|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-368 |
1.87e-78 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 245.55 E-value: 1.87e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 9 VCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLAL 88
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 89 LQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIA 168
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 169 GSLLLLGRGGAPRvDPHSASGRGLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALL 248
Cdd:cd17477 161 ALVPLLLTRRAAP-EIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 249 QLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTP-LIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVA 327
Cdd:cd17477 240 QWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1544322166 328 QLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLV 368
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-371 |
1.06e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 101.49 E-value: 1.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 12 AVISIGLALGLTM----PLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLA 87
Cdd:COG2807 22 AIVLVALNLRPAItsvgPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 88 LLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKwRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLI 167
Cdd:COG2807 102 LAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 168 AGSLLLLGRGGAPRVDPHSASGRGLWAFCRGLP-AIAWAVVLF----AAFEAMILTLLPVYGLRQGFPQAVALAMVSTVV 242
Cdd:COG2807 181 ALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRsPLAWLLTLFfglqSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 243 VGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRA 322
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1544322166 323 NAHVAQLWG-IGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLVRLR 371
Cdd:COG2807 341 LSGMAQSVGyLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-333 |
3.13e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 3.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 2 RWGSYFAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAA 81
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 82 SIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWF 161
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 162 GVCLLIAGSLLLLGRGGAPRVDPHSASG-----RGLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALA 236
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARlrgslRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 237 MVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRD 316
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*..
gi 1544322166 317 DALVRANAHVAQLWGIG 333
Cdd:COG2814 328 EARGRASGLYNSAFFLG 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-371 |
1.94e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.26 E-value: 1.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 9 VCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLAL 88
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 89 LQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIA 168
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 169 GSLLLLGRGGAPR----------VDPHSASGRGLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQ-GFPQAVALAM 237
Cdd:cd17325 161 LLALVLALLLLPEprpppnkravSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 238 VSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDD 317
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1544322166 318 ALVRANAHVAQLWGIGCLLGPLATGAASQWISGHAL-PLMMALGAAGFVVLVRLR 371
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPfLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-370 |
5.65e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 78.74 E-value: 5.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 2 RWGSYFAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAA 81
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 82 SIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLvALYGTGYALSQLSGPVLLTFIGTADDRGFW- 160
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLGLSLSWh 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 161 ----------FGVCLLIAGSLLLLGRGGAPRVDPHSASGRGLWAFcRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQ-GF 229
Cdd:COG0738 165 lpylilavllLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKN-PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 230 PQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALIL 309
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544322166 310 IGERYRDDALVRANAhVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLVRL 370
Cdd:COG0738 324 ALDGLGKRTAAAVSA-VLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-338 |
1.61e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.07 E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 9 VCSAVISIGLALGLTMPLVSLRL-ESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLA 87
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 88 LLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLI 167
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 168 AGSLLLLGRGGAPRVDPHSASGRGLW----------AFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAM 237
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEArlslivawkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 238 VSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQT---PLIWPLLVLFGASAGGLFTLALILIGERY 314
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTlssLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 1544322166 315 RDDALVRANAHVAQLWGIGCLLGP 338
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-380 |
4.33e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.99 E-value: 4.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 32 ESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFI 111
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 112 LGESWINQLAVEKWRGR----LVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIAGSLLLLGRGGAPRVDPHSA 187
Cdd:COG2223 113 VGIALVSKWFPPDRRGLalglAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 188 SGRGLWAFCRGLPAIAWAVVL----FAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSG 263
Cdd:COG2223 193 ASLRDQLEALRDPRFWLLSLLyfgtFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 264 LFGGCGLVLLLSSLAIPLLLQT-PLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATG 342
Cdd:COG2223 273 VLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1544322166 343 AASQWISGHALPLMM--ALGAAGFVVLVRLRGAIPADEEA 380
Cdd:COG2223 353 ALLDATGSYTAAFLVfaVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-368 |
1.14e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.69 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 9 VCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLAL 88
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 89 LQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIA 168
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 169 GSLLLLGRGGAPRVDPHSASGRGLWAFC--------------RGLPAIAWAVVLFAAFEAMILTLLPVYGLRQG-FPQAV 233
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASsksvlkllkrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 234 ALAMVSTVVVGDALLQLPIGWLADRV-SRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGE 312
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1544322166 313 RYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLV 368
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
8-361 |
1.21e-13 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 71.57 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 8 AVCSAVISIGLALG--LTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGL 85
