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Conserved domains on  [gi|1499888720|gb|RMV04221|]
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DnaB domain-containing protein [Pseudomonas syringae pv. tomato]

Protein Classification

replicative DNA helicase( domain architecture ID 11416751)

replicative DNA helicase unwinds the DNA duplex at the chromosome replication fork

EC:  3.6.4.12
Gene Ontology:  GO:0003678|GO:0003677|GO:0005524|GO:0016887|GO:0006269
PubMed:  10049800

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
25-432 1.17e-135

Replicative DNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 397.14  E-value: 1.17e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  25 FDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRI 100
Cdd:COG0305    19 LDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGEleevGG--AAYLAELAENVPSAANIEYYARI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 101 VLERSALRRVVEAAEVIKDSA-SESLPVADIIALAQQATADLRDLGApdRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GH 178
Cdd:COG0305    97 VKEKALLRRLIEAGTEIVELAyDEDEDVDELLDEAEQKIFEIAEKRS--SKGFVSISDILKEALERIEELYKNGGGItGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAcVDSGVG-LIVSMEMTKEELVTRGIASVGGVSLTRLDE 257
Cdd:COG0305   175 PTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAA-IKEGKPvAIFSLEMSAEQLVMRLLSSEARIDSSKLRT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 258 GhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTA 337
Cdd:COG0305   254 G-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRSENRQQEISEISRS 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PDSEEgqNGVTELIVGKCRHAK 413
Cdd:COG0305   333 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDeyynPDSED--KGIAEIIIAKQRNGP 410

                         410
                  ....*....|....*....
gi 1499888720 414 TGSCLVQQQGQYVRFVNFA 432
Cdd:COG0305   411 TGTVKLAFDGEYTRFENLA 429
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
25-432 1.17e-135

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 397.14  E-value: 1.17e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  25 FDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRI 100
Cdd:COG0305    19 LDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGEleevGG--AAYLAELAENVPSAANIEYYARI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 101 VLERSALRRVVEAAEVIKDSA-SESLPVADIIALAQQATADLRDLGApdRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GH 178
Cdd:COG0305    97 VKEKALLRRLIEAGTEIVELAyDEDEDVDELLDEAEQKIFEIAEKRS--SKGFVSISDILKEALERIEELYKNGGGItGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAcVDSGVG-LIVSMEMTKEELVTRGIASVGGVSLTRLDE 257
Cdd:COG0305   175 PTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAA-IKEGKPvAIFSLEMSAEQLVMRLLSSEARIDSSKLRT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 258 GhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTA 337
Cdd:COG0305   254 G-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRSENRQQEISEISRS 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PDSEEgqNGVTELIVGKCRHAK 413
Cdd:COG0305   333 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDeyynPDSED--KGIAEIIIAKQRNGP 410

                         410
                  ....*....|....*....
gi 1499888720 414 TGSCLVQQQGQYVRFVNFA 432
Cdd:COG0305   411 TGTVKLAFDGEYTRFENLA 429
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 25-432 1.44e-123

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 366.36  E-value: 1.44e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  25 FDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRI 100
Cdd:TIGR00665  22 IDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGEleevGG--LAYLAELASNVPSAANIEYYAEI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 101 VLERSALRRVVEAA-EVIKDSASESLPVADIIALAQQATADLRDlgAPDRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GH 178
Cdd:TIGR00665 100 VKEKAILRRLIQAGtEIVELAYDPTGDVEELLDEAEQKIFEIAE--SRTSKGFKSIKEILKEAVEEIEELYERKGGItGV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEG 258
Cdd:TIGR00665 178 PTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVMRMLSSESRVDSQKLRTG 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 259 hTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTAL 338
Cdd:TIGR00665 258 -RLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSGSGRSENRQQEVSEISRSL 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 339 KNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PDSEEgqNGVTELIVGKCRHAKT 414
Cdd:TIGR00665 337 KALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDeyynPDSED--KGIAEIIIAKQRNGPT 414

                         410
                  ....*....|....*...
gi 1499888720 415 GSCLVQQQGQYVRFVNFA 432
Cdd:TIGR00665 415 GTVKLAFLGEYTRFENLA 432
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 179-430 5.56e-104

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 309.83  E-value: 5.56e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEG 258
Cdd:cd00984     3 PTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLRTG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 259 HtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEG-LGIVVVDYIGLIAAEGAGQNRTLELGKISTA 337
Cdd:cd00984    83 R-LDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGgLGLIVIDYLQLIRGSKRAENRQQEVAEISRS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQNGVTELIVGKCRHAKTG 415
Cdd:cd00984   162 LKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEyyDKDSEDKGIAEIIIAKNRNGPTG 241

                         250
                  ....*....|....*
gi 1499888720 416 SCLVQQQGQYVRFVN 430
Cdd:cd00984   242 TVYLAFNPEYTRFTD 256
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 177-430 2.42e-101

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 303.18  E-value: 2.42e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 177 GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLD 256
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 257 EGhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKIST 336
Cdd:pfam03796  81 TG-QLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 337 ALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQnGVTELIVGKCRHAKT 414
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEyyNPKEPE-GKAEIIIAKQRNGPT 238

                         250
                  ....*....|....*.
gi 1499888720 415 GSCLVQQQGQYVRFVN 430
Cdd:pfam03796 239 GTVKLAFLGEYTRFEN 254
PRK05748 PRK05748
replicative DNA helicase; Provisional
 7-432 3.26e-94

