|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-409 |
1.59e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 181.99 E-value: 1.59e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 8 RYWKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCL 87
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 88 FIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmN 167
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF--G 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 168 WQIMLFIITGLLVVMTLvfavvikgsqpqapaavsqtvapaalapeedgqasglfsLRMISAYAMYFATCYGYYMIVTWL 247
Cdd:COG2271 163 WRAAFLILGLPGLLLAL---------------------------------------LRFWLLALAYFLVYFALYGFLTWL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 248 PSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGL 327
Cdd:COG2271 204 PTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 328 LGkLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVmGFYISAAILLVGTAIFFTVNVLM 407
Cdd:COG2271 284 GL-GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA-AFLLLAALALLAALLALLLLRET 361
|
..
gi 1540736099 408 KR 409
Cdd:COG2271 362 RK 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-403 |
3.50e-45 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 160.04 E-value: 3.50e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 13 IVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGL-SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQiML 172
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF--GWR-WA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 173 FIITGLL-VVMTLVFAVVIKgsqpqapaavsqtvapaalapeedgqasglfslRMISAYAMYFATCYGYYMIVTWLPSFL 251
Cdd:cd17319 160 FIIEGLLgLLLAVLWWFYLR---------------------------------QVWGLALGYFGINYALYGLLTWLPTYL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 252 QQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRF-RNKKVQLIIFLELCAAVMLVCTVISpDSTMLLISLILYGLLGK 330
Cdd:cd17319 207 KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlRGARRLVIIIGLLLAAVGLLLAYLT-TSPVVAVILLSLAGFGI 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 331 LAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17319 286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-409 |
5.20e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 152.34 E-value: 5.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 8 RYWKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCL 87
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL-SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 88 FIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmN 167
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 168 WQIMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALApeedgqasgLFSLRMISAYAMYFATCYGYYMIVTWL 247
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA---------LRDPRFWLLSLLYFGTFGSFIGFSSWL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 248 PSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDSTMLLISLILYGL 327
Cdd:COG2223 229 PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA-LMALGLLLLALALGSLWLFLVLFLLLGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 328 LGKLAVdPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTVNVLM 407
Cdd:COG2223 308 ALGGGN-GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
..
gi 1540736099 408 KR 409
Cdd:COG2223 387 RR 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-362 |
2.21e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.95 E-value: 2.21e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 6 DPRYWKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGF 85
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 86 CLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFn 165
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 166 mNWQIMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPeedgqasglfslRMISAYAMYFATCYGYYMIVT 245
Cdd:COG2814 162 -GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRP------------RLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 246 WLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFleLCAAVMLVCTVISPDSTMLLISLILY 325
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL--LLLALGLLLLALAGSLWLLLLALFLL 306
|
330 340 350
....*....|....*....|....*....|....*..
gi 1540736099 326 GLLGKLAVdPIMISFVADNAPKKGYGTSFGVFNFFGM 362
Cdd:COG2814 307 GFGFGLLF-PLLQALVAELAPPEARGRASGLYNSAFF 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-401 |
1.09e-36 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 137.71 E-value: 1.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 17 LCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGA-SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIIT 176
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA---PFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 177 GLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLFSLrmisaYAMYFATCYGYYMIVTWLPSFLQQERG 256
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL-----FLAIFVLAFAFGALEPFLPLYAAELGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 257 FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqlIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLaVDPI 336
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL--ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGL-VFPA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 337 MISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKvMGFYISAAILLVGTAIFF 401
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA-TPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-401 |
1.45e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 118.30 E-value: 1.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 17 LCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGL-SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFIIT 176
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 177 GLLVVMTLVFAVVIkgsqPQAPAAVSQTVAPAALAPEEDGQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERG 256
Cdd:cd06174 160 ALALLAAILLLLVV----PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 257 FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVdPI 336
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL-LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL-PL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 337 MISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFF 401
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-369 |
4.16e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 116.36 E-value: 4.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 17 LCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIIT 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 177 GLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALApeedgqASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFlQQERG 256
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA------WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 257 FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPI 336
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 1540736099 337 MISFVADNAPKKGYGTSFGVFNFFGMSSSVIAP 369
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
46-401 |
9.71e-29 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 115.34 E-value: 9.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNA--TSLTMVYAGSLLAGMGCGSYYGSAY 123
Cdd:cd17380 32 SKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMT 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 124 SLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQiMLFIITGLLvvmTLVFAVVIkgsqpqapaavsQ 203
Cdd:cd17380 112 SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY--GWP-SVFYFFGLL---GLLWALVW------------L 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 204 TVAPAALApeedgqasglfslrMISAyamYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFsSALVAFASVPGALFFSRM 283
Cdd:cd17380 174 IYLPPVWA--------------IIVA---HFCMNWGFYILLSWLPTYFHEVLVPLAKGWVF-NVVPWLVMFPSSNVAGWL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 284 SDRFRNKKV---------QLIIFLELCAAVMLVCTVISPDSTMLLISLILyGLLGkLAVDPIMISfVADNAPKKGyGTSF 354
Cdd:cd17380 236 ADHLISRGWtvtsvrklmQSIGFLGPALFLLLLSHTDSFSLALLCMSVAL-GLSA-FSSSGVLVN-HQDIAPNYA-GIVF 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1540736099 355 GVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFF 401
Cdd:cd17380 312 GISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-399 |
3.93e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 114.59 E-value: 3.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 13 IVVVLCLGWAViwiyrTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:COG2807 24 VLVALNLRPAI-----TSVGPLLPEIRADLGL-SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIML 172
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL--GWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 173 FIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALApeedgqasglfSLRMISAYAMYFATCYGYYMIVTWLPSFLq 252
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWR-----------SPLAWLLTLFFGLQSLLYYAVVAWLPPIL- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 253 QERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDStMLLISLILYGlLGKLA 332
Cdd:COG2807 243 RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG-LLGLAGLLGLLLAPGS-LPWLWAVLLG-LGQGG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 333 VDPIMISFVADNAP-KKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAI 399
Cdd:COG2807 320 LFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
33-401 |
2.15e-27 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 111.87 E-value: 2.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 33 PIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAG 112
Cdd:cd17324 20 GLLPDIARDFGV-SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 113 MGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIITGLLVVMTLVFAVVIKG 192
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL--GWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 193 SQPQAPAAVSQTVAPAALapeedgqasgLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFA 272
Cdd:cd17324 177 LPPKKPGSLGLLSSLLLL----------LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 273 SVPGALFFSRMSDRFRNKKvqLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVdPIMISFVADNAPkKGYGT 352
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH-SALQTRVLRLAP-EARGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1540736099 353 SFGVFNFFGMSSSVIAPFLTGVISDSTGSkVMGFYISAAILLVGTAIFF 401
Cdd:cd17324 323 ASSLYLAAYNLGGALGAALGGLVLDHGGW-AGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-400 |
1.04e-26 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 109.99 E-value: 1.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 30 VLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSL 109
Cdd:cd17489 14 LLLPVLPLYAHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 110 LAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNwqiMLFIITGLLVVMTLVFAVV 189
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA---VLFIVAAVLALLALLLVFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 190 IKGsqpqapaavsQTVAPAALAPEEDGQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLqQERGFegVAIGFSSALV 269
Cdd:cd17489 170 VKD----------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYA-AERGI--SNAGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 270 AFASVPGALFFSRMSDRFRNKKVqlIIFLELCAAVMLVCTVISPDSTMLLISLILYGlLGKLAVDPIMISFVADNAPKKG 349
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTV--IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYG-LGFGLLFPALQALAVDLVPPHR 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1540736099 350 YGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAAILLVGTAIF 400
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM-FLLAAVVVLLALVLY 363
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-400 |
2.80e-26 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 108.86 E-value: 2.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGcgsyYGSAYSL 125
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG----YGSVQPG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 126 SSENI----PLERRGLATAVINSGSALGMAIGliASSLLVKSFNMNWQIMLFIITGLLVVMTLVFAVVIKGSQ-PQAPAA 200
Cdd:cd17475 105 GGRAImrwfPPRERGLAMGIRQTGVPLGGALA--AALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPaASAATE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 201 VSQTVAPAALAPEEDGqasglfSLRMISAYAmyFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFF 280
Cdd:cd17475 183 SASTLLRSLKEVLRNR------DVWLIAIAG--ALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 281 SRMSDR-FRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAV--DPIMISFVADNAPKKGYGTSFGVF 357
Cdd:cd17475 255 GRVSDRvFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIgwNGLYLTLVAESAGPEQAGTALGLA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1540736099 358 NFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIF 400
Cdd:cd17475 335 NTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-395 |
1.18e-25 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 107.25 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 11 KKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFII 90
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGL-SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 91 ATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSEnipLERRgLATAVINSGSA---LGMAIG-LIASSLLVKSFNM 166
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA---LGPE-TAASRLNLLHAffsLGALLGpLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 167 NWQIMLFIITGLLVVMTLVFAVVikgsqpqapaAVSQTVAPAALAPEEDGQASGLFSLRMISAYA-MYFATCYGYYMIVT 245
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRS----------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGlAIFLYVGAEGAIGD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 246 WLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqlIIFLELCAAVMLVCTVISPDSTMLLISLILY 325
Cdd:COG0738 232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL--LRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 326 GLLGKLAVdPIMISFVADNAPKKGyGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVmGFYISAAILLV 395
Cdd:COG0738 310 GLGLSLMF-PTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRA-AFLVPLVCYLL 376
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-401 |
4.43e-25 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 104.99 E-value: 4.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 14 VVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAH-SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGlSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLV--KSFNMNWQI 170
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIplLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 171 MlFIITGLLVVMTLvfavvikgsqpqapaavsqtvapaalapeedgqasgLFSLRMISAYAMYFATCYGYYMIVTWLPSF 250
Cdd:cd17316 161 L-FLIGALPALLAL------------------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 251 LQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGk 330
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFV- 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1540736099 331 LAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFF 401
Cdd:cd17316 283 GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-403 |
1.92e-23 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 100.81 E-value: 1.92e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 13 IVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGW-SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNATSLTMVYAGS-LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNmnWQIM 171
Cdd:cd17355 83 VLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG--WRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 172 LFIITGL-LVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLFSLRMISayamYFATCYGYYMIVTWLPSF 250
Cdd:cd17355 161 LLVLALLaLLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALA----FFLCGFAVVGLIVHLVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 251 LQqERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDSTMLLISLILYGLLGk 330
Cdd:cd17355 237 LA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA-LRALGLALLLLLPFPPLALLLFAALFGLGW- 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 331 LAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17355 314 GATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-403 |
1.29e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 95.33 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17474 16 SIVDPILPAIAEALGA-SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVksfNMNWQIMlFIITGLLVVMTLVFAV 188
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA---AISWRYP-FFLLAALIPVAFLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 189 VIKGSQPQAPAAVSQTVAPAALAPEEDGqasglfslRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSAL 268
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLRDLKKALRGR--------GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 269 VAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVcTVISPDSTMLLISLILYGLLGKLaVDPIMISFVADNAPKK 348
Cdd:cd17474 243 WSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLL-LGFVPSLALLLIAIVLFGLGLGL-NLPLLTTLVTELAPEE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 349 GYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAAILLVGTAIFFTV 403
Cdd:cd17474 321 ERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLLALL 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-283 |
3.56e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 92.95 E-value: 3.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 11 KKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFII 90
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGA-SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 91 ATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQI 170
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 171 MLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSF 250
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270
....*....|....*....|....*....|...
