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Conserved domains on  [gi|1534102283|gb|RSE15598|]
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DMT family transporter [Escherichia coli]

Protein Classification

DMT family transporter( domain architecture ID 11490012)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; similar to Escherichia coli biotin transporter and inner membrane transporter YicL

Gene Ontology:  GO:0006810|GO:0005886
PubMed:  11432728
TCDB:  2.A.7.3

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
11-273 1.34e-79

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


:

Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 241.83  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  11 WAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRgNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLF 90
Cdd:TIGR00950   1 WGTTGVVIGQYLEGQVPLYFAVFRRLIFALLLLLPLLRRR-PPLKRLLRLLLLGALQIGVFYVLYFVAVKRLPVGEAALL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  91 TVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWIGLLLVQLSNITFAIGMVGYKRLMETRP--MP 168
Cdd:TIGR00950  80 LYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGNLSINPAGLLLGLGSGISFALGTVLYKRLVKKEGpeLL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 169 QHNAfAWFYLGAFLVAVIAWFLLGNAQKMPqttLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLV 248
Cdd:TIGR00950 160 QFTG-WVLLLGALLLLPFAWFLGPNPQALS---LQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAEPLVALLL 235
                         250       260
                  ....*....|....*....|....*
gi 1534102283 249 NLAIWHQQPHWPTFITGALVILASL 273
Cdd:TIGR00950 236 GLLILGETLSLPQLIGGALIIAAVL 260
 
Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
11-273 1.34e-79

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 241.83  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  11 WAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRgNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLF 90
Cdd:TIGR00950   1 WGTTGVVIGQYLEGQVPLYFAVFRRLIFALLLLLPLLRRR-PPLKRLLRLLLLGALQIGVFYVLYFVAVKRLPVGEAALL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  91 TVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWIGLLLVQLSNITFAIGMVGYKRLMETRP--MP 168
Cdd:TIGR00950  80 LYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGNLSINPAGLLLGLGSGISFALGTVLYKRLVKKEGpeLL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 169 QHNAfAWFYLGAFLVAVIAWFLLGNAQKMPqttLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLV 248
Cdd:TIGR00950 160 QFTG-WVLLLGALLLLPFAWFLGPNPQALS---LQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAEPLVALLL 235
                         250       260
                  ....*....|....*....|....*
gi 1534102283 249 NLAIWHQQPHWPTFITGALVILASL 273
Cdd:TIGR00950 236 GLLILGETLSLPQLIGGALIIAAVL 260
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
1-278 1.16e-30

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 116.48  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283   1 MALLIITTILWAFSFSFyGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSL-----KTVGLYMLVGAMQLGVMYMLS 75
Cdd:COG0697     5 ILLLLLAALLWGSSFVA-IKLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLpplsrRDWLLLLLRGLLGLALAFLLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  76 FRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRY--DQVTDHFWIGLLLVQLSNITFAI 153
Cdd:COG0697    84 FLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGpgGGGGGGSLLGDLLALLAALSWAL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 154 GMVGYKRLMETRPMPQhnAFAWFYLGAFLVAVIAWFLLGNAqkMPQTTLQWGILVFLGVVASGIGYFMWNYGATQVDAGT 233
Cdd:COG0697   164 YTVLTRRLSRRLDPLT--LTFWQMLVGALLLLPLALLTGLP--LPLSAAAWLALLYLGLFGTALAYLLWFRALRRLGASR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1534102283 234 LGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRK 278
Cdd:COG0697   240 AAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALR 284
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
138-275 6.37e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 42.18  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 138 WIGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFllgnAQKMPQTTLQWGILVFLGVVASGI 217
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFT----GGKLVIPLKSWLALLYLGVLGTFL 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1534102283 218 GYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWV 275
Cdd:pfam00892  77 GFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
 
Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
11-273 1.34e-79

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 241.83  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  11 WAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRgNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLF 90
Cdd:TIGR00950   1 WGTTGVVIGQYLEGQVPLYFAVFRRLIFALLLLLPLLRRR-PPLKRLLRLLLLGALQIGVFYVLYFVAVKRLPVGEAALL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  91 TVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWIGLLLVQLSNITFAIGMVGYKRLMETRP--MP 168
Cdd:TIGR00950  80 LYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGNLSINPAGLLLGLGSGISFALGTVLYKRLVKKEGpeLL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 169 QHNAfAWFYLGAFLVAVIAWFLLGNAQKMPqttLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLV 248
Cdd:TIGR00950 160 QFTG-WVLLLGALLLLPFAWFLGPNPQALS---LQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAEPLVALLL 235
                         250       260
                  ....*....|....*....|....*
gi 1534102283 249 NLAIWHQQPHWPTFITGALVILASL 273
Cdd:TIGR00950 236 GLLILGETLSLPQLIGGALIIAAVL 260
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
1-278 1.16e-30