Cdd:cd06180 1 LAGALALAVAMGIGrfAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 86 LALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALY----GTGYALSQLSGPVLLTFIGTADDRGFWF 161
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLfagvGLGIALSGLLVPAGLGGGLSWRAGWLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 162 GVCLLIAGSLLLLGRGGAPRVDPHSASGRGLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTV 241
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 242 VVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLaIPLLLQTPL-IWPLLVLFGASAGGLFTLALILIGERYRDDALv 320
Cdd:cd06180 241 GLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVL-LPLLSPGPAgLVLSAVLFGGTFMAITALVMALARELAPPAAP- 318
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1544322166 321 RANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGA 361
Cdd:cd06180 319 RALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAA 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-368 |
3.53e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.90 E-value: 3.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 1 MRWGSYFAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGA 80
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 81 ASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDrgfW 160
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG---W 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 161 FGVCLLIAGSLLllgrggaprvdphsasgrgLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVST 240
Cdd:COG2271 164 RAAFLILGLPGL-------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 241 VVVGDALLQLPIGWLADRVSRSG--LFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDA 318
Cdd:COG2271 225 PFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1544322166 319 LVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLV 368
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
18-373 |
1.30e-11 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 65.45 E-value: 1.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 18 LALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLL 97
Cdd:PRK03633 20 LAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFWSWLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 98 LRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGF-WfgVCLLIAGSLLLLGR 176
Cdd:PRK03633 100 WRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVSTELMSVLpW--VTGLVLAAILPLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 177 GGAPRVDPHSASGRGLWAFCRGLPA-------IAWAVVLfaafeAMILTLLPVYGLRQGFPQA-----VALaMVSTVVVG 244
Cdd:PRK03633 178 TRILNQQAENHDSTSIWPMLKLRQArlgvngcIISGIVL-----GSLYGLMPLYLNHQGMSDAsigfwMAL-LVSAGILG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 245 dallQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIpllLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANA 324
Cdd:PRK03633 252 ----QWPIGRLADRFGRLLVLRVQVFVVILGSIAM---LSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHELVAMNQ 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1544322166 325 HVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLVrLRGA 373
Cdd:PRK03633 325 ALLLSYTVGSLLGPSFTAMLMQNYSDNLLFIMIASVSFIYLLML-LRKA 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
7-368 |
2.13e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 7 FAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLL 86
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 87 ALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLL 166
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 167 IAGSLLLLGRGGAPRVDPHSASGRGLWAFCRGLP-------AIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVS 239
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLrnprlrlAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 240 TVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERyRDDAL 319
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEAR 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1544322166 320 VRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLV 368
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
197-371 |
6.03e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 6.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 197 RGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSS 276
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 277 LAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLM 356
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|....*
gi 1544322166 357 MALGAAGFVVLVRLR 371
Cdd:COG2814 170 NAVLALLALLLLLRL 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-147 |
9.59e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 9.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 7 FAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLL 86
Cdd:cd06173 212 LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544322166 87 ALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVL 147
Cdd:cd06173 292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
42-370 |
1.21e-06 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 50.06 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 42 GVMASTPAVGVLLGAMIAGRLAARVGTPRLMQL--CLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQ 119
Cdd:pfam06779 31 GLLAAANYAGYLAGALLASFAWRHGASRLRPALlaGLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAVMIFGSSLILG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 120 LAVEKWRGRLVALY----GTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIAGSLLLLGR-GGAPRVDPHSASGRGLWA 194
Cdd:pfam06779 111 HATAARRAFVGALLfagvGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLpRRAPRHASAPAPAAKPLQ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 195 FCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADrvsRSGLFGGCGLVLLL 274
Cdd:pfam06779 191 RSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAK---RWGTRPALTAALLI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 275 SSLAIPL-LLQTPLIWPLL--VLFGASAGGLFTLALILIGERYrDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGH 351
Cdd:pfam06779 268 QALGVLLsLLSPSPAGLAVssLLFGGTFMAITSLVMQLARELA-PPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGL 346
|
330
....*....|....*....
gi 1544322166 352 ALPLMMALGAAGFVVLVRL 370
Cdd:pfam06779 347 TPALLLAAAALVLAALIVL 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
35-154 |
1.32e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 35 GYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGE 114
Cdd:cd17473 229 GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLN 308
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1544322166 115 SWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTA 154
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-368 |
2.99e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 2.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 18 LALGLTMPLVSlRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLL 97
Cdd:cd17316 16 FLIGFVAPVLA-AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 98 LRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVCLLIAGSLLLLGRG 177
Cdd:cd17316 95 LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 178 GAPRVdphsasgrglwafcrGLPAIAWAVVLFAAFeaMILTLLPVYGLR-QGFPQAVALAMVSTVVVGDALLQLPIGWLA 256
Cdd:cd17316 175 LRRRT---------------LLLILLWFFISFGYY--GLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 257 DRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGAS--AGGLFTLALILIGERYRDDALVRANAHVAQLWGIGC 334
Cdd:cd17316 238 DRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSffVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317
|
330 340 350
....*....|....*....|....*....|....