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 291.86  E-value: 3.26e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   7 SLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPN---LPS-GGrtLAYAS 82
Cdd:PRK05748   13 SIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDqgdLEEvGG--LSYLA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  83 EIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSASES-LPVADIIALAQQATADLRDlgAPDRKDYYKYSEVLTP 161
Cdd:PRK05748   91 ELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPeDDADEILDEAEKKIFEVSE--RRNKSGFKNIKDVLVK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 162 VIDGIDSRFNGAKQL-GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAC-VDSGVgLIVSMEMTKEEL 239
Cdd:PRK05748  169 AYDRIEMLHNQTGDItGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATkTDKNV-AIFSLEMGAESL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 240 VTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQR-KEGLGIVVVDYIGLI 318
Cdd:PRK05748  248 VMRMLCAEGNIDAQRLRTGQ-LTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQeHGGLGLILIDYLQLI 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 319 AAEG-AGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PD 393
Cdd:PRK05748  327 QGSGrSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDdyydEE 406

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1499888720 394 SEEgqNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFA 432
Cdd:PRK05748  407 TEN--KNTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 195-379 2.36e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  195 KNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVgLIVSMEMTKEElvtrgiasvggvsltrldeghtlqdedwpkitsAVN 274
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGV-IYIDGEDILEE---------------------------------VLD 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  275 VLHHSKLFVCDEEGMTAARIRsTARQVQRKEGLGIVVVDYIGliAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQ 354
Cdd:smart00382  48 QLLLIIVGGKKASGSGELRLR-LALALARKLKPDVLILDEIT--SLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTN 124

                          170       180
                   ....*....|....*....|....*
gi 1499888720  355 lnrgstNRTDKKPRPSDLRDSGQIE 379
Cdd:smart00382 125 ------DEKDLGPALLRRRFDRRIV 143
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
25-432 1.17e-135

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 397.14  E-value: 1.17e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  25 FDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRI 100
Cdd:COG0305    19 LDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGEleevGG--AAYLAELAENVPSAANIEYYARI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 101 VLERSALRRVVEAAEVIKDSA-SESLPVADIIALAQQATADLRDLGApdRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GH 178
Cdd:COG0305    97 VKEKALLRRLIEAGTEIVELAyDEDEDVDELLDEAEQKIFEIAEKRS--SKGFVSISDILKEALERIEELYKNGGGItGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAcVDSGVG-LIVSMEMTKEELVTRGIASVGGVSLTRLDE 257
Cdd:COG0305   175 PTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAA-IKEGKPvAIFSLEMSAEQLVMRLLSSEARIDSSKLRT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 258 GhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTA 337
Cdd:COG0305   254 G-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRSENRQQEISEISRS 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PDSEEgqNGVTELIVGKCRHAK 413
Cdd:COG0305   333 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDeyynPDSED--KGIAEIIIAKQRNGP 410

                         410
                  ....*....|....*....
gi 1499888720 414 TGSCLVQQQGQYVRFVNFA 432
Cdd:COG0305   411 TGTVKLAFDGEYTRFENLA 429
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 25-432 1.44e-123

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 366.36  E-value: 1.44e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  25 FDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRI 100
Cdd:TIGR00665  22 IDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGEleevGG--LAYLAELASNVPSAANIEYYAEI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 101 VLERSALRRVVEAA-EVIKDSASESLPVADIIALAQQATADLRDlgAPDRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GH 178
Cdd:TIGR00665 100 VKEKAILRRLIQAGtEIVELAYDPTGDVEELLDEAEQKIFEIAE--SRTSKGFKSIKEILKEAVEEIEELYERKGGItGV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEG 258
Cdd:TIGR00665 178 PTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVMRMLSSESRVDSQKLRTG 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 259 hTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTAL 338
Cdd:TIGR00665 258 -RLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSGSGRSENRQQEVSEISRSL 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 339 KNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PDSEEgqNGVTELIVGKCRHAKT 414
Cdd:TIGR00665 337 KALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDeyynPDSED--KGIAEIIIAKQRNGPT 414

                         410
                  ....*....|....*...
gi 1499888720 415 GSCLVQQQGQYVRFVNFA 432
Cdd:TIGR00665 415 GTVKLAFLGEYTRFENLA 432
phage_DnaB TIGR03600
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ...
 7-421 3.10e-123

phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274672 [Multi-domain]  Cd Length: 420  Bit Score: 365.19  E-value: 3.10e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   7 SLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPSGGRT--LAYASEI 84
Cdd:TIGR03600   1 SIEAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVggLAYLAEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  85 ARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSA--SESLPVADIIALAQQATADLrDLGAPDRKDYYKYSEVLTPV 162
Cdd:TIGR03600  81 SNNTPSAANISSYARIVREKAKERKLIAACQRIITLAcsPDGGTAEQKVEEAQAALLAL-TMSDGQEDGFVTFGEVLEDV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 163 IDGIDSRFNGAKQL-GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVT 241
Cdd:TIGR03600 160 VRDLDKRFNPKGELtGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLGE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 242 RGIASVGGVSLTRLDEGHTlQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRK-EGLGIVVVDYIGLIAA 320
Cdd:TIGR03600 240 RLLASKSGINTGNIRTGRF-NDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKkGGLDLIVVDYIQLMAP 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 321 EgAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQ 398
Cdd:TIGR03600 319 A-RGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGyyDAREPP 397

                         410       420
                  ....*....|....*....|...
gi 1499888720 399 NGVTELIVGKCRHAKTGSCLVQQ 421
Cdd:TIGR03600 398 AGIAELILAKNRHGPTGTVELLF 420
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 179-430 5.56e-104

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 309.83  E-value: 5.56e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEG 258
Cdd:cd00984     3 PTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLRTG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 259 HtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEG-LGIVVVDYIGLIAAEGAGQNRTLELGKISTA 337
Cdd:cd00984    83 R-LDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGgLGLIVIDYLQLIRGSKRAENRQQEVAEISRS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQNGVTELIVGKCRHAKTG 415
Cdd:cd00984   162 LKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEyyDKDSEDKGIAEIIIAKNRNGPTG 241

