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Conserved domains on  [gi|1541778243|gb|RTP18082|]
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peptidoglycan endopeptidase [Enterobacter hormaechei]

Protein Classification

C40 family peptidase( domain architecture ID 1903322)

C40 family peptidase is a cell-wall hydrolase that cleaves peptide cross-bridges between glycan chains and is essential for bacterial growth and viability; typically cleaves the linkage between D-Glu and diaminopimelic acid (or Lys) within peptidoglycan stem peptides; contains a Cys-His-His catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpC super family cl43273
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
1-103 4.07e-04

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG0791:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 38.14  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541778243   1 MIGVPWANRACSFDKVDCWGLCVLYYRHVlGIELhqtPGYeAGEDFFTCYQ--------GDVVFWRkvdkpveggifvgY 72
Cdd:COG0791   110 YLGTPYVWGGTSPSGFDCSGLVQYVYRQA-GISL---PRT-SADQAAAGTPvsrselqpGDLVFFR-------------T 171

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1541778243  73 RGTQPAHVGLVL-NRQALHSRGENGSVRMDSL 103
Cdd:COG0791   172 GGGGISHVGIYLgNGKFIHASSSGKGVRISSL 203
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
1-103 4.07e-04

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 38.14  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541778243   1 MIGVPWANRACSFDKVDCWGLCVLYYRHVlGIELhqtPGYeAGEDFFTCYQ--------GDVVFWRkvdkpveggifvgY 72
Cdd:COG0791   110 YLGTPYVWGGTSPSGFDCSGLVQYVYRQA-GISL---PRT-SADQAAAGTPvsrselqpGDLVFFR-------------T 171

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1541778243  73 RGTQPAHVGLVL-NRQALHSRGENGSVRMDSL 103
Cdd:COG0791   172 GGGGISHVGIYLgNGKFIHASSSGKGVRISSL 203
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 3-103 1.74e-03

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 35.34  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541778243   3 GVPWANRACSFDKVDCWGLCVLYYRHVlGIELHQTPGYEAGEDFFTCYQ-----GDVVFWRkvdkpveggifvGYRGTQp 77
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPKsepqrGDLVFFG------------TGKGIS- 66

                          90       100
                  ....*....|....*....|....*..
gi 1541778243  78 aHVGLVL-NRQALHSRGENGsVRMDSL 103
Cdd:pfam00877  67 -HVGIYLgNGQMLHASTGGG-VSISSL 91
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
1-103 4.07e-04

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 38.14  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541778243   1 MIGVPWANRACSFDKVDCWGLCVLYYRHVlGIELhqtPGYeAGEDFFTCYQ--------GDVVFWRkvdkpveggifvgY 72
Cdd:COG0791   110 YLGTPYVWGGTSPSGFDCSGLVQYVYRQA-GISL---PRT-SADQAAAGTPvsrselqpGDLVFFR-------------T 171

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1541778243  73 RGTQPAHVGLVL-NRQALHSRGENGSVRMDSL 103
Cdd:COG0791   172 GGGGISHVGIYLgNGKFIHASSSGKGVRISSL 203
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 3-103 1.74e-03

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 35.34  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541778243   3 GVPWANRACSFDKVDCWGLCVLYYRHVlGIELHQTPGYEAGEDFFTCYQ-----GDVVFWRkvdkpveggifvGYRGTQp 77
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPKsepqrGDLVFFG------------TGKGIS- 66

                          90       100
                  ....*....|....*....|....*..
gi 1541778243  78 aHVGLVL-NRQALHSRGENGsVRMDSL 103
Cdd:pfam00877  67 -HVGIYLgNGQMLHASTGGG-VSISSL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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