 132.35  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  40 AASTGSGFEFDRAIMLAMRVPGHPdtptgpaWLPSAVRDVTALGSSIVLTAVVVVTATFLGLRRRMRSVALVLLATISGS 119
Cdd:cd03392     3 VVQAGWLTAFDQSVLSLLRSLRTP-------LLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 120 LAVTLIKALVGRSRPDLIDrLMVEASHSFPSGHAANSAIVYLTLATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLG 199
Cdd:cd03392    76 ALNTLLKLLVQRPRPPLHL-LVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLG 154

                         170       180
                  ....*....|....*....|....*...
gi 1567928536 200 VHWPSDVLAGWVFGSGWAIAWWRLELKL 227
Cdd:cd03392   155 VHYPSDVLAGWLLGLAWLALLILLYRRL 182
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 106-221 2.97e-23

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 90.98  E-value: 2.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 106 RSVALVLLATISGSLAVTLIKALVGRSRPDLIDRLM--------VEASHSFPSGHAANSAIVYLTLATLLLPilqeREMR 177
Cdd:cd01610     3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGpdgdplllTEGGYSFPSGHAAFAFALALFLALLLPR----RLLR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1567928536 178 RFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:cd01610    79 LLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 40-223 2.10e-22

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 90.48  E-value: 2.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  40 AASTGSGFEFDRAIMLAMRVPGHPDTPTGPAWLPSAVRDVTALGSSIVLTAVVVVTATFLGLRRRMRSVALVLLATISGS 119
Cdd:COG0671     3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 120 LAVT----LIKALVGRSRP----DLIDRLMVEASHSFPSGHAANSAIVYLTLATLLLpilqeremRRFVIVVALLLTGVI 191
Cdd:COG0671    83 LLLLllllLLKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLP--------RRWLAALLLALALLV 154

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1567928536 192 GISRVYLGVHWPSDVLAGWVFGSGWAIAWWRL 223
Cdd:COG0671   155 GLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
acidPPc smart00014
Acid phosphatase homologues;
112-221 1.49e-21

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 86.25  E-value: 1.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  112 LLATISGSLAVTLIKALVGRSRPDLID----------RLMVEASHSFPSGHAANSAIVYLTLATLLlpilQEREMRRFVI 181
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSigdacctpnfLLTLEAGYSFPSGHTAFAFAFALFLLLYL----PARAGRKLLI 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1567928536  182 VVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:smart00014  77 FLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 108-227 3.24e-19

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 81.93  E-value: 3.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 108 VALVLLATISGSLAVTLIKALVGRSRP----DLIDRLMVEA---SHSFPSGHAANSAivylTLATLLLPILQEREMRRFV 180
Cdd:cd03395    59 LLVLLAVGFADQLASGFLKPLVARLRPcnalDGVRLVVLGDqggSYSFASSHAANSF----ALALFIWLFFRRGLFSPVL 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1567928536 181 IVVALLltgvIGISRVYLGVHWPSDVLAGWVFGSGWAIAWWRLELKL 227
Cdd:cd03395   135 LLWALL----VGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSWL 177
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 111-226 3.75e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 80.16  E-value: 3.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 111 VLLATISGSLAVTLIKALVGRSRPDLIDRL---------MVEASHSFPSGHAANSAIVYLTLATLLLPILQERemRRFVI 181
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEgglvpapstLPGLGYSFPSGHSATAFALALLLALLLRRLRKIV--RVLLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1567928536 182 VVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWWRLELK 226
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 111-221 8.68e-13

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 62.73  E-value: 8.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 111 VLLATISGSLAVTLIKALVGRSRPDLIDRlmveASHSFPSGHAANSaivyLTLATLLlpilQEREMRRFVIVVALLLTGV 190
Cdd:cd03394     8 LAEAAALTAAVTEGLKFAVGRARPDGSNN----GYRSFPSGHTASA----FAAATFL----QYRYGWRWYGIPAYALASL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1567928536 191 IGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:cd03394    76 VGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 101-213 8.16e-12

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 61.95  E-value: 8.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 101 LRRRMRSVALVLLATISGSLAVTLIKALVGRSRPDL-IDRLM-----VEASH---SFPSGHAANSAIVYLTLAtLLLPIl 171
Cdd:cd03389    64 FPKAAWAGLFLFATVALSGILVNLLKFIIGRARPKLlFDDGLygfdpFHADYaftSFPSGHSATAGAAAAALA-LLFPR- 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1567928536 172 qeremRRFVivvALLLTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:cd03389   142 -----YRWA---FILLALLIAFSRVIVGAHYPSDVIAGSLLG 175
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 100-221 9.34e-12