                         250
                  ....*....|....*
gi 1499888720 416 SCLVQQQGQYVRFVN 430
Cdd:cd00984   242 TVYLAFNPEYTRFTD 256
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 177-430 2.42e-101

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 303.18  E-value: 2.42e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 177 GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLD 256
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 257 EGhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKIST 336
Cdd:pfam03796  81 TG-QLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 337 ALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQnGVTELIVGKCRHAKT 414
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEyyNPKEPE-GKAEIIIAKQRNGPT 238

                         250
                  ....*....|....*.
gi 1499888720 415 GSCLVQQQGQYVRFVN 430
Cdd:pfam03796 239 GTVKLAFLGEYTRFEN 254
PRK05748 PRK05748
replicative DNA helicase; Provisional
 7-432 3.26e-94

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 291.86  E-value: 3.26e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   7 SLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPN---LPS-GGrtLAYAS 82
Cdd:PRK05748   13 SIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDqgdLEEvGG--LSYLA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  83 EIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSASES-LPVADIIALAQQATADLRDlgAPDRKDYYKYSEVLTP 161
Cdd:PRK05748   91 ELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPeDDADEILDEAEKKIFEVSE--RRNKSGFKNIKDVLVK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 162 VIDGIDSRFNGAKQL-GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAC-VDSGVgLIVSMEMTKEEL 239
Cdd:PRK05748  169 AYDRIEMLHNQTGDItGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATkTDKNV-AIFSLEMGAESL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 240 VTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQR-KEGLGIVVVDYIGLI 318
Cdd:PRK05748  248 VMRMLCAEGNIDAQRLRTGQ-LTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQeHGGLGLILIDYLQLI 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 319 AAEG-AGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD----PD 393
Cdd:PRK05748  327 QGSGrSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDdyydEE 406

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1499888720 394 SEEgqNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFA 432
Cdd:PRK05748  407 TEN--KNTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
PRK08760 PRK08760
replicative DNA helicase; Provisional
 6-432 6.17e-92

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 286.81  E-value: 6.17e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   6 YSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNlpSGGRTL----AYA 81
Cdd:PRK08760   35 HSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEWFES--QGKLEQvgdgAYL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  82 SEIARNIPSTANWAGYQRIVLERSALRRVVE-AAEVIKDS-ASESLPVADIIALAQQATADLRDLGAPDRKDYYKYSEVL 159
Cdd:PRK08760  113 IELASTTPSAANIAAYAEIVRDKAVLRQLIEvGTTIVNDGfQPEGRESIELLASAEKAVFKIAEAGARGRTDFVAMPGAL 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 160 TPVIDGIDSRF-NGAKQLGHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEE 238
Cdd:PRK08760  193 KDAFEELRNRFeNGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKGVAVFSMEMSASQ 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 239 LVTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLI 318
Cdd:PRK08760  273 LAMRLISSNGRINAQRLRTGA-LEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREHDLGLIVIDYLQLM 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 319 AAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP---DSE 395
Cdd:PRK08760  352 SVPGNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFIYRDDyynKEN 431

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1499888720 396 EGQNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFA 432
Cdd:PRK08760  432 SPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRFDNLA 468
PRK07004 PRK07004
replicative DNA helicase; Provisional
 6-435 1.21e-87

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 275.25  E-value: 1.21e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   6 YSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVgieYPNLPSGGRT-----LAY 80
Cdd:PRK07004   17 HSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITV---YEALTTSGKAeevggLAY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  81 ASEIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSA--SESLPVADIIALAQQATADLRDLGAPDRKDYYKYSEV 158
Cdd:PRK07004   94 LNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAfnPQGKEVRQLLDEAESKVFSIAEEGARGTQGFLEIGPL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 159 LTPVIDGIDSRFNGAKQ---LGHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIAcVDSGVGLIV-SMEM 234
Cdd:PRK07004  174 LTQVVERIDTLYHTANPsdvTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVA-VEYGLPVAVfSMEM 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 235 TKEELVTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEG-LGIVVVD 313
Cdd:PRK07004  253 PGTQLAMRMLGSVGRLDQHRMRTGR-LTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQCGkLGLIIID 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 314 YIGLIAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD-- 391
Cdd:PRK07004  332 YLQLMSGSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIYRDev 411

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1499888720 392 --PDSEEgqNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFAGNP 435
Cdd:PRK07004  412 ynPDSPD--KGTAEIIIGKQRNGPIGPVRLTFLGQYTKFDNFAGAQ 455
PRK08840 PRK08840
replicative DNA helicase; Provisional
 6-440 3.68e-80

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 256.07  E-value: 3.68e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   6 YSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGiEYPNLPS-----GGrtLAY 80
Cdd:PRK08840   22 HSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLS-EHLERREqledvGG--FAY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  81 ASEIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSA--SESLPVADIIALAQQATADLRDLGAPDRKDYYKYSEV 158
Cdd:PRK08840   99 LADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGydPQGRTSEDLLDMAESKVFAIAEARTSENEGPQNVDSI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 159 LTPVIDGIDSRFNGAKQ--LGHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTK 236
Cdd:PRK08840  179 LEKTLERIELLYKTPQDgvTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQDKPVLIFSLEMPA 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 237 EELVTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSK-LFVCDEEGMTAARIRSTARQVQRKE-GLGIVVVDY 314
Cdd:PRK08840  259 EQLMMRMLASLSRVDQTKIRTGQ-LDDEDWARISSTMGILMEKKnMYIDDSSGLTPTEVRSRARRIAREHgGLSMIMVDY 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 315 IGLIAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD--- 391
Cdd:PRK08840  338 LQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDevy 417