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 116.48  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283   1 MALLIITTILWAFSFSFyGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSL-----KTVGLYMLVGAMQLGVMYMLS 75
Cdd:COG0697     5 ILLLLLAALLWGSSFVA-IKLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLpplsrRDWLLLLLRGLLGLALAFLLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  76 FRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRY--DQVTDHFWIGLLLVQLSNITFAI 153
Cdd:COG0697    84 FLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGpgGGGGGGSLLGDLLALLAALSWAL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 154 GMVGYKRLMETRPMPQhnAFAWFYLGAFLVAVIAWFLLGNAqkMPQTTLQWGILVFLGVVASGIGYFMWNYGATQVDAGT 233
Cdd:COG0697   164 YTVLTRRLSRRLDPLT--LTFWQMLVGALLLLPLALLTGLP--LPLSAAAWLALLYLGLFGTALAYLLWFRALRRLGASR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1534102283 234 LGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRK 278
Cdd:COG0697   240 AAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALR 284
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
2-288 1.86e-08

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 54.44  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283   2 ALLIITTILWAFSFSFyGEYLAGHVDSYFAVLVRVGLAALVFLPFLRT--RGNSLKTVGLYMLVGAMqLGVMYMLSFRAY 79
Cdd:COG5006    12 LLVLLSALSVQLGAAL-AKLLFPGVGPLGVTALRLAFAALILLLIFRPwrRRLTRRDWLALLLYGVA-LAGMNLLFYLAI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283  80 LYLTVSELLLFTVLTPLYITLIydiMSKRRLRWgyaFSALLAVIGAGIIRYDQVTDH--FWIGLLLVQLSNITFAIGMVG 157
Cdd:COG5006    90 ARIPLGIAVALEFLGPLAVALL---GSRRRRDL---LWVALALAGVVLLLPVGLSGGslDPVGVLFALGAAACWALYILL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 158 YKRLMETRPMPQHNAFAwFYLGAFLVAVIAWFLLGNAQKMPQttlQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIM 237
Cdd:COG5006   164 GRRVGARLPGLTGLALG-MLVAALVLLPFGLPTAGPALLDPP---VLLLGLGVAVLSSVLPYSLEMVALRRLPARTFGIL 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1534102283 238 NNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRKWVAPRSSQTA 288
Cdd:COG5006   240 MSLEPAVAALAGWLVLGEVLTPLQWLGIALVVAASAGATLTARRRPPPAAA 290
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
138-275 6.37e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 42.18  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 138 WIGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFllgnAQKMPQTTLQWGILVFLGVVASGI 217
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFT----GGKLVIPLKSWLALLYLGVLGTFL 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1534102283 218 GYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWV 275
Cdd:pfam00892  77 GFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
3-130 1.60e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 41.03  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283   3 LLIITTILWAFSFsFYGEYLAGHVDSYFAVLVRVGLAALVFLPFL----RTRGNSLKTVGLYMLVGAMQLGVMYMLSFRA 78
Cdd:pfam00892   6 LALLAALIWAIYF-VFSKILLRRISPLTLTFWRFLIAGILLLPFAlftgGKLVIPLKSWLALLYLGVLGTFLGFLLYFYG 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1534102283  79 YLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRY 130
Cdd:pfam00892  85 LKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
OpgE COG2194
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ...
137-226 3.07e-03

Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441797 [Multi-domain]  Cd Length: 537  Bit Score: 39.07  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1534102283 137 FWIGLLLvqlsNITFaigmvgYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFLLGNAQKmpqtTLQWGILVFLGVVASG 216
Cdd:COG2194    18 LYFALFL----NLPF------WGRLLAILPLDGVNLLFLLSLPLLLLAALNLLLSLLAWR----YLFKPLLILLLLISAA 83
                          90
                  ....*....|
gi 1534102283 217 IGYFMWNYGA 226
Cdd:COG2194    84 ASYFMDFYGV 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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