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 62.61  E-value: 9.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 100 GLRRRMRSVALVLLATISGSLAVTLIKALVGRSRP-DLID--------RLMV------EASHSFPSGHAAnSAIVYLTLA 164
Cdd:COG3907    90 RLRRYRRRLLYLLLSLALGLLVVSLLKSHTGRPCPwDLVEfggdapyvPLFEpgpagaGPGRCFPAGHAS-AGFALLALY 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1567928536 165 TLLLPILqeREMRRFVIVVALLLTGVIGISRVYLGVHWPSDVL--AGWVFGSGWAIAWW 221
Cdd:COG3907   169 FLLRRRR--PRLARLGLAAGLALGLLMGLAQMLRGAHFLSHTLwsAWICWLVALLLYWL 225
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 110-223 3.66e-11

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 60.31  E-value: 3.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 110 LVLLATISGSLAVT-LIKALVGRSRPDLIDRLM------------------------VEASHSFPSGHAANSA--IVYLT 162
Cdd:cd03390    49 LGLLLSVSLNGVITnVLKNYAGRPRPDFLARCFpdggtpsdtlvgidicctgdpgvlKEGRKSFPSGHSSFAFagLGFLS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1567928536 163 L---ATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWWRL 223
Cdd:cd03390   129 LylaGKLHIFDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 110-213 1.27e-10

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 57.38  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 110 LVLLATISGSLAvTLIKALVGRSRPDLIDRLM-----VEASHSFPSGHAANSAIVYLTLATLLlpilqereMRRFVIVVA 184
Cdd:cd03393    18 LGLALCASGYLN-AALKEVFKIPRPFTYDGIQaiyeeSAGGYGFPSGHAQTSATFWGSLMLHV--------RKKWFTLIG 88

                          90       100
                  ....*....|....*....|....*....
gi 1567928536 185 LLLTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:cd03393    89 VVLVVLISFSRLYLGVHWPSDVIGGVLIG 117
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 98-220 1.35e-10

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 58.85  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536  98 FLGLRRRMRSVALVLLATISGSLAVTLIKALVGRSRP-DLID--------------RLMVEASHSFPSGHAANSaivYLT 162
Cdd:cd03396    59 RKRLRRRRRALLLLILVIGLGLLVVAILKSHWGRPRPwDLTEfggdapytplfsgpSNGCGKGCSFPSGHASAG---FAL 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1567928536 163 LATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFgsGWAIAW 220
Cdd:cd03396   136 LALYFLFRRRRPRLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLL--VWLIAL 191
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 101-221 1.50e-09

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 54.97  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 101 LRRRMRSVALVLLATISGSLAVTLIKALVGRSRPDLIDRLmVEASHSFPSGHAANSA--IVYLTLATLLLPILQEREMRR 178
Cdd:cd03382    37 LFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPCSGAYF-VRSGYGMPSSHSQFMGffAVYLLLFIYLRLGRLNSLVSR 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1567928536 179 FVIVVALL-LTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:cd03382   116 FLLSLGLLlLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILWF 159
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 112-218 3.09e-09

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 54.17  E-value: 3.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 112 LLATIsgsLAVTLIKALVGRSRPDLID----------------------------RLMVEASHSFPSGHAANS--AIVYL 161
Cdd:cd03384    13 LFATQ---LLTDLGKYVTGRLRPHFLDvckpnytdltcsldhqyiadctcctgdpDLIREARLSFPSGHASLSmyAAVFL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1567928536 162 TL-ATLLLPILQEREMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAI 218
Cdd:cd03384    90 ALyLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIAL 147
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 112-213 2.23e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 51.94  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567928536 112 LLATISGSLAVTLIKALVGRSRP-----DLIDRLMVEaSHSFPSGHAANSAIVYLTLATLLLPILQeremrrFVIVVaLL 186
Cdd:cd03391    53 LLGLLLDIITVAILKALVRRRRPaynspDMLDYVAVD-KYSFPSGHASRAAFVARFLLNHLVLAVP------LRVLL-VL 124

                          90       100
                  ....*....|....*....|....*..
gi 1567928536 187 LTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:cd03391   125 WATVVGISRVLLGRHHVLDVLAGAFLG 151
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 147-214 1.48e-07