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1499888720 392 -PDSeeGQNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFAGnPRATDE 440
Cdd:PRK08840  418 nPDS--PLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDNYAG-PAFDDE 464
PRK06904 PRK06904
replicative DNA helicase; Validated
 6-440 1.01e-79

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 254.92  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   6 YSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGieyPNLPSGGRT-----LAY 80
Cdd:PRK06904   25 HSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLTLD---QALKTKGKSdevggFAY 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  81 ASEIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSA--SESLPVADIIALAQQ---ATADLRDLGAPDRKDYYKY 155
Cdd:PRK06904  102 LAELSNNTPSAANILAYADIVREKAILRELISVGNNIAKNAysPKGQDIKDILDEAERdvfSIAEKRTTANEGPQNVINL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 156 SEVLTPVIDGIDSRFNGAKQLGHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMT 235
Cdd:PRK06904  182 LENTIDKIENLAATPTNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLVFSLEMP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 236 KEELVTRGIASVGGVSLTRLDEGHTLQDEDWPKITSAVNVL-HHSKLFVCDEEGMTAARIRSTARQVQRKEG-LGIVVVD 313
Cdd:PRK06904  262 AEQIMMRMLASLSRVDQTKIRTGQNLDQQDWAKISSTVGMFkQKPNLYIDDSSGLTPTELRSRARRVYRENGgLSLIMVD 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 314 YIGLIAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP- 392
Cdd:PRK06904  342 YLQLMRAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLIMFIYRDEv 421

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1499888720 393 --DSEEGQNGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFAGNPRATDE 440
Cdd:PRK06904  422 ynETTEDNKGVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNLANIPQYYDK 471
PRK08006 PRK08006
replicative DNA helicase DnaB;
6-440 1.15e-78

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 252.24  E-value: 1.15e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   6 YSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYP---NLPSGGrTLAYAS 82
Cdd:PRK08006   29 HSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLErqgQLDSVG-GFAYLA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  83 EIARNIPSTANWAGYQRIVLERSALRRVVEAAEVIKDSA--SESLPVADIIALAQQATADLRDLGAPDRKDYYKYSEVLT 160
Cdd:PRK08006  108 ELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGydPQGRTSEDLLDLAESRVFQIAESRANKDEGPKNIADILD 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 161 PVIDGIDSRFNGAKQ--LGHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEE 238
Cdd:PRK08006  188 ATVARIEQLFQQPHDgvTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPVLIFSLEMPGEQ 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 239 LVTRGIASVGGVSLTRLDEGHtLQDEDWPKITSAVNVLHHSK-LFVCDEEGMTAARIRSTARQVQRKE-GLGIVVVDYIG 316
Cdd:PRK08006  268 IMMRMLASLSRVDQTRIRTGQ-LDDEDWARISGTMGILLEKRnMYIDDSSGLTPTEVRSRARRIFREHgGLSLIMIDYLQ 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 317 LIAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDPDSEE 396
Cdd:PRK08006  347 LMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHE 426

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1499888720 397 GQN--GVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFAGnPRATDE 440
Cdd:PRK08006  427 NSDlkGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAG-PQYDDE 471
PRK05595 PRK05595
replicative DNA helicase; Provisional
 36-430 6.74e-76

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 244.35  E-value: 6.74e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  36 DFAYDDNAAMYQAIINTHATGQPVDVVTVgIEypNLPS-------GGRTlaYASEIARNIPSTANWAGYQRIVLERSALR 108
Cdd:PRK05595   40 DFYRDSHKVIFSAIIELYQKDIAVDMLTL-TE--NLKStdkleaaGGVT--YITELSNSIVSTANIQSYIKIVKDKSTLR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 109 RVVEAA-EVIKDSASESLPVADIIALAQQATADLRDlgAPDRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GHSSGLKDLD 186
Cdd:PRK05595  115 RLIKSStEIIENSYNNQDDVEKVIDSAEKKIFDISE--KRTTSDFEPLSNVLERGFEQIENLFNNKGETtGVASGFRELD 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 187 ELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEGhTLQDEDW 266
Cdd:PRK05595  193 AKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLEMSKEQLAYKLLCSEANVDMLRLRTG-NLEDKDW 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 267 PKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTALKNMAKELN 346
Cdd:PRK05595  272 ENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHGIDMILIDYLQLMSGGKGSESRQQEVSEISRSIKALAKEME 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 347 VPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQNGVTELIVGKCRHAKTGSCLVQQQGQ 424
Cdd:PRK05595  352 CPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEyyNKETEDKNVAECIIAKQRNGPTGTVKLAWLGQ 431


                  ....*.
gi 1499888720 425 YVRFVN 430
Cdd:PRK05595  432 YSKFGN 437
PRK07773 PRK07773
replicative DNA helicase; Validated
 31-384 5.37e-71

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 241.19  E-value: 5.37e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  31 RITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGRTlaYASEIARNIPSTANWAGYQRIVLERSA 106
Cdd:PRK07773   51 RLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLleriGGAP--YLHTLISTVPTAANADYYARIVAEKAL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 107 LRRVVEAA-EVIKDSASESLPVADIIALAQQATADLRDLGApdRKDYYKYSEVLTPVIDGIDS-RFNGAKQLGHSSGLKD 184
Cdd:PRK07773  129 LRRLIEAGtRIVQYGYAEGADVAEVVDRAQAEIYDVTDRRL--SEDFVALEDLLQPTFDEIDAiASSGGLARGVPTGFTE 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 185 LDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEGHtLQDE 264
Cdd:PRK07773  207 LDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMSKEQLVMRLLSAEAKIKLSDMRSGR-MSDD 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 265 DWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTALKNMAKE 344
Cdd:PRK07773  286 DWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEANLGLIVVDYLQLMTSGKKYENRQQEVSEISRHLKLLAKE 365