gi 1540736099 251 LQQERGFEGVAIGFSSALVAFASVPGALFFSRM 283
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
46-400 |
3.57e-21 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 94.61 E-value: 3.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNAT--SLTMVYAGSLLAGMGCGSYYGSAY 123
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 124 SLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSfnMNWQiMLFIITGLLVVmtLVFAVVIkgsqpqapaavsq 203
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCES--LGWP-SIFYIFGGLGL--LWCLLWF------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 204 tvapaalapeedgqasgLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRM 283
Cdd:cd17318 196 -----------------FLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 284 SDRFRNKKVQLIIFLE--------LCAAVMLVCTV-ISPDSTMLLISLILYGLLGKLAVDPIMISFVaDNAPKKGyGTSF 354
Cdd:cd17318 259 ADWLRSRGILSTTTVRklftsigfLGPGVFLIALGyLGSNATLAVVFLTLSVGLSGACYSGFLVNHL-DLAPNYA-GTLM 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1540736099 355 GVFNFFGMSSSVIAPFLTGVI---SDSTGSKVMGFYISAAILLVGTAIF 400
Cdd:cd17318 337 GITNTAATIAGIISPLIVGAIvknDQTIGQWRIVFFISAAIYILGAIFY 385
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-380 |
1.92e-20 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 92.05 E-value: 1.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 19 LGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNA 98
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGL-SKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 99 TSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIgLIASSLLVKSFNMNWQIMLFIITGL 178
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGL-LPPLVLFGIAELYSWHWVFIVPGII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 179 LVVMTLVFAVVIKGSqPQAP------------AAVSQTVAPAALAPEEDGQASGLFSLRMISAYAMYFATCYGYYMIVTW 246
Cdd:TIGR00881 160 AIIVSLICFLLLRDS-PQSCglppaeempneePDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 247 LPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFleLCAAVMLVCTVI-----SPDSTMLLIS 321
Cdd:TIGR00881 239 SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAV--FFMALIIVSLLVywlnpAANPLMDLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1540736099 322 LILYGLLGKlavDPIMI--SFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTG 380
Cdd:TIGR00881 317 LFALGFLVY---GPQMLigVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-406 |
2.31e-20 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 91.49 E-value: 2.31e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSL 125
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 126 SSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIitglLVVMTLVFAVVIKGSqpqapaavsqtv 205
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF--GWRSVFLL----GGVPPLILLPLLRGT------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 206 apaalapeedgqasglfslrmISAYAMYFATCYGYYMIVTWLPSfLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSD 285
Cdd:cd17365 174 ---------------------LLLWVTFFMGLLLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 286 RFRNKKVQLIIFleLCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSS 365
Cdd:cd17365 232 RFGPKRVLALFF--ALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGA 309
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1540736099 366 VIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTVNVL 406
Cdd:cd17365 310 ILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
46-375 |
3.75e-20 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 91.65 E-value: 3.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSL 125
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNAL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 126 SSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIITGLLVVMTLVFAVVI------------KGS 193
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF--GWRSLFYVGGIAPLLLLLLLMRFLpesidflvskrpETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 194 QPQAPAAVSQTVAPAALAPEEDGQA------------SGLFSLRMISAYAMYFATCYGYYMIVTWLPsFLQQERGFEGVA 261
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALPEQKSTqgtkrsvfkalfQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 262 IGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDP-IMISF 340
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYaLMALF 366
|
330 340 350
....*....|....*....|....*....|....*
gi 1540736099 341 VADNAPKKGYGTSFGVfnffGMSSSVIAPFLTGVI 375
Cdd:TIGR00895 367 YPTAIRATGVGWAIGI----GRLGAIIGPILAGYL 397
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-407 |
4.07e-20 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 91.21 E-value: 4.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 19 LGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNA 98
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGL-DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 99 TSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLL--VKSFNMNWQIMLF--I 174
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpLLPPEIAWRVLFLlgA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 175 ITGLLVVMtlvfavvIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLFSLRMISAYAMYFATC--YGYYMIVTWLPSFLQ 252
Cdd:cd17371 165 LPALLVLF-------IRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGalGGYYGITTWLPSYLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 253 QERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKvqLIIFLELCAAVMLVCTVISPDSTMLLisLILYGLLGKLA 332
Cdd:cd17371 238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN--NFALFALGSAISILLYFFLPLSPTLI--LILGFPLGFFA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1540736099 333 VDPI--MISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGskvmgfyISAAILLVGTAIFFTVNVLM 407
Cdd:cd17371 314 SGPFsgMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGS-------LGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
17-401 |
1.21e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 86.84 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 17 LCLGWAVIWIYRTVLTPIFPEIQQTIGaHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG 96
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLG-LSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFIIT 176
Cdd:cd17478 80 FAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 177 GLLVvmtlvfAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLFSLRMISayamyFATCYGYYMIVTWLPSFLQQeRG 256
Cdd:cd17478 159 GLAV------ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIV-----FLRSWVLSSLTTFLPFYLVQ-RG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 257 FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLavdPI 336
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV-IIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF---PV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 337 MISFVADNAPKKgYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAAILLVGTAIFF 401
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-401 |
8.86e-18 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 84.59 E-value: 8.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 14 VVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATL 93
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLI-DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 94 LIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSlLVKSFNMNWQiMLF 173
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGG-LVAQATGGWR-WAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 174 IITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDgqASGLFSLR-MISAYAMYFATCYGYYMIVTWLPSFLQ 252
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD--LKALAKNPsFILSTLGFTAVSFVTGALAFWAPTFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 253 QERG----FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQliIFLELCAAVMLVCT-------VISPDSTMLLIS 321
Cdd:cd17328 236 RAFGvgdlSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPR--ADPLVCAVGLLAAApflflalVLALSNLLLAWV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 322 LILYGLLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMS-SSVIAPFLTGVISDSTGSK-----------VMGFYIS 389
Cdd:cd17328 314 LLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLlGDAGSPYLIGLISDLLRQNkdsplaeaaslQYALLLC 393
|
410
....*....|..
gi 1540736099 390 AAILLVGTAIFF 401
Cdd:cd17328 394 SFVLVLGGFFFL 405
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-400 |
1.30e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.76 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 17 LCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG 96
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGA-SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIIT 176
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRW---IFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 177 GLLVVMTLVFAVVIKGsqpqapaavsqtvapaalapeedgqasglfslrmisAYAMYFATCYGYYMIVTWLPSFLQQERG 256
Cdd:cd17321 157 VPIGLVALLLARTFSG------------------------------------AVLAAFLLGAALGGLLFLLPLYLQGVLG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 257 FEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqLIIFLELCAAVMLVCTVISPDSTM--LLISLILYGLLGKLAVD 334
Cdd:cd17321 201 YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLV-LVAGLLLTAVGLLLLALLGADSSVwlLLPGLVLLGLGLGLFAT 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1540736099 335 PIMISFVAdNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIF 400
Cdd:cd17321 280 PLTNAALS-SVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAF 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
29-403 |
1.40e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.78 E-value: 1.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17473 16 AAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERR----GLATAVINSGSALGMAIGLIASSLlvksfnmNWQiMLFIITGL-LVVMT 183
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERakmlGLQSAAMSLGGVVFLLLGGALAEI-------GWR-APFLVYLLaLPVLI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 184 LVFAVVIKGSQPQAPAAVSQTVAPAALAPeedgqasglfsLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIG 263
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAATAAALPW-----------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 264 FSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFleLCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVdPIMISFVAD 343
Cdd:cd17473 237 LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF--ALMALGFLLLALASGLWVVLLGAILAGLGFGLLL-PTLNSWAMS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 344 NAPKKGYGTSFGVFN---FFGMSSSviaPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17473 314 LVPPELRGRAMGIVTsafFLGQFLS---PLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-402 |
2.20e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 80.31 E-value: 2.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAHSNAeMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17320 16 DMYLPALPAIARDLGASASA-VQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIITGLLVVMTLVFAV 188
Cdd:cd17320 95 FLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF--GWRAIFVFLALLGLLLLLLVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 189 VIKGSQPQAPAAVSQTVAPAALAPeedgqasgLFSLRMISAYAMYFATCYGYYMI-VTWLPSFLQQERGFEGVAIGFSSA 267
Cdd:cd17320 173 FLPETLPEEKRKPLLSSLLRAYKR--------VLKNRRFLGYALALGLSFAGLFAyLAAAPFIYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 268 LVAFASVPGALFFSRMSDRFRNKKV--QLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISFVADNA 345
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRLlrLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1540736099 346 PKKGyGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSkVMGFYISAAILLVGTAIFFT 402
Cdd:cd17320 325 PHVA-GTASALLGFLQFLIGALAGALVGLLPNGTAL-PMGLLILVLGLLALLLLILL 379
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-401 |
2.30e-16 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 79.95 E-value: 2.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 64 MQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMgcGSYYGSAYSLSSENIPLERRGLATAVIN 143
Cdd:cd17472 48 FQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 144 SGSALGMAIGLIASSLLVKSFNMNWqimLFIITGLLVVMTLVFAV-VIKGSQPQapaavsqtvaPAALAPEEDGQASGLF 222
Cdd:cd17472 126 ASIGIAFAISMVLGPLLAAHLGVSG---LFLITAILSLVSLLILLfFVPDPPKI----------VQISEKEKKKLKKLLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 223 SLRMISAYAMYFATCYGYYMIVTWLPSFLQQeRGFEGVAIGFSSALVAFASVPGALFFSRMSDRfRNKKVQLIIFLELCA 302
Cdd:cd17472 193 NKRLLRLDFSIFILHFVLMAFFYILPLLLTQ-LGGGKGQLWKVYLPAILIGFILMVPFVIYAEK-KGKMKQVFVSSILLI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 303 AVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSK 382
Cdd:cd17472 271 AVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYS 350
|
330
....*....|....*....