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 50.51  E-value: 1.48e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1567928536 147 SFPSGHAANSAIVYLTLATLL---LPILQEREMRrfvivvallltgvIGISRVYLGVHWPSDVLAGWVFGS 214
Cdd:cd03380   144 SYPSGHATFGGAAALVLAELFperAAELLARAAE-------------AGNSRVVAGVHWPSDVEAGRILGE 201
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
 149-220 6.07e-07

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 48.92  E-value: 6.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1567928536 149 PSGHAANSAIVYLTLATLLLPILQEREMRRFVIVVALLLTGV----IGISRVYLGVHWPSDVLAGWVfgSGWAIAW 220
Cdd:cd03381    75 PSGHAMGTTAVLLVMVTALLSHLAGRKRSRFLRVMLWLVFWGvqlaVCLSRIYLAAHFPHQVIAGVI--SGIAVAE 148
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 146-221 1.51e-06

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 46.45  E-value: 1.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1567928536 146 HSFPSGHAANSAIVYLTLATLLLPILQEREMrrFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFGSGWAIAWW 221
Cdd:cd03388    78 YGFPSTHAMNATAISFYLLIYLYDRYQYPFV--LGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLILLFRF 151
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 147-217 2.48e-06

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 45.71  E-value: 2.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1567928536 147 SFPSGHAansaIVYLTLATLLLpILQEREMRRFVIVVALLltgvIGISRVYLGVHWPSDVLAGWVFGSGWA 217
Cdd:cd03385    78 SFPSDHT----TLFFSIAFSLL-LRRRKWAGWILLILALL----VAWSRIYLGVHYPLDMLGAALVAVLSA 139
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 147-214 3.86e-06

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 46.56  E-value: 3.86e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1567928536 147 SFPSGHAAnsaIVYLTlATLLLPILQEREmrrfvivVALLLTG-VIGISRVYLGVHWPSDVLAGWVFGS 214
Cdd:cd03397   151 SYPSGHTA---AGYAW-ALILAELVPERA-------DEILARGsEYGQSRIVCGVHWPSDVMGGRIMAA 208
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 143-209 2.39e-05

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 44.25  E-value: 2.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1567928536 143 EASHSFPSGHAANSAIVYLTLATLLLPilqereMRRFVIVVALLL--TGVIGiSRVYLGVHWPSDVLAG 209
Cdd:PRK10699  154 ETGFAFPSGHTMFAASWALLAVGLLWP------RRRYKTVALLMLwaTGVMG-SRLLLGMHWPRDLVVA 215
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 149-213 6.45e-05

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 43.19  E-value: 6.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567928536 149 PSGHAANSAIVYLTLATLLLPILQEREMRRFVIVVAL--LLTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:PLN02525   87 PSSHTLNTVCLSGYLLHYVLSYLQNVDASVIFAGLALfcLLVALVGFGRLYLGMHSPIDIIAGLAIG 153
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 147-209 5.70e-04

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 40.10  E-value: 5.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1567928536 147 SFPSGHAANSAIVYLTLATL-----LLPILQEREMRRFVIVVALLLTGV------IGISRVYLGVHWPSDVLAG 209
Cdd:cd03398   146 SYPSGHATFAGAAATVLKALfgsdkVPDTVSEPDEGGPSTGVTRVWAELneladeVAISRVYAGVHFRSDDAAG 219
PAP2_3 pfam14378
PAP2 superfamily;
147-213 1.05e-03

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 38.86  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567928536 147 SFPSGHAANSAIVYLTLATLLlpilqereMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:pfam14378 126 AMPSLHVAWALLCALALWRLR--------RTRILRWLAVAYNVLMIVSTVATGNHYLLDVVAGVALA 184
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 143-213 1.25e-03

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 38.84  E-value: 1.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1567928536 143 EASHSFPSGHAanSAIVYLTLATLLLpilqereMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFG 213
Cdd:PRK11837  100 AADDSFPSDHG--TVIFTFALAFLFW-------HRLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVG 161
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 148-222 3.90e-03

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 37.29  E-value: 3.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567928536 148 FPSGHAANSAIVYLTLAtlllpilqeREMRRFVIVVALLLTGVIGISRVYLGVHWPSDVLAGWVFG--SGWAIAWWR 222
Cdd:cd03386   119 FPSLHVAWAVLAALFLW---------RHRRRLLRWLAVLWPLLIWLSTLYLGNHYFIDLVGGIALAllSFYLARRVR 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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