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1499888720 345 LNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADV 384
Cdd:PRK07773  366 LEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGDTLI 405
PRK05636 PRK05636
replicative DNA helicase; Provisional
 32-432 1.04e-70

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 232.42  E-value: 1.04e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  32 ITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIE---YPNLPSGGRTlAYASEIARNIPSTANWAGYQRIVLERSALR 108
Cdd:PRK05636   98 LTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVIVAGRldrTNDLERVGGA-PYLHTLIQSVPTAANARYYAEIVSEKAVLR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 109 RVVEAAEVIKD---SASESLPVADIIALAQQATADLRDLGAPDrkDYYKYSEVLTPVIDGIDS-RFNGAKQLGHSSGLKD 184
Cdd:PRK05636  177 RLVDAGTRVVQlgyEGDEGAEIDSVIDRAQQEVFAVSQKNQSE--DYAVLADILDPTMDELEMlSSQGGIATGIPTGFKD 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 185 LDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEGHtLQDE 264
Cdd:PRK05636  255 LDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSLEMSKSEIVMRLLSAEAEVRLSDMRGGK-MDED 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 265 DWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRTLELGKISTALKNMAKE 344
Cdd:PRK05636  334 AWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKHDLKLIVVDYLQLMSSGKRVESRQQEVSEFSRQLKLLAKE 413

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 345 LNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRdPDSEEGQN---GVTELIVGKCRHAKTGSCLVQQ 421
Cdd:PRK05636  414 LDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYR-PDSQDKDDeraGEADIILAKHRGGPIDTVQVAH 492

                         410
                  ....*....|.
gi 1499888720 422 QGQYVRFVNFA 432
Cdd:PRK05636  493 QLHYSRFVDMA 503
PRK09165 PRK09165
replicative DNA helicase; Provisional
 46-432 4.43e-68

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 225.15  E-value: 4.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  46 YQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRIVLErSALRR--------VVEA 113
Cdd:PRK09165   63 YEAIAKIIRKGKLATPVTLKTFLENDEAlgelGG--VQYLAKLATEAVTIINARDYGRIIYD-LALRRelinigedVVNN 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 114 AEvikdSASESLPVADIIALAQQATADLRDLGAPDrKDYYKYSEVLTPVIDGIDSRFNGAKQL-GHSSGLKDLDELIRGL 192
Cdd:PRK09165  140 AY----DAPVDVAPQEQIEDAEQKLYELAETGRYE-GGFQSFGTAITEAVDMANAAFKRDGHLsGISTGLRDLDSKLGGL 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 193 RNKNMIVIAGLPGSGKTTLGVQIAQHIA--------------CVDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRLDEG 258
Cdd:PRK09165  215 HPSDLIILAGRPSMGKTALATNIAFNAAkayrreaqpdgskkAVNGGVVGFFSLEMSAEQLATRILSEQSEISSSKIRRG 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 259 HtLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLI--AAEGAGQNRTLELGKIST 336
Cdd:PRK09165  295 K-ISEEDFEKLVDASQELQKLPLYIDDTPALSISQLRARARRLKRQHGLDLLVVDYLQLIrgSSKRSSDNRVQEISEITQ 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 337 ALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD-------------PDSEEGQN---- 399
Cdd:PRK09165  374 GLKALAKELNIPVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQDADVVMFVYREeyylkrkepregtPKHEEWQEkmek 453

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1499888720 400 --GVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFA 432
Cdd:PRK09165  454 vhNKAEVIIAKQRHGPTGTVKLAFESEFTRFGDLA 488
PRK08506 PRK08506
replicative DNA helicase; Provisional
 4-444 5.53e-61

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 206.01  E-value: 5.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   4 ELYSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEypnLPSGGRtlaYASE 83
Cdd:PRK08506    3 ELYDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKK---LPKDKK---IDEE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  84 IARNIPST---ANWAGYQRIVLERSALRRVVEAAEVIKDSA-SESLPVADIIALAQQATADL-RDLGAPDRKDYykySEV 158
Cdd:PRK08506   77 ILLEILATnpiDNIEAYVEEIKEKSIKRELLSLANTIPEQAvEEDQKSSDILDEVERELYSItNGSNSEDFKDS---KEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 159 LTPVIDGIDSRFN-GAKQL-GHSSGLKDLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIacVDSGVGLIV-SMEMT 235
Cdd:PRK08506  154 IESTMEHIKKQKRlGNKDIiGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKA--LNQDKGVAFfSLEMP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 236 KEELVTRGIASVGGVSLTRLDEGhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQ-RKEGLGIVVVDY 314
Cdd:PRK08506  232 AEQLMLRMLSAKTSIPLQNLRTG-DLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKsQHPEIGLAVIDY 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 315 IGLIAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRD--- 391
Cdd:PRK08506  311 LQLMSGSGNFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDdvy 390

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1499888720 392 ----------PDSEEG--------QNGV---TELIVGKCRHAKTGSCLVQQQGQYVRFVNFAGNPraTDEDVEM 444
Cdd:PRK08506  391 kereekekekKAKKEGkeerrihfQNKSieeAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPIES--HYEEGEE 462
PRK06321 PRK06321
replicative DNA helicase; Provisional
 36-433 1.20e-56