gi 1544322166 335 LLGPLATGAASQWISGHALPLMMALGAAGFVVLV 368
Cdd:cd17316 318 GGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
202-387 |
7.01e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 202 IAWAVVLFAAFEAMILTLLPVYGLRQ-GFPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIP 280
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 281 LLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALG 360
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180
....*....|....*....|....*..
gi 1544322166 361 AAGFVVLVRLRGAIPADEEATGLEASE 387
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-371 |
7.81e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 7.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 35 GYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALL-----QSYPVWLLLRLLIGVQLTVV 109
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 110 FILGESWINQLAVEKWRGRLVALYGTGYALSQLSGP----VLLTFIGT----ADDRGFWFGVCLLIAGSLLLLGRGGAPR 181
Cdd:cd06173 110 GPARQALLPELVPKEQLVRANALNSLATQLARIIGPalggLLVALLGPggafAINALSFLLSALLLLFIRRPPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 182 VDPHSASGRGLWAFCRGLPAIAW---AVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVV-VGDALLQLPIGWLAD 257
Cdd:cd06173 190 SSLLLRDLREGLRYLRRSPLLRLlllALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 258 RVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLG 337
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330 340 350
....*....|....*....|....*....|....
gi 1544322166 338 PLATGAASQWISGHALPLMMALGAAGFVVLVRLR 371
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-312 |
8.70e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 8.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 21 GLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRL 100
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 101 LIGVQLTVVFILGESWINQLAvEKWRGRLVALYGTGYALSQLSGPVLLTFI--GTADDRGFWFGVCLLIAGSLLLLGRGG 178
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALvaLFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 179 APRVDPHSASGRGLWAFCRGLPAIAWAVVLFAAF-----EAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIG 253
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrswvLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544322166 254 WLADRVSRSGLFGGCglvLLLSSLAIPLLLQTPLIW--PLLVLFGASAGGLFTLALILIGE 312
Cdd:cd17478 252 PLSDRFGRRRVIIAS---LLLAAPFLLLFLLTPGIWsyILLVLAGFLLFASFPVTVVLAQE 309
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-370 |
9.72e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 9.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 9 VCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLAL 88
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 89 LQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVClliA 168
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA---A 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 169 GSLLLLGRGGAPRVDPHSASGRGLWAFCRGLPAIAWAVVLFAAF--------EAMILTLLPVYGLRQGFPQAVALAMVST 240
Cdd:cd17489 158 VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALilflasiaYGAISTFLPLYAAERGISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 241 VVVgdALLQLPIGWLADRVSRSGLFGGCGLVLllsSLAIPLLLQTPLIWPLL---VLFGASAGGLFTLALILIGERYRDD 317
Cdd:cd17489 238 IAL--LLSRPFSGKLSDRKGPKTVIIPGLLLL---ALGLLLLSFAGSPWMLLlaaVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1544322166 318 ALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLVRL 370
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-283 |
1.51e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.34 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 2 RWGSYFAVCSAVISIGLALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAA 81
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 82 SIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRG--F 159
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRwiF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 160 WFGVCLLIAGSLLLLGRGGAPRVDPHSASGRGLWAFCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVS 239
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1544322166 240 TVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLL 283
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-141 |
2.63e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 1 MRWGSYFAVCSAVISIGLALGLTMPLVSLRL-ESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTG 79
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1544322166 80 AASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQ 141
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
16-368 |
1.01e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 16 IGLALGLTMPLVSLRL-ESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPV 94
Cdd:cd17329 11 NRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 95 WLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTAD-DRGFWFG----VCLLIAG 169
Cdd:cd17329 91 FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSfRLLFLAAavlfLLAALVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 170 SLLLLGRGGAPRVDPHSASGRGLWAFCRGLPAIAW--AVVLFAAFEAMILTLLPVYGLRQGF--PQAVALA-MVSTVVVg 244
Cdd:cd17329 171 LFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFllASFLISLIYFQLESTLPVYVVEILGlgESLLGLLlALNALLI- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 245 dALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANA 324
Cdd:cd17329 250 -VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1544322166 325 HVAQLWGIGCLLGPLATGaasqWISGHALPLMMALGAAGFVVLV 368
Cdd:cd17329 329 FYALAWGLGRAIGPLVGG----LLLDLLGPGLPWLILAALGLIA 368
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-144 |
1.23e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.88 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 18 LALGLTMPLVSlrlESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLL 97
Cdd:TIGR00895 34 AAMGFAAPAIS---AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1544322166 98 LRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGYALSQLSG 144
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVG 157
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
197-370 |
1.32e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 197 RGLPAIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSS 276
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 277 LAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLM 356
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|....