gi 1540736099 383 VMGFYISAAILLVGTAIFF 401
Cdd:cd17472 351 SVFLTILILALLWLLVSFL 369
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-403 |
2.89e-16 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 79.96 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 48 AEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAG-SLLAGMGCGSYYGSAYSLS 126
Cdd:cd17353 38 ASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGyGVLGGIGAGIGYITPVSTA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 127 SENIPlERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIITGLLV-VMTLVFAVVIKGSQPQAPAAVSQTV 205
Cdd:cd17353 118 VKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT---TFLILGIIFlIIIVIGAFLIRDPPKGWVPPGVDPL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 206 APAALAPEEDGQASGLF-SLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMS 284
Cdd:cd17353 194 ANNAENSPRDYTPREMLrTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 285 DRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGklAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSS 364
Cdd:cd17353 274 DKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYG--GGFALFPALTADFFGTKNAGTNYGLLYTAKGVG 351
|
330 340 350
....*....|....*....|....*....|....*....
gi 1540736099 365 SVIAPFLTGVIsDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17353 352 GLIGPIIAAYV-LYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-191 |
1.07e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.92 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 14 VVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATL 93
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 94 LIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLF 173
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT---PF 357
|
170
....*....|....*...
gi 1540736099 174 IITGLLVVMTLVFAVVIK 191
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
46-327 |
3.93e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 73.46 E-value: 3.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSL 125
Cdd:PRK11551 48 DVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 126 SSENIPLERRGLATAVINSGSALGmaiGLIASSL-LVKSFNMNWQiMLFIITGL--LVVMTLVFAVVIKGSQPQAPAAVS 202
Cdd:PRK11551 128 TSEAVGPRLRGTAVSLMYCGVPFG---GALASVIgVLAAGDAAWR-HIFYVGGVgpLLLVPLLMRWLPESRAFAQAAGAG 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 203 QTVAPAALAPEEDGQASGLFSLrmisaYAMYFATCYGYYMIVTWLPSFLqQERGFEGVAIGFSSALVAFASVPGALFFSR 282
Cdd:PRK11551 204 KQRAPVLRALFGEGRATATLLL-----WISYFFTLIVLYFLLNWLPSLL-VGQGLSRSQAGLVQIAFNIGGALGSLLIGA 277
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1540736099 283 MSDRFRNKKVQLIIFLELCAAvmLVCTVISPDSTMLLISLILYGL 327
Cdd:PRK11551 278 LMDRLRPRRVVLLIYAGILAS--LAALAAAPSFAGMLLAGFAAGL 320
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-402 |
9.36e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 72.26 E-value: 9.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 53 IASFYFFAYTGMQIP----AGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSE 128
Cdd:cd17329 36 IVGLVLALSAVAGIVasliGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 129 NIPLERRGLATAVINSGSALGMAIG-LIASSLLVKSFNmnwqiMLFIITGLL-VVMTLVFAVVIKGSQPQAPAAvsqtva 206
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIGpLLGGLLLLYSFR-----LLFLAAAVLfLLAALVLLFLLPETRPKRRAA------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 207 paalapEEDGQASGLFSLRMISAYAMYFATCYGYYMIVTW----LPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSR 282
Cdd:cd17329 185 ------EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQlestLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVAR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 283 MSDRFRNKKvqLIIFLELCAAVMLVCTVISPDSTMLLISLILYGlLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGM 362
Cdd:cd17329 259 LVERFRLRK--ILMIGILLFAIGFAVLAFANTLAVLILAMIVLT-LGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWG 335
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1540736099 363 SSSVIAPFLTGVISDSTGSKvMGFYISAAILLVGTAIFFT 402
Cdd:cd17329 336 LGRAIGPLVGGLLLDLLGPG-LPWLILAALGLIAAALLLG 374
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
29-395 |
1.93e-13 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 1.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIpgFCLFIIAT-LLIGNATSLTMVYAG 107
Cdd:cd17339 16 TSVGPLLPEIRDDLGL-SASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLL--LALLLLAAgILLRSLGGIALLFLG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 108 SLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFIITGLLVVMTLVFA 187
Cdd:cd17339 93 TALAGAGIAVGNVLLPSLIKRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGGGWRGALAIWALPALLALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 188 VVIKGSQPQAPAAVSQTVapaalapeedgqaSGLFSLRMISAYAMYFA-TCYGYYMIVTWLPSFLQqERGFEGVAIGFSS 266
Cdd:cd17339 172 PQLRRRKRAAAAAAPLTK-------------ISVWRSPLAWQVTLFMGlQSLLFYTLMAWLPTILI-DAGLSAATAGWLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 267 ALVAFASVPGALFFSRMSDRFRNKKVqLIIFLELCAAVMLVCTVISPdSTMLLISLILYGLLGKLAVdPIMISFVADNAP 346
Cdd:cd17339 238 SLFQLVGIPASLLVPILATRLKNQRP-IVVLLAVLFIIGVLGLLFAP-TALALLWAVLLGLGGGAAF-SLALTLISLRSS 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 347 kkgygTSFGVFNFFGMSSSV------IAPFLTGVISDSTGSKVMGFYISAAILLV 395
Cdd:cd17339 315 -----DPAEAAALSGMAQSVgyllaaLGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-403 |
2.95e-13 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 70.66 E-value: 2.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 34 IFPEIQQTIGaHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAG-SLLAG 112
Cdd:cd17352 25 LFVELLEEFG-ESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 113 MGCGSYYGSAYSLSSeNIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMlFIITGLLVVMTLVFAVVIKg 192
Cdd:cd17352 104 LGLGLIYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNY--GWRGA-LLILGGLCLNLCVCGLLLR- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 193 sqpqapaavsqtvapaalapeedgqasgLFSLR--MISAYAMYFATcYGYYMIVTWLPSFLqQERGFEGVAIGFSSALVA 270
Cdd:cd17352 179 ----------------------------LLKDPtfVLLALGVSFAM-LGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 271 FASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGlLGKLAVDPIMISFVADNAPKKGY 350
Cdd:cd17352 229 ISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFG-FCSGSYSSLTPVILADLVGLEKL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 351 GTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17352 308 SNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-402 |
2.97e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 2.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 45 HSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLI-----PGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYY 119
Cdd:cd06173 31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIladllRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 120 GSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIITGLLVVMTLVFAVVIKGSQPQAPA 199
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG---AFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 200 AVSQTVAPAALAPEEDGQASGLfsLRMISAYAMYFATCYGYYMIVtwLPSFLQQERGFEGVAIGFSSALVAFASVPGALF 279
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRRSPL--LRLLLLALALFALLGGALTVL--LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 280 FSRMSDRFRNKKvqLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGkLAVDPIMISFVADNAPKKGYGTSFGVFNF 359
Cdd:cd06173 264 LGRLSKRRRRGR--LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAG-GLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1540736099 360 FGMSSSVIAPFLTGVISDSTGSkVMGFYISAAILLVGTAIFFT 402
Cdd:cd06173 341 LNSGAMPLGALLAGLLADALGL-SAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
13-399 |
4.08e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 70.13 E-value: 4.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 13 IVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:cd17314 4 VLYVSFLLSAMSTGFILSWSLFYQPWQDAFGY-SSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNA-TSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAIGLIASSLLVKSfnMNWQIM 171
Cdd:cd17314 83 TYLSYVfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVF--YGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 172 LFIItGLLVVMTLVFAVVIKGSQPQapaavsqtVAPAALAPEEDGQASGLFSLRMISAYAM---YFATCYGYYMIVTWLP 248
Cdd:cd17314 160 YTIL-GILAAIVLSVVSLLGFKEPP--------DNQARLHVQKKKTQTMGEIFRDKVFWILfiaIFLVLIGGFLFIANMA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 249 SFLqqeRGFEGVAIGFSSALVAFASVP---GALFFSRMSDRFRNKKVQLIIFLELcAAVMLVCTVIS---PDSTMLLISL 322
Cdd:cd17314 231 SLV---RSLQLDAPSFVTKLMSIYGLFnafGRLLWGIVADFFGGRLSTLSILLTI-LGLGLCAFLFLlkmTPVGLVLTGS 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 323 ILYGLLGKL-AVDPIMISFVADNAPkkgYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAI 399
Cdd:cd17314 307 LLGFSYGGLfTVYPATVSTVFGTES---FATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAI 381
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
80-419 |
4.38e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 4.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 80 VLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIP-LERRGLATAVINSGSALGMAIGLIASS 158
Cdd:COG2211 89 IPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPP 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 159 LLVKSFNMN----WQIMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTvapaalapeedGQASGLFSLR-MISAYAMY 233
Cdd:COG2211 169 PLVAAFGGDaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLK-----------ESLKALLKNRpFLLLLLAY 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 234 FATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISP 313
Cdd:COG2211 238 LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL-LAALGLLLLFFLGP 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 314 DSTMLLISLILYGLLGKLAVDPIMISFVADNAP-------KKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTG------ 380
Cdd:COG2211 317 GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaa 396
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1540736099 381 --------SKVMGFYISAAILLVGTAIFFTVNVLMKRTTPTRTATEA 419
Cdd:COG2211 397 qspsaltgIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-403 |
8.22e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.14 E-value: 8.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17503 13 TIVNVALPTIMGDLGA-SLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIITGLLVVMTLVFAV 188
Cdd:cd17503 92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW---IFYINLPIGILALLLAP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 189 VIKgsqpqapaavsqtvapaaLAPEEDGQasglFSLRMISAYAMYFatcyGYYMIVTWLPSFLQQERGFEGVAIGFSSAL 268
Cdd:cd17503 169 LLD------------------LRLFKDRN----FTLGLLLSFLLGL----GLFGAMFLLPLYLQNVLGYSAFESGLVLAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 269 VAFASVPGALFFSRMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDSTMLLIS--LILYGLLGKLAVDPIMISFVADNAP 346
Cdd:cd17503 223 GGLASAILSPLVGRLLDKFGPRLLLLAGLL-LLALGTLLLAFLTPDTSLWLIIlpLFIRGLGMGLVFMPLNTLALNSLPP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 347 KK-GYGTS-FGVFNFFGMS--SSVIAPFLTGVISD--STGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:cd17503 302 EQiGDATAlFNTIRQLGGSigTALLATLLTNRTQFhhSRLSELLAQQVQKQALIIAFNDAFLV 364
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-401 |