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 194.68  E-value: 1.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  36 DFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPS----GGrtLAYASEIARNIPSTANWAGYQRIVLERSALRRVV 111
Cdd:PRK06321   48 DFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQlnviGG--PSYLITLAEFAGTSAYIEEYAEIIRSKSILRKMI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 112 EAAEVI-KDSASESLPVADIIALAQQATADLRDLGAPdrKDYYKYSEVLTPVIDGID-----------SRFNGAKQLGHS 179
Cdd:PRK06321  126 QTAKEIeKKALEEPKDVATALDEAQNLLFKISQTTNL--AQYVLVADKLKGLTSSKDkpfllqlqerqEAFQQSAQGDSS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 180 SGLK-------DLDELIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIaCVDSGVGL-IVSMEMTKEELVTRGIASVGGVS 251
Cdd:PRK06321  204 PMISgipthfiDLDKMINGFSPSNLMILAARPAMGKTALALNIAENF-CFQNRLPVgIFSLEMTVDQLIHRIICSRSEVE 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 252 LTRLDEGhTLQDEDWPKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLGIVVVDYIGLIAAEG---AGQNRT 328
Cdd:PRK06321  283 SKKISVG-DLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMKESYDIQFLIIDYLQLLSGSGnlrNSESRQ 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 329 LELGKISTALKNMAKELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHR----DPDSEEgqnGVTEL 404
Cdd:PRK06321  362 TEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIEQDSDLVMFLLRreyyDPNDKP---GTAEL 438

                         410       420
                  ....*....|....*....|....*....
gi 1499888720 405 IVGKCRHAKTGSCLVQQQGQYVRFVNFAG 433
Cdd:PRK06321  439 IVAKNRHGSIGSVPLVFEKEFARFRNYAA 467
PRK06749 PRK06749
replicative DNA helicase; Provisional
 31-430 1.36e-54

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 187.85  E-value: 1.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  31 RITTADFAYDDNAAMYQAIINTHATGQPVDVVT-VGIEYPNLPSGGRTLAYASEIARNIPSTANWAGYQRIVLERSALRR 109
Cdd:PRK06749   27 RLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTfTSRVDPNFLKGIGGMEYFIGLMDGVPTTSNFSYYEGLVRGAWKMYQ 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 110 vveaAEVIKDSASESLPV-ADIIALAQQATAdlrdLGAPDRKDYYKYSEVLTPVIDGIDSRFNGAKQL-GHSSGLKDLDE 187
Cdd:PRK06749  107 ----AGVLGHKMGERLIAeKSEKIIGETITA----LCELEEKDCVCEFDLKDALVDLYEELHQDAKEItGIETGYTSLNK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 188 LIRGLRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVGLIvSMEMTKEELVTRGIASVGGVSLTRL-DEGHTLQDEDW 266
Cdd:PRK06749  179 MTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAKSGAAVGLF-SLEMSSKQLLKRMASCVGEVSGGRLkNPKHRFAMEDW 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 267 PKITSAVNVLHHSKLFVCDEEGMTAARIRSTARQVQRKEGLG--IVVVDYIGLIAAEGAGQ-NRTLELGKISTALKNMAK 343
Cdd:PRK06749  258 EKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKkiLIIVDYLQLITGDPKHKgNRFQEISEISRKLKLLAR 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 344 ELNVPVIVLAQLNRGSTNRTDKKPRPSDLRDSGQIEADADVVILVHRDP--DSEEGQNGVTELIVGKCRHAKTGSCLVQQ 421
Cdd:PRK06749  338 ELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDyyDKETMQKEMTEIHVAKHRNGPVGSFKLRF 417


                  ....*....
gi 1499888720 422 QGQYVRFVN 430
Cdd:PRK06749  418 LKEFGRFVE 426
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 198-417 1.23e-19

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 87.63  E-value: 1.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 198 IVIAGLPGSGKTTLGVQIAQHIACV-DSGVGLIvSMEMTKEElVTRGIAsvgGVSLTRLDEGHTLQDEDWPKitsAVNVL 276
Cdd:cd19483     1 VTIGAGSGIGKSTIVRELAYHLITEhGEKVGII-SLEESVEE-TAKGLA---GKHLGKPEPLELPRDDITEE---EEDDA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 277 HHS-----KLFVCDEEG-MTAARIRSTARQVQRKEGLGIVVVDYI-GLIAAEGAGQNRTlELGKISTALKNMAKELNVPV 349
Cdd:cd19483    73 FDNelgsgRFFLYDHFGsLDWDNLKEKIRYMVKVLGCKVIVLDHLtILVSGLDSSDERK-ELDEIMTELAALVKELGVTI 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499888720 350 IVLAQLNRGSTNRTD---KKPRPSDLRDSGQIEADADVVILVHRDPDSE-EGQNGVTELIVGKCRHAK-TGSC 417
Cdd:cd19483   152 ILVSHLRRPGGGKGHeegGEVSESDLRGSSAIAQLSDYVIGLERNKQADdPVERNTTRVRVLKNRFTGeTGIA 224
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
179-410 2.14e-12

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 66.48  E-value: 2.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIR-GLRNKNMIVIAGLPGSGKTTLGVQIAQHiACVDSGVGLIVSMEMTKEELVTRgIASVgGVSLTRLDE 257
Cdd:COG0467     3 PTGIPGLDELLGgGLPRGSSTLLSGPPGTGKTTLALQFLAE-GLRRGEKGLYVSFEESPEQLLRR-AESL-GLDLEEYIE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 258 GHTLQDEDWPKITSAVNVlhhsklfvcdeeGMTAARIRSTARQVQRKeglgIVVVDYIGLIAAEGAGQNRTLElgkISTA 337
Cdd:COG0467    80 SGLLRIIDLSPEELGLDL------------EELLARLREAVEEFGAK----RVVIDSLSGLLLALPDPERLRE---FLHR 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499888720 338 LKNMAKELNVPVIVLAQLNRGSTNRTDkkprpsdlrdsGQIEADADVVILVHRDpdsEEGQNGVTELIVGKCR 410
Cdd:COG0467   141 LLRYLKKRGVTTLLTSETGGLEDEATE-----------GGLSYLADGVILLRYV---ELGGELRRALSVLKMR 199
DnaB pfam00772
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 4-103 2.98e-11

DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.


