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Conserved domains on  [gi|1544322158|gb|RUE15234|]
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RidA family protein [Pseudomonas aeruginosa]

Protein Classification

RidA family protein( domain architecture ID 10150280)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 10-115 3.28e-59

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


:

Pssm-ID: 100007  Cd Length: 105  Bit Score: 177.34  E-value: 3.28e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  10 ERMSQIVVHNGTVYLAGQVGEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQWLPRG 89
Cdd:cd06150     1 ARMSQAVVHNGTVYLAGQVADDTSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADM-ADFAAMNAVWDAWVPPG 79

                          90       100
                  ....*....|....*....|....*.
gi 1544322158  90 VAPARATVEAKLCEPEILVEMSVVAA 115
Cdd:cd06150    80 HAPARACVEAKLADPGYLVEIVVTAA 105
 
Name Accession Description Interval E-value
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 10-115 3.28e-59

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 177.34  E-value: 3.28e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  10 ERMSQIVVHNGTVYLAGQVGEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQWLPRG 89
Cdd:cd06150     1 ARMSQAVVHNGTVYLAGQVADDTSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADM-ADFAAMNAVWDAWVPPG 79

                          90       100
                  ....*....|....*....|....*.
gi 1544322158  90 VAPARATVEAKLCEPEILVEMSVVAA 115
Cdd:cd06150    80 HAPARACVEAKLADPGYLVEIVVTAA 105
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 12-117 1.02e-34

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 116.05  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  12 MSQIVVHNGTVYLAGQVGED-----MSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQWL 86
Cdd:COG0251    17 YSQAVRVGNLVFVSGQVPLDpdtgeLGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDM-ADFAAVNEVYAEYF 95

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1544322158  87 PRGvAPARATVE-AKLCEpEILVEMSVVAALP 117
Cdd:COG0251    96 GEG-RPARTAVGvAALPK-GALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 11-115 2.43e-28

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 99.68  E-value: 2.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  11 RMSQIVVHNGTVYLAGQVGEDMSAG------VEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQ 84
Cdd:pfam01042   8 PYSQAVKAGNLVYVSGQIPLDPDTGklvegdVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADM-NDFAEVNEVYAE 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1544322158  85 WLPRGVAPARATVEAKLCEPEILVEMSVVAA 115
Cdd:pfam01042  87 YFDADKAPARSAVGVAALPLGALVEIEAIAV 117
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 13-116 1.38e-18

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 75.02  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  13 SQIVVHNGTVYLAGQV------GEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWL 86
Cdd:TIGR00004  17 SQAVKVGNTVYVSGQIpldpstGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLN-DFAEVNEVYGQYF 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 1544322158  87 pRGVAPARATVEAKLCEPEILVEMSVVAAL 116
Cdd:TIGR00004  96 -DEHYPARSAVQVAALPKGVLVEIEAIAVK 124
PRK11401 PRK11401
enamine/imine deaminase;
12-114 9.77e-06

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 41.59  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  12 MSQIVVHNGTVYLAGQVGEdMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWLPRGVA 91
Cdd:PRK11401   23 LGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLN-DFATINEVYKQFFDEHQA 100

                          90       100
                  ....*....|....*....|....*
gi 1544322158  92 --PARATVEAKLCEPEILVEMSVVA 114
Cdd:PRK11401  101 tyPTRSCVQVARLPKDVKLEIEAIA 125
 
Name Accession Description Interval E-value
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 10-115 3.28e-59

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 177.34  E-value: 3.28e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  10 ERMSQIVVHNGTVYLAGQVGEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQWLPRG 89
Cdd:cd06150     1 ARMSQAVVHNGTVYLAGQVADDTSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADM-ADFAAMNAVWDAWVPPG 79

                          90       100
                  ....*....|....*....|....*.
gi 1544322158  90 VAPARATVEAKLCEPEILVEMSVVAA 115
Cdd:cd06150    80 HAPARACVEAKLADPGYLVEIVVTAA 105
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 12-114 2.18e-36

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 119.59  E-value: 2.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  12 MSQIVVHNGTVYLAGQVGED-----MSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWL 86
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDpdgelVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMA-DFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 1544322158  87 PRGVAPARATVEAKLCEPEILVEMSVVA 114
Cdd:cd00448    80 GEGPPPARTAVGVAALPPGALVEIEAIA 107
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 12-117 1.02e-34

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 116.05  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  12 MSQIVVHNGTVYLAGQVGED-----MSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQWL 86
Cdd:COG0251    17 YSQAVRVGNLVFVSGQVPLDpdtgeLGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDM-ADFAAVNEVYAEYF 95

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1544322158  87 PRGvAPARATVE-AKLCEpEILVEMSVVAALP 117
Cdd:COG0251    96 GEG-RPARTAVGvAALPK-GALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 11-115 2.43e-28