9.03e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 69.11 E-value: 9.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 32 TPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGK-KVVLIPGFCLFIIATLLIGNATSLTMVYAGSLL 110
Cdd:cd17370 19 RSILPLFLVVLGA-SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPLLALAGSWQLVLLLRIL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 111 AGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQ--IMLFIITGLLVVMTLVFaV 188
Cdd:cd17370 98 ERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRtiFLLAAIPALLALLILLF-V 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 189 VIKGSQPQAPAAVSQTVAPAALAPeedgqasglfSLRMISAYAMYFATCYGYYMivtwLPSFLQQERGFEGVAIGFSSAL 268
Cdd:cd17370 177 VKEYPRPPKLRKKSKKTSLKKLPK----------AFWLYLLAVALFALGNFSFA----FLILRAQELGLSAALIPLLYAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 269 VAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVctVISPDSTMLLISLILYGLlGKLAVDPIMISFVADNAPKK 348
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF--ALGSSLWLLLLGFILWGL-YMGAQESIERAAVADLVPAE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 349 GYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVmGFYISAAILLVGTAIFF 401
Cdd:cd17370 320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA-AFLFSAVLALIALLLLL 371
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
26-404 |
1.41e-12 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 68.48 E-value: 1.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 26 IYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVY 105
Cdd:cd06180 13 IGRFAYTPLLPLMLAELGL-SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 106 AGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAI-GLIASSLLVKSfnMNWQIMLFIITGLLVVMTL 184
Cdd:cd06180 92 ALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGG--LSWRAGWLALALLSAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 185 VFAVVIkGSQPQAPAAVSqtvapaalAPEEDGQASGLFSLRMISayamYFATCYGYYMIVTWLPSFLQQERGFEGVAIGF 264
Cdd:cd06180 170 LSFLLL-RRGPSAPTEAS--------AAESAPGLNRPLWRLALA----YGLFGFGYIITATFLPLIARETGAGSLLAGLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 265 SSaLVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLvcTVISPDSTMLLISLILYGlLGKLAVDPIMISFVADN 344
Cdd:cd06180 237 WS-LFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLL--PLLSPGPAGLVLSAVLFG-GTFMAITALVMALAREL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 345 APkKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTVN 404
Cdd:cd06180 313 AP-PAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
13-395 |
1.43e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 68.45 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 13 IVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIAT 92
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGL-SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 93 LLIGNATSL-----TMVYAGsLLAGMG---CGSYYGSAYSLSSeniplerRGLATAVINSGSALGMAIGLIASSLLVKSF 164
Cdd:cd17312 83 IFMGFSTSLwffavLWGLNG-LFQSMGwppCVKLLGNWFSKKE-------RGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 165 NmnWQiMLFIITGLLVvmtLVFAVVIKgsqpqapaavsqtvapaalapeedgqasglFSLRMISAYAMYFATCYGYYMIV 244
Cdd:cd17312 155 G--WR-AAFLVPGIVG---LVVAIILF------------------------------FFLRDSPPYVWVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 245 -----TWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCtVISPDSTMLL 319
Cdd:cd17312 199 ryaclDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLA-LFWFFPHNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 320 ISLILYGLLGKLAVDPIMI---SFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTG-SKVMGFYISAAILLV 395
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLiggAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGwSTVFYFLISAALLSV 357
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
16-375 |
1.82e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 68.12 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 16 VLCLGWAVIWIYRTVLTPIFPEIQQTigahSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLI 95
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNL----NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 96 GNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAIG-LIASSLLVKSFNMNWqimLFI 174
Cdd:cd17333 79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGpLIATSLLTSELSWSW---AYL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 175 ITGLLVVMTLVFAVVIKGSQPQapaAVSQTVAPAALAPEEDGQASGLFSLRMISAYAMYFAtcYGYYMIVTWLPSFLQQE 254
Cdd:cd17333 155 IIGLIYLLLAILILLTLFPELP---SARNPQQSVGAFSASASRLLRNPSIILGALALFLYV--GAETAFSSWVPSYLVEK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 255 RGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFleLCAAVMLVCTVISPDSTMLLISLILYGlLGKLAVD 334
Cdd:cd17333 230 KHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSG--SGALLGLLILLLAPTLVVGLVATALLG-LFMAALF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1540736099 335 PIMISFVADNAPKKGYGTSfGVFNFFGMSSSVIAPFLTGVI 375
Cdd:cd17333 307 PTILSLGISNLPYAKGKGT-SVLLAAGSIGGAIIPFIMGFI 346
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
69-399 |
1.19e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 66.11 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 69 GILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSgsal 148
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVS---- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 149 GMAIGLIASSLLVKSFN--MNWQIMLFIitGLLVVMTLVFavvIKGSQPQAPAAVSQTVAPAALAPEEDGQAS-----GL 221
Cdd:PRK12307 150 GFGIGNIIAAYFMPSFAeaYGWRAAFFV--GLLPVLLVIY---IRARAPESKEWEEAKLSGKGKHSQSAWSVFslsmkGL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 222 FSLRMISAYAMYFATCYGYY----MIVTWLPSFLQQErGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIif 297
Cdd:PRK12307 225 FNRAQFPLTLCVFIVLFSIFganwPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSI-- 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 298 lELCAAVMLVCTVIS-PDSTMLLISLILYGLLG-KLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVI 375
Cdd:PRK12307 302 -GLLMSFLFIFPLFRiPQDNYLLLGACLFGLMAtNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWL 380
|
330 340
....*....|....*....|....*....
gi 1540736099 376 SDSTGSKVMGFYISAA-----ILLVGTAI 399
Cdd:PRK12307 381 GITMGLGAALTFIVAFwtatiLLIIGLSI 409
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
19-399 |
6.92e-11 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 63.41 E-value: 6.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 19 LGWAVIWIYRTVLTPIFPEIQQTIGaHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIG-- 96
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYG-LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfv 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 --NATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFI 174
Cdd:cd17345 89 psATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 175 ITGLLVVMTLVFAVVIKGSQPQA----PAAVSQTVAPAALAPEEDGQAsglFSLRMI---------SAYAMYFATCYGY- 240
Cdd:cd17345 169 FPAIIAIIVAVIVLFLGKDTPESeglpPIEEYKGDYPEEADGEEEEQE---LSAWEIfvkyvlknkLLWYIAIANVFVYl 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 241 --YMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDR-FRNKKVQLIIFlelCAAVMLVCTVISPDSTM 317
Cdd:cd17345 246 vrYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKlFKGRRAPTGII---FMILVIVALIVYWLAPN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 318 LLISLILYGLLGKLAVDPIMISFVA--DNAPKKGYGTSFGVFNFFG-MSSSVIAPFLTGVISDSTG--SKVMGFYISAAI 392
Cdd:cd17345 323 VLVDLIALIALGFLIYGPVMLIGLQalELVPKKAAGTAAGLTGLFGyLGGSVLATALIGIIVDHFGwnGGFIVLLASCIL 402
|
....*..
gi 1540736099 393 LLVGTAI 399
Cdd:cd17345 403 AIIFLAL 409
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-188 |
1.12e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 63.03 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 15 VVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAemGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLL 94
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNS--TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 95 IGNATSLTMVYAGSLLAGMGCGSyYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFI 174
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYI 157
|
170
....*....|....
gi 1540736099 175 ITGLLVVMTLVFAV 188
Cdd:cd06179 158 NAIFNALALILLFF 171
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-399 |
5.17e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.65 E-value: 5.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 45 HSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYS 124
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 125 LSSENIPLERRGLATAVINSGSALGMAIG-LIASSLLVKSFnmnwqiMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSq 203
Cdd:cd17477 108 WLNALATNENRGRVLGLYSTVLGLGFALGpLLLALVGTAGA------LPFLIAAVLLLLALVPLLLTRRAAPEIEEAES- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 204 tvapaalapeedgqaSGLFSLRMISAYAMYFATCYGYYM--IVTWLPSFLQQErGFEGVAIGFSSALVAFASVPGALFFS 281
Cdd:cd17477 181 ---------------ISLRRLLRIAPLALLGAFVAGFLEgaFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 282 RMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGklAVDPIMISFVADNAPKKGYGTSFGVFNFFG 361
Cdd:cd17477 245 WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAG--PLYTLALALAGDRLPGDELVAANAALLLLY 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 1540736099 362 MSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAI 399
Cdd:cd17477 323 GLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-372 |
1.04e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.52 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 68 AGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSA 147
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 148 LGMAIgliasSLLVKSFNMNWQIMLFIITGLLVVMTLVFAVVIKgsqpqapaavsqtvapaalapeedgqasglfslRMI 227
Cdd:cd17317 125 LGYML-----LALLAYLIRDWRWLQLAISLPGLLFLLLLWWLPR---------------------------------RTI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 228 SAYAMYFATCYGYYMIVTWLPSFlqqergfeGVAIGFSSALVAFASVPGALFFSRMSDRFRnKKVQLIIFLELCAAVMLV 307
Cdd:cd17317 167 IVGLIWFVTSLVYYGLSLNSSNL--------GGNLYLNFFLSGLVEIPAYFLALLLLDRLG-RRWTLSGSLLLAGLACLV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 308 CTVISPDSTMLLISLILYGLLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLT 372
Cdd:cd17317 238 TALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV 302
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-152 |
1.23e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.22 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 10 WKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFI 89
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 90 IATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAI 152
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
230-403 |
1.45e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 230 YAMYFATCYGYYMIVTWLPSFLQQErGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqLIIFLELCAAVMLVCT 309
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRL-LLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 310 ViSPDSTMLLISLILYGLLGKlAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGsKVMGFYIS 389
Cdd:cd17325 80 F-ATSYWQLLLARFLQGLASA-AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVC 156
|
170
....*....|....