Pssm-ID: 395624 [Multi-domain]  Cd Length: 103  Bit Score: 59.94  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720   4 ELYSLEAEHGLLGALLLDASLFDAITARITTADFAYDDNAAMYQAIINTHATGQPVDVVTVGIEYPNLPSGGRT--LAYA 81
Cdd:pfam00772   2 PPHNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVggIAYL 81

                          90       100
                  ....*....|....*....|..
gi 1499888720  82 SEIARNIPSTANWAGYQRIVLE 103
Cdd:pfam00772  82 AELAANVPSAANIEYYARIVKE 103
PRK07773 PRK07773
replicative DNA helicase; Validated
 378-432 1.80e-09

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 60.15  E-value: 1.80e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1499888720 378 IEADADVVILVHRD----PDSEEGqnGVTELIVGKCRHAKTGSCLVQQQGQYVRFVNFA 432
Cdd:PRK07773  828 IEQDADVVILLYRPdyydRDDPRG--GEAEFIVAKHRNGPTGTVTLAFQLHLSRFANLA 884
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
185-396 3.09e-09

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 57.99  E-value: 3.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 185 LDELIRG-LRNKNMIVIAGLPGSGKTTLGVQIAQHIAC--------VDSGVGLIVSMEMTKEELVTRGIASVGGVSLTRL 255
Cdd:COG3598     2 RRWLVPGlLPEGGVTLLAGPPGTGKSFLALQLAAAVAAggpwlgrrVPPGKVLYLAAEDDRGELRRRLKALGADLGLPFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 256 DEGHTLQdedwpkITSAVNVLHHSKLfvcdeegmtAARIRSTARQvqrkEGLGIVVVDyiGLIAAEGAGQNRTLELGKIS 335
Cdd:COG3598    82 DLDGRLR------LLSLAGDLDDTDD---------LEALERAIEE----EGPDLVVID--PLARVFGGDENDAEEMRAFL 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1499888720 336 TALKNMAKELNVPVIVLAQLNRGSTNRTDKKprpsDLRDSGQIEADADVVILVHRDPDSEE 396
Cdd:COG3598   141 NPLDRLAERTGAAVLLVHHTGKGGAGKDSGD----RARGSSALRGAARSVLVLSREKGEDL 197
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 179-412 8.76e-07

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 49.57  E-value: 8.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIR-GLRNKNMIVIAGLPGSGKTTLGVQIAqHIACVDSGVGLIVSMEMTKEELVTRGiASVGgvsltrlde 257
Cdd:cd01124     2 KTGIPGLDELLGgGIPKGSVTLLTGGPGTGKTLFGLQFL-YAGAKNGEPGLFFTFEESPERLLRNA-KSFG--------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 258 ghtlQDEDWPKITsavnvlhhSKLFVCDEEGMTAAR-----IRSTARQVQRKEGLGIVVVDYIGLIAAEGAGQNRtleLG 332
Cdd:cd01124    71 ----WDFDEMEDE--------GKLIIVDAPPTEAGRfsldeLLSRILSIIKSFKAKRVVIDSLSGLRRAKEDQMR---AR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 333 KISTALKNMAKELNVPVIVLAQLNRGstnrtdkkpRPSDLRDSGQIEADADVVILVhrdpDSEEGQNGVTELI-VGKCRH 411
Cdd:cd01124   136 RIVIALLNELRAAGVTTIFTSEMRSF---------LSSESAGGGDVSFIVDGVILL----RYVEIEGELRRTIrVLKMRG 202


                  .
gi 1499888720 412 A 412
Cdd:cd01124   203 T 203
AAA_25 pfam13481
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
 188-359 1.08e-06

AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.


Pssm-ID: 463892 [Multi-domain]  Cd Length: 193  Bit Score: 48.92  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 188 LIRGLRNKN-MIVIAGLPGSGKTTLGVQIAQHIA----------CVDSGVGLIVSMEMTKEELVTRGIASvggvsltrld 256
Cdd:pfam13481  25 LIKGLLPAGgLGLLAGAPGTGKTTLALDLAAAVAtgkpwlggprVPEQGKVLYVSAEGPADELRRRLRAA---------- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 257 eGHTLQDEDWPKITSAVNVLhhsKLFVCDEEGMTAAR-IRSTARQVQRKEGLGIVVVDyiGLIAAEGAGQNRTLELGKIS 335
Cdd:pfam13481  95 -GADLDLPARLLFLSLVESL---PLFFLDRGGPLLDAdVDALEAALEEVEDPDLVVID--PLARALGGDENSNSDVGRLV 168

                         170       180
                  ....*....|....*....|....
gi 1499888720 336 TALKNMAKELNVPVIVLAQLNRGS 359
Cdd:pfam13481 169 KALDRLARRTGATVLLVHHVGKDG 192
PRK05973 PRK05973
replicative DNA helicase; Provisional
 187-374 1.55e-06

replicative DNA helicase; Provisional


Pssm-ID: 168322 [Multi-domain]  Cd Length: 237  Bit Score: 49.26  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 187 ELIRGLRNKNMIVIAGLPGSGKTTLGVQIAqhIACVDSG-VGLIVSMEMTKEELVTRgiasvggvsLTRLDEGHTlqded 265
Cdd:PRK05973   56 ELFSQLKPGDLVLLGARPGHGKTLLGLELA--VEAMKSGrTGVFFTLEYTEQDVRDR---------LRALGADRA----- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 266 wpkitsavnvlHHSKLFVCD-EEGMTAARIrstARQVQRKEGLGIVVVDYIGLIaaegaGQNR-TLELGKISTALKNMAK 343
Cdd:PRK05973  120 -----------QFADLFEFDtSDAICADYI---IARLASAPRGTLVVIDYLQLL-----DQRReKPDLSVQVRALKSFAR 180

