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Conserved domains on  [gi|1544678969|gb|RUH69628|]
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YopR family type III secretion effector [Pseudomonas aeruginosa]

Protein Classification

YopR/YscH family type III secretion effector( domain architecture ID 10020800)

YopR/YscH family type III secretion effector similar to Yersinia enterocolitica Yop proteins translocation protein H that belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
type_III_yopR TIGR02509
type III secretion effector, YopR family; Members of this family are type III secretion system ...
 15-141 3.20e-45

type III secretion effector, YopR family; Members of this family are type III secretion system effectors, named differently in different species and designated YopR (Yersinia outer protein R), encoded by the YscH (Yersinia secretion H) gene. This Yops protein is unusual in that it is released to extracellularly rather than injected directly into the target cell as are most Yops. [Cellular processes, Pathogenesis]


:

Pssm-ID: 131561  Cd Length: 131  Bit Score: 143.82  E-value: 3.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544678969  15 SASPKAANLPAVDQVLAFEQALGGEPPAAGRRLAGLENGALSERLLQRFAQP--LQGLEADRLELKAMLRAELPLGRQQQ 92
Cdd:TIGR02509   1 LENKLAISDPATQRELLWQQYQQGKPAAGTADLVPELLSPVKERLLGRFGGQqlPVVPPIDRLELRAMLRQFDPLGRQQE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544678969  93 TFLLQLLGAVEHAP--GGEYLAQLARRELQVLIPLNGMLDNLVRNSHKLDL 141
Cdd:TIGR02509  81 AALLQLLGKLKSLPqvGMEYLSDLARRELMTLIPKNGMVDNLMRNSHKLDL 131
 
Name Accession Description Interval E-value
type_III_yopR TIGR02509
type III secretion effector, YopR family; Members of this family are type III secretion system ...
 15-141 3.20e-45

type III secretion effector, YopR family; Members of this family are type III secretion system effectors, named differently in different species and designated YopR (Yersinia outer protein R), encoded by the YscH (Yersinia secretion H) gene. This Yops protein is unusual in that it is released to extracellularly rather than injected directly into the target cell as are most Yops. [Cellular processes, Pathogenesis]


Pssm-ID: 131561  Cd Length: 131  Bit Score: 143.82  E-value: 3.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544678969  15 SASPKAANLPAVDQVLAFEQALGGEPPAAGRRLAGLENGALSERLLQRFAQP--LQGLEADRLELKAMLRAELPLGRQQQ 92
Cdd:TIGR02509   1 LENKLAISDPATQRELLWQQYQQGKPAAGTADLVPELLSPVKERLLGRFGGQqlPVVPPIDRLELRAMLRQFDPLGRQQE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544678969  93 TFLLQLLGAVEHAP--GGEYLAQLARRELQVLIPLNGMLDNLVRNSHKLDL 141
Cdd:TIGR02509  81 AALLQLLGKLKSLPqvGMEYLSDLARRELMTLIPKNGMVDNLMRNSHKLDL 131
T3SS_needle_reg pfam09025
YopR, type III needle-polymerization regulator; The YopR core domain, predominantly found in ...
 55-142 3.54e-18

YopR, type III needle-polymerization regulator; The YopR core domain, predominantly found in the Gammaproteobacteria virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR. YopR controls the selective access of early (YscF, YscI and YscP) substrates to the type III secretion machines of yersiniae and other Gammaproteobacteriae. YopR is a mobile regulatory component thought to function as a checkpoints probing the completion of discrete intermediary stages in the assembly of the type III injection pathway. The location of secreted YopR (into the medium) is directly controlling the secretion of YscF, the polymerized needle protein pfam09392, thereby impacting the assembly of type III machines.


Pssm-ID: 286158  Cd Length: 145  Bit Score: 75.44  E-value: 3.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544678969  55 LSERLLQRFAQpLQGL---EADRLELKAMLRAELPLGRQQQTFLLQLLGAVEHAPGGEYLAQLARRELQVLIPLNGMLDN 131
Cdd:pfam09025  56 VKEELLGDFGG-HQGMaepPTDRPELRAMLAQFFPLGAQKEQALLHVLAEIKPLPEMTYLSDLIREELSFLIPKNAMVDN 134

                          90
                  ....*....|.
gi 1544678969 132 LVRNSHKLDLE 142
Cdd:pfam09025 135 LMTNSHKLDLS 145
 
Name Accession Description Interval E-value
type_III_yopR TIGR02509
type III secretion effector, YopR family; Members of this family are type III secretion system ...
 15-141 3.20e-45

type III secretion effector, YopR family; Members of this family are type III secretion system effectors, named differently in different species and designated YopR (Yersinia outer protein R), encoded by the YscH (Yersinia secretion H) gene. This Yops protein is unusual in that it is released to extracellularly rather than injected directly into the target cell as are most Yops. [Cellular processes, Pathogenesis]


Pssm-ID: 131561  Cd Length: 131  Bit Score: 143.82  E-value: 3.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544678969  15 SASPKAANLPAVDQVLAFEQALGGEPPAAGRRLAGLENGALSERLLQRFAQP--LQGLEADRLELKAMLRAELPLGRQQQ 92
Cdd:TIGR02509   1 LENKLAISDPATQRELLWQQYQQGKPAAGTADLVPELLSPVKERLLGRFGGQqlPVVPPIDRLELRAMLRQFDPLGRQQE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544678969  93 TFLLQLLGAVEHAP--GGEYLAQLARRELQVLIPLNGMLDNLVRNSHKLDL 141
Cdd:TIGR02509  81 AALLQLLGKLKSLPqvGMEYLSDLARRELMTLIPKNGMVDNLMRNSHKLDL 131
T3SS_needle_reg pfam09025
YopR, type III needle-polymerization regulator; The YopR core domain, predominantly found in ...
 55-142 3.54e-18

YopR, type III needle-polymerization regulator; The YopR core domain, predominantly found in the Gammaproteobacteria virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR. YopR controls the selective access of early (YscF, YscI and YscP) substrates to the type III secretion machines of yersiniae and other Gammaproteobacteriae. YopR is a mobile regulatory component thought to function as a checkpoints probing the completion of discrete intermediary stages in the assembly of the type III injection pathway. The location of secreted YopR (into the medium) is directly controlling the secretion of YscF, the polymerized needle protein pfam09392, thereby impacting the assembly of type III machines.


Pssm-ID: 286158  Cd Length: 145  Bit Score: 75.44  E-value: 3.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544678969  55 LSERLLQRFAQpLQGL---EADRLELKAMLRAELPLGRQQQTFLLQLLGAVEHAPGGEYLAQLARRELQVLIPLNGMLDN 131
Cdd:pfam09025  56 VKEELLGDFGG-HQGMaepPTDRPELRAMLAQFFPLGAQKEQALLHVLAEIKPLPEMTYLSDLIREELSFLIPKNAMVDN 134

                          90
                  ....*....|.
gi 1544678969 132 LVRNSHKLDLE 142
Cdd:pfam09025 135 LMTNSHKLDLS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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