gi 1540736099 390 AAILLVGTAIFFTV 403
Cdd:cd17325 157 AALALLALVLALLL 170
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
50-403 |
2.31e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 58.82 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 50 MGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVY---AGSLLAGMGCGSYYGSAYSLS 126
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYqliVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 127 SENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMN-WQIMLF--IITGLLVVMTLVFA------VVIKGSQPQA 197
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDgWRIPLGlqLVPALLLIIGLLFLpesprwLVEKGRLEEA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 198 ---------PAAVSQTVAP-----AALAPEEDGQASGLFSL-----RMISAYAMYFATCYGYYMIVTWLPSFLQQERGF- 257
Cdd:pfam00083 208 revlaklrgVPDVDRELDEikdslEAGQEAEKASWKELFSTktrrqRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLs 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 258 EGVAIGFSSALVAFASVPGALFFsrmSDRFRNKKVQLIiflelCAAVMLVCTVI------------SPDSTMLLISLILY 325
Cdd:pfam00083 288 DSFLVTIIVGVVNFVFTFIAIFL---VDRFGRRPLLLL-----GAAGMAICFVIlgivallgvsksDWAGIVAIVFIALF 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 326 GLLGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTV 403
Cdd:pfam00083 360 IAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFV 437
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-401 |
3.24e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 3.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 232 MYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqlIIFLELCAAVMLVCTVI 311
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV--LLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 312 SPDSTMLLISLILYGLlGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAA 391
Cdd:pfam07690 82 ASSLWLLLVLRVLQGL-GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA-FLILAI 159
|
170
....*....|
gi 1540736099 392 ILLVGTAIFF 401
Cdd:pfam07690 160 LSLLAAVLLL 169
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
46-403 |
4.82e-09 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 57.83 E-value: 4.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKF-GKKVVLIPGFCLFIIATLLIGNAT-SLTMVYAGSLLAGMGCGSYYGSAY 123
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYvFKWSIGIGMFLSSVISIVIPWAAGgGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 124 SLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSfNMNWQiMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQ 203
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCES-WGGWP-MIFYVFGIVGCAWSLLWFVFPADDPSIHPCISK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 204 TVApAALAPEEDGQASG----------LFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSAL-VAFA 272
Cdd:TIGR00894 232 FEK-KYINSSLQGQKGStrqslpikaiPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLpYLFA 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 273 SVPGALF-----FSRMSDRFRNKKVQLII--FLELCAAVMLVCTV-ISPDSTMLLISLILYGLLGKLAVDPIMISFVaDN 344
Cdd:TIGR00894 311 WLCSIFAgyladFLKSSKTLSLTAARKIFngIGGLGPGIFAYALPyLSAAFYLTIIILTLANAVSSGPLAGVLINSL-DL 389
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1540736099 345 APKKgYGTSFGVFNFFGMSSSVIAPFLTGVI--SDSTGSKVMGFYISAAILLVGTaIFFTV 403
Cdd:TIGR00894 390 APRF-LGFIKGITGLPGFIGGLIASTLAGNIlsQDSKNVWLIVFLIMAFVNILCV-IFYLI 448
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
250-405 |
4.94e-09 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 57.86 E-value: 4.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 250 FLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqliIFLELCAAVMLVCTVISPDSTMLLisLILYGLLG 329
Cdd:COG2270 264 YAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRV---ILVSLVIWIVVCLAAYFLTTALAF--WILGLLIG 338
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1540736099 330 kLAVDPIMI---SFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAILLVGTAIFFTVNV 405
Cdd:COG2270 339 -LVMGGIQAlsrSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKV 416
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
51-403 |
7.05e-09 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 57.10 E-value: 7.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 51 GLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVY--AGSLLAGMGCGSYYGSAYSL-SS 127
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYliAVRALEGLGEGVTFPAMHAMwAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 128 ENIPLERRGLATaVINSGSALGMAIGLIASSLLVksFNMNWqIMLFIITGLLVVMTLVFAVVikgsqpqapaavsqtvap 207
Cdd:cd17381 148 WAPPLERSRLLT-ISYAGAQLGTVVSLPLSGLIC--YYLDW-TYVFYIFGAVGLLWFFLWIW------------------ 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 208 aalapeedgqasglFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRF 287
Cdd:cd17381 206 --------------LVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 288 RNK---------KVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISFVaDNAPKKGyGTSFGVFN 358
Cdd:cd17381 272 REKqnfstvcvrKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHL-DIAPSYA-GILLGITN 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1540736099 359 FF----GMSSSVIAPFLTGviSDSTGSKVMGFYISAAILLVGtAIFFTV 403
Cdd:cd17381 350 TFatipGMVGPVIAKSLTH--NNTVEEWQTVFYISAAINVFG-AIFFTI 395
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-399 |
1.19e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 56.43 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17504 13 TMLSPALPTIQREFGT-SAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGcGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKsfNMNWQIMLFIITGLLVVMTLVFAV 188
Cdd:cd17504 92 ALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ--HLGWRWIFWTAAPVAVLLAALVPL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 189 VikgsqpqapaavsqtvapaalapeedgQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQER----GFEGVAIGF 264
Cdd:cd17504 169 I---------------------------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 265 SSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKL--AVDPIMISFVA 342
Cdd:cd17504 222 LLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAfaSLPNIVVESVP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1540736099 343 DNAPKKGYGTSFGVFNFFGMSSSVIA---------PFLTGVISDSTGSKVmGFYISAAILLVGTAI 399
Cdd:cd17504 302 PDRTGIATGMNTVLRTIGSAIGPAIAgailttytvSITSGGVPTEGAYVL-AFLIGAALALAALLL 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-187 |
1.65e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 10 WKKIVVVLCLGWAVIWIYRTVLTpIFPEIQQTIGAHSNAEMGLIASFYFFAYT-GMQIPAGILVDKFGKKVVLIPGFCLF 88
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLY 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 89 IIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNW 168
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
170
....*....|....*....
gi 1540736099 169 qimLFIITGLLVVMTLVFA 187
Cdd:cd17474 356 ---PFLVGAAIALAAAVLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
25-397 |
2.14e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.69 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 25 WIYRTVLTPIFPEIQQTIGAHSNAeMGLIASFYFFAYTGMQIPAGILVDKFGK-KVVLIPGFCLFIIATLLIGNATSLTM 103
Cdd:cd17490 9 WFSQYVYVPFLSPYAESLGASLSM-IGIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPSPWG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 104 VYAGSLLAGMGcGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNwqiMLFIITGLLVVMT 183
Cdd:cd17490 88 LLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMR---APFLLAALAGVLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 184 LVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQasgLFSLRMISAYAMYFATCYGYymivtwLPSFLQQErGFEGVAIG 263
Cdd:cd17490 164 FILSLFIKEERREKKPVLTELKELLSVLKDKKLL---FFSLLAILQQMITFSTTFGF------TPLIAKQL-GASSFQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 264 FSSALVAFASVPGALFF-SRMSDRFRNKKVQLIIFLELCAAVMLVCTVisPDSTMLLISLILYGLLGKLaVDPIMISFVA 342
Cdd:cd17490 234 LLSIIYLLPNALASLLSgTLFYKKLGERNTIIIGFLLLGAYCFLIPFA--PNLTLLYLLQALNGFGTGI-LFPLLMSLSI 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 343 DNAPKKGYGTSFGVFNFF---GMSssvIAPFLTGVISDSTGsKVMGFYISAAILLVGT 397
Cdd:cd17490 311 EGVPAEQRSTAMGFFQAIyalGMF---LGPVLVGIISEAFG-LQTGFFVIGVIALLAA 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-184 |
2.48e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 9 YWKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLF 88
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 89 IIATLLIGNA--TSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIG--LIASSLLVKSF 164
Cdd:cd17316 254 GILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAppLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 1540736099 165 NMNWQIMLFIITGLLVVMTL 184
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
224-401 |
5.30e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 5.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 224 LRMISAYAMYFATCYGYYMIVTWLPsFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqlIIFLELCAA 303
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV--LLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 304 VMLVCTVISPDSTMLLISLILYGLLGKLAVdPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKV 383
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170
....*....|....*...
gi 1540736099 384 MgFYISAAILLVGTAIFF 401
Cdd:COG2814 166 V-FLVNAVLALLALLLLL 182
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
29-188 |
6.64e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 54.11 E-value: 6.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAHSNaeMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17502 13 TIVATALPTIVAEFGGLSL--VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNW---------QIMLFIITGLL 179
Cdd:cd17502 91 AIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWcfyinlpigGLALALLRTIL 170
|
....*....
gi 1540736099 180 VVMTLVFAV 188
Cdd:cd17502 171 LSSIFGFLF 179
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
51-401 |
7.07e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.12 E-value: 7.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 51 GLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGsYYGSAYSLSSENI 130
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 131 PLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMnwqIMLFIITGLLVVMTLVFAVVIkgsqpqapaavsqtvapaal 210
Cdd:cd17330 116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY---ALPFLVAAALALLNLVLVLFF-------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 211 apeedgqasgLFSLRMISAYAMYFATCYGYYMIVtwLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRfRNK 290
Cdd:cd17330 173 ----------LPPLRRLLLVYFLIALAFAGLESV--FSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAK-RLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 291 KVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVdPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPF 370
Cdd:cd17330 240 ERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF-PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPL 318
|
330 340 350
....*....|....*....|....*....|.