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1499888720 344 ELNVPVIVLAQLNRgSTNRTdKKPRPsDLRD 374
Cdd:PRK05973  181 ERGLIIVFISQIDR-SFDPS-AKPLP-DIRD 208
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 179-252 2.05e-06

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 48.50  E-value: 2.05e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1499888720 179 SSGLKDLDELIRG-LRNKNMIVIAGLPGSGKTTLGVQIAQHIACVDsGVGLIVSMEMTKEELvtRGIASVGGVSL 252
Cdd:cd19488     2 STGIPGLDDILRGgLPPRRLYLVEGAPGTGKTTLALQFLLEGAANG-ETGLYITLSETEQEL--RAVALSHGWSL 73
41 PHA02542
41 helicase; Provisional
 191-383 1.54e-05

41 helicase; Provisional


Pssm-ID: 222864 [Multi-domain]  Cd Length: 473  Bit Score: 47.36  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 191 GLRNKNM-IVIAGLpGSGKTTLGVQIAQhiACVDSGVG-LIVSMEMTKEELVTRGIASVGGVSLTRLDeghtlqDEDWPK 268
Cdd:PHA02542  186 GAERKTLnVLLAGV-NVGKSLGLCSLAA--DYLQQGYNvLYISMEMAEEVIAKRIDANLLDVSLDDID------DLSKAE 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 269 ITSAVNVLHHS---KLFVCD--EEGMTAARIRSTARQVQRKEGL--GIVVVDYIGLIAA---EGAGQNRTLELGKISTAL 338
Cdd:PHA02542  257 YKAKMEKLRSKtqgKLIIKQypTGGAHAGHFRALLNELKLKKNFkpDVIIVDYLGICASsrlRVSSENSYTYVKAIAEEL 336

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1499888720 339 KNMAKELNVPVIVLAQLNRGSTNRTDkkPRPSDLRDSGQIEADAD 383
Cdd:PHA02542  337 RGLAVEHDVVVWTAAQTTRSGWDSSD--VDMSDTAESAGLPATAD 379
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 179-354 1.71e-04

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 42.69  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELIRGLRNKNMIV-IAGLPGSGKTTLGVQIAqhIACVDSGVGLI-VSMEmtkeelvtrgiasvgGVSLTRLD 256
Cdd:cd01394     2 STGSKSLDSLLGGGVERGTITqIYGPPGSGKTNICLQLA--VEAAKQGKKVVyIDTE---------------GLSPERFQ 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 257 EghtLQDEDWPKITSAVNVLHHSKLfvcDEEGMTAARIRSTArqvqRKEGLGIVVVDYIGLI--AAEGAGQNRTLELGKI 334
Cdd:cd01394    65 Q---IAGERFESIASNIIVFEPYSF---DEQGVAIQEAEKLL----KSDKVDLVVVDSATALyrLELGDDSEANRELSRQ 134

                         170       180
                  ....*....|....*....|
gi 1499888720 335 STALKNMAKELNVPVIVLAQ 354
Cdd:cd01394   135 MSKLLSIARKYDIPVVITNQ 154
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 195-379 2.36e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  195 KNMIVIAGLPGSGKTTLGVQIAQHIACVDSGVgLIVSMEMTKEElvtrgiasvggvsltrldeghtlqdedwpkitsAVN 274
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGV-IYIDGEDILEE---------------------------------VLD 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720  275 VLHHSKLFVCDEEGMTAARIRsTARQVQRKEGLGIVVVDYIGliAAEGAGQNRTLELGKISTALKNMAKELNVPVIVLAQ 354
Cdd:smart00382  48 QLLLIIVGGKKASGSGELRLR-LALALARKLKPDVLILDEIT--SLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTN 124

                          170       180
                   ....*....|....*....|....*
gi 1499888720  355 lnrgstNRTDKKPRPSDLRDSGQIE 379
Cdd:smart00382 125 ------DEKDLGPALLRRRFDRRIV 143
ATPase pfam06745
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ...
 179-259 5.59e-04

KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.


Pssm-ID: 429095 [Multi-domain]  Cd Length: 231  Bit Score: 41.46  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499888720 179 SSGLKDLDELI-RGLRNKNMIVIAGLPGSGKTTLGVQIAQHiACVDSGV-GLIVSMEMTKEELVtRGIASVgGVSLTRL- 255
Cdd:pfam06745   2 KTGIPGLDEILkGGFPEGRVVLITGGPGTGKTIFGLQFLYN-GALKYGEpGVFVTLEEPPEDLR-ENARSF-GWDLEKLe 78


                  ....
gi 1499888720 256 DEGH 259
Cdd:pfam06745  79 EEGK 82
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
197-222 6.79e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.20  E-value: 6.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1499888720 197 MIVIAGLPGSGKTTLGVQIAQHIACV 222
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAV 26
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
193-218 6.98e-03

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 37.84  E-value: 6.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 1499888720 193 RNKNMIVIAGLPGSGKTTLGVQIAQH 218
Cdd:COG1428     1 MKPRYIAVEGNIGAGKTTLARLLAEH 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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