gi 1544322166 357 MALGAAGFVVLVRL 370
Cdd:COG0477 174 NAPLGLLALVLRLR 187
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
25-371 |
1.81e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 25 PLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIgLLALLQSYPVWLLLRLLIGV 104
Cdd:cd17339 20 PLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGI-LLRSLGGIALLFLGTALAGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 105 QLTVVFILGESWINQLAVEKwRGRLVALYGTGYALSQ-----LSGPVLLTFIGTADDRGFWFGVCLLIAGSLLLLGRGGA 179
Cdd:cd17339 99 GIAVGNVLLPSLIKRDFPRR-VGLMTGLYTTSMNLGAalasgLSVPLAQALGGGWRGALAIWALPALLALLIWLPQLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 180 PRVDPHSA--SGRGLWAfcrglPAIAWAVVLFAAFEAM----ILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIG 253
Cdd:cd17339 178 KRAAAAAAplTKISVWR-----SPLAWQVTLFMGLQSLlfytLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 254 WLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQlwGIG 333
Cdd:cd17339 253 ILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMAQ--SVG 330
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1544322166 334 CLL---GPLATGAASQWISGHALPLMMALGAAGFVVLVRLR 371
Cdd:cd17339 331 YLLaalGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLG 371
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
18-104 |
1.92e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.98 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 18 LALGLTMPLVSLRLESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLL 97
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFL 89
|
....*..
gi 1544322166 98 LRLLIGV 104
Cdd:cd17390 90 SRIPLGI 96
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-314 |
2.51e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.67 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 34 WGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILG 113
Cdd:cd17371 29 FGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 114 ESWINQLAVEKWRGRLVALYGTGYA--------LSQLSGPVLLTFIGTaddRG-FWFGVCLLIAGSLLLLGRGGAPRVDP 184
Cdd:cd17371 109 AALMAEYVPARHRGKALGYVQSGWAvgwllatlLAALLFPLLPPEIAW---RVlFLLGALPALLVLFIRRFVKEPPQWQA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 185 HSASGR-------GLWAFCRGLPAIAWAVVLFAAFEAM----ILTLLPVYG-LRQGFPQAVALAMVSTVVVGDALLQLPI 252
Cdd:cd17371 186 ARAARRhfadrpsLRELFSPPLLRTTLLASLLATGALGgyygITTWLPSYLtGERGLSFEGSAGYLVVTILGGFLGYLAG 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1544322166 253 GWLADRVSRSGLFggcGLVLLLSSLAIPLLLQTP----LIWPLLVLFGASAGGLFTLALILIGERY 314
Cdd:cd17371 266 GFLADRIGRRNNF---ALFALGSAISILLYFFLPlsptLILILGFPLGFFASGPFSGMGAYLTELF 328
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
40-312 |
3.18e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 40 AIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQ 119
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 120 LAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTAddRGFWFGVCLLIAGSLLLLGRGGA-----PRVDPHSASGRGLWA 194
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALH--YGWRAAFVVAGLVSILAAVLFWLfyrepPAASAATESASTLLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 195 ------FCRGLPAIAWAVVLFAAFEAMILTLLPVYGLRQ-GFPQAVALAMVSTVVVGDALLQLPIGWLADRV---SRSGL 264
Cdd:cd17475 190 slkevlRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfggRRRPV 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1544322166 265 FGGCGLVLLLSSLAIPLLLQTPLIW---PLLVLFGASAGGLFTLALILIGE 312
Cdd:cd17475 270 LVITAAIAAAALLVLSLLSPGTPLWllvLLLILLGLFAIGWNGLYLTLVAE 320
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
50-151 |
5.18e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 5.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 50 VGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQL----TVVFILGESWINQlaveKW 125
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIggiwVQAVVLNTEFLPK----KQ 213
|
90 100
....*....|....*....|....*.
gi 1544322166 126 RGRLVALYGTGYALSQLSGPVLLTFI 151
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFI 239
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-151 |
1.09e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 50 VGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRL 129
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV 115
|
90 100
....*....|....*....|..