gi 1540736099 371 LTGVISDSTGsKVMGFYISAAILLVGTAIFF 401
Cdd:cd17330 319 LAGPLYSFLG-PGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
64-402 |
1.28e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.41 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 64 MQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNA-TSLTMVYAGSLLAGMGCGSYYGSAYSLsSENIPLERRGLATAVI 142
Cdd:cd17341 50 LRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLGFAGANFASGQPWA-SFWFPKEKIGGAAGGI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 143 ----NSGSALGMAIG-LIASSLLVKSFNMNWQiMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPaalapeedgQ 217
Cdd:cd17341 129 agagNMGVAVSQLLApLIAGAIVFDGGFVGWR-NAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKV---------Q 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 218 ASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIF 297
Cdd:cd17341 199 LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 298 LELCAAVMLVCTVISPDSTMLLISLILYGLLGKLA-----VDPIMISFVAdnapKKGYGTSFGVFNFFGMSSSVIAPFLT 372
Cdd:cd17341 279 IVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAgagngSVFRMVPFIF----RRELGAVTGLVGAIGGLGGFFLPLLF 354
|
330 340 350
....*....|....*....|....*....|
gi 1540736099 373 GVISDSTGSKVMGFYISAAILLVGTAIFFT 402
Cdd:cd17341 355 GSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
29-402 |
1.42e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.04 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAHSNAEM----GLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMV 104
Cdd:cd17391 13 SLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 105 YAGSLLAGMGCGsYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQimlFIITGLLVV--- 181
Cdd:cd17391 93 LILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNV---FFITGGLLFlaf 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 182 -MTLVFavVIKGSQPQAPAAVSQTVAPAALAPEEDGQASgLFSLRMISAYAMYfatcygyyMIVTWLPSFLQQERGFEGV 260
Cdd:cd17391 169 lLTLFF--VKEDFKPVEKKKMVSTKEVWNSVPNPSLLIS-LFVTTFIIQLANQ--------SIEPILTLYIRQLMGDASN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 261 aIGFSSALVAFASVPGALFFS----RMSDRFRNKKVqLIIFLeLCAAVMLVCTVISPDSTMLLISLILYGLlGKLAVDPI 336
Cdd:cd17391 238 -LAFISGLVFSATGVSSLLSAprlgKLGDRIGHHRI-LLGAL-LASALLYIPQAFVQTPWQLGILRFLLGL-ATGGLLPA 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1540736099 337 MISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAAILLVGTAIFFT 402
Cdd:cd17391 314 INSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAV-FVVTALLVLLNAIWSFI 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
46-200 |
2.07e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNAT-SLTMVYAGSLLAGMGCGSYYGSAYS 124
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFA 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1540736099 125 LSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNmNWQIMLFIITGLLVVmTLVFAVVIKGSQPQAPAA 200
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALV-ALVLTLLLYRRPRRAAAA 392
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
44-401 |
3.34e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 52.14 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 44 AHSNAEMGLIASFYFFAYTGMQIPAGILV-----DKFGKKVVLIpgFCLFI--IATLLIGNATSLTMV--YAGSLLA--- 111
Cdd:cd17369 35 PAVDPAAGTLAAFATFGVGFLARPLGGVVfghfgDRIGRKKTLV--LTLLLmgIATFLIGLLPTYAQIgiLAPILLVllr 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 112 ---GMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIG----LIASSLLVKSFNMNWQIML-FIITGLLVvmt 183
Cdd:cd17369 113 llqGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAtgvfLLLSALLSDEAFLSWGWRIpFLLSAVLV--- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 184 lVFAVVIKGSQPQAPAAVSQTVAPAALAPEEDGQASGLfSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGF---EGV 260
Cdd:cd17369 190 -AVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRH-WRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVdrsTVL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 261 AIGFSSALVAFASVPgalFFSRMSDRFRNKKVQLI--IFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMI 338
Cdd:cd17369 268 LAVLIASVVAAITIP---LFGWLSDRVGRRPVYLAgaLLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAA 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 339 SFVADNAPKKGY-GTSFGvFNFFGMSSSVIAPFLTGVISDSTGSKV-MGFYISAAILLVGTAIFF 401
Cdd:cd17369 345 FLAELFPTRVRYtGASLG-YQLGAILGGGFAPLIATALVAATGSWWpVALYLAALAVISLVAALF 408
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
66-186 |
3.96e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 51.81 E-value: 3.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 66 IPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSG 145
Cdd:cd17358 59 LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLL 138
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1540736099 146 SALGMAIGLIASSLLvksfnmNWQIMLFIITGLLVVMTLVF 186
Cdd:cd17358 139 VNIGILLGYVLGSFL------PWRTLALIGAIPPVVFLILL 173
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
57-403 |
5.93e-07 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 51.09 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 57 YFFAYTGMQIPAGILVDKFG-KKVVLIPGFCLFIIATLLIGNATS--LTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLE 133
Cdd:cd17398 48 YMLTYIPLIFPATWLLEKYGlRVTVLLGSFLNCLGAWLKLFSSSPdlFWVAMAGQTICALAQVFILGIPPRLAAVWFGPD 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 134 RRGLATAVINSGSALGMAIGLIASSLLVKS------FNMNWQIMLFIITGllvVMTLVFAVVIKGSQPQAPAAVSQ-TVA 206
Cdd:cd17398 128 EVSTATAIGVFGNQLGVALGFVLPPLLVPNsenkdeIGKGLSILFYGVAG---ICTALFILVIIFFKEKPPIPPSRaQAA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 207 PAALAPEEDGQASGLFSLRMISAYaMYFATCYG-----YYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFS 281
Cdd:cd17398 205 AQELRSEDQSYLGSLKRLFKNKGF-LLLLITYGintgvYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAG 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 282 RMSDRFRNKKVQLIIFLeLCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVD--PIMISFVADNAPKKGYGTSFGVFNF 359
Cdd:cd17398 284 IWLDKTKKYKETTIIVY-ILSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGylPVGFEFAAELTYPEPEGTSSGLLNA 362
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1540736099 360 FGMSSSVIAPFLTGVISDSTGSKVmGFYISAAILLVGTAIFFTV 403
Cdd:cd17398 363 SAQIFGIIFTLVMGALLDKVGALA-SNIVLSVALLLGTILTAFI 405
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-117 |
6.71e-07 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 51.06 E-value: 6.71e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1540736099 57 YFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGS 117
Cdd:PRK11652 52 YLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGV 112
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-190 |
1.94e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 9 YWKKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLF 88
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 89 IIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNW 168
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170 180
....*....|....*....|..
gi 1540736099 169 qimLFIITGLLVVMTLVFAVVI 190
Cdd:cd06173 365 ---VFLLAGALLLLAALLLLLL 383
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
36-189 |
2.28e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 36 PEIQQTIGAhSNAEMGLIASFYFFAYT-GMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMG 114
Cdd:cd17490 219 PLIAKQLGA-SSFQLGLLSIIYLLPNAlASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFG 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1540736099 115 CGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWqimLFIITGLLVVMTLVFAVV 189
Cdd:cd17490 298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT---GFFVIGVIALLAAILSLA 369
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
250-405 |
3.17e-06 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 49.19 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 250 FLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFlelcaavMLVCTVISPDSTMLLISL------- 322
Cdd:pfam11700 309 FAKTELGMSTSQLTLLNIVAMIAAVLGAFLWPFVSRRFNLKTKQTLIA-------CIVLFELIPLYGLLGIILgkiglkn 381
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 323 --------ILYGLL--GKLAVDPIMISFVAdnaPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYISAAI 392
Cdd:pfam11700 382 pwefwvlqAFYGLVlgGLRSYSRSLYSELI---PRGKEAQFFSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAIL 458
|
170
....*....|...
gi 1540736099 393 LLVGTAIFFTVNV 405
Cdd:pfam11700 459 LVVPLPLLLLVDV 471
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
22-403 |
4.23e-06 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 48.55 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 22 AVIWIyrtVLTPIFPEIQQTIGAHSNaEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLL----IGN 97
Cdd:cd17334 17 AMQWI---TFSPIADEARTFFDLSAS-QINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLkcipLGQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 98 ATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFIITG 177
Cdd:cd17334 93 QPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPKGTKKEFGAVFYG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 178 LLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEE----DGQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQ 253
Cdd:cd17334 173 EFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVilelQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLAQILL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 254 ERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAV----MLVCTVISPDSTMLLISLiLYGLLG 329
Cdd:cd17334 253 PFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVctffMLLVDRYGLPYVTLAFYL-LCGLLG 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1540736099 330 --KLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgfYISAAILLVGTAIFFTV 403
Cdd:cd17334 332 ffQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESK--YLLWFILCTVGSCLGAL 405
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
12-401 |
5.44e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 48.10 E-value: 5.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 12 KIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNaEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIA 91
Cdd:cd17343 3 TIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKS-DLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 92 TLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIM 171
Cdd:cd17343 82 TVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY--GWRST 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 172 LFIITGLLVVMTLVFAVVIKGSQ-----PQAPAAVSQtvAPAALAPEEDGQASGLFS---LRMISayAMYFATCYGYYMI 243
Cdd:cd17343 160 LSISGTVAVVMSVVCLLFIKNEPsdvglNNIEEEESK--GKKKKSPRGESTLKELLLspfLWLLS--LGYLVVFGVKTAV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 244 VTWLPSFLQQERGFEG-VAIGFSSALVA---FASVPGALFFSRMSDRFRNKK-------VQLIIFLELCAAVMLVCTVIS 312
Cdd:cd17343 236 TDWGQLFLIQDKGQSAlTGSSFMSSLEVggfVGSIAAGYLSDWAVAKHGSSSrgnprmpLALVFMAGLTVSLHLFRVHIT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 313 PDSTMLLISLILYgLLGKLAVDPIMISFVA--DNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKvMGFYISA 390
Cdd:cd17343 316 SDSSELFILLLGF-LIGFSLYGPIAIFGVIanESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWR-TAFLLLE 393
|
410
....*....|.