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 99.68  E-value: 2.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  11 RMSQIVVHNGTVYLAGQVGEDMSAG------VEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVWDQ 84
Cdd:pfam01042   8 PYSQAVKAGNLVYVSGQIPLDPDTGklvegdVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADM-NDFAEVNEVYAE 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1544322158  85 WLPRGVAPARATVEAKLCEPEILVEMSVVAA 115
Cdd:pfam01042  87 YFDADKAPARSAVGVAALPLGALVEIEAIAV 117
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 13-116 1.38e-18

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 75.02  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  13 SQIVVHNGTVYLAGQV------GEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWL 86
Cdd:TIGR00004  17 SQAVKVGNTVYVSGQIpldpstGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLN-DFAEVNEVYGQYF 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 1544322158  87 pRGVAPARATVEAKLCEPEILVEMSVVAAL 116
Cdd:TIGR00004  96 -DEHYPARSAVQVAALPKGVLVEIEAIAVK 124
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 13-114 4.07e-14

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 63.34  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  13 SQIVVHNGTVYLAGQVGED-----MSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWLp 87
Cdd:cd06154    14 SRAVRVGNWVFVSGTTGYDydgmvMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIA-DFEAVGRAHGEVF- 91

                          90       100
                  ....*....|....*....|....*...
gi 1544322158  88 RGVAPARATVEAKL-CEPEILVEMSVVA 114
Cdd:cd06154    92 GDIRPAATMVVVSLlVDPEMLVEIEVTA 119
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 11-116 3.98e-13

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 60.35  E-value: 3.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  11 RMSQIVVHNGTVYLAGQVG--EDMS--AGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDADFEGMNRVWDQWL 86
Cdd:cd02198     2 GYSPAVRVGDTLFVSGQVGsdADGSvaEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMAAHLPAFAAVKDEYF 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1544322158  87 PRGvAPARATVE-AKLCEPEILVEMSVVAAL 116
Cdd:cd02198    82 KEP-YPAWTAVGvAWLARPGLLVEIKVVAVR 111
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 19-115 6.73e-12

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 57.27  E-value: 6.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  19 NGTVYLAGQVGEDMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIdADFEGMNRVW----DQWLPrgvaPAR 94
Cdd:cd06155     7 GGLLWISNVTASESDETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDM-SDFAEVNSVYgtffDKPNP----PSR 81

                          90       100
                  ....*....|....*....|.
gi 1544322158  95 ATVEAKLcEPEILVEMSVVAA 115
Cdd:cd06155    82 VCVECGL-PEGCDVQLSCVAA 101
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 36-114 1.11e-08

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 49.18  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  36 VEQQTRETLAAIERLLEEAG-----TDKTRILSVTIYLKDIdADFEGMNRVWDQWLPRGVapARATVEAKLCEPEILVEM 110
Cdd:cd06153    34 VEAQTRETLENIEALLEAAGrgggaQFLADLLRLKVYLRDR-EDLPAVRAILAARLGPAV--PAVFLQADVCRPDLLVEI 110


                  ....
gi 1544322158 111 SVVA 114
Cdd:cd06153   111 EAVA 114
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 37-114 1.18e-07

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 46.54  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  37 EQQTRETLAAIERLLEEAGTDKTRILSVTIYL-----KDIDADFEGMNRVWDQWL---PRGVAPARATVE-AKLCEPEIL 107
Cdd:cd06151    40 ETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpaLDGKMDFAGFMKAYRQFFgtaEQPNKPARSTLQvAGLVNPGWL 119


                  ....*..
gi 1544322158 108 VEMSVVA 114
Cdd:cd06151   120 VEIEVVA 126
PRK11401 PRK11401
enamine/imine deaminase;
12-114 9.77e-06

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 41.59  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  12 MSQIVVHNGTVYLAGQVGEdMSAGVEQQTRETLAAIERLLEEAGTDKTRILSVTIYLKDIDaDFEGMNRVWDQWLPRGVA 91
Cdd:PRK11401   23 LGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLN-DFATINEVYKQFFDEHQA 100

                          90       100
                  ....*....|....*....|....*
gi 1544322158  92 --PARATVEAKLCEPEILVEMSVVA 114
Cdd:PRK11401  101 tyPTRSCVQVARLPKDVKLEIEAIA 125
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 13-117 3.73e-03

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 34.61  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544322158  13 SQIVVHNGTVYLAGQVG------EDMSAGVEQQTRETLAAIERLLEEAGTDktRILSVTIYLKDiDADFEGMNRVWDQWL 86
Cdd:cd06156     2 SQAIVVPKVAYISGQIGlipatmTLLEGGITLQAVLSLQHLERVAKAMNVQ--WVLAAVCYVTD-ESSVPIARSAWSKYC 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1544322158  87 PRGVAPARATVEAKLCEPEILVemSVVAALP 117
Cdd:cd06156    79 SELDLEDESRNESDDVNPPLVI--VVVPELP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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