gi 1544322166 130 VALYGTGYALSQLSGPVLLTFI 151
Cdd:cd17317 116 GILFGLFWALGYMLLALLAYLI 137
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
39-147 |
1.51e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 39 FAIGVMASTPAVGVLLGAMIAGR-LAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWI 117
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
90 100 110
....*....|....*....|....*....|
gi 1544322166 118 NQLAVEKWRGRLVALYGTGYALSQLSGPVL 147
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLL 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
207-375 |
1.56e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 207 VLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTP 286
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 287 LIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVV 366
Cdd:cd06174 86 LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLA 165
|
....*....
gi 1544322166 367 LVRLRGAIP 375
Cdd:cd06174 166 AILLLLVVP 174
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
201-338 |
3.11e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 201 AIAWAVVLFAAFEAMILTLLPVYGLRQGFPQAVALAMVSTVVVGDALLQLPIGWLADR--VSRSGLFGGCGLVLLLSSLA 278
Cdd:cd17352 187 LLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLA 266
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 279 IPLLLQTPLIWPLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGP 338
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGP 326
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
32-133 |
3.20e-03 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 39.19 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 32 ESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFI 111
Cdd:PRK10489 252 EVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISSL 331
|
90 100
....*....|....*....|..
gi 1544322166 112 LGESWINQLAVEKWRGRLVALY 133
Cdd:PRK10489 332 LQYTLLQTQTPDEMLGRINGLW 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-371 |
3.58e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 8 AVCSAVISIGLALGLTMPLVSLRLES---WGYGSFAIGVMASTPAVGvlLGAMIAGRLAARVGTPRLMQLCLLTGAASIG 84
Cdd:cd17355 6 AVTFLILILSWGIRYYFGVFIIPIIAefgWSRAVISLAFTVGLLAFG--LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 85 LLALLQSYPVWLLLRLLIGVQLTVVfiLGESWINQLAVEKWRGRLVALYGTGYALSQLSGPVLLTFIGTADDRGFWFGVC 164
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGT--LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 165 LLIAGSLLLLGRGGAPRVDPHSASGRGLWAFCRGLPAIAWAV----------VLFAAF------EAMILTLLPVYGLRQG 228
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLkealrsasfwLLALAFflcgfaVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 229 FPQAVALAMVSTVVVGDALLQLPIGWLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIWPL-LVLFGASAGGLFTLAL 307
Cdd:cd17355 242 ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1544322166 308 ILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMALGAAGFVVLVRLR 371
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-370 |
4.12e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 58 IAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLVALYGTGY 137
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 138 ALSQLSGPVLLTFIGTADDRGFWFGVCLLIAGSLLLLGRGGAP---RVDPHSASGRGLWAFC---RGLPAIAWAVVLFAA 211
Cdd:cd17474 133 GLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEpkeKAKSSSATKLRDLKKAlrgRGLLTFLVSAFLYFF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 212 FEAMILTLLPVY-GLRQGFPQAVALAMVSTVVVGDALLQLPIG-WLADRVSRSGLFGGCGLVLLLSSLAIPLLLQTPLIW 289
Cdd:cd17474 213 LYFAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 290 PLLVLFGASAGGLFTLALILIGERYRDDALVRANAHVAQLWGIGCLLGPLATGAASQWISGHALPLMMA-LGAAGFVVLV 368
Cdd:cd17474 293 IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAaIALAAAVLLA 372
|
..
gi 1544322166 369 RL 370
Cdd:cd17474 373 LL 374
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
7-153 |
6.63e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.33 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 7 FAVCSAVISIGLALGLTMPLVSLRLESWGYG----SFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAAS 82
Cdd:cd17358 5 FVANLGSFSFGIAVGWSSPALPSLMSDNSLSlpltVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILG 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544322166 83 IGLLALLQSYPVWLLLRLLIGVQLTVVFILGESWINQLAVEKWRGRLvalyGTGYALSQLSGPVLLTFIGT 153
Cdd:cd17358 85 WLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL----GSLNQLLVNIGILLGYVLGS 151
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
35-133 |
7.77e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 7.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 35 GYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVFILGE 114
Cdd:cd17315 30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVP 109
|
90
....*....|....*....
gi 1544322166 115 SWINQLAVEKWRGRLVALY 133
Cdd:cd17315 110 LYISEIAPAKIRGALGTLN 128
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-139 |
9.65e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 37.57 E-value: 9.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322166 31 LESWGYGSFAIGVMASTPAVGVLLGAMIAGRLAARVGTPRLMQLCLLTGAASIGLLALLQSYPVWLLLRLLIGVQLTVVF 110
Cdd:cd17365 26 AQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAM 105
|
90 100
....*....|....*....|....*....
gi 1544322166 111 ILGESWINQLAVEKWRGRLVALYGTGYAL 139
Cdd:cd17365 106 PNAITLVSEYAPARRRSLAVTLMFCGYPL 134
|
|
| |
