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Conserved domains on  [gi|1499888761|gb|RMV04262|]
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AsnC family transcriptional regulator, partial [Pseudomonas syringae pv. tomato]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
11-102 3.26e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 101.78  E-value: 3.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761  11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHLSVDLHT-EEVT 89
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRlDEFA 82

                          90
                  ....*....|...
gi 1499888761  90 RKLEEkiilCPEV 102
Cdd:COG1522    83 EALAA----IPEV 91
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
11-102 3.26e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 101.78  E-value: 3.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761  11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHLSVDLHT-EEVT 89
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRlDEFA 82

                          90
                  ....*....|...
gi 1499888761  90 RKLEEkiilCPEV 102
Cdd:COG1522    83 EALAA----IPEV 91
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 11-102 1.36e-25

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 91.81  E-value: 1.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761   11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHlsVDLHTEEVTR 90
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVG--VTLENPDKLE 78

                           90
                   ....*....|..
gi 1499888761   91 KLEEKIILCPEV 102
Cdd:smart00344  79 EFLEKLEKLPEV 90
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-88 3.45e-15

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 66.71  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761   4 LKKNSTALDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHLSVDL 83
Cdd:PRK11169    5 KKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84


                  ....*
gi 1499888761  84 HTEEV 88
Cdd:PRK11169   85 GAPDV 89
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
12-52 3.60e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 58.15  E-value: 3.60e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1499888761  12 DAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLE 52
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-62 3.93e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 3.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1499888761  12 DAIDLKILSIMQANCLTTTSkLAEVLSMSETPCWRRLKRLEDEGFIEGYQA 62
Cdd:cd00090     6 DPTRLRILRLLLEGPLTVSE-LAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
11-102 3.26e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 101.78  E-value: 3.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761  11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHLSVDLHT-EEVT 89
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRlDEFA 82

                          90
                  ....*....|...
gi 1499888761  90 RKLEEkiilCPEV 102
Cdd:COG1522    83 EALAA----IPEV 91
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 11-102 1.36e-25

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 91.81  E-value: 1.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761   11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHlsVDLHTEEVTR 90
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVG--VTLENPDKLE 78

                           90
                   ....*....|..
gi 1499888761   91 KLEEKIILCPEV 102
Cdd:smart00344  79 EFLEKLEKLPEV 90
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-88 3.45e-15

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 66.71  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888761   4 LKKNSTALDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFVHLSVDL 83
Cdd:PRK11169    5 KKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84


                  ....*
gi 1499888761  84 HTEEV 88
Cdd:PRK11169   85 GAPDV 89
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
12-52 3.60e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 58.15  E-value: 3.60e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1499888761  12 DAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLE 52
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-57 2.80e-12

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 55.90  E-value: 2.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1499888761  14 IDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFI 57
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-62 3.93e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 3.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1499888761  12 DAIDLKILSIMQANCLTTTSkLAEVLSMSETPCWRRLKRLEDEGFIEGYQA 62
Cdd:cd00090     6 DPTRLRILRLLLEGPLTVSE-LAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 11-77 9.69e-05

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 38.92  E-value: 9.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499888761  11 LDAIDLKILSIMQANCLTTTSKLAEVLSMSETPCWRRLKRLEDEGFIEGYQAMLNKEALGFEVIAFV 77
Cdd:PRK11179    7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFI 73
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 11-58 2.92e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 2.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1499888761  11 LDAIDLKILSIMQANC-LTTTSKLAEVLSMSETPCWRRLKRLEDEGFIE 58
Cdd:COG2512    13 LLEDERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 28-58 3.67e-03

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 34.82  E-value: 3.67e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1499888761  28 TTTSKLAEVLSMSETPCWRRLKRLEDEGFIE 58
Cdd:COG1339    23 ISSSELAKRLGISQQTASRRLQELEDAGLIE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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