gi 1540736099 391 AILLVGTAIFF 401
Cdd:cd17343 394 ILCAITVVILF 404
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-258 |
8.90e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 47.71 E-value: 8.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 36 PEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGC 115
Cdd:PRK10473 27 PRIAADLNA-SEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 116 GSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQiMLFIITGLLVVMTLVFAV-VIKGSQ 194
Cdd:PRK10473 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKF--PWQ-SLFYTMAAMGILVLLLSLfILKETR 182
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1540736099 195 PQApaavsqtvAPAALAPEEDGQASgLFSLRMISAYAMyfaTCYGYYMIVTWL---PSFLQQERGFE 258
Cdd:PRK10473 183 PAR--------APAASSKPRENSES-LLNRFFLSRLVI---TTLSVTVILTFVntsPVLLMEQMGFS 237
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-186 |
1.15e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 47.26 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 52 LIASFYFFAYTGMQIpAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLT---MVYAGSLLAGMGCGSYYGSAYSLSSE 128
Cdd:cd17357 54 IVSIFFIGGAIGSFI-SAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIACGLSTGFVPMYLQE 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 129 NIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNWQIMLFIITGLLVVMTLVF 186
Cdd:cd17357 133 ISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAAL 190
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
36-401 |
1.67e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.48 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 36 PEIQQTIGAhSNAEMGL-IASFYFFAYTGMQIpAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMG 114
Cdd:cd17393 23 PAIKDRLGL-SDAALGLlLLALGVGALVAMPL-AGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 115 CGSyygSAYSLSSENIPLERRgLATAVINS----GSALGMAIGLIASSLLVKSFNMNWQIMLFIITGLLVVMTLVFAVvi 190
Cdd:cd17393 101 NGA---LDVAMNAQGVAVERA-YGRPIMSSlhamWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRAL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 191 kgsqpqapaavsQTVAPAALAPEEDGQASGLFSLRMISAY---AMYFATCYGYYMIVTWLPSFLQQERGFEGvaigfSSA 267
Cdd:cd17393 175 ------------LPGTGEAAEDRPDGAGKPGFLLPNRLLLllgLLALAAALAEGAAADWSALYLRDVLGASA-----ALA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 268 LVAFASVPGALFFSRMS-DRFRNK--KVQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGlLGKLAVDPIMISFVADN 344
Cdd:cd17393 238 ALGYAVFSLAMTVGRLFgDRLVDRfgDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMG-LGLSVVVPLAFSAAGAL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 345 APKKGyGTSFGVFNFFGMSSSVIAPFLTGVISDSTG-SKVMGFYISAAILLVGTAIFF 401
Cdd:cd17393 317 PGLAA-GIAVARVATLGYLGFLVGPPLIGFLADATGlRTAFLVVALLALLVALLARAV 373
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
68-186 |
2.82e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.03 E-value: 2.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 68 AGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSA 147
Cdd:cd17315 54 GGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMIT 133
|
90 100 110
....*....|....*....|....*....|....*....
gi 1540736099 148 LGMAIGLIASSLLVKSFNMNWQIMLFIITGLLVVMTLVF 186
Cdd:cd17315 134 FGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLM 172
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
14-111 |
3.53e-05 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 45.68 E-value: 3.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 14 VVVLCLGWAvIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATL 93
Cdd:cd17394 1 LALVTSLFF-LWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGAL 79
|
90
....*....|....*...
gi 1540736099 94 LIGNATSLtMVYAGSLLA 111
Cdd:cd17394 80 LFIPAASL-RTYGLFLIA 96
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
67-414 |
3.60e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.07 E-value: 3.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 67 PAGILVDKFGKKVVLIP------GFCLFIIATLLIGNatsLTMVYAGSLLagMGCGS-YYGSA-YSLSSENIPLERRGLA 138
Cdd:PRK08633 66 PAGFLADKFSKNRVIRIvklfevGLTLLIVLAYYLGW---FWLAFAVTFL--LGAQSaIYSPAkYGIIPELVGKENLSRA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 139 TAVINSGSALGMAIGLIASSLLV-KSFNMNWQIML---FIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEE 214
Cdd:PRK08633 141 NGLLEAFTIVAILAGTALFSFLFeSVNGNTPSEILgriAPAGLVLLAVAVLGLIFAYRLPKVPAAAPEVFDKKKYLFPKL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 215 DGQA-SGLFSLR--MISAYAMYFATCYGYYMIVTwLPSFLQQERGF-EGVAIGFSSALVAFASVPGALFFSRMSDRfrnk 290
Cdd:PRK08633 221 LWRNlKLLRSDRvlWLAIIGLSYFWFISQLAQAN-FPAYAKEVLGLdNTFQVQYLLAASAIGIGIGSLLAGRLSGR---- 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 291 KVQLIIF----LELCAAVMLVCTVISPDSTMLLisLILYGLLGKLAVDPIMiSFVADNAPKKGYGTSFGVFNFFGMSSSV 366
Cdd:PRK08633 296 HIELGLVplgaLGLALSLFLLPTAPSLASVLVL--FFLFGFSAGLFIVPLN-ALIQFRAPEKELGKVLAANNFLQNVGML 372
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1540736099 367 IAPFLTGVISDSTGSKVMGFYISAAILLVGTAI------FFTVNVLMKRTTPTR 414
Cdd:PRK08633 373 LFLALTTLFSGLGLSPAGLFYLIALVTLIGTLYtllllpDSLLRFLLLLLMHTR 426
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-186 |
5.58e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 5.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 12 KIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDK-FGKKVVLIPGFCLFII 90
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 91 ATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNmNWQI 170
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF-GLTG 361
|
170
....*....|....*.
gi 1540736099 171 MLFIITGLLVVMTLVF 186
Cdd:cd06174 362 AFLVLAVLLLLAAILL 377
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
31-197 |
1.33e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 31 LTPIFPEIQQTIGAHSNAEMGLI-ASFYFFAYTGMQIpaGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSL 109
Cdd:PRK03893 39 ITLVLTEVQGEFGLTTVQAASLIsAAFISRWFGGLLL--GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 110 LAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFnmNWQIMLFIitGLLVVmtlVFAVV 189
Cdd:PRK03893 117 VIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVW--GWRALFFI--GILPI---IFALW 189
|
....*...
gi 1540736099 190 IKGSQPQA 197
Cdd:PRK03893 190 LRKNLPEA 197
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
69-411 |
1.75e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 43.44 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 69 GILVDKFGKKVVLIPGFCLFIIATLLI---------GNATSLTMVYAgSLLAGMGCGSYYGSAYSLSSENIPLERRGLAT 139
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIavtptyatiGIWAPIILLLA-RLLQGLSVGGEYGTSATYLSEVAPPGRRGFYS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 140 A----VINSGSALGMAIGLIASSLL----VKSFnmNWQImLFIITGLLVvmtlVFAVVIKGSQPQAPAavsqTVAPAALA 211
Cdd:cd17367 140 SfqyvTLIGGQLLALGVLLVLQHTLgedqMAAW--GWRI-PFLLGGVLA----VVVLWLRRGLEETES----FEAIAESN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 212 PEEDGQASGLfsLRMISAYAMYFATCYG----YYMIVTWLPSFLQQERGF---EGVAIGFSSALVAFASVPgalFFSRMS 284
Cdd:cd17367 209 EASAGTLREL--RRHPRELLLVVGLTAGgtlaFYTWTTYLQKFLVNTAGFskgDATWITTAALLVFMLLQP---LGGRLS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 285 DRFRNKKVQLIIF-LELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISFVADNAPKK----GYGTSFGVFN- 358
Cdd:cd17367 284 DRIGRRPLLLFFGiGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHvralGVGLPYALAVa 363
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1540736099 359 FFGMSSSVIAPFLTGVISDStgskvmGFYISAAILLvgtAIFFTVNVLMKRTT 411
Cdd:cd17367 364 IFGGTAPYVALWLKSIGHEW------VFFWYVAGLI---AISLVVYLRMPETR 407
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
239-405 |
1.98e-04 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 43.41 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 239 GYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFR--NKKVQLIIflelcaavmLVCTVISPDST 316
Cdd:cd17483 291 GINTISSTAVLFAKSQLHMSTLQLILIGLLTPITAILGAFFFPRIQRRFNlsTKTMLMLI---------VVLTALIPLYG 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 317 MLLISLILYGLLGKLAVDPIMISFVADNAPKKGYGTS--------------FGVFNFFGMSSSVIAPFLTGVISDSTGSK 382
Cdd:cd17483 362 LLGFFTGKFGLKHPWEMYVLAVWFGFFLGGLQSYSRSlfselippgheaefFSLFSITDKGSSWIGPLVVGAIIDATGNI 441
|
170 180
....*....|....*....|...
gi 1540736099 383 VMGFYISAAILLVGTAIFFTVNV 405
Cdd:cd17483 442 RYGFIFLFALFVLPLPLLWFVNV 464
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
29-186 |
2.21e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.95 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 29 TVLTPIFPEIQQTIGAHSNAeMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGS 108
Cdd:cd17323 16 SIYSPALPQIAEDFHVSEEV-ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1540736099 109 LLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNMNW-QIMLFIITGLLVVMTLVF 186
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWiFWFLAIISGFCLILIFLF 173
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
46-184 |
4.46e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 42.34 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSL 125
Cdd:cd17362 37 SSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVY 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1540736099 126 SSENIPLERRGLATAVINSGSALGMAIGLIASSLLVKSFNmNWQIMLFIITGLLVVMTL 184
Cdd:cd17362 117 IAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVG-GWRYMYGLAAPPALLLGI 174
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
224-403 |
8.44e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 8.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 224 LRMISAYAMYFATCYGYYMIVTWLPSfLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVqLIIFLELCAA 303
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV-LLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 304 VMLVCtVISPDSTMLLISLILYGLLGKLAVdPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKV 383
Cdd:COG0477 92 ASLLC-GLAPSPELLIAARALQGIGAGGLM-PGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180
....*....|....*....|
gi 1540736099 384 MgFYISAAILLVGTAIFFTV 403
Cdd:COG0477 170 I-FLINAPLGLLALVLRLRL 188
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
46-295 |
8.50e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.19 E-value: 8.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 46 SNAEMGLIASFYFFAYTGMQIPAGILV-----DKFGKKVVLIPGFCLFIIATLLIG--------NATSLTMVYAGSLLAG 112
Cdd:cd17366 33 GDPTAQLLATFATFAVAFLVRPLGGLVfgplgDKYGRQKVLAITIILMAASTFCIGllptyatiGVWAPILLLLARMVQG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 113 MGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLI---ASSLLVKSFNMN---WQIMLFIITGLLVVmtlvf 186
Cdd:cd17366 113 FSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGlvtLLTLLLTEAQMLdwgWRIPFLIAAPLGLV----- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 187 avvikgsqpqapaavsqtvapaalapeedgqasGLFSLR-MISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFS 265
Cdd:cd17366 188 ---------------------------------GLYLRRpLLICIGLVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLV 234
|
250 260 270
....*....|....*....|....*....|
gi 1540736099 266 SALVAFASVPGALFFSRMSDRFRNKKVQLI 295
Cdd:cd17366 235 IIIIMVTMLVLQPFLGRLSDRVGRKPVYAA 264
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-176 |
1.78e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.38 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 69 GILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSAL 148
Cdd:TIGR00898 148 GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSL 227
|
90 100
....*....|....*....|....*....
gi 1540736099 149 G-MAIGLIAssllvkSFNMNWQIMLFIIT 176
Cdd:TIGR00898 228 GlVLLPLVA------YFIPDWRWLQLAVS 250
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
68-399 |
1.99e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.02 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 68 AGILVDKFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSA 147
Cdd:cd17396 55 AGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFP-KASGSANILVKAFVS 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 148 LG-MAIGLIASSLLVKsfNMNWQIMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAALAPEedgqasgLFSLRM 226
Cdd:cd17396 134 FGqFLLPFIIAFLAAN--NLWYGWSFIVPAAVLVLNALLLLKLSFPPQTVTAANTKQKEIPVKREKP-------KFLIEG 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 227 ISAYAMYFATCYGYYMIVTWLPSFLQQergFEGVAIGFSSALVAFASVpGALFFSRMSDRFRNKKVQLIIFLEL-----C 301
Cdd:cd17396 205 IALILIGFTSTATFYLFSQWMPKYGSA---VAGMGEAESLKLISYYSM-GSLVCVFITAVLLKRYVRPIWILVLypiisL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 302 AAVMLVCTVISPDSTMLLISLILYGLLGklAVDPIMISFVADNAPkKGYGTSFGVFNFFGMSSSVIAPFLTGVIsDSTGS 381
Cdd:cd17396 281 LALFVLYLVPSPDVCILGAFVIGFFAAG--GVLQLGLTLMAEFFP-KGKGKVTGIYMIASSLANFVIPLITGII-ASAIG 356
|
330
....*....|....*...
gi 1540736099 382 KVMGFYISAAILLVGTAI 399
Cdd:cd17396 357 IAYIFLFDFGIALLGLLL 374
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
268-402 |
2.01e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 39.90 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 268 LVAFASVPGALFFSRMSDRFRNKKVqliIFLELCAaVMLVCTVIS--PDSTMLLISLILYGL-LGklAVDPIMISFVADN 344
Cdd:cd17482 232 LTQFVAFPGALLFGWLAERFGAKRA---ILVSLVI-YILICIYAYfmLTAWDFWILAALIGLvQG--GIQALSRSLFGRL 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 345 APKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFyISAAILLVGTAIFFT 402
Cdd:cd17482 306 IPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTGSSRYGI-LSLIVLFVIGGILLA 362
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
19-161 |
2.12e-03 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 40.02 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 19 LGWAVIWIYR--TVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLipGFCLFIIATLLIG 96
Cdd:cd17382 18 LGVAIVRMVNnfTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVF--GLAIFVTSTLNML 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 97 NATSLTM----VYAGSLLAGMGCGSYYGSAYSLSSE-NIPLERRGLATAVInSGSALGMAIGLIASSLLV 161
Cdd:cd17382 96 IPIAARVhygcVIFVRILQGLVEGVTYPACHGIWRKwAPPLERSRLATTAF-CGSYAGAVVGMPLSGILV 164
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
239-403 |
2.83e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 239 GYYMIVTWLPSFLQQeRGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVISPdsTML 318
Cdd:cd17489 11 SFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 319 LISLILYGLlGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMgFYISAAILLVGTA 398
Cdd:cd17489 88 LVLRLIHGI-GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL-FIVAAVLALLALL 165
|
....*
gi 1540736099 399 IFFTV 403
Cdd:cd17489 166 LVFLV 170
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
34-115 |
3.49e-03 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 39.49 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 34 IFPEIQQTIGAhSNAEMGLIASFYFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLLI---GNATSLTMVYAGSLL 110
Cdd:PRK10133 48 LLPQFQQAFTL-TNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFwpaAEIMNYTLFLVGLFI 126
|
....*..
gi 1540736099 111 --AGMGC 115
Cdd:PRK10133 127 iaAGLGC 133
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
232-403 |
4.20e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 232 MYFATCYGYYMIVTWLPSFLQQErGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVI 311
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 312 SPdsTMLLISLILYGLlGKLAVDPIMISFVADNAPKKGYGTSFGVFNFFGMSSSVIAPFLTGVISDS-TGSKVMGFYISA 390
Cdd:cd06174 83 SF--WLLLLGRFLLGL-GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAA 159
|
170
....*....|...
gi 1540736099 391 AILLVGTAIFFTV 403
Cdd:cd06174 160 ALALLAAILLLLV 172
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
68-187 |
4.53e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 68 AGILVDKFGKKVVLIPGFCLFIIATLLI--GNATSLTMVYAGSLLaGMGCGSYYGSAYSLSSENIPLERRGLATAVINSG 145
Cdd:cd17371 265 GGFLADRIGRRNNFALFALGSAISILLYffLPLSPTLILILGFPL-GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNV 343
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1540736099 146 SALGMAIGLIASSLLVKSFNMNWQIMLFIITGLLVVMTLVFA 187
Cdd:cd17371 344 GRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
11-307 |
4.95e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 38.92 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 11 KKIVVVLCLGWAVIWIYRTVLTPIFPEIQQTIGAHSNAEMGLIASFYFFAYTGMQIPAgILVDKFGKKVVLipgfcLFII 90
Cdd:PRK10091 2 KKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIA-LFSSRYSLKHIL-----LFLV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 91 ATLLIGNA-----TSLTMVYAGSLLAGMGCGSYYGSAYSLSSENIPLERRGLATAVINSGSALGMAIGLIASSLLvkSFN 165
Cdd:PRK10091 76 ALCVIGNAmftlsSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYL--SQE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 166 MNWQIMLFIIT--GLLVVMTLVFAVvikgsqPQAPAavsqtvapaalapEEDGQASGLFS-LRMISAYAMYFATCYGYYM 242
Cdd:PRK10091 154 FSWRYTFLLIAvfNIAVLASIYFWV------PDIRD-------------EAKGGLREQFHfLRSPAPWLIFAATMFGNAG 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1540736099 243 IVTW---LPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLV 307
Cdd:PRK10091 215 VFAWfsyIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLML 282
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
74-403 |
5.12e-03 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 38.91 E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 74 KFGKKVVLIPGFCLFIIATLLIGNATSLTMVYAG-SLLAGMGCGSYYGSAYSLSSENIPlERRGLATAVINSGSALGMAI 152
Cdd:cd17423 64 RYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCiGLLSGLGWALVFAPTMATVSRYFS-RRRSLATGLALTGVGLSSFA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 153 GLIASSLLVKSFNmnWQIMLFIITGLLVVMTLVFAVVIKGSQPQAPAAVSQTVAPAalapeedgQASGLFSLRMISAYAM 232
Cdd:cd17423 143 LSPLFQLLLDTYA--WRGALLLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAA--------FGLSLLTHRAFLRYAL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 233 YFATC-YGYYMIVTWLPSFLQqERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQLIIFLELCAAVMLVCTVI 311
Cdd:cd17423 213 ATTLInTGYFIPYVHLVAHAR-ALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 312 SPDSTMLLISLILYGLL-GKLAvdPIMISFVADNApkkGYGTSFGVFNFFGMSSSV---IAPFLTGVISDSTGSKVMGFY 387
Cdd:cd17423 292 AKVYGSLLALAVAYGFCaGALA--PLVFSVLPELV---GVERVLNATGLLQMIESVgglLGPPLSGWLRDITGDYTASFL 366
|
330
....*....|....*.
gi 1540736099 388 ISAAILLVGTAIFFTV 403
Cdd:cd17423 367 VAGSFLLLGSLILLTL 382
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
69-394 |
6.77e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.51 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 69 GILVDKFGKKVVLIPGFCLFIIATLLI---------GNATSLTMVYAgSLLAGMGCGSYYGSAYSLSSENIPLERRGLAT 139
Cdd:cd17368 61 GAYADRIGRKPAMTLTLAIMALGTLLIalaptyatiGIAAPLLVLLA-RLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 140 AVINSGSALGMAIGLIASSLLVKSFNMN------WQIMLFIitGLLVvmtLVFAVVIKGSQPQAPAAVSqtvAPAALAPE 213
Cdd:cd17368 140 SWQSASQQVAIVAGALVGYLLSLTLTAEalaewgWRIPFFI--GLLI---IPLGLWLRRSLEETEAFLE---RKARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 214 EDGQASGLFSLRMISAYAMYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASVPGALFFSRMSDRFRNKKVQ 293
Cdd:cd17368 212 ELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 294 LIIFLE--LCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVDPIMISfVADNAPKKGYGTSFG-VFNFFGMSSSVIAPF 370
Cdd:cd17368 292 LVITLAalVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVA-LVELFPVRVRSTGFSlVYALAVAIFGGFAQF 370
|
330 340
....*....|....*....|....*
gi 1540736099 371 LTGVISDSTGSKVM-GFYISAAILL 394
Cdd:cd17368 371 IVTWLIELTGSPLApAWYLMGAALL 395
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
57-399 |
9.68e-03 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 37.84 E-value: 9.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 57 YFFAYTGMQIPAGILVDKFGKKVVLIPGFCLFIIATLlIGNATSLTMVYAGSLLAGMGCG----------SYYGSAYSLS 126
Cdd:cd17456 48 YMLTYIPLIFPVAWLLDKRGLRVIALVGSALNCLGAW-IKTGSARPDLFPVTVLGQLVCSvaqvfilgmpSRIASVWFGS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 127 SEniplerRGLATAVINSGSALGMAIGLIASSLLVKSFN----MNWQI-MLFIITGLLVVMTLVFAVVIKGSQPQAPAAV 201
Cdd:cd17456 127 SE------VSTACSIGVFGNQLGVAIGFLLPPVLVPNIDdldeLAYHIsIMFYGTAAVATLLFILVIIVFQEKPKIPPSQ 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 202 SQTVAPAALAPEEDGQASGL-------FSLRMISayamYFATCYGYYMIVTWLPSFLQQERGFEGVAIGFSSALVAFASV 274
Cdd:cd17456 201 AQAAIQSIPSQDYSYLQSILrllknvnFILLVVS----YGLNTGCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGM 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540736099 275 PGALFFSRMSDRFRNKKvQLIIFLELCAAVMLVCTVISPDSTMLLISLILYGLLGKLAVD--PIMISFVADNAPKKGYGT 352
Cdd:cd17456 277 VGALISGIWLDRTKTYK-QTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLGFFMTGylPLGFEFAAELTYPESEGT 355
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1540736099 353 SFGVFNFFGMSSSVIAPFLTGVISDSTGSKVMGFYIsAAILLVGTAI 399
Cdd:cd17456 356 SSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFL-CAFLLVGTIL 401
|